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Co-infection between tuberculosis and malaria : a consideration on
Co-infection between tuberculosis and malaria : a consideration on

... Human immunodeficiency virus (HIV) infection/ acquired immunodeficiency syndrome (AIDS) and malaria are counted as worst diseases for the following: (i) together cause 4 million deaths every year; and (ii) pregnant women are at high risk of developing anaemia and infection of placenta1. Children bor ...
How do vaccines work Feb 2017
How do vaccines work Feb 2017

... • proteins • polysaccharides • others ...
Introduction to monoclonal antibodies
Introduction to monoclonal antibodies

... like cytokines in the blood and tissue interstitium thereby preventing these molecules from binding to their receptors and thus, preventing cytokine activation of the receptors (A). Alternatively, antibodies or therapeutic mAbs can bind to target receptors on a cell surface to block its activation. ...
Antibodies: Structure and Function Chpt. 4
Antibodies: Structure and Function Chpt. 4

... – Even though same isotypes within one species small differences (1-4 a/a) arise in different individuals (form of polymorphism) – If injected with such Ab you generate antiallotype Ab • Ex. During pregnancy • Blood transfusion ...
Antibodies: Structure and Function Chpt. 4
Antibodies: Structure and Function Chpt. 4

... – Even though same isotypes within one species small differences (1-4 a/a) arise in different individuals (form of polymorphism) – If injected with such Ab you generate antiallotype Ab • Ex. During pregnancy • Blood transfusion ...
BIO 401
BIO 401

... 11. Finally, additional diversity arises throughout the variable region but predominantly at the hypervariable regions (CDR regions) from somatic hypermutation rates exclusively in the variable region (not spilling over into the constant region). The diversity, which arises from the hypermutation, i ...
Monoclonal Antibodies as a novel class of cancer therapeutics
Monoclonal Antibodies as a novel class of cancer therapeutics

... The human HER-2/neu (c-erbB2) gene product, like the epidermal growth factor receptor, is a transmembrane receptor protein that includes an intracellular tyrosine kinase domain. ...
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幻灯片 1

... Dominant Epitope Epitope in primary immune response Cryptic Epitope Epitope in continuous immune response ...
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Cross‐presentation of malaria antigen by brain microvessels: why

... Cerebral malaria (CM) is one of the most serious complications of Plasmodium falciparum malaria. The disease mainly affects children under five in endemic areas and is the leading cause of death. Red blood cells (RBCs) infected with P. falciparum express parasite‐derived molecules on the surface, whi ...
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| Specific antigen(s) in sarcoidosis: a link to autoimmunity?

... Pulmonary sarcoidosis is a systemic granulomatous disease of unknown origin characterised by an increase in immune cells in the lower respiratory tract, mainly macrophages and CD4+ T-cells. These cells bear signs of regular activation by a nominal antigen, and release cytokines and chemokines shapin ...
Crabtree2
Crabtree2

... activation. However, null mutants of the IL-2, IL2 receptor, Jnk, NFAtc2 and a number of other positive signaling molecules also show paradoxical activation. Nevertheless CTLA4 is very likely to be a negative regulator of the antigen receptor signaling pathway acting by competing for B7 which is the ...
Blood group terminology 2004: from the International Society of
Blood group terminology 2004: from the International Society of

... consists of one or more antigens controlled at a single gene locus, or by two or more very closely linked homologous genes with little or no observable recombination between them. Each system has been shown to be genetically discrete from every other system. Collections consist of serologically, bio ...
BLOOD
BLOOD

... Red Blood Cells continued… • Lifespan is 120 days • Erythropoeisis- Formation of new red blood cells. Near the end of the process, red cells eject their nucleus, which causes the indentation • Anemia- lower than normal RBCs or hemoglobin • Hypoxia- Deficiency of oxygen – Signals for erythropoiesis ...
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... 1. Phagocytosis is a component of innate and aquired immunity. It is the principal means of destroying pathogenic bacteria and fungi. Phagocytosis initiates the process of antigen presentation. 2. Many phagocytic receptors recognize a diverse array of microbial pathogens. Some pathogens (e.g., S. pn ...
BKLR1
BKLR1

... It is clear that the above model does not contain empty moves and so it is real-time. With this transducer, we simulate the self and non-self recognition process of the vertebrates' immune system [5]. Alternatively, we can construct the detector transducer in such way, that the binding sites are wo ...
Dermatrust report, March 2013 During last year my research has
Dermatrust report, March 2013 During last year my research has

... antigen challenge in young and old individuals. Over the last couple of years our group has been studying immune responses to VZV by injecting old and young volunteers with VZV antigen into the skin of the forearm and subsequently sampling the injected skin site by either taking a biopsy or performi ...
Cardiovascular
Cardiovascular

... 3. Formed elements include: erythrocytes (RBC), leukocytes (WBC), platelets (thrombocytes which are cell fragments from megakaryocyte). Origin of blood: Blood cells originate in red bone marrow from hematopoietic stem cells (pluripotent or hematocytoblasts). These in turn will differentiate (progeni ...
中六生物科教材
中六生物科教材

... 3. Memory - formation of specific memory cells in the immune response so that the second invasion of the same antigen will result in a more rapid, stronger and long-lasting response (secondary response). Memory is absent in non-specific immune response. 10. Explain inflammatory response. Phagocytosi ...
Adaptive Immunity
Adaptive Immunity

... immune response and react with products of that response • Most are large, complex molecules • Antigenic determinant sites (epitopes) – site on antigen that reacts with specific antibody or T cell receptor – valence is number of epitopes on an antigen ...
Complexities of the Dombrock blood group system
Complexities of the Dombrock blood group system

... Based on the knowledge that the Do glycoprotein is attached to the RBC membrane via a GPI linkage, and on the assignment of the DO to the short arm of chromosome 12,37 expressed sequence tags from terminally differentiating human erythroid cells were analyzed in silico. A candidate gene, DOK1, was d ...
Antigen design and administration
Antigen design and administration

... processing, or phosphorylation of certain sequences on the protein. However, whilst antibodies raised against peptides will recognize the peptide, it does not always follow that the antibody directed against the peptide will recognize the native protein because the synthetic peptide may not sufficie ...
Basic Antibody Structure
Basic Antibody Structure

... - The IgA and IgM found in external secretions differs from that found in serum by the presence of an additional component referred to as the "secretory component". ...
Nursing of Adult Patients with Medical & Surgical Conditions
Nursing of Adult Patients with Medical & Surgical Conditions

... – Transplantation of tissue between members of the same species ...
Answers to Chapter 43 worksheet
Answers to Chapter 43 worksheet

... bacterium making molecular recognition difficult. ...
Yersinia enterocolitica immunodominant 60 kDa antigen, common to a
Yersinia enterocolitica immunodominant 60 kDa antigen, common to a

... Willem et al. (1985) suggested that arthritis was induced by a T-cell clone which recognized an epitope on the mycobacterial 65 kDa antigen. The development of the arthritis-like Reiter’s syndrome is often preceded by various bacterial infections, e.g. with Y . enterocolitica, Shigella jlexneri, Sal ...
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Duffy antigen system

Duffy antigen/chemokine receptor (DARC) also known as Fy glycoprotein (FY) or CD234 (Cluster of Differentiation 234) is a protein that in humans is encoded by the DARC gene.The Duffy antigen is located on the surface of red blood cells, and is named after the patient in which it was discovered. The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The protein is also the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system.
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