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UNIT 7: Immunology and Vaccinology
UNIT 7: Immunology and Vaccinology

...  A refrigerator for storing vaccines  cold boxes for transporting and storing vaccines  Ice packs to keep vaccines cool  Material to separate ice packs from the vaccines when using cold boxes (e.g. shredded paper, cardboard, bubble wrap or Styrofoam). Refrigerators and Freezers It is recommended ...
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... In vertebrates, we speak mainly of two defense mechanisms: specific and nonspecific. The specific includes two methods of defense or protection from some diseases: innate and adaptive immunity. Innate immunity is the first line of defense against microorganisms (skin and some specialized cells that ...
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Lecture 2 - Immunology of TB
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... Practical Intro to Equipment for Infection Control – Bruce Gamage Review Answers to Descriptive Epidemiology assignment (Ebola) Herd Immunity Exercise Assigned (Due in 2 weeks) Readings: Nelson Review chapter 14 4. January 28, 2012 – Herd Immunity and Community Control Measures The Reproductive Numb ...
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Correlates of Protection against Norovirus Infection
Correlates of Protection against Norovirus Infection

... genetic diversity poses a potential problem in developing vaccination strategies to prevent infection and illness. While most infections are caused by the GII.4 genotype, new variants emerge every two to three years, replacing the previously dominant variant [1]. The epochal evolution of strains and ...
Virus and Immune Response
Virus and Immune Response

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Ebola virus disease and vaccine

... The first replicating Ebola virus vaccine shown to be protective in NHPs . It was identified by the WHO expert panel as one of the most advanced candidates for use in the West Africa outbreak. In this vaccine, the VSV GP was replaced with ZEBOV (Zaire Ebola virus) GP. A transient rVSV viremia may oc ...
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Herd immunity



Herd immunity (also called herd effect, community immunity, population immunity, or social immunity) is a form of indirect protection from infectious disease that occurs when a large percentage of a population has become immune to an infection, thereby providing a measure of protection for individuals who are not immune. In a population in which a large number of individuals are immune, chains of infection are likely to be disrupted, which stops or slows the spread of disease. The greater the proportion of individuals in a community who are immune, the smaller the probability that those who are not immune will come into contact with an infectious individual.Individual immunity can be gained through recovering from a natural infection or through artificial means such as vaccination. Some individuals cannot become immune due to medical reasons and in this group herd immunity is an important method of protection. Once a certain threshold has been reached, herd immunity will gradually eliminate a disease from a population. This elimination, if achieved worldwide, may result in the permanent reduction in the number of infections to zero, called eradication. This method was used for the eradication of smallpox in 1977 and for the regional elimination of other diseases. Herd immunity does not apply to all diseases, just those that are contagious, meaning that they can be transmitted from one individual to another. Tetanus, for example, is infectious but not contagious, so herd immunity does not apply.The term herd immunity was first used in 1923. It was recognized as a naturally occurring phenomenon in the 1930s when it was observed that after a significant number of children had become immune to measles, the number of new infections temporarily decreased, including among susceptible children. Mass vaccination to induce herd immunity has since become common and proved successful in preventing the spread of many infectious diseases. Opposition to vaccination has posed a challenge to herd immunity, allowing preventable diseases to persist in or return to communities that have inadequate vaccination rates.
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