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Tubersol - VaccineShoppeCanada
Tubersol - VaccineShoppeCanada

... Due to immature immune systems, many infants <6 months of age who are infected with M. tuberculosis do not react to tuberculin tests. (4) Older infants and children develop tuberculin sensitivity 3-6 weeks or more after initial infection. (4) Pregnant Women Animal reproduction studies have not been ...
2013 Alternative vaccine delivery methods
2013 Alternative vaccine delivery methods

... (see Chapter 32), as well as for administering bacille CalmetteGuérin (BCG) to prevent tuberculosis (see Chapter 35). The cutaneous route has both demonstrated and hypothetical advantages over other delivery methods, as described here and as reviewed by others.23–44 Reduced dosages of various vaccin ...
Pharmacology - www . paulnika . com
Pharmacology - www . paulnika . com

... Describe the onset and offset of neuromuscular block at the diaphragm, larynx and adductor pollicis after administration of 2.5 x ED 95 dose of vecuronium. Comment on the differences observed. What are the clinical implications of these differences?(03a) ...
Shock - Calgary Emergency Medicine
Shock - Calgary Emergency Medicine

... vessels will decrease due to clot formation, vasoconstriction etc Fluid resus may increase hemorrhage: • Raises BP increasing hydraulic pressure • Vasodilate • Dilute clotting factors ...
hepatitis resource guide
hepatitis resource guide

... some of the vaccination and screening sites have limitations of who may use their services. You are encouraged to call a testing/screening site to confirm that this information is still current. Glossary of acronyms and terms used in this guide: HAV: Hepatitis A virus HBV: Hepatitis B virus HCV: Hep ...
Viral Exanthems - American Academy of Dermatology
Viral Exanthems - American Academy of Dermatology

...  Exanthems are rashes that occur abruptly and affect multiple areas of the skin simultaneously.  Morbilliform means “composed of erythematous macules and papules that resemble a measles rash.”  Distinct viral exanthems are seen in measles, rubella, erythema infectiosum, and roseola infantum.  Ca ...
Section III - Immunization of Special Populations
Section III - Immunization of Special Populations

... are at particular risk of infection with encapsulated bacteria such as Streptococcus pneumonia (pneumococcal), Neisseria meningitidis (meningococcal), and Haemophilus influenzae type b (Hib). In some immunocompromised individuals, even a less than optimal response to vaccine may provide important be ...
editorial contents
editorial contents

... have a much more immediate appeal. And it is undeniable that for many centuries both human and animal physicians were preoccupied with reacting to ailments and attempting to subdue them; they had little time to consider how they might get ahead of the game, but gradually the clearest thinkers, those ...
Slide 1
Slide 1

... • Approved by the FDA in April 2007 • Intended for use in adults from 18 to 65 years of age and is given as two doses one month apart • Vaccine will not be sold commercially; instead it will be purchased by the US government for inclusion in the National Stockpile for distribution by public health o ...
Varicella (Chickenpox) and Herpes Zoster (Shingles): Healthcare Professionals
Varicella (Chickenpox) and Herpes Zoster (Shingles): Healthcare Professionals

... • Two live attenuated varicella virus vaccines licensed for use in US: Varivax® and Proquad® • Both vaccines may be used for first and second doses of varicella vaccine • Varivax ® (1,400 pfu) is the single-antigen varicella vaccine licensed in 1995 for use among healthy persons aged ≥ 12 months • P ...
Ocular Effects of Serotonin Antidepressants
Ocular Effects of Serotonin Antidepressants

... been reported with duloxetine.12 This effect does not seem to cause major visual discomfort or problems, unless it becomes associated with a dramatic increase in IOP and with eventual glaucoma attacks. The mydriatic effects of SSRIs are likely to be reversible after cessation of therapy, especially ...
2016 MnVFC Replacement Method Sites: Policies and Procedures Manual (PDF)
2016 MnVFC Replacement Method Sites: Policies and Procedures Manual (PDF)

... MnVFC-eligible children and the MnVFC program replaces the private vaccine that was administered. Only sites with grandfathered status are allowed to use the replacement method. If you received this version of the 2017 manual, you have been identified by MDH as a replacement method site. If you beli ...
Immunisation Guidelines for Ireland
Immunisation Guidelines for Ireland

... The year in which each of the principal childhood vaccines was introduced to Ireland is indicated at the start of the relevant chapter. Changes to recommended immunisation schedule Since the publication of the last version of these guidelines in 2002 there have been a number of changes to the recomm ...
Sydney Arthur Monckton Copeman (1862-1947)
Sydney Arthur Monckton Copeman (1862-1947)

... Daniel made only one puncture-and they claimed to have inoculated 20,000 persons without a single fatality. Another inoculator, named Adams, succeeded in obtaining a very attenuated virus which usually gave rise to only one vesicle at the site of puncture and a very mild form of smallpox. A notewort ...
Topical Steroid Workshop
Topical Steroid Workshop

... • A reluctance to use prescribed topical steroids due to perceived side effects • Reassurance is essential to gain full concordance with treatment. REMEMBER: Appropriate topical steroid use limits potential side effects almost entirely. ...
Infection Prevention and Control in Residential Facilities for
Infection Prevention and Control in Residential Facilities for

... orative effort began with a needs assessment1 and establishment of a memorandum of understanding between SHEA and RMHC. While RMHC was involved in establishing this effort, the intention has always been to create a guideline that could be used by any such residential facility. If a familycentered re ...
Travel Immunizations - American Academy of Family Physicians
Travel Immunizations - American Academy of Family Physicians

... – Repeat after 3 years, then every 5 years ...
Minnesota Vaccines for Children Separate Stock Clinics: Policies and Procedures Manual 2015
Minnesota Vaccines for Children Separate Stock Clinics: Policies and Procedures Manual 2015

... MnVFC Requirements vs. Best Practices Federal law established the VFC program and set the policies that govern it, as described in this manual. The manual simplifies MnVFC requirements in a way we hope will be clear and workable for you. For that reason, it does not try to cover the full range of im ...
Dose-Response Study of N,N-Dimethyltryptamine in Humans
Dose-Response Study of N,N-Dimethyltryptamine in Humans

... research setting. Thus, the neuroendocrine, cardiovascular, and autonomic (pupil diameter and rectal temperature) effects of graded doses of DMT, in 11 experienced hallucinogen users, were described in the preceding article [14]. However, the generalizability of animal to human data is more problema ...
Biological Feasibility of Measles Eradication
Biological Feasibility of Measles Eradication

... Recent progress in reducing global measles mortality has renewed interest in measles eradication. Three biological criteria are deemed important for disease eradication: (1) humans are the sole pathogen reservoir; (2) accurate diagnostic tests exist; and (3) an effective, practical intervention is a ...
Maintenance asthma medication
Maintenance asthma medication

... person to specific allergens that trigger their allergy symptoms. • IT is not effective for food allergies or intolerances, irritants such as cigarette smoke, odors or fumes. • Allergy mixtures are tailored specifically for each patient based on their standardized skin tests. Our board certified all ...
File - Briaunna Burgi E
File - Briaunna Burgi E

... How is the diagnosis of ASD made? Clinical research requires objective and reliable diagnoses. In clinical practice, history and observation can be augmented by several screening tools (eg, Childhood Autism Rating Scale, Pervasive Developmental Disorder Screening Test, Checklist for Autism in Toddle ...
Tetanus Toxoid For Booster Use Only
Tetanus Toxoid For Booster Use Only

... Following routine use of tetanus toxoid in the United States (US), the occurrence of tetanus decreased dramatically from 560 reported cases in 1974 to an average of 50-100 cases reported annually from the mid 1970s through the late 1990s. The case-fatality rate has been relatively constant at approx ...
Infectious Disease Assessment for Migrants
Infectious Disease Assessment for Migrants

... • All children aged 12 months to <10 years according to the “late entrants catch-up schedule” Vaccinate if non-immune (vaccination not required in anti-HBc positive): • All migrants originating from countries with a prevalence of ≥2% • Children born to parents from countries with a prevalence of ...
mortality trends of hiv-infected patients after the introduction of highly
mortality trends of hiv-infected patients after the introduction of highly

... was used to perform univariate, bivariate, and multivariate analyses. Univariate analysis described the frequencies of antiviral drugs regimens used, mortality rates, and demise causes. Quality differences between patient groups were analyzed with the chi-square or the Fisher exact test. Risk ratios ...
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Non-specific effect of vaccines



Non-specific effects of vaccines (also called “heterologous effects"" or ""off-target effects"") are effects which go beyond the specific protective effects against the targeted diseases. Non-specific effects can be strongly beneficial, increasing protection against non-targeted infections, but also at times negative, increasing susceptibility to non-targeted infections. This depends on both the vaccine and the sex of the infant.All live attenuated vaccines studied so far (BCG vaccine, measles vaccine, oral polio vaccine, smallpox vaccine) have been shown to reduce mortality more than can be explained by prevention of the targeted infections. In contrast, inactivated vaccines (diphtheria-tetanus-pertussis vaccine (DTP), hepatitis B vaccine, inactivated polio vaccine) may increase overall mortality despite providing protection against the target diseases.These effects may be long-lasting, at least up to the time point where a new type of vaccine is given. The non-specific effects can be very pronounced, with significant effects on overall mortality and morbidity. In a situation with herd immunity to the target disease, the non-specific effects can be more important for overall health than the specific vaccine effects.The non-specific effects should not be confused with the side effects of vaccines (such as local reactions at the side of vaccination or general reactions such as fever, head ache or rash, which usually resolve within days to weeks - or in rare cases anaphylaxis). Rather, non-specific effects represent a form of general immunomodulation, with important consequences for the immune system’s ability to handle subsequent challenges.It is estimated that millions of child deaths in low income countries could be prevented every year if the non-specific effects of vaccines were taken into consideration in immunization programs.
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