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Lecture Outline ()
Lecture Outline ()

... • thromboxane A2, an eicosanoid that promotes aggregation, degranulation & vasoconstriction ...
Document
Document

... phagocytize the immune complexes these cells will degranulate in the area of immune complex deposition and trigger inflammation. Unable to eat -------try to digest outside cell. ...
Hypersensitivity TYPE I Hypersensitivity Classic allergy Allergens
Hypersensitivity TYPE I Hypersensitivity Classic allergy Allergens

... causing inflammation and tissue damage. – Continued macrophage activation can cause chronic inflammation resulting in tissue lesions, scarring, and granuloma formation.  Delayed is relative because DTH response arise 24-72 hours after exposure rather than within minutes. ...
Chapter 17: Specific Host Defenses
Chapter 17: Specific Host Defenses

... plasma, lymph, mucus, etc.) and the surface of B cells.  Defense against bacteria, bacterial toxins, and viruses that circulate freely in body fluids, before they enter ...
PowerPoint Presentation - I. Introduction to class
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... plasma, lymph, mucus, etc.) and the surface of B cells.  Defense against bacteria, bacterial toxins, and viruses that circulate freely in body fluids, before they enter ...
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Section 18 Immunity in the Fetus and Newborn

... the intestine 5-14 days later. • There is an early intestinal IgM response that switch to IgA by 2 weeks. ...
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The Immune System

... certain bacteria, fungi, etc.) that could invade the body. But, some pathogens make it into the body. Most of them are devoured or destroyed before they can do much harm. ...
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TITLE of LESSON Immune system – Components of the immune

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... Cyotkines, that drive the polarization of Classically Activated Macrophages (M1/Pro-inflammatory) are TNFa and IFN-g. Figure: “The Early TNF-a response at day 1 is significantly higher in γδ T-cell-deficient mice suggesting that these Gamma Delta T-cells regulate TNF-a expression. ...
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... • ~20 blood proteins that circulate in an inactive form • Include C1–C9, factors B, D, and P, and regulatory proteins • Major mechanism for destroying foreign substances ...
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... pain, redness, heat, and swelling. The inflammatory response is beneficial and has the following functions: To destroy the cause of the infection and remove it and its products from the body. If this fails, to limit the effects on the body by confining the infection to a small area. ...
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... • Some globulins are produced in the liver and are transport proteins for lipids, metal ions, and fat-soluble vitamins. • Other globulins are produced by plasma cells (a type of leukocyte) during the immune response. These globulins are also known as antibodies. – Clotting proteins • Most produced i ...
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Zinc Importer ZIP2 and the Dendritic Cell Response to Histoplasma

... When exposed to heat-killed Hc, CD40 high, CD80 high, and MHCII high cell populations increased by 21.1%, 19.6%, and 40.6% respectively in ZIP2 silenced BMDCs compared to scramble RNA controls. In ZIP2 silenced BMDCs exposed to live Hc, CD40 high, CD80 high, and MHCII high populations increased by 1 ...
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... from the blood capillaries and into the spaces within the tissues to provide food, oxygen, and hormones to the cells. – Lymph fluid is the remaining or left over interstitial fluid that has not been reabsorbed into the blood. It removes cellular waste products, pathogens, and dead blood cells from t ...
The Immune Response
The Immune Response

... Helper T (CD4) cells help other immune cells. Some helper T cells help B cells produce antibodies against foreign antigens. Others help activate killer T cells to kill foreign or abnormal cells or help activate macrophages enabling them to ingest foreign or abnormal cells more efficiently.  The Th1 ...
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... – People survived ravages of epidemic diseases when faced with the same disease again – Immunity: The state of protection from infectious disease ...
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IgM Humoral immune response to thymus

... neutralize and eliminate extracellular pathogens and their toxins Cell mediators of humoral immunity are B lymphocites ...
BIOL212ImmuneSystemNotes
BIOL212ImmuneSystemNotes

... Antibodies may also bind to toxins in body fluids and prevent them from entering body cells In opsonization, antibodies bind to antigens on bacteria creating a target for macrophages or neutrophils, triggering phagocytosis Antigen-antibody complexes may bind to a complement protein—which triggers a ...
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Complement system



The complement system is a part of the immune system that helps or complements the ability of antibodies and phagocytic cells to clear pathogens from an organism. It is part of the innate immune system, which is not adaptable and does not change over the course of an individual's lifetime. However, it can be recruited and brought into action by the adaptive immune system.The complement system consists of a number of small proteins found in the blood, in general synthesized by the liver, and normally circulating as inactive precursors (pro-proteins). When stimulated by one of several triggers, proteases in the system cleave specific proteins to release cytokines and initiate an amplifying cascade of further cleavages. The end-result of this activation cascade is massive amplification of the response and activation of the cell-killing membrane attack complex. Over 30 proteins and protein fragments make up the complement system, including serum proteins, serosal proteins, and cell membrane receptors. They account for about 5% of the globulin fraction of blood serum and can serve as opsonins.Three biochemical pathways activate the complement system: the classical complement pathway, the alternative complement pathway, and the lectin pathway.
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