Stratifying prostate cancer patients into phases of care in the UK
... We present new 2010 estimates for prostate cancer and comparative figures for breast, colorectal and lung cancer (Figure 3). The number of patients going through the care pathway in a specific year with prostate cancer is estimated to be around 266,000 in 2010 (including flows in and out). Around a ...
... We present new 2010 estimates for prostate cancer and comparative figures for breast, colorectal and lung cancer (Figure 3). The number of patients going through the care pathway in a specific year with prostate cancer is estimated to be around 266,000 in 2010 (including flows in and out). Around a ...
selective activation of members of the signal transducers and
... of the STAT family in human prostate cancer tissues. Our results demonstrate that in addition to Stat3, Stat6 is selectively activated in prostate cancer. Stat6 activity levels in the tumor were significantly higher than in matched normal prostates adjacent to tumors or in normal prostates from nonc ...
... of the STAT family in human prostate cancer tissues. Our results demonstrate that in addition to Stat3, Stat6 is selectively activated in prostate cancer. Stat6 activity levels in the tumor were significantly higher than in matched normal prostates adjacent to tumors or in normal prostates from nonc ...
Prostate Cancer - Statistics Canada
... (Chart 2). When the percentage who reported being tested in the previous year was considered, just two provinces differed significantly from the national figure: Ontario, which at almost 29% was high, and Alberta, which at 21% was low. Sharp rise in incidence in early 1990s In 1998, 16,163 men aged ...
... (Chart 2). When the percentage who reported being tested in the previous year was considered, just two provinces differed significantly from the national figure: Ontario, which at almost 29% was high, and Alberta, which at 21% was low. Sharp rise in incidence in early 1990s In 1998, 16,163 men aged ...
Male Reproductive System
... o Some men are affected by age 50, but most are affected by age 85 o Enlarged mucosal & submucosal prostatic glands ...
... o Some men are affected by age 50, but most are affected by age 85 o Enlarged mucosal & submucosal prostatic glands ...
PSA screening for prostate cancer
... first treatment shown to prolong life in prostate cancer in prospective and randomized trials using combination with non steroidal antiandrogens,6–9 we realized that only a few months of life could be added in patients with metastatic disease using the best available treatment which we had just deve ...
... first treatment shown to prolong life in prostate cancer in prospective and randomized trials using combination with non steroidal antiandrogens,6–9 we realized that only a few months of life could be added in patients with metastatic disease using the best available treatment which we had just deve ...
Contemporary hormone therapy with LHRH agonists for prostate
... Oral oestrogen (diethylstilbestrol – DES) was originally one of the main therapeutic options for treating prostate cancer. While many studies confirmed its efficacy of androgen suppression, and even improved overall survival, thorough analyses revealed it was associated with life-threatening cardiov ...
... Oral oestrogen (diethylstilbestrol – DES) was originally one of the main therapeutic options for treating prostate cancer. While many studies confirmed its efficacy of androgen suppression, and even improved overall survival, thorough analyses revealed it was associated with life-threatening cardiov ...
Correction: Imputation of the Rare HOXB13 G84E Mutation and
... The sentence “The age-specific risk of prostate cancer among G84E mutation carriers was higher than among non-carriers, and this difference increased with age.” in the abstract is incorrect. The correct sentence is: “The age-specific risk of prostate cancer among G84E mutation carriers was higher th ...
... The sentence “The age-specific risk of prostate cancer among G84E mutation carriers was higher than among non-carriers, and this difference increased with age.” in the abstract is incorrect. The correct sentence is: “The age-specific risk of prostate cancer among G84E mutation carriers was higher th ...
Prostate cancer in the African-Caribbean community
... of prostate cancer in African-American men.13 SNPs within the CYP3A4 gene cause a genetic variant CYP3A4*1B, which is associated with aggressive characteristics in African-American men diagnosed with prostate cancer.14 TMPRSS2 is an androgen-responsive protease specific to prostate cells and ERG is ...
... of prostate cancer in African-American men.13 SNPs within the CYP3A4 gene cause a genetic variant CYP3A4*1B, which is associated with aggressive characteristics in African-American men diagnosed with prostate cancer.14 TMPRSS2 is an androgen-responsive protease specific to prostate cells and ERG is ...
Comparison of Recommendations by Urologists and
... BOUT 180 400 MEN WILL BE diagnosed as having prostate cancer in the United States this year, most with clinically localized disease.1 The majority of these men will choose among 3 primary therapies: radical prostatectomy, external beam radiotherapy, or brachytherapy. The choice among these therapies ...
... BOUT 180 400 MEN WILL BE diagnosed as having prostate cancer in the United States this year, most with clinically localized disease.1 The majority of these men will choose among 3 primary therapies: radical prostatectomy, external beam radiotherapy, or brachytherapy. The choice among these therapies ...
Lipoidal permeability central to drug ADME
... unbound concentration in TBW. • Apparent accumulation is membrane binding in tissues. • PPB not important in vivo. • Less lipoidal permeable drugs can be excluded (brain) or accumulated (liver) in certain tissues • Lyosomal accumulation may not be active drug. ...
... unbound concentration in TBW. • Apparent accumulation is membrane binding in tissues. • PPB not important in vivo. • Less lipoidal permeable drugs can be excluded (brain) or accumulated (liver) in certain tissues • Lyosomal accumulation may not be active drug. ...
Screening programme for cancers
... no screening for five years. More liver cancers were detected in the screened group, but the two groups did not differ significantly regarding liver cancer mortality. – 2. Alpha-fetoprotein plus ultrasound screening vs alphafetoprotein screening. This trial, with an inadequate sample size, showed no ...
... no screening for five years. More liver cancers were detected in the screened group, but the two groups did not differ significantly regarding liver cancer mortality. – 2. Alpha-fetoprotein plus ultrasound screening vs alphafetoprotein screening. This trial, with an inadequate sample size, showed no ...
Anemia in Men With Advanced Prostate Cancer - hem
... • Anemia in men with advanced prostate cancer may be caused by several factors, including androgen deprivation, nutritional decline, bone marrow infiltration, treatment-related toxicity, and the chronic inflammatory state. • Castration is a well-documented cause of anemia. Combined androgen blockade ...
... • Anemia in men with advanced prostate cancer may be caused by several factors, including androgen deprivation, nutritional decline, bone marrow infiltration, treatment-related toxicity, and the chronic inflammatory state. • Castration is a well-documented cause of anemia. Combined androgen blockade ...
Annals of Internal Medicine - Urological Sciences Research
... Clinicians and policymakers should understand the evidence but individualize decision-making to the specific patient or ...
... Clinicians and policymakers should understand the evidence but individualize decision-making to the specific patient or ...
Diagnosis and Treatment of Localized Prostate Cancer
... a measure of the glandular architecture. Tumor cells with a lower score are more capable of forming glandularappearing tissue than cells with a higher score. The pathologist grades the most prevalent cells in a tumor on a scale of 1 to 5, with 1 generally being the most differentiated and 5 being th ...
... a measure of the glandular architecture. Tumor cells with a lower score are more capable of forming glandularappearing tissue than cells with a higher score. The pathologist grades the most prevalent cells in a tumor on a scale of 1 to 5, with 1 generally being the most differentiated and 5 being th ...
Provenge
... No visceral metastasis, pathologic long bone fracture, or spinal cord compression Life expectancy of greater than 6 months Serum prostate-specific antigen (PSA) level of 5 ng/ml or more Serum testosterone level less than 50 ng/dl (17 nmol/l) Progressive disease based on imaging studies or PSA measur ...
... No visceral metastasis, pathologic long bone fracture, or spinal cord compression Life expectancy of greater than 6 months Serum prostate-specific antigen (PSA) level of 5 ng/ml or more Serum testosterone level less than 50 ng/dl (17 nmol/l) Progressive disease based on imaging studies or PSA measur ...
PA12-04 Cook Lay summary Principal Investigator: Professor Gary
... There are supportive preclinical data confirming that other forms of imaging can target osteoclasts (bone cells) and tumour blood vessel formation and preliminary human data confirming uptake in bone metastases in prostate cancer. However, there are no studies specifically investigating the ability ...
... There are supportive preclinical data confirming that other forms of imaging can target osteoclasts (bone cells) and tumour blood vessel formation and preliminary human data confirming uptake in bone metastases in prostate cancer. However, there are no studies specifically investigating the ability ...
Sensitivity and Specificity of International Prostate Symptom Score
... the present study showed that the total IPSS score was significantly higher in the cancerous patients, and also the mean score of IPSS in different categories of severity were higher in them, but in the severe category, the IPSS score was significantly higher in the case group. Also, results showed ...
... the present study showed that the total IPSS score was significantly higher in the cancerous patients, and also the mean score of IPSS in different categories of severity were higher in them, but in the severe category, the IPSS score was significantly higher in the case group. Also, results showed ...
2014 Five-Year Relative Survival Rates Top Five Causes of Cancer
... Number of approvals, including new indications ...
... Number of approvals, including new indications ...
