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A Genetics Perspective On Prostate Cancer
A Genetics Perspective On Prostate Cancer

... To date, the most definitive risk factors for prostate cancer are age, race/ethnicity, and family history. The disease affects primarily older men, with men over the age of 65 at highest risk (Zwang et al., 2003). Approximately 32% of all patients are diagnosed before the age of 65 (Ostrander, Marki ...
Patients diagnosed with metastatic breast, lung and prostate
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... IOD) of AR staining in nuclei of the tumor biopsy specimens (Video Pro 32; Leading Edge P/L, Adelaide, South Australia and Leica Australia P/L). Briefly, images ofAR staining were captured using a Panasonic and, from these measurements, the mean receptor level per nucleus color CCD video camera (mod ...
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tumor markers and PET/CT imaging for tumor recurrence Serum detection
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Cancer EPID 624 - Epidemiology of Chronic Disease
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... o Modifiable risk factors for cancer in general. o Exercise o Diet ...
Prostate Cancer - Alberta Health Services
Prostate Cancer - Alberta Health Services

...  Serum PSA should be checked in fit men between the ages of 50 and 75 years, where clinically indicated.  Serum PSA screening increases the detection rate of early stage clinically significant prostate cancers; early detection may improve overall survival.(7)  Fit men between the ages of 50 and 7 ...
transforming growth factor beta and prostate cancer
transforming growth factor beta and prostate cancer

... inhibits the in vivo growth of cancer xenografts via induction of apoptosis and upregulation of the cell cycle inhibitor p27fiP1[lo] In addition, prostate cancer cells that exhibit up-regulation of the TGF-P and downregulation of their receptors, can also locally inhibit immune surveillance of prost ...
Prostate Cancer Risk Management Programme PSA testing in asymptomatic men
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Comparative effectiveness research in localized prostate cancer

... The Institute of Medicine designated prostate cancer treatment for localized (earlystage) disease as one of the 25 most important areas for comparative effectiveness research (Box 1) [101]. The advent of prostate-specific antigen (PSA) testing in the late 1980s has led to an epidemic of prostate can ...
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... treatment will be most effective. 3. Cancer treatment is becoming increasingly effective, with the result that survival times in certain types of cancer now exceed 5years for more then half the patients in developed countries. However, 5year survival rate is around 20% in many developing countries, ...
Intra-tibial injection of human prostate cancer cell line CWR22 elicits
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... We investigated the utility of CWR22 human prostate cancer cells for modeling human metastatic prostate cancer, specifically their ability to induce bone formation following intra-tibial injections in the nude rat. Prostate cancer is unique in regard to its tropism for bone and ability to induce new ...
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human prostate cancer precursors and pathobiology
human prostate cancer precursors and pathobiology

... COX-2. We also found a consistent increase of staining for COX-2 in a fraction of the epithelial cells in proliferative inflammatory atrophy (PIA) lesions (see discussion of PIA below). Western blotting and quantitative reverse transcriptasepolymerase chain reaction analyses confirmed these patterns ...
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Prostate-specific antigen

Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), is a glycoprotein enzyme encoded in humans by the KLK3 gene. PSA is a member of the kallikrein-related peptidase family and is secreted by the epithelial cells of the prostate gland. PSA is produced for the ejaculate, where it liquefies semen in the seminal coagulum and allows sperm to swim freely. It is also believed to be instrumental in dissolving cervical mucus, allowing the entry of sperm into the uterus.PSA is present in small quantities in the serum of men with healthy prostates, but is often elevated in the presence of prostate cancer or other prostate disorders. The United States Preventive Services Task Force (USPSTF, 2012) does not recommend PSA screening, noting that the test may result in “overdiagnosis” and “overtreatment” because ""most prostate cancer is asymptomatic for life"" and treatments involve risks of complications including impotence (erectile dysfunction) and incontinence. The USPSTF concludes ""the potential benefit does not outweigh the expected harms."" PSA is not a unique indicator of prostate cancer, but may also detect prostatitis or benign prostatic hyperplasia. 30 percent of patients with high PSA have prostate cancer diagnosed after biopsy.
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