Schrodinger Workshop
... workshop will consist of both lecture and hands-on application using tools in Schrodinger’s Small Molecule Drug Discovery Suite. Topics covered will include methods for structure preparation, small molecule library preparation, and using the Maestro graphical user interface. Session 2: Structure-bas ...
... workshop will consist of both lecture and hands-on application using tools in Schrodinger’s Small Molecule Drug Discovery Suite. Topics covered will include methods for structure preparation, small molecule library preparation, and using the Maestro graphical user interface. Session 2: Structure-bas ...
What is a peptide?
... For chronic disease, bid SC injections may not be convenient Long-acting release (LAR) was achieved by less soluble salt form with biodegradable polymers – once-monthly IM administration Drug release rate is controlled in LAR with less peak-to-trough fluctuation than sc injections, thereby min ...
... For chronic disease, bid SC injections may not be convenient Long-acting release (LAR) was achieved by less soluble salt form with biodegradable polymers – once-monthly IM administration Drug release rate is controlled in LAR with less peak-to-trough fluctuation than sc injections, thereby min ...
Product Monograph
... Symptomatic hypotension has occurred after administration of MAVIK® usually after the first or second dose or when the dose was increased. It is more likely to occur in patients who are volume and salt depleted as a result of diuretic therapy, dietary salt restriction, dialysis, diarrhea, or vomitin ...
... Symptomatic hypotension has occurred after administration of MAVIK® usually after the first or second dose or when the dose was increased. It is more likely to occur in patients who are volume and salt depleted as a result of diuretic therapy, dietary salt restriction, dialysis, diarrhea, or vomitin ...
Modafinil Enhances Two-Year Outcome from Monoamine Oxidase
... changes in cellular and tissue structure, impairing neuroplasticity [47]. Some areas of the brain may not recover with treatment, resulting in permanent alterations of neuroplasticity [8]. Mood disorders have a societal impact through days lost from work [9]. The World Health Organization has identi ...
... changes in cellular and tissue structure, impairing neuroplasticity [47]. Some areas of the brain may not recover with treatment, resulting in permanent alterations of neuroplasticity [8]. Mood disorders have a societal impact through days lost from work [9]. The World Health Organization has identi ...
A Population Model, as made by Breugel!
... Develop the dosage regimen to “hit target” But will it? How precisely? How to evaluate the expected precision? ...
... Develop the dosage regimen to “hit target” But will it? How precisely? How to evaluate the expected precision? ...
Medicines and Falls in Hospital
... Medicines and Falls in Hospital All patients should have their drug burden reviewed with respect to its propensity to cause falls. The history should establish the reason the drug was given, when it started, whether it is effective and what its side effects have been. An attempt should be made to re ...
... Medicines and Falls in Hospital All patients should have their drug burden reviewed with respect to its propensity to cause falls. The history should establish the reason the drug was given, when it started, whether it is effective and what its side effects have been. An attempt should be made to re ...
Safety Pharmacology for Oncology Pharmaceuticals at CDER
... for cytotoxic agents for treatment of end-stage cancer patients. However, for cytotoxic agents with novel mechanisms of action, there may be value in conducting safety pharmacology studies.” ...
... for cytotoxic agents for treatment of end-stage cancer patients. However, for cytotoxic agents with novel mechanisms of action, there may be value in conducting safety pharmacology studies.” ...
Postoperative bleeding in CABG Patients: New Study in Southwest
... of some drugs surgery can be a good way to reduce the risk of bleeding after surgery ornonuse of some drugs can reduce the risk of bleeding after surgery with a minimum of morbidity and mortality. It is suggested that other researchers after designing clinical trials and using lower doses for effect ...
... of some drugs surgery can be a good way to reduce the risk of bleeding after surgery ornonuse of some drugs can reduce the risk of bleeding after surgery with a minimum of morbidity and mortality. It is suggested that other researchers after designing clinical trials and using lower doses for effect ...
First Major European Viral Hepatitis Study Reports Serious Gaps in
... viral hepatitis. The European region can and should take the lead in implementing it. These Hep-CORE results serve as an unprecedented analysis of regional and national gaps, clearly showing where there are deficient policies and, by default, what action needs to be taken.” For example, despite an u ...
... viral hepatitis. The European region can and should take the lead in implementing it. These Hep-CORE results serve as an unprecedented analysis of regional and national gaps, clearly showing where there are deficient policies and, by default, what action needs to be taken.” For example, despite an u ...
Recommendations for nondrug therapy
... Mechanisms of action of diuretics. Sixty percent of filtered sodium is resorbed in the proximal convoluted tubule (obligatory resorption). The more distal segments of the nephron can modulate excretion of only a fraction of the total filtered sodium. Diuretics that impair sodium resorption in the th ...
... Mechanisms of action of diuretics. Sixty percent of filtered sodium is resorbed in the proximal convoluted tubule (obligatory resorption). The more distal segments of the nephron can modulate excretion of only a fraction of the total filtered sodium. Diuretics that impair sodium resorption in the th ...
Treatment Outcomes in Patients Receiving Combination
... a large proportion of those infected, while younger ages, primary and secondary education levels, were associated with higher risk of HIV infection with 5.9 % and 5.4 % prevalence, respectively [1,4]. The problem of HIV/AIDS in Nigeria further compounds the nation’s poor health indices. The Nigerian ...
... a large proportion of those infected, while younger ages, primary and secondary education levels, were associated with higher risk of HIV infection with 5.9 % and 5.4 % prevalence, respectively [1,4]. The problem of HIV/AIDS in Nigeria further compounds the nation’s poor health indices. The Nigerian ...
Antihypertensive-Drugs.15.Mar.2011
... sympathetic activity (use is not associated with reflex tachycardia) Inhibition of aldosterone secretion contributes to the antihypertensive effects of ACE-I Influence on the arteriolar and left ventricular remodelling that are believed to be important in the pathogenesis of human essential hyperten ...
... sympathetic activity (use is not associated with reflex tachycardia) Inhibition of aldosterone secretion contributes to the antihypertensive effects of ACE-I Influence on the arteriolar and left ventricular remodelling that are believed to be important in the pathogenesis of human essential hyperten ...
What is Bioavailability and Bioequivalence?
... Bioequivalence studies are a surrogate marker for clinical effectiveness and safety data as it would not normally be is accepted that if plasma concentrations of the active ingredient of the generic and innovator medicines are the same, then their concentration at the site of action and therefore th ...
... Bioequivalence studies are a surrogate marker for clinical effectiveness and safety data as it would not normally be is accepted that if plasma concentrations of the active ingredient of the generic and innovator medicines are the same, then their concentration at the site of action and therefore th ...
Clinical Discussion of Special Populations - M
... – A drug under review for approval is expected to be used by women of reproductive age – After approval, use of a drug in lactating women becomes evident (e.g., via reports in the medical literature or lay press) – A new indication is being sought for an approved drug and there is evidence of use or ...
... – A drug under review for approval is expected to be used by women of reproductive age – After approval, use of a drug in lactating women becomes evident (e.g., via reports in the medical literature or lay press) – A new indication is being sought for an approved drug and there is evidence of use or ...
guide on handling look alike, sound alike medications
... Look Alike Sound Alike (LASA) medications involve medications that are visually similar in physical appearance or packaging and names of medications that have spelling similarities and/or similar phonetics. As more medicines and new brands are being marketed in addition to the thousands already ava ...
... Look Alike Sound Alike (LASA) medications involve medications that are visually similar in physical appearance or packaging and names of medications that have spelling similarities and/or similar phonetics. As more medicines and new brands are being marketed in addition to the thousands already ava ...
FDA approves first buprenorphine implant for
... obligations, as well as the possibility of the development of tolerance or development of physical dependence. Physical dependence is not the same as addiction. Newer diagnostic terminology uses the term “opioid use disorder,” which includes both milder forms of problematic opioid use as well as ad ...
... obligations, as well as the possibility of the development of tolerance or development of physical dependence. Physical dependence is not the same as addiction. Newer diagnostic terminology uses the term “opioid use disorder,” which includes both milder forms of problematic opioid use as well as ad ...
Progress in the treatment of rheumatic disease
... Immuno-adsorption For refractory cases of RA, immuno-adsorption with a protein A column has been applied with reasonable success and without major side effects [19]. The use of this treatment can be offered in desperate cases. ...
... Immuno-adsorption For refractory cases of RA, immuno-adsorption with a protein A column has been applied with reasonable success and without major side effects [19]. The use of this treatment can be offered in desperate cases. ...
Conversion verapamil to diltiazem
... Available brands for generic Diltiazem with manufacturers details. Click on the desired brand to find out the drug price. In recent years, management strategies for atrial fibrillation have expanded significantly, and new drugs for ventricular rate control and rhythm conversion have been. Atrial fib ...
... Available brands for generic Diltiazem with manufacturers details. Click on the desired brand to find out the drug price. In recent years, management strategies for atrial fibrillation have expanded significantly, and new drugs for ventricular rate control and rhythm conversion have been. Atrial fib ...
Provision or distribution of growth hormone for
... In the United States, GH is commonly marketed, distributed, and prescribed for antiaging under the pretext of “offlabel use.”14 However, off-label distribution or marketing of GH to treat aging or aging-related conditions is illegal. Unlike most FDA-approved medications, GH can only be distributed f ...
... In the United States, GH is commonly marketed, distributed, and prescribed for antiaging under the pretext of “offlabel use.”14 However, off-label distribution or marketing of GH to treat aging or aging-related conditions is illegal. Unlike most FDA-approved medications, GH can only be distributed f ...
new recreational drug use
... during the course of treatment. Further, because therapy for a drug-related toxic effect can be at direct odds with that for another, physicians need to carefully prioritise medical issues. Additional challenges exist for clinicians in an outpatient setting, because they are less likely to encounter ...
... during the course of treatment. Further, because therapy for a drug-related toxic effect can be at direct odds with that for another, physicians need to carefully prioritise medical issues. Additional challenges exist for clinicians in an outpatient setting, because they are less likely to encounter ...
Marijuana exposure in animals
... drug testing can help confirm exposure, but the amount of drug ingested, time elapsed since ingestion, and water consumption after ingestion may affect the results.1 Increased water consumption may elicit a false negative result.6 Obtaining an accurate history can be difficult in cases of illicit dr ...
... drug testing can help confirm exposure, but the amount of drug ingested, time elapsed since ingestion, and water consumption after ingestion may affect the results.1 Increased water consumption may elicit a false negative result.6 Obtaining an accurate history can be difficult in cases of illicit dr ...
GHB or gamma-hydroxybutyrate
... doses, anaesthetic properties (that means it knocks you out). Depressant drugs slow brain and central nervous system activity. GHB has been identified as a 'date-rape drug' because it leaves users with amnesia, impaired movement and speech. It can be easily camouflaged in drinks as it is difficult t ...
... doses, anaesthetic properties (that means it knocks you out). Depressant drugs slow brain and central nervous system activity. GHB has been identified as a 'date-rape drug' because it leaves users with amnesia, impaired movement and speech. It can be easily camouflaged in drinks as it is difficult t ...
Bad Pharma
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Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients is a book by British physician and academic Ben Goldacre about the pharmaceutical industry, its relationship with the medical profession, and the extent to which it controls academic research into its own products. The book was published in September 2012 in the UK by the Fourth Estate imprint of HarperCollins, and in February 2013 in the United States by Faber and Faber.Goldacre argues in the book that ""the whole edifice of medicine is broken"" because the evidence on which it is based is systematically distorted by the pharmaceutical industry. He writes that the industry finances most of the clinical trials into its own products and much of doctors' continuing education, that clinical trials are often conducted on small groups of unrepresentative subjects and negative data is routinely withheld, and that apparently independent academic papers may be planned and even ghostwritten by pharmaceutical companies or their contractors, without disclosure. Goldacre calls the situation a ""murderous disaster,"" and makes suggestions for action by patients' groups, physicians, academics and the industry itself.Responding to the book's publication, the Association of the British Pharmaceutical Industry issued a statement arguing that the examples the book offers are historical, that the concerns have been addressed, that the industry is among the most regulated in the world, and that it discloses all data in accordance with international standards.In January 2013 Goldacre joined the Cochrane Collaboration, British Medical Journal and others in setting up AllTrials, a campaign calling for the results of all past and current clinical trials to be reported. The British House of Commons Public Accounts Committee expressed concern in January 2014 that drug companies were still only publishing around 50 percent of clinical-trial results.