Treatment of late stage sleeping sickness caused by T.b. gambiense
... total protein binding of melarsoprol is 79% as determined by ultrafiltration [14]. The exact mode of action of melarsoprol remains unclear, but the drug was shown to unspecifically bind to disulphide moieties of proteins [15]. Early studies performed in urine indicated that melarsoprol was only elim ...
... total protein binding of melarsoprol is 79% as determined by ultrafiltration [14]. The exact mode of action of melarsoprol remains unclear, but the drug was shown to unspecifically bind to disulphide moieties of proteins [15]. Early studies performed in urine indicated that melarsoprol was only elim ...
EVALUATION OF TAMARIND SEED POLYSACCHARIDE AS ABIODEGRADABLE CARRIER FOR COLON SPECIFIC DRUG DELIVERY
... drug delivery. Hence an attempt was made to develop matrix tablet based formulation using TSP which protects the drug in upper GIT and release the major amount of drug in colon due to degradation by bacterial enzymes. The matrix tablets were prepared by wet granulation techniqu ...
... drug delivery. Hence an attempt was made to develop matrix tablet based formulation using TSP which protects the drug in upper GIT and release the major amount of drug in colon due to degradation by bacterial enzymes. The matrix tablets were prepared by wet granulation techniqu ...
NURSING PROCESS FOCUS Clients Receiving Conventional
... Drugs in the nonphenothiazine class have the same therapeutic effects and efficacy as the phenothiazines. They are also believed to act by the same mechanism as the phenothiazines, that is, by blocking postsynaptic D2 dopamine receptors. As a class, they offer no significant advantages over the phen ...
... Drugs in the nonphenothiazine class have the same therapeutic effects and efficacy as the phenothiazines. They are also believed to act by the same mechanism as the phenothiazines, that is, by blocking postsynaptic D2 dopamine receptors. As a class, they offer no significant advantages over the phen ...
Combination Antipsychotics: Pros, Cons, and Questions
... use of combination antipsychotic medications is increasing since the advent of second generation antipsychotics, despite the extreme paucity of evidence for (or against) this practice. It is worth noting that in the initial decades after the introduction of first generation antipsychotics in North A ...
... use of combination antipsychotic medications is increasing since the advent of second generation antipsychotics, despite the extreme paucity of evidence for (or against) this practice. It is worth noting that in the initial decades after the introduction of first generation antipsychotics in North A ...
Is Hepatitis Virus Resistance to Antiviral Drugs a Threat?
... patient, all possible single, double, and possibly triple mutants are generated each day and can be selected by DAA administration.14 The pre-existence of viral variants bearing amino acid substitutions that confer resistance to the different classes of drugs in treatment-naive patients has been sho ...
... patient, all possible single, double, and possibly triple mutants are generated each day and can be selected by DAA administration.14 The pre-existence of viral variants bearing amino acid substitutions that confer resistance to the different classes of drugs in treatment-naive patients has been sho ...
Drugs for Pulmonary Arterial Hypertension – Project Protocol
... The availability of two new PAH drugs — macitentan and potentially riociguat — in Canada will augment the complexity of PAH therapy, including options for combination therapy; the latter being based on the concurrent use of drugs with different mechanisms of action. There are two possibilities for c ...
... The availability of two new PAH drugs — macitentan and potentially riociguat — in Canada will augment the complexity of PAH therapy, including options for combination therapy; the latter being based on the concurrent use of drugs with different mechanisms of action. There are two possibilities for c ...
Aspirin - Welcome to lipmed.org
... address unmet health needs. Additionally, Bayer provides education and supports charitable organizations that encourage patient/physician dialogue about cardiovascular disease risk and management. ...
... address unmet health needs. Additionally, Bayer provides education and supports charitable organizations that encourage patient/physician dialogue about cardiovascular disease risk and management. ...
Rise of Hallucinogen Use
... was dismissed from Harvard for promoting LSD, but he continued to advocate its use as a positive mind-altering experience and identified psychedelics as part of a countercultural or lifestyle choice. Although nonmedical use of LSD continued to rise throughout the 1960s, scientific interest declined. ...
... was dismissed from Harvard for promoting LSD, but he continued to advocate its use as a positive mind-altering experience and identified psychedelics as part of a countercultural or lifestyle choice. Although nonmedical use of LSD continued to rise throughout the 1960s, scientific interest declined. ...
Searching Databases - Creighton University
... This is especially true of writing in professional and scientific journals. The third point to remember is that computer retrieval systems search for words not for concepts. They only find items with the word combinations you ask for. If you ask most search systems to search for the term fruit they ...
... This is especially true of writing in professional and scientific journals. The third point to remember is that computer retrieval systems search for words not for concepts. They only find items with the word combinations you ask for. If you ask most search systems to search for the term fruit they ...
Side-effects of antituberculosis drug treatment in patients with chronic renal failure
... A high incidence of side-effects associated with antituberculous drug treatment in patients with chronic renal failure was found, occurring in 11 of 24 (46%) patients overall and nine of 16 (56%) dialysis patients. This resulted in a change in antituberculous medication in most cases and is in marke ...
... A high incidence of side-effects associated with antituberculous drug treatment in patients with chronic renal failure was found, occurring in 11 of 24 (46%) patients overall and nine of 16 (56%) dialysis patients. This resulted in a change in antituberculous medication in most cases and is in marke ...
Analgesia and sedation in emergency situations and in the pediatric
... an anxiolytic, inducing rapid sedation and its main advantage is that it causes short-term memory loss. It is four times more powerful than diazepam. Respiratory depression is dose-dependent and hypotension might occur in hypovolemic patients, even with the administration of moderate doses. After th ...
... an anxiolytic, inducing rapid sedation and its main advantage is that it causes short-term memory loss. It is four times more powerful than diazepam. Respiratory depression is dose-dependent and hypotension might occur in hypovolemic patients, even with the administration of moderate doses. After th ...
Medical Billing and Coding Program
... Pharmacy Technicians may work in retail pharmacies, mail order pharmacies, home infusion pharmacies, long term care facilities, hospitals, clinics, pharmacy benefit managers and large industrial complexes. The demand for Pharmacy Technicians continues to grow with demand expected to increase substan ...
... Pharmacy Technicians may work in retail pharmacies, mail order pharmacies, home infusion pharmacies, long term care facilities, hospitals, clinics, pharmacy benefit managers and large industrial complexes. The demand for Pharmacy Technicians continues to grow with demand expected to increase substan ...
Case
... Ventricular Rate Control: Drugs Compared with placebo, beta-blockers are associated with a reduced risk of new-onset AF in patients with HFrEF and sinus rhythm. Beta-blockers have also been reported to reduce symptomatic AF recurrences, but this finding may be driven by the beneficial effect of r ...
... Ventricular Rate Control: Drugs Compared with placebo, beta-blockers are associated with a reduced risk of new-onset AF in patients with HFrEF and sinus rhythm. Beta-blockers have also been reported to reduce symptomatic AF recurrences, but this finding may be driven by the beneficial effect of r ...
Twynsta
... The frequency of adverse reactions was not related to gender, age, or race. The adverse reactions that occurred in the placebo-controlled factorial design trial in ≥2% of patients treated with TWYNSTA and at a higher incidence in TWYNSTA-treated patients (n=789) than placebotreated patients (n=46) w ...
... The frequency of adverse reactions was not related to gender, age, or race. The adverse reactions that occurred in the placebo-controlled factorial design trial in ≥2% of patients treated with TWYNSTA and at a higher incidence in TWYNSTA-treated patients (n=789) than placebotreated patients (n=46) w ...
The role of adherence in tuberculosis HIV-positive patients treated in
... recover from tuberculosis. The mortality was 14.3%, much higher than the 4.7% for the global fatality rate of tuberculosis in Portugal [19]. Immunosuppression associated with HIV infection contributes to the development of tuberculosis [2, 7, 11]. In the current study, no association between the lev ...
... recover from tuberculosis. The mortality was 14.3%, much higher than the 4.7% for the global fatality rate of tuberculosis in Portugal [19]. Immunosuppression associated with HIV infection contributes to the development of tuberculosis [2, 7, 11]. In the current study, no association between the lev ...
Lecture : Contents : Treatment of Urinary Tract Infection
... di & tri-valent cations ( Ca, Mg, Fe, AL) impair absorption Protein binding 40-80 % Distributed well, including , prostatic tissues (so it can be used with patient who has Prostatitis ) Cross placenta and excreted in milk ...
... di & tri-valent cations ( Ca, Mg, Fe, AL) impair absorption Protein binding 40-80 % Distributed well, including , prostatic tissues (so it can be used with patient who has Prostatitis ) Cross placenta and excreted in milk ...
Prescribing Information
... Influenza can be associated with a variety of neurologic and behavioral symptoms that can include events such as hallucinations, delirium, and abnormal behavior, in some cases resulting in fatal outcomes. These events may occur in the setting of encephalitis or encephalopathy but can occur in uncomp ...
... Influenza can be associated with a variety of neurologic and behavioral symptoms that can include events such as hallucinations, delirium, and abnormal behavior, in some cases resulting in fatal outcomes. These events may occur in the setting of encephalitis or encephalopathy but can occur in uncomp ...
Development of Tamper Deterrent Formulations
... incentivized the pharmaceutical industry to search for innovative solutions. The best approach to address prescription opioid abuse is to develop molecules that can alleviate pain but have no or minor euphoric and physical dependence effects. Thus far, no molecules with these attributes have been su ...
... incentivized the pharmaceutical industry to search for innovative solutions. The best approach to address prescription opioid abuse is to develop molecules that can alleviate pain but have no or minor euphoric and physical dependence effects. Thus far, no molecules with these attributes have been su ...
Betnesol Preparations
... In patients with liver failure, blood levels of corticosteroid may be increased, as with other drugs which are metabolized by the liver. Psychic derangements may appear when corticosteroids are used, ranging from euphoria, insomnia, mood swings, personality changes, and severe depression, to frank p ...
... In patients with liver failure, blood levels of corticosteroid may be increased, as with other drugs which are metabolized by the liver. Psychic derangements may appear when corticosteroids are used, ranging from euphoria, insomnia, mood swings, personality changes, and severe depression, to frank p ...
comparative efficacy of combined use of diclofenac with
... glycinomimetic activity and is being used in rheumatology and orthopedic field for its myorelaxant property8.It has been reported that thiocolchicoside produces muscle relaxation without any subjective or objective sedative side effects7 as well as anti-inflammatory and analgesic effects 9. METHODOL ...
... glycinomimetic activity and is being used in rheumatology and orthopedic field for its myorelaxant property8.It has been reported that thiocolchicoside produces muscle relaxation without any subjective or objective sedative side effects7 as well as anti-inflammatory and analgesic effects 9. METHODOL ...
February-March 2015 - Medical Arts Pharmacy
... of the NSAID. Proton pump-inhibitors (PPIs), such as Pantoloc (pantoprazole) or Prevacid (lansoprazole), is the drug class of choice for prevention of stomach bleeding from NSAID use. PPIs help to reduce the acid that the stomach makes which helps to protect patients from potential bleeding with NSA ...
... of the NSAID. Proton pump-inhibitors (PPIs), such as Pantoloc (pantoprazole) or Prevacid (lansoprazole), is the drug class of choice for prevention of stomach bleeding from NSAID use. PPIs help to reduce the acid that the stomach makes which helps to protect patients from potential bleeding with NSA ...
Pharmacology as a tool to dose individualize cancer therapy
... 1. What is the optimal starting (labeled) dose for the indicated population? – Historically, the optimal starting dose was the maximal safe dose, usually as determined in phase 1 studies • <1/3 of patients with DLT ...
... 1. What is the optimal starting (labeled) dose for the indicated population? – Historically, the optimal starting dose was the maximal safe dose, usually as determined in phase 1 studies • <1/3 of patients with DLT ...
Guidelines for Medicines Optimisation in Patients with Acute Kidney
... Is the patient taking any other medications which could exacerbate AKI? Consider withholding them. Is the patient prescribed any medications where the dose needs to be amended in renal impairment? Amend medication doses appropriate to the patient’s degree of renal impairment. In house guidelines for ...
... Is the patient taking any other medications which could exacerbate AKI? Consider withholding them. Is the patient prescribed any medications where the dose needs to be amended in renal impairment? Amend medication doses appropriate to the patient’s degree of renal impairment. In house guidelines for ...
Physicians` attitude towards voluntary reporting of adverse drug
... practitioners (GPs), medical specialists (MSs – internists, cardiologists, anesthetists, rheumatologists, gastroenterologists, neurologists, and psychiatrists), surgical specialists (SSs) and pediatric specialists (PSs). A knowledge and attitude questionnaire was designed. The pharmacists from ...
... practitioners (GPs), medical specialists (MSs – internists, cardiologists, anesthetists, rheumatologists, gastroenterologists, neurologists, and psychiatrists), surgical specialists (SSs) and pediatric specialists (PSs). A knowledge and attitude questionnaire was designed. The pharmacists from ...
Bad Pharma
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Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients is a book by British physician and academic Ben Goldacre about the pharmaceutical industry, its relationship with the medical profession, and the extent to which it controls academic research into its own products. The book was published in September 2012 in the UK by the Fourth Estate imprint of HarperCollins, and in February 2013 in the United States by Faber and Faber.Goldacre argues in the book that ""the whole edifice of medicine is broken"" because the evidence on which it is based is systematically distorted by the pharmaceutical industry. He writes that the industry finances most of the clinical trials into its own products and much of doctors' continuing education, that clinical trials are often conducted on small groups of unrepresentative subjects and negative data is routinely withheld, and that apparently independent academic papers may be planned and even ghostwritten by pharmaceutical companies or their contractors, without disclosure. Goldacre calls the situation a ""murderous disaster,"" and makes suggestions for action by patients' groups, physicians, academics and the industry itself.Responding to the book's publication, the Association of the British Pharmaceutical Industry issued a statement arguing that the examples the book offers are historical, that the concerns have been addressed, that the industry is among the most regulated in the world, and that it discloses all data in accordance with international standards.In January 2013 Goldacre joined the Cochrane Collaboration, British Medical Journal and others in setting up AllTrials, a campaign calling for the results of all past and current clinical trials to be reported. The British House of Commons Public Accounts Committee expressed concern in January 2014 that drug companies were still only publishing around 50 percent of clinical-trial results.