Hypoxia Oxidative phosphorylation contribution to ATP production
... constitutively expressed. A heme-based receptor detects O2 levels and leads to an oxygen-dependent modification of HIF1. This modification allows HIF1 to be ubiquinated, which targets it for destruction. When HIF1 is not modified, it can dimerize with ARNT to form a heterodimer transcription factor ...
... constitutively expressed. A heme-based receptor detects O2 levels and leads to an oxygen-dependent modification of HIF1. This modification allows HIF1 to be ubiquinated, which targets it for destruction. When HIF1 is not modified, it can dimerize with ARNT to form a heterodimer transcription factor ...
Cardiomyopathy in Children And Adolescents: What Begins in
... Family history of uncle with AICD for Arrhythmia 4 years previously. No attempts made at family history or screening. Genetic testing becomes available 2 years ago and 2 younger siblings with negative echoes screened. One positive with no evidence of cardiomyopathy at this time. ...
... Family history of uncle with AICD for Arrhythmia 4 years previously. No attempts made at family history or screening. Genetic testing becomes available 2 years ago and 2 younger siblings with negative echoes screened. One positive with no evidence of cardiomyopathy at this time. ...
Maize Metabolic Network Construction and Transcriptome Analysis
... growth and developmental stages. Although our representation of the maize metabolic network mainly focuses on catalytic events performed by a small number of genes encoding enzymes and transporters that are responsible for phenotype and function, it is important to bear in mind that a proportionally ...
... growth and developmental stages. Although our representation of the maize metabolic network mainly focuses on catalytic events performed by a small number of genes encoding enzymes and transporters that are responsible for phenotype and function, it is important to bear in mind that a proportionally ...
Lipid metabolism in cancer
... serving as fat storage depots, and acting as signaling molecules. All of these processes are critical in cancer not only for generating the membrane constituents necessary for proliferating cells, but also for the energetic, biophysical, and signaling pathways that drive diverse aspects of tumorigen ...
... serving as fat storage depots, and acting as signaling molecules. All of these processes are critical in cancer not only for generating the membrane constituents necessary for proliferating cells, but also for the energetic, biophysical, and signaling pathways that drive diverse aspects of tumorigen ...
Amino Acid Analysis Recommendations
... Please mention the analyser used, the elution program used, set up of the analysing program, internal standards used and what is found and the amino acids which could not be identified. ...
... Please mention the analyser used, the elution program used, set up of the analysing program, internal standards used and what is found and the amino acids which could not be identified. ...
Prioritizing risk pathways: a novel association
... diseases are available, genome-wide association studies (GWA) have greater power to detect genetic variants, even if many markers are tested across the genome. All published GWA studies have led to the discovery of novel genes for several complex diseases, but there are limitations (Wang et al., 200 ...
... diseases are available, genome-wide association studies (GWA) have greater power to detect genetic variants, even if many markers are tested across the genome. All published GWA studies have led to the discovery of novel genes for several complex diseases, but there are limitations (Wang et al., 200 ...
determination of tantalum in high-tantalum ferro-alloys
... tantalum-182 combined into a single flat-topped peak. As was expected, high results were obtained due to self-shielding in the tantalum standard. The results for the 5 per cent sample were, however, much higher, relatively, than those for the 20 per cent sample, thus indicating that there was also s ...
... tantalum-182 combined into a single flat-topped peak. As was expected, high results were obtained due to self-shielding in the tantalum standard. The results for the 5 per cent sample were, however, much higher, relatively, than those for the 20 per cent sample, thus indicating that there was also s ...
The road to knowledge: from biology to databases and back again
... HumanCyc enables selecting, for instance, only small molecule reactions. The exact representation of a metabolic reaction differs per database. For example, each database uses a different terminology in its data model to refer to the metabolites before the arrow, e.g., ‘substrates’ or ‘input’, and a ...
... HumanCyc enables selecting, for instance, only small molecule reactions. The exact representation of a metabolic reaction differs per database. For example, each database uses a different terminology in its data model to refer to the metabolites before the arrow, e.g., ‘substrates’ or ‘input’, and a ...
Analysis of Whole-Body Branched-Chain Amino Acid Metabolism in
... understanding the mechanisms of cell autonomous metabolic alterations such as the influence of different oncogenic signals on nutrient utilization and the effects of altered regulation of specific enzymes on metabolic fluxes through different pathways (Cairns, et al., 2011). While these studies have ...
... understanding the mechanisms of cell autonomous metabolic alterations such as the influence of different oncogenic signals on nutrient utilization and the effects of altered regulation of specific enzymes on metabolic fluxes through different pathways (Cairns, et al., 2011). While these studies have ...
ppt - Bio 5068
... NMR Assignments 4D NMR Experiments • Consider a 4D NMR experiment as a collection of 3D NMR experiments still some ambiguities present when correlating multiple 3D triple-resonance experiments 4D NMR experiments make definitive sequential correlations increase in spectral resolution – Overlap ...
... NMR Assignments 4D NMR Experiments • Consider a 4D NMR experiment as a collection of 3D NMR experiments still some ambiguities present when correlating multiple 3D triple-resonance experiments 4D NMR experiments make definitive sequential correlations increase in spectral resolution – Overlap ...
Long-chain 3-hydroxyacyl-coenzyme A - UvA-DARE
... been described in the literature who have had a combined deficiency with a marked reduction of all three enzyme activities of the trifunctional protein. 5-7 Still, the exact frequency of the combined deficiency is unknown because most reports on LCHAD deficiency lack data on the activities of enoyl- ...
... been described in the literature who have had a combined deficiency with a marked reduction of all three enzyme activities of the trifunctional protein. 5-7 Still, the exact frequency of the combined deficiency is unknown because most reports on LCHAD deficiency lack data on the activities of enoyl- ...
Anesthesia in a Child with Pyruvate Dehydrogenase Deficiency: A
... report an infant with the severe form that is usually fatal in the neonatal period. Since their report, it appears that treatment of the disease has changed from that described in their patient. The use of thiamine and a ketogenic diet is now the treatment of choice. Our patient also had the milder ...
... report an infant with the severe form that is usually fatal in the neonatal period. Since their report, it appears that treatment of the disease has changed from that described in their patient. The use of thiamine and a ketogenic diet is now the treatment of choice. Our patient also had the milder ...
Bio 226: Cell and Molecular Biology
... Oleosomes: oil-storing organelles with only outer leaflet • Put oils between the leaflets as they are made • Add oleosin proteins to outside: curve the membrane ...
... Oleosomes: oil-storing organelles with only outer leaflet • Put oils between the leaflets as they are made • Add oleosin proteins to outside: curve the membrane ...
Biochemistry
... A 50-year-old woman with myocardial infarction has been delivered to the intensive care unit. Which enzyme's activity will be most increased during the first two days? A *Aspartate aminotransferase B Alanine aminotransferase C Alanine aminopeptidase D LDH4 E LDH5 ...
... A 50-year-old woman with myocardial infarction has been delivered to the intensive care unit. Which enzyme's activity will be most increased during the first two days? A *Aspartate aminotransferase B Alanine aminotransferase C Alanine aminopeptidase D LDH4 E LDH5 ...
A viability-linked metagenomic analysis of
... thought to be strongly influenced by the human microbiome. The cleanroom itself has previously been posited as representing an extreme environment [17], characterized by rigorous cleaning and bioburden control regimens, controlled humidity (45 ± 5 %) and temperature (25° C), and a paucity of availab ...
... thought to be strongly influenced by the human microbiome. The cleanroom itself has previously been posited as representing an extreme environment [17], characterized by rigorous cleaning and bioburden control regimens, controlled humidity (45 ± 5 %) and temperature (25° C), and a paucity of availab ...
Secondary metabolism is a term for pathways and products
... Metabolites: Metabolites are the intermediates and products of metabolism. The term metabolite is usually restricted to small molecules. A primary metabolite is directly involved in the normal growth, development, and reproduction. A secondary metabolite is not directly involved in those processes, ...
... Metabolites: Metabolites are the intermediates and products of metabolism. The term metabolite is usually restricted to small molecules. A primary metabolite is directly involved in the normal growth, development, and reproduction. A secondary metabolite is not directly involved in those processes, ...
Integration of Metabolism
... during starvation, fasting, low-carb diets, or uncontrolled diabetes ...
... during starvation, fasting, low-carb diets, or uncontrolled diabetes ...
S2 Table: Contribution of different substrates to respiration of
... Addition of OXPHOS modulators were indicated as "+" in the first column as following: 2 mM ADP (+ADP), 10 µM cytochrome c (not shown), 2 µM FCCP (+FCCP), 0.5 µM rotenone (+Rotenone), and finally 2.5 µg/mL antimycin A (+ Antimycin). For all G3P measurements, experiments started after the addition of ...
... Addition of OXPHOS modulators were indicated as "+" in the first column as following: 2 mM ADP (+ADP), 10 µM cytochrome c (not shown), 2 µM FCCP (+FCCP), 0.5 µM rotenone (+Rotenone), and finally 2.5 µg/mL antimycin A (+ Antimycin). For all G3P measurements, experiments started after the addition of ...
allosteric activator
... change of enzyme synthesis and degradation so that ultimately determine enzyme level at any point in time. In many instances, transcriptional regulation determines the concentrations of specific enzyme, with enzyme proteins degradation playing a minor role. In other instances, protein synthesis is c ...
... change of enzyme synthesis and degradation so that ultimately determine enzyme level at any point in time. In many instances, transcriptional regulation determines the concentrations of specific enzyme, with enzyme proteins degradation playing a minor role. In other instances, protein synthesis is c ...
2 Organic Acidemias
... Developmental delay. The differential diagnosis of developmental delay with other neurologic findings unaccompanied by acidosis or hyperammonemia is extremely long. A high index of suspicion is required to keep an organic acidemia in mind when these symptoms prevail. ...
... Developmental delay. The differential diagnosis of developmental delay with other neurologic findings unaccompanied by acidosis or hyperammonemia is extremely long. A high index of suspicion is required to keep an organic acidemia in mind when these symptoms prevail. ...
aciduria—lessons from 50 genes and 977 3-Methylglutaconic patients
... Searching the database of the LGEM at the RUMC revealed 20991 urinary organic acid profiles measured between 1992 and 2010. In 647 (3 %) samples of 388 patients 3-MGA-uria was detected. Of these patients 69 did not fulfil the inclusion criteria, another 92 met the exclusion criteria (see 2.2), conse ...
... Searching the database of the LGEM at the RUMC revealed 20991 urinary organic acid profiles measured between 1992 and 2010. In 647 (3 %) samples of 388 patients 3-MGA-uria was detected. Of these patients 69 did not fulfil the inclusion criteria, another 92 met the exclusion criteria (see 2.2), conse ...
Detection of aneuploidy in a single cell using the Ion ReproSeq PGS
... System provides a simple, cost-effective, and scalable aneuploidy detection solution in a workflow as little as 8 hours long. After isolation of a single cell or multiple cells from a preimplantation embryo, DNA extraction and library construction with barcoding are performed using the Ion SingleSeq ...
... System provides a simple, cost-effective, and scalable aneuploidy detection solution in a workflow as little as 8 hours long. After isolation of a single cell or multiple cells from a preimplantation embryo, DNA extraction and library construction with barcoding are performed using the Ion SingleSeq ...
CV Protection in the EMPA-REG OUTCOME Trial: A
... improvement in glycemic control, small decrease in body weight, and persistent reductions in blood pressure and uric acid leveldmay be at play. We hypothesize that under conditions of mild, persistent hyperketonemia, such as those that prevail during treatment with SGLT2 inhibitors, b-hydroxybutyrat ...
... improvement in glycemic control, small decrease in body weight, and persistent reductions in blood pressure and uric acid leveldmay be at play. We hypothesize that under conditions of mild, persistent hyperketonemia, such as those that prevail during treatment with SGLT2 inhibitors, b-hydroxybutyrat ...
THE APPLICATION OF TANDEM MASS SPECTROMETRY TO
... will be nearly the same for batch species. Because the blood spot is a dry sample, a liquid standard cannot be uniformly mixed with the original sample. As a result, adding the standard to the methanol extracts causes the loss of a certain degree of accuracy and precision because of variations in bo ...
... will be nearly the same for batch species. Because the blood spot is a dry sample, a liquid standard cannot be uniformly mixed with the original sample. As a result, adding the standard to the methanol extracts causes the loss of a certain degree of accuracy and precision because of variations in bo ...