drug name: anastrozole
... 4. Santen RJ, Harvey HA. Use of aromatase inhibitors in breast carcinoma. EndocrineRelated Cancer 1999;6(1):75-92. 5. Geisler J, King N, Dowsett M, et al. Influence of anastrozole (Arimidex), a selective, nonsteroidal aromatase inhibitor, on in vivo aromatisation and plasma oestrogen levels in postm ...
... 4. Santen RJ, Harvey HA. Use of aromatase inhibitors in breast carcinoma. EndocrineRelated Cancer 1999;6(1):75-92. 5. Geisler J, King N, Dowsett M, et al. Influence of anastrozole (Arimidex), a selective, nonsteroidal aromatase inhibitor, on in vivo aromatisation and plasma oestrogen levels in postm ...
NIDA InfoFacts: Steroids (Anabolic-Androgenic)
... The immediate effects of AAS in the brain are mediated by their binding to androgen (male sex hormone) and estrogen (female sex hormone) receptors on the surface of a cell. This AAS–receptor complex can then shuttle into the cell nucleus to influence patterns of gene expression. Because of this, the ...
... The immediate effects of AAS in the brain are mediated by their binding to androgen (male sex hormone) and estrogen (female sex hormone) receptors on the surface of a cell. This AAS–receptor complex can then shuttle into the cell nucleus to influence patterns of gene expression. Because of this, the ...
Late cardiotoxicity
... and to as much as 36% when the total dose was at least 601 mg/m2 The prognosis of the cardiomyopathy, once developed, is grave, and it is difficult to predict which individuals will develop heart failure on a case-by case basis. Children treated with anthracycline can develop cardiotoxicity even whe ...
... and to as much as 36% when the total dose was at least 601 mg/m2 The prognosis of the cardiomyopathy, once developed, is grave, and it is difficult to predict which individuals will develop heart failure on a case-by case basis. Children treated with anthracycline can develop cardiotoxicity even whe ...
Therapeutic applications of ricin and some alkaloids
... are given to patients through gums, dermal patches, lozenges, or nasal sprays in an effort to wean them off their dependence. However, in a few situations, smoking has been observed to apparently be of therapeutic value to patients. These are often referred to as "Smoker’s Paradoxes" [10]. Although ...
... are given to patients through gums, dermal patches, lozenges, or nasal sprays in an effort to wean them off their dependence. However, in a few situations, smoking has been observed to apparently be of therapeutic value to patients. These are often referred to as "Smoker’s Paradoxes" [10]. Although ...
Effect of Ergot Alkaloids on 3H-Flunitrazepam Binding to Mouse
... ing site, the barbiturate binding site and the steroid binding site that seems to mediate rapid, nongenomic effects of neuroactive steroid hormones in the brain2,3. The recognition sites for other classes of compounds on GABAA receptors were also hypotesized2. Ergot drugs have been used clinically i ...
... ing site, the barbiturate binding site and the steroid binding site that seems to mediate rapid, nongenomic effects of neuroactive steroid hormones in the brain2,3. The recognition sites for other classes of compounds on GABAA receptors were also hypotesized2. Ergot drugs have been used clinically i ...
The relative roles of growth hormone and IGF-1 in controlling
... from the perspective of primitive organisms. In primitive organisms that do not have a pituitary gland, ligands with structural similarities to both insulin and IGF-1 are synthesized in the olfactory region of the brain and secreted in response to food intake (3). This results in direct linking of f ...
... from the perspective of primitive organisms. In primitive organisms that do not have a pituitary gland, ligands with structural similarities to both insulin and IGF-1 are synthesized in the olfactory region of the brain and secreted in response to food intake (3). This results in direct linking of f ...
I. Adrenergic Nervous System: Overview
... destruction of their walls.[6] The enlarged air sacs (alveoli) of the lungs reduces the surface area available for the movement of gases during respiration. This can cause breathlessness in severe cases. The exact mechanism for the development of emphysema is not understood, although it it known to ...
... destruction of their walls.[6] The enlarged air sacs (alveoli) of the lungs reduces the surface area available for the movement of gases during respiration. This can cause breathlessness in severe cases. The exact mechanism for the development of emphysema is not understood, although it it known to ...
The Science Of Anabolic Steroid Abuse
... Target Organs and Physiological Effects of Testosterone and Metabolites ...
... Target Organs and Physiological Effects of Testosterone and Metabolites ...
Some drugs can cause taste disturbances
... Some of the most common culprits are surprising. Lunesta causes a metallic aftertaste in up to one-third of patients...especially at higher doses. If patients complain, lower the dose or switch to another sleeping agent. ACE inhibitors can cause a metallic, sweet, or salty taste. It's most common wi ...
... Some of the most common culprits are surprising. Lunesta causes a metallic aftertaste in up to one-third of patients...especially at higher doses. If patients complain, lower the dose or switch to another sleeping agent. ACE inhibitors can cause a metallic, sweet, or salty taste. It's most common wi ...
Vicodin and liver Disease
... today.” On the other hand, opiates, such as hydrocodone bitartrate and codeine, while safe for the liver, are highly addictive. “Vicodin is currently the most popular prescription drug in the United States.” Some patients become addicted to the opiate component of Vicodin and consume increasing amou ...
... today.” On the other hand, opiates, such as hydrocodone bitartrate and codeine, while safe for the liver, are highly addictive. “Vicodin is currently the most popular prescription drug in the United States.” Some patients become addicted to the opiate component of Vicodin and consume increasing amou ...
CP47,497-C8 and JWH073, commonly found in `Spice` herbal
... We next examined the ability of these two compounds to promote CB1 receptor internalization. To ensure a better comparison with our previous report on the effects of JWH018 and to account for differences in passage number and other cell culture variables, we tested JWH018 alongside our analyses of C ...
... We next examined the ability of these two compounds to promote CB1 receptor internalization. To ensure a better comparison with our previous report on the effects of JWH018 and to account for differences in passage number and other cell culture variables, we tested JWH018 alongside our analyses of C ...
12 Modelling of large herbivore – vegetation interactions in a
... spsind002s/cup_prod1/PRODENV/000000~1/00DA26~1/S00000~2/00D226~1/ 000000~4/000007342.3D Proof by: QC by: ...
... spsind002s/cup_prod1/PRODENV/000000~1/00DA26~1/S00000~2/00D226~1/ 000000~4/000007342.3D Proof by: QC by: ...
Guggulsterone Activates Multiple Nuclear Receptors and Induces
... Staudinger et al., 2001a,b). The CYP3A4 gene encodes the most abundant drug-metabolizing cytochrome P450 in human liver and is responsible for the biotransformation of nearly 60% of all clinically prescribed drugs (Maurel, 1996; Guengerich, 1999). The administration of PXR activators should thus be ...
... Staudinger et al., 2001a,b). The CYP3A4 gene encodes the most abundant drug-metabolizing cytochrome P450 in human liver and is responsible for the biotransformation of nearly 60% of all clinically prescribed drugs (Maurel, 1996; Guengerich, 1999). The administration of PXR activators should thus be ...
Hepatoprotective Effects of Schisandra sphenanthera Extract
... 2001b; Xie et al., 2001). In PXR null mice, PCN failed to prevent LCAinduced cholestasis and liver damage. In addition, glycyrrhizin, a PXR agonist, has been demonstrated to protect against LCA-induced cholestasis (Wang et al., 2012b). These findings suggest that PXR plays an important role in bile ...
... 2001b; Xie et al., 2001). In PXR null mice, PCN failed to prevent LCAinduced cholestasis and liver damage. In addition, glycyrrhizin, a PXR agonist, has been demonstrated to protect against LCA-induced cholestasis (Wang et al., 2012b). These findings suggest that PXR plays an important role in bile ...
Molecular determinants of drug–receptor binding kinetics
... maximal, diffusion-limited on-rate (kon 109 M1 s1) [2,58] would have a residence time of 1 s. Importantly, tR and t1/2 are independent of drug concentration. Thus, even when the free concentration of a long-residence-time drug falls below the Kd, a significant population of receptors will still ...
... maximal, diffusion-limited on-rate (kon 109 M1 s1) [2,58] would have a residence time of 1 s. Importantly, tR and t1/2 are independent of drug concentration. Thus, even when the free concentration of a long-residence-time drug falls below the Kd, a significant population of receptors will still ...
Respiratory Pharmacology
... – Interactions: caffeine, Tagamet, fluoroquinolones, other CNS drugs ...
... – Interactions: caffeine, Tagamet, fluoroquinolones, other CNS drugs ...
Noncompartment Model
... Mathematical treatment remains same, for drug or metabolite, provided elimination follows first order kinetics Drug disposition kinetics need not be described in detail ...
... Mathematical treatment remains same, for drug or metabolite, provided elimination follows first order kinetics Drug disposition kinetics need not be described in detail ...
T s e n
... Pancuronium requires renal excretion Vecuronium and rocuronium are exreted into the biliary system ...
... Pancuronium requires renal excretion Vecuronium and rocuronium are exreted into the biliary system ...
Modelling the impact of hydrography and lower trophic production
... larvae early life history models (Beyer and Laurence, 1980), and fish individual-based models (Letcher et al., 1996) exist, but generally pay little attention to food-web connections to lower trophic levels. To overcome this shortcoming in the future we firstly define which are the key zooplankton t ...
... larvae early life history models (Beyer and Laurence, 1980), and fish individual-based models (Letcher et al., 1996) exist, but generally pay little attention to food-web connections to lower trophic levels. To overcome this shortcoming in the future we firstly define which are the key zooplankton t ...
Anticoagulants
... caused by elevated VLDL levels (LDL receptor can recognize Apo-E in VLDL). Also reduce VLDL synthesis in liver - requires cholesterol Some statins are also indicated for raising HDL-C levels ...
... caused by elevated VLDL levels (LDL receptor can recognize Apo-E in VLDL). Also reduce VLDL synthesis in liver - requires cholesterol Some statins are also indicated for raising HDL-C levels ...
Novartis Award for Hypertension Research Reconsidering the Roles
... progesterone receptor (PR)/androgen receptor (AR) subfamily of steroid hormone receptors from a common primordial ancestral protein.3 These studies and their implications for the basic biology of aldosterone action have been discussed elsewhere.4 The present review focuses on the clinical study (Ran ...
... progesterone receptor (PR)/androgen receptor (AR) subfamily of steroid hormone receptors from a common primordial ancestral protein.3 These studies and their implications for the basic biology of aldosterone action have been discussed elsewhere.4 The present review focuses on the clinical study (Ran ...
7 Alma Jarkas
... of two atoms of strontium bound to an organic ion, ranelic acid. It is used in Europe for the treatment of osteoporosis. it’s an effective drug . it’s not universal It blocks differentiation of osteoclasts while promoting their apoptosis, thus inhibiting bone resorption. It also promotes bone fo ...
... of two atoms of strontium bound to an organic ion, ranelic acid. It is used in Europe for the treatment of osteoporosis. it’s an effective drug . it’s not universal It blocks differentiation of osteoclasts while promoting their apoptosis, thus inhibiting bone resorption. It also promotes bone fo ...
Osteoporosis from androgen deprivation therapy in prostate cancer
... turnover. The initial ADT associated bone loss is not only significantly higher, but persists when compared to the slowing in later menopause.15 While the magnitude and prevalence of low BMD among men commencing ADT is unknown,16 BMD loss is estimated at 3–5% annually in the first few years17 with m ...
... turnover. The initial ADT associated bone loss is not only significantly higher, but persists when compared to the slowing in later menopause.15 While the magnitude and prevalence of low BMD among men commencing ADT is unknown,16 BMD loss is estimated at 3–5% annually in the first few years17 with m ...
Powerpoint - Sara Parr Syswerda
... “management driven by explicit goals, policies, protocols, and practices, and made adaptable by monitoring and research based on our best understanding of the ecological interactions and processes necessary to sustain ecosystem composition, structure, and function.” ...
... “management driven by explicit goals, policies, protocols, and practices, and made adaptable by monitoring and research based on our best understanding of the ecological interactions and processes necessary to sustain ecosystem composition, structure, and function.” ...
Toxicodynamics
Toxicodynamics, termed pharmacodynamics in pharmacology, describes the dynamic interactions of a toxicant with a biological target and its biological effects. A biological target, also known as the site of action, can be binding proteins, ion channels, DNA, or a variety of other receptors. When a toxicant enters an organism, it can interact with these receptors and produce structural or functional alterations. The mechanism of action of the toxicant, as determined by a toxicant’s chemical properties, will determine what receptors are targeted and the overall toxic effect at the cellular level and organismal level.Toxicants have been grouped together according to their chemical properties by way of quantitative structure-activity relationships (QSARs), which allows prediction of toxic action based on these properties. endocrine disrupting chemicals (EDCs) and carcinogens are examples of classes of toxicants that can act as QSARs. EDCs mimic or block transcriptional activation normally caused by natural steroid hormones. These types of chemicals can act on androgen receptors, estrogen receptors and thyroid hormone receptors. This mechanism can include such toxicants as dichlorodiphenyltrichloroethane (DDE) and polychlorinated biphenyls (PCBs). Another class of chemicals, carcinogens, are substances that cause cancer and can be classified as genotoxic or nongenotoxic carcinogens. These categories include toxicants such as polycyclic aromatic hydrocarbon (PAHs) and carbon tetrachloride (CCl4). The process of toxicodynamics can be useful for application in environmental risk assessment by implementing toxicokinetic-toxicodynamic (TKTD) models. TKTD models include phenomenas such as time-varying exposure, carry-over toxicity, organism recovery time, effects of mixtures, and extrapolation to untested chemicals and species. Due to their advantages, these types of models may be more applicable for risk assessment than traditional modeling approaches.