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DNA Viruses
DNA Viruses

... • Protomers not grouped in capsomeres • Bound together to form a ribbon which folds ...
International Collaboration for the Genomics of HIV
International Collaboration for the Genomics of HIV

... International Collaboration for the Genomics of HIV  HIV acquisition: no significant associations (after accounting for survivor bias), with the exception of CCR5Δ32 homozygosity: p=3E13. No replication of all other previously ...
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... The eclipse phase: expression of virus proteins and replication of nucleic acid.  Virus particles have been disassembled so no infectious particles are present  Expression of virus proteins  Highly regulated: temporal and quantitative  Replication of virus nucleic acid Assembly: production of ne ...
Immunology Stack
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HIV



The human immunodeficiency virus (HIV) is a lentivirus (a subgroup of retrovirus) that causes HIV infection and acquired immunodeficiency syndrome (AIDS). AIDS is a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. Without treatment, average survival time after infection with HIV is estimated to be 9 to 11 years, depending on the HIV subtype. Infection with HIV occurs by the transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk. Within these bodily fluids, HIV is present as both free virus particles and virus within infected immune cells.HIV infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages, and dendritic cells. HIV infection leads to low levels of CD4+ T cells through a number of mechanisms, including apoptosis of uninfected bystander cells, direct viral killing of infected cells, and killing of infected CD4+ T cells by CD8 cytotoxic lymphocytes that recognize infected cells. When CD4+ T cell numbers decline below a critical level, cell-mediated immunity is lost, and the body becomes progressively more susceptible to opportunistic infections.
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