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biochemistry of microbes
biochemistry of microbes

... and is secured inside when the viral proteases make the final cleavages. The processes, which guide the RNA to the capsid, are still poorly understood. Once the genomes have been packaged into mature virions, the virus particles await the cell's lysis (bursting), when they will be released to infect ...
Title Univers Bold Italic, 36pt Align Left
Title Univers Bold Italic, 36pt Align Left

... happen in people who are around pigs • Swine flu viruses do not normally infect humans, however, human infections with swine flu do occur, and cases of human-tohuman spread of swine flu viruses have been documented ...
Development and Evaluation of a Real-Time RT-qPCR for Detection of Crimean-Congo
Development and Evaluation of a Real-Time RT-qPCR for Detection of Crimean-Congo

... A new CCHFV-S RT-qPCR was set up based on the Ssegment, and the performance was evaluated using different CCHFV strains prior testing the clinical samples. Strains representing five genotypes tested were shown to be detected (Table 1). The LOD was determined using six parallel tests of dilution seri ...
Murine leukemia virus transmembrane protein R
Murine leukemia virus transmembrane protein R

... budding. Gag [Pr65gag in Murine leukemia virus (MLV)] is translated in the cytoplasm. The assembly of Gag and viral RNA into the core particle differs among retroviruses. Betaand spumaretroviruses, as exemplified by Mason–Pfizer monkey virus (MPMV), assemble their core in the cytoplasm, whereas most ...
Prevention and treatment of koala retrovirus (KoRV) infection
Prevention and treatment of koala retrovirus (KoRV) infection

... are active against these simian viruses, but this cannot be assumed. For example, although many drugs in the NRTI class work well against simian viruses, their potency against simian viruses may be less than against HIV, and drugs of the non-nucleoside RT inhibitor (NNRTI) class, which act via a dif ...
Evidence for biotype-specific effects of bovine viral diarrhoea virus
Evidence for biotype-specific effects of bovine viral diarrhoea virus

... epidemiological dead end because the main route of spread of BVDV within a group of calves is via respiratory infection (Bielefeldt Ohmann, 1983 ; Wentink et al., 1991). In summary, our data highlight the biological effect of the BVDV biotype on virological and serological events during acute infect ...
INTRODUCTION TO PLANT VIRUSES
INTRODUCTION TO PLANT VIRUSES

... In 1935, Stanley announced the isolation of this virus in an apparently crystalline state but considered that the virus was a globulin containing no phosphorus. In 1936, however, Bawden and his colleagues described the isolation from TMV-infected plants of a liquid crystalline nucleoprotein containi ...
Vaccines
Vaccines

... Clearly, here secreted antibodies are important. Although in the case of influenza serum antibodies may be important ...
How Does Infection Occur?/The Chain of Infection
How Does Infection Occur?/The Chain of Infection

... Susceptible Host = An individual who can contract the disease Humans become susceptible if … a. Large numbers of pathogens invade the body b. Body defenses are weak-immune system down ...
Causes Of Feline Leukemia
Causes Of Feline Leukemia

... analysis, which will indicate if there are typical antibodies or antigens that are released by the body if the virus is present. Feline leukemia is not a treatable condition, but you must keep an eye on the cat's condition and administer treatment to all secondary diseases or infections. Fluid thera ...
Full text in pdf format
Full text in pdf format

... epitopes for neutralization of SRCV The different nature of SRCV has been suggested by others who found that isolates of IHNV from chinook salmon in California had biochem~cal(Hsu et al. 1986) or growth (Mulcahy et al. 1984) characteristics that were unlike isolates recovered from other hosts or geo ...
Glycoprotein J of infectious laryngotracheitis virus is required for
Glycoprotein J of infectious laryngotracheitis virus is required for

... Agriculture standard challenge strain (USDA-ch) and their characterization in cell culture and embryonated chicken eggs. Our data indicate that gJ plays a role during release of infectious virus from cells. As a prerequisite for the generation and characterization of gJ deletion mutants and their re ...
Vaccination
Vaccination

... Monoclonal Antibody • Derived from a single type, or clone, of antibody-producing cells (B cells). • Antibody is specific to a single antigen or closely related group of antigens. • Used for diagnosis and therapy of certain cancers and autoimmune and infectious diseases . ...
Miscellaneous proposal
Miscellaneous proposal

... identified as ‘velogenic Newcastle disease’. There are a number of non-pathogenic strains of avian paramyxovirus 1–Newcastle disease that circulate in poultry populations. These strains are ubiquitous throughout most of the world and pose no significant risk. The OIE has a definition of Newcastle di ...
Genomic and phylogenetic characterization of Brazilian yellow fever
Genomic and phylogenetic characterization of Brazilian yellow fever

... ellow fever (YF) is an infectious disease transmitted by Culicidae mosquitoes carrying yellow fever virus (YFV). This virus, the prototype species of the family Flaviviridae, genus Flavivirus, has a positive-sense, single-strand genome, composed of approximately 11,000 nucleotides (nt), encoding 10 ...
Molecular Characterization of Complete Genome of a Thai Highly
Molecular Characterization of Complete Genome of a Thai Highly

... and has approximately 15 kb in length (Wootton et al., 2000). It contains two large open reading frames (ORFs), ORF1a and ORF1ab, and other eight ORFs (ORF2a, ORF2b, and ORF3-7). ORF1a and ORF1ab are translated into replicase and 14 non-structural proteins (Nsp). The remaining ORFs encode structural ...
Detect Dengue-Zika White Paper
Detect Dengue-Zika White Paper

... quantification of viral load and is considerably more sensitive than serological methods and easier to perform than viral isolation. Within the last decade, there have been a number of molecular-based assays developed for the detection of DENV, CHIKV, and ZIKV in serum and/or mosquito samples, inclu ...
Quantumdotsbased fluoroimmunoassay for the rapid and sensitive
Quantumdotsbased fluoroimmunoassay for the rapid and sensitive

... from central China in 2005 were detected using the sFLISA and VI. The diagnostic performance of sFLISA was compared with that of VI, the current standard of AIV detection. As shown in Table 1, 44 samples were detected positive among all 103 samples in VI, but five more samples were detected positive ...
Lesson Plans - Paw Paw Public Schools
Lesson Plans - Paw Paw Public Schools

... The flu is caused by a variety of related viruses. Flu viruses are highly mutable and each flu season can produce a new strain of the flu. Each year, the flu causes an average of 20,000 deaths in the U.S., mostly among the elderly. Some flu strains, such as the Spanish Flu of 1918, are more lethal t ...
EVALUATION OF IN VITRO VIRUCIDAL ACTIVITY OF VIRKON®S
EVALUATION OF IN VITRO VIRUCIDAL ACTIVITY OF VIRKON®S

... Viral titration of the produced viral stock, conserved in aliquots at -20°C, reported a value of 107 TCID50/ml. The 96-well plates used in residual infectivity tests of the virus treated with the disinfectant were read at inverted microscope, evaluating the presence/absence of the cytopathic effect. ...
Highly Pathogenic Avian Influenza Highly pathogenic avian
Highly Pathogenic Avian Influenza Highly pathogenic avian

... Highly Pathogenic Avian Influenza (HPAI) Implementing good biosecurity practices is the best way to prevent any poultry disease, especially HPAI. These steps can help you keep your poultry healthy: • Keep your distance Isolate your poultry from visitors and other poultry. • Keep it clean. Prevent ge ...
An experimental study on early pathogenesis of a very virulent
An experimental study on early pathogenesis of a very virulent

... antigen form the dominant cell population in the lymphoid tissues including bursa, spleen and thymus to replace the depleted lymphoid cells. As in previous studies, our results showed specific positive signals in reticular epithelial cells (Nunoya et al., 1992; Tanimura et al., 1995). Other studies ...
Very Rapid Generation/Amplification of Defective Interfering
Very Rapid Generation/Amplification of Defective Interfering

... disappeared after being dominant for at least 10 months, but R N A virus populations can evolve very rapidly during persistence (Holland et al., 1982). To examine the stability of this rapid generation phenotype, a clonal pool of 110 month C A R 4 was passaged five times at low multiplicity (0.1 ml ...
FELINE LEUKEMIA VIRUS What is Feline Leukemia virus?
FELINE LEUKEMIA VIRUS What is Feline Leukemia virus?

... How can we diagnose the infection? An in clinic test kit is used to diagnose the infection. A small amount of blood is first collected. At Vaudreuil Veterinary Clinic, the test is performed in house. The test detects the circulating viral antigen in the blood. The result is obtained after 40 minutes ...
SARS and Emerging Infectious Diseases: A Challenge to Place
SARS and Emerging Infectious Diseases: A Challenge to Place

... e-mail message describing an infectious disease in Guangdong Province with more than 100 deaths. On 11 February, the Chinese Ministry of Health officially confirmed the reports to the WHO, and on the following day reported that the outbreak dated back to 16 November 2002, that influenza had been rul ...
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Influenza A virus



Influenza A virus causes influenza in birds and some mammals, and is the only species of influenza virus A. Influenza virus A is a genus of the Orthomyxoviridae family of viruses. Strains of all subtypes of influenza A virus have been isolated from wild birds, although disease is uncommon. Some isolates of influenza A virus cause severe disease both in domestic poultry and, rarely, in humans. Occasionally, viruses are transmitted from wild aquatic birds to domestic poultry, and this may cause an outbreak or give rise to human influenza pandemics.Influenza A viruses are negative-sense, single-stranded, segmented RNA viruses.The several subtypes are labeled according to an H number (for the type of hemagglutinin) and an N number (for the type of neuraminidase). There are 18 different known H antigens (H1 to H18) and 11 different known N antigens (N1 to N11). H17 was isolated from fruit bats in 2012. H18N11 was discovered in a Peruvian bat in 2013.Each virus subtype has mutated into a variety of strains with differing pathogenic profiles; some are pathogenic to one species but not others, some are pathogenic to multiple species.A filtered and purified influenza A vaccine for humans has been developed, and many countries have stockpiled it to allow a quick administration to the population in the event of an avian influenza pandemic. Avian influenza is sometimes called avian flu, and colloquially, bird flu. In 2011, researchers reported the discovery of an antibody effective against all types of the influenza A virus.
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