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Sophic`s SCan-MarK Explorer™ Overview
Sophic`s SCan-MarK Explorer™ Overview

... brings “omics” to Oncologists Research – The Biology of Cancer Scientists can accelerate their research by using the SCan-MarK knowledgebase to explore the underlying pathways and mechanisms that are the root cause of the cancer. Integrated pathway databases and annotated biological entities can be ...
Bonus 2-Preventing_Medication_Errors
Bonus 2-Preventing_Medication_Errors

... Unreported errors can affect the health of patients and cause legal ramifications for the nurse. In severe cases, adverse reactions caused by medication errors might require the initiation of lifesaving interventions for the patient. After such an event, the patient may need intense supervision and ...
Notes - marric
Notes - marric

... Remember the differences between Mitosis and Meiosis? Where does Crossing Over Occur? Genetic swapping occurs between paired homologous chromosomes in our sex cells— ...
Sedative-HypnoticsJGeneral Depressants alcohol (ethyl alcohol, or
Sedative-HypnoticsJGeneral Depressants alcohol (ethyl alcohol, or

... them regularly, regardless of the obstacles, pain, or cost. In popular or lay terms, they are pleasurable. It should come as no surprise that these two drugs are widely used for recreational purposes, that is, to get high. Most users can overcome the impulse to become dependent on cocaine and amphet ...
VISUAL ALTERATION
VISUAL ALTERATION

... ORAL BETA BLOCKERS AND CALCIUM CHANNEL BLOCKERS? ...
Photoreactivity of drugs
Photoreactivity of drugs

... formulation. Evaluation of in vitro photostability is therefore essential to ensure adequate quality over the entire life span of the drug. It is important to be aware that the photoreactivity of a drug substance is dependent on its concentration in the actual preparation and on the type of infusion ...
Certified Medication Technician Student Manual
Certified Medication Technician Student Manual

... A systemic effect means that the drug effect is felt throughout the body. For example, when an analgesic is taken for a headache and the person also has a sore back, the medication will affect both parts of the body and should relieve both areas of pain. Because of the different types of effects pos ...
Topical Pain Control Medication
Topical Pain Control Medication

... & therefore can be attributed to passive diffusion  As surface area  & thickness of epidermis , the rate of transdermal flux   The underlying epidermal layers & the dermis area are an aqueous environment ...
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... propellant system and improve miscibility of surfactants in  the propellants.  A surfactant may be included to aid in valve  lubrication, improve homogeneity of the dispersion or  enhance the solubility of the API in the propellant/cosolvent  system.  Typical surfactants, which are allowed by the FD ...
Study Guide Part II
Study Guide Part II

... 14. In a flowering plant, eggs are produced by meiosis in the 15. Which of the following flower parts produces male gametophytes? 16. How does the sperm of an angiosperm reach the egg? 17. A seed is a mature 18. A mature ovary, specialized as a vessel that houses and protects seeds, is a 19. Know wh ...
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Genetic Variability and allele frequencies Schistosomiasis – human

... •Imagine mating as a process of throwing all the eggs and sperm into a (very big) bucket, and when they collide and fuse, they make a new individual. These individuals grow into adults, and do the genes in a ...
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Opiate Chemistry and Metabolism - New Zealand Institute of Chemistry
Opiate Chemistry and Metabolism - New Zealand Institute of Chemistry

... feelings of euphoria, and they are all to some extent dependence-inducing. For these reasons they are used both medically and illicitly. To determine whether or not one of these drugs has been taken it is important to understand their respective metabolic pathways (the chain of reactions that they u ...
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Dessert_Lisa Miller_UKPharmSci

... dessert-like formulation which could be used as drug delivery carrier in patient with swallowing difficulties. ...
Prescription_Medications
Prescription_Medications

... Other weight-loss drugs that curb appetite are only approved by the FDA for short-term use (a few weeks), but some doctors prescribe them for longer periods (see the box “What is ‘off-label’ use?”). These medications are also controlled substances because of their potential for abuse. Most weightlos ...
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... • Genes for different traits can segregate independently during the formation of gametes (sex cells). • Mendel wondered if the gene for one trait, such as pea color, had anything to do with another trait such as pea shape. ...
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... interactions in HIV-infected patients? A. Extremely comfortable: I wrote the book on drug interactions. B. Somewhat comfortable: I keep up on the topic and/or have access to a pharmacist. C. Uncomfortable: I know they exist but have a difficult time recognizing them. D. Drug interactions? Isn’t this ...
ISMP Medication Safety Alert
ISMP Medication Safety Alert

... problems at your practice site. To promote such a process, the following selected items from the April—June 2016 issues of the ISMP Medication Safety Alert! have been prepared for an interdisciplinary committee to stimulate discussion and action to reduce the risk of medication errors. Each item inc ...
Genetic Practice Problems
Genetic Practice Problems

... 8) One gene has alleles A and a, a second gene has alleles B and b, and a third gene has alleles C and c. A) List the possible gametes that can be formed from the following genotypes: 1. Aa 2. BbCc 3. AAcc ...
Antidepressant
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... serotonin and norepinephrine. These agents may be effective in treating depression in patients in whom SSRIs are ineffective, in addition to treat the painful symptoms that associate depression such as backache and muscle aches. The SNRIs, unlike the tricyclic antidepressants, have little activity a ...
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Psychiatric Medications in the Medically Ill

... Determines plasma levels and availability at biologically active sites Altered by disease of the gastrointestinal tract, liver, heart and kidneys ...
Chapater 12 - IND/NDA/ANDA/AADA
Chapater 12 - IND/NDA/ANDA/AADA

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... WITHDRAWAL Sometimes indicated antidepressants - depression, agoraphobia, sedation -blockers - tremor, palpitations carbamazepine - fits (high dose Bz) sedative antihistamines Not helpful buspirone, clonidine, nifedipine, ? Alpidem, ? Gabapentin ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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