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Roach: Introductory Clinical Pharmacology
Roach: Introductory Clinical Pharmacology

... • Expected outcomes include: – Optimal response to drug therapy – Support of patient needs related to management of adverse reactions – Absence of injury – Compliance with the prescribed therapeutic regimen Copyright © 2008 Lippincott Williams & Wilkins. ...
Genetic Drift
Genetic Drift

Combination therapy for HYPERTENSION
Combination therapy for HYPERTENSION

... method to predict which agent will work for an individual patient. This method usually requires a lengthy titration period with a loss of patient confidence in the prescribing physician. In many patients the ideal monotherapy may never be found. ...
genetics notes kelly
genetics notes kelly

... EX: A, B, O blood alleles produce A, B, O, or AB blood types 5) POLYGENIC TRAIT- trait determined by more than one gene EX: skin color, intelligence, eye color “bell curve” 6) EPISTASIS- Gene at one locus alters the phenotypic expression of a gene at another locus EX: Coat color pigment not deposite ...
What are some other side effects of this drug?
What are some other side effects of this drug?

... What do I need to tell my doctor BEFORE I take this drug? • If you have an allergy to exemestane or any other part of this drug. • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; ...
Apicoectomy Treatment
Apicoectomy Treatment

... during treatment. Depending on the anesthesia and medications administered, I may need a designated driver to take me home. Rarely, temporary or permanent nerve injury can result from an injection. I understand that all medications have the potential for accompanying risks, side effects, and drug in ...
Course Competency Learning Outcomes
Course Competency Learning Outcomes

... Comparing and contrasting genes, chromosomes, and genomes. Explaining how genetics and the environment can influence gender determination. Describing gene linkage. Analyzing sex influence and linkage. Explaining genetic anomalies caused by changes in chromosome number. Summarizing genetic anomalies  ...
Medication And Health
Medication And Health

... Management, and Medication Medication (Drugs) – evidence based medicines, treatment guidelines, and top 20 prescription drugs Risk Factors for Cardio-Vascular Disease (CVD) – the leading cause of death in US and developed countries Drugs - used for diabetes, high cholesterol, and hypertension Drug I ...
Behavioral and Psych Emergencies
Behavioral and Psych Emergencies

... seeing a psychologist at the Student Health Center because a young women named Tatiana Tarasoff rejected his affections. The psychologist, reasoning that Poddar was dangerous because of his pathological attachment to Tarasoff & b/c he intended to purchase a gun, notified the police both verbally and ...
Product Monograph Template - Standard
Product Monograph Template - Standard

... individuals may be extensive or ultra-rapid metabolizers due to a specific CYP2D6*2x2 genotype. These individuals convert codeine into its active metabolite, morphine, more rapidly and completely than other people. This rapid conversion results in higher than expected serum morphine levels. Even at ...
UBE2A deficiency syndrome: Mild to severe intellectual disability
UBE2A deficiency syndrome: Mild to severe intellectual disability

... history of recurrent respiratory infections requiring hospital admission, but no immune deficiencies were detected. Extensive metabolic screening including a muscle biopsy did not show any abnormalities. No other affected family members were reported. ...
Pharmacodynamics
Pharmacodynamics

... (how drugs work on the body)  many drugs inhibit enzymes Enzymes control a number of metabolic processes A very common mode of action of many drugs  in the patient (ACE inhibitors)  in microbes (sulfas, penicillins)  in cancer cells (5-FU, 6-MP)  some drugs bind to:  proteins (in patient, or m ...
fiorinal - aralez pharmaceuticals
fiorinal - aralez pharmaceuticals

... individuals may be extensive or ultra-rapid metabolizers due to a specific CYP2D6*2x2 genotype. These individuals convert codeine into its active metabolite, morphine, more rapidly and completely than other people. This rapid conversion results in higher than expected serum morphine levels. Even at ...
Stress Ulcer Prophylaxis
Stress Ulcer Prophylaxis

... The minor: 2 or more of the following: 1-sepsis 2-shock 3- ICU>1 week 4- Occult Bleeding within 6 days 5-High dose corticosteroids (250mg Hydrocortisone ,50mg Methylprednisone) 6- hepatic failure, renal failure, 7- organ transplantation 8-administration of nonsteroidal anti-inflammatory agent 9- ISS ...
nursing process focus
nursing process focus

...  Avoid use of salt substitute without hyperkalemia resulting in cardiac approval of health care provider dysrhythmias. Patient receiving  Avoid increasing potassium rich foods potassium supplements should avoid use while taking a potassium supplement, of salt substitute since most use including ba ...
Nature and Nurture
Nature and Nurture

8.1 INTRO to Genetics Practice Monohybrid Crosses
8.1 INTRO to Genetics Practice Monohybrid Crosses

... Law of Dominance What letters should be used to represent the following traits? ...
The Hardy-Weinberg Equilibrium Lab
The Hardy-Weinberg Equilibrium Lab

... © 2001 WGBH Educational Foundation and Clear Blue Sky Productions, Inc. All rights reserved. ...
2009 - PTU
2009 - PTU

... 2. O.P. Agarwal: Chemistry of Natural Products, Vol. I and II, 7th edn, Goel Publishing House, Meerut, 1983. ...
debenham group practice job description
debenham group practice job description

Drugeruptions - Postgraduate Medical Journal
Drugeruptions - Postgraduate Medical Journal

... with their therapeutic indications. The results of one survey suggested that 30% of prescriptions from general practitioners was based on data supplied by drug companies. In 1985 it is also increasingly common to find that patients, when faced with a chronic disease have sought several medical opini ...
Oral Medications in Optometric Practice
Oral Medications in Optometric Practice

... •  These are well known: PSCs and increased IOP . . . IOP increases are rare; PSCs are not! •  10 mg per day or less for one year or less has almost no chance of PSC formation •  16 mg per day for several years has a 75% chance of PSC formation •  Overall, general population has a 0.5% chance of PSC ...
Brand-Name vs Generic Finasteride Jan-Feb 2016
Brand-Name vs Generic Finasteride Jan-Feb 2016

... is the central ingredient. The second is known as the excipient, which is the inactive substance that serves as the vehicle for the API itself. If the drug is in a syrup form, then the excipient is the liquid that has been used to make it as such.² APIs are commonly referred to as “bulk pharmaceutic ...
CHAPTER 64B8-36
CHAPTER 64B8-36

... (1) Injectable products shall not be ordered by the pharmacist. (2) No oral medicinal drugs shall be ordered by a pharmacist for a pregnant patient or nursing mother. (3) In any case of dispensing hereunder, the amount or quantity of drug dispensed shall not exceed a 34-day supply or standard course ...
Prodrugs:
Prodrugs:

... circumvent deficiencies inherent to the active drug; for example, prodrugs for improving site specificity, prodrugs to bypass high first-pass metabolism, prodrugs for improving stability, prodrugs for reducing adverse effects, prodrugs for improving drug targeting, and prodrugs for improving absorpt ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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