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Profile Documents Logout
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Prior Authorization Form
Prior Authorization Form

... (Please document dose reduction or reason for high dose [if applicable]) *If the above information is not available, please attach the patient’s chart notes documenting clinical improvement. *If you have any questions regarding your patient’s plan drug limits you may call us at: 1-800-711-4555. For ...
Intro to Genetics - MacWilliams Biology
Intro to Genetics - MacWilliams Biology

...  uppercase letters for dominant traits  lower case letters for recessive traits  i.e. AA, Aa, aa (NOT AB) ...
gene pool conservation - University of Hawaii at Manoa
gene pool conservation - University of Hawaii at Manoa

... of new discoveries has to do with the existence of generic variation from The natural pwu!ation of the individual to individual in natural ~~lpulationr. human species displays suchvariabilliy, and it is not hard foithe casual observer to recognize that both genes and environment are involved. Some d ...
Suggestion from clinicians
Suggestion from clinicians

... 120 % in plasma concentrations in healthy volunteers [44]. Similarly, such inhibition was found most likely to increase the total exposure of etravirine by 41 % after a single dose of etravirine 100 mg and multipledose omeprazole, an effect that was not observed with multiple-dose ranitidine [46]. T ...
Cell Cytotoxicity against Multiple Myeloma (MM
Cell Cytotoxicity against Multiple Myeloma (MM

... • Infusion of KIR-HLA mis-matched NK cells appears to provide antitumour efficacy in AML patients (Miller, Soignier et al. 2005). • In vitro, tumour cells are sensitive to killing by NK cells whose KIR fail to recognise HLA class I on the target cells (KIR-HLA mis-matched), but not by KIR-HLA matche ...
Instructions for the Medical Use of Arbidol
Instructions for the Medical Use of Arbidol

... the human body when taken orally at the recommended dosages. Pharmacokinetics: The drug is absorbed quickly and spreads to organs and tissues. The maximum blood level (concentration) after taking a 50 mg dose occurs 1.2 hours after administration; for a 100 mg dose, 1.5 hours after administration. A ...
Substance Abuse - Tennessee Dental Hygienist`s Association
Substance Abuse - Tennessee Dental Hygienist`s Association

... (http://www.drugabuse.gov/related‐topics/trends‐statistics/monitoring‐future) revealed a rise in marijuana use in this age group while alcohol use revealed a historic low. Teen cigarette smoking was also reported to be in decline. This group reported survey data in 2010 of teenagers that inferred us ...
CB064-4.19 - Workforce3One
CB064-4.19 - Workforce3One

... the U.S. Department of Labor’s Employment and Training Administration. The solution was created by the grantee and does not necessarily reflect the official position of the U.S. Department of Labor. The Department of Labor makes no guarantees, warranties, or assurances of any kind, express or implie ...
Reflection Paper co-development of PG biomarkers and Assays in
Reflection Paper co-development of PG biomarkers and Assays in

... The increasing knowledge of variation within the human genome is being used for the development of personalised and stratified medicine, with the aims of decreasing the number of adverse drug reactions and increasing the efficacy of drug therapy. Significant pharmacogenomic research has focused on u ...
04-pain - Pat Heyman
04-pain - Pat Heyman

... Diclofenac (Voltaren) Ketorolac (Toradol) can be given IM Indomethacin (Indocin) Nabumetone (Relafen) ...
Download: Generic Antithrombotic Drugs
Download: Generic Antithrombotic Drugs

... • Complex drugs/compositional variations may occur leading to safety/efficacy compromise. • Minimal requirements from regulatory bodies which can be easily fulfilled. • Newer guidelines from peer groups and regulatory bodies are needed to validate the generic antithrombotic drugs. ...
Slide 1
Slide 1

... i.e., can the test detect both the presence and absence of mutations. Clinical Validity – does the test result predict the presence or absence of disease ...
What is pharmaceutics? - University of Toronto
What is pharmaceutics? - University of Toronto

... • Deals with many aspects of interactions both inside and outside the body • It’s not trivial to design and implement a dosage form that is both safe and effective for the drug’s intended use! ...
Population Genetics
Population Genetics

... • Mutation rate (µ): 10-5 to 10-6 per generation • Pt = Poe-µt t= # of generations • To reduce P by ½, if µ= 10-5 & Po =0.96 • Requires 69,000 generations • Mutation source of genetic variation does not really cause rapid evolutionary change ...
Ciclosporin - Wolverhampton Formulary
Ciclosporin - Wolverhampton Formulary

... be explained to the patient by the doctor initiating treatment. It is important that patients are consulted about treatment and are in agreement with it. Patients who have undergone renal transplant are under regular follow-up, which provides opportunities to discuss drug therapy. The doctor who pre ...
Genetic Testing for Cancer Susceptibility
Genetic Testing for Cancer Susceptibility

... The individual’s genetic disorder is associated with a potential significant cancer List the potential cancer type: ...
Ocular Pharmacology
Ocular Pharmacology

... Factor influencing systemic drug penetration into ocular tissue:  Lipid solubility of the drug: more penetration with high lipid  solubility  Protein binding: more effect with low protein binding  Eye inflammation: more penetration with ocular inflammation ...
3 - Fossilized.org
3 - Fossilized.org

... Albinism is a rare genetically inherited trait that is only expressed in the phenotype of homozygous recessive individuals (aa). The most characteristic symptom is a marked deficiency in the skin and hair pigment melanin. This condition can occur among any human group as well as among other animal s ...
Slide 1
Slide 1

... Clinical Vignette Kristen Lee, PGY 2 May 13, 2009 ...
The Get Out of Jail Free Gene
The Get Out of Jail Free Gene

... ethnic groups, it is not far-fetched to think that a judge might take ethnicity into account when sentencing. Some believe that the link between antisocial behaviour and genes is so strong that genetic information should be accorded the same status as mental illness or an abusive childhood in decidi ...
Complement genotyping request form
Complement genotyping request form

... If no, an invoice will be sent to the referring clinician. If this patient has not been referred to the National aHUS Service, to whom should the invoice be addressed (if not the referring clinician)? ...
Prescribing Information
Prescribing Information

... Some individuals may be ultra-rapid metabolizers because of a specific CYP2D6 genotype (gene duplications denoted as *1/*1xN or *1/*2xN). The prevalence of this CYP2D6 phenotype varies widely and has been estimated at 0.5 to 1% in Chinese and Japanese, 0.5 to 1% in Hispanics, 1 to 10% in Caucasians, ...
Chapters 6 & 7 Genetics
Chapters 6 & 7 Genetics

... Identify each type of inheritance? • Both alleles are expressed in heterozygote • More than two alleles are possible for a trait • The dominant allele masks the recessive allele • Additive effect of two or more genes • Intermediate phenotype in heterozygotes • A gene at one locus controls a gene at ...
Trospium.
Trospium.

... If you are taking an extended release capsule: Swallow each capsule whole, do not crush or chew it. Some improvement is possible in the first week, while maximum benefit may take months of therapy. Tell your physician or pharmacist if you are taking any prescription medications or over-the-counter m ...
Biological Components of Substance Abuse and Addiction (Part 3 of 8)
Biological Components of Substance Abuse and Addiction (Part 3 of 8)

... ubstance abuse and addiction are complex phenomena that defy simple explanation or description. A tangled interaction of factors contributes to an individual’s seeking out, using, and perhaps subsequently abusing drugs. Since more individuals experiment with drugs than eventually develop substance a ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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