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Punnett PP
Punnett PP

... Heterozygous individuals have two different alleles for a gene – like the rat in the do now. (Hetero = different) ◦ Example: Bb = one brown eye allele, one blue eye allele ...
Opioid - American Society of Addiction Medicine
Opioid - American Society of Addiction Medicine

... plan ahead of time is strongly recommended. ...
to open the MS Word version of the Quarterly Action Agenda
to open the MS Word version of the Quarterly Action Agenda

... Don’t abbreviate drug names in computerized prescriber order entry (CPOE) systems (17) Space limitations in CPOE drug name For these and other combination fields can be problematic for products, display both the brand and combination products. In one hospital, generic names of the drug when GENVOYA ...
ACE 130 reviewer#1. defense RCT merge crit.
ACE 130 reviewer#1. defense RCT merge crit.

... to the drug regime because the NMBs have a confounding effect on the outcomes assessed. The basis for this statement is as follows. IV and volatile agent techniques if titrated to unconsciousness without the use of NMBs and ceiling dose protocols will be equivalent in their ability to render the pat ...
Lopressor - Novartis Pharmaceuticals Corporation
Lopressor - Novartis Pharmaceuticals Corporation

... plasma have been reported. Metoprolol is not a significant P-glycoprotein substrate. Metabolism: Lopressor is primarily metabolized by CYP2D6. Metoprolol is a racemic mixture of R- and S- enantiomers, and when administered orally, it exhibits stereo selective metabolism that is dependent on oxidatio ...
Genetics Powerpoint 2/7/17
Genetics Powerpoint 2/7/17

... • The law of independent assortment states that genes for different traits can segregate or switch independently during the formation of gamates. ...
How Much Animal Data are Required to Move
How Much Animal Data are Required to Move

... • The rat toxicity is monitorable. • Clinical pathology can be monitored in humans before histopathological doses • FDA makes you start at a very low dose, but you are allowed to dose upward with careful ...
Major Drug Conventions
Major Drug Conventions

... • The strength of the drug is not relevant; only the similarity of its effects to the substances already controlled. • The Single Convention of Narcotics Drugs of 1961 could not regulate the many newly discovered substances , since its scope was limited to drugs with cannabis, coca, and opium like e ...
Issue 25, January 2006 - Medication Access Program
Issue 25, January 2006 - Medication Access Program

... integral role in calcium absorption, vitamin D insufficiency can lead to reduced calcium absorption, bone loss, and an increased risk of fractures. There are two sources of obtaining vitamin D, sunlight and diet. For many Americans, these sources alone are not enough and a vitamin D supplement is wa ...
Opioid Treatment Agreement | Patient Name
Opioid Treatment Agreement | Patient Name

... count of my pills at any time. This is performed routinely for all patients to improve the overall safety of using opioids. Urine drug monitoring will also look for other substance use that increases the risks associated with using opioids. Further refills/prescriptions will be tied to completion of ...
PPT - ACoP7
PPT - ACoP7

... Factor Xa (FXa) inhibitor, CS-3030. Predicted human pharmacokinetics (PK), biomarker responses (PD), and clinical outcomes were obtained using appropriate projection methods and PK/PD data from cynomolgus monkey, together with literature data. Models were developed for anti-FXa activity and fold-inc ...
Previous Discussion Section Notes
Previous Discussion Section Notes

... 9. What is one concern with taking dietary supplements (concerning their development process)? Give one example of a dietary supplement discussed in class and what it has been proposed to be useful for. No FDA approval process, no regulation. Ex: Leptoprin (weight loss) 10. What is involved in the p ...
Intervention Study 2016 Trust-wide
Intervention Study 2016 Trust-wide

... – Ensured nurses faxed the prescription chart to pharmacy – Ensured pharmacy obtained the branded product (tacrolimus - brand specific) – Endorsed prescription chart : With brand name, Adoport® Critical medicine – do not omit doses. If no stock on ward, order from pharmacy; if out of hours, contact ...
RIFAMPIN
RIFAMPIN

... It is well absorbed after oral administration. Rifampin is widely distributed in tissue and body fluids. It can reach TB cavities, sputum and penetrate macrophage killing TB bacilli. Rifampin is excreted mainly through liver and small amount is excreted in urine, saliva and tears. It give red orange ...
Induced Phototoxicity
Induced Phototoxicity

... The goal of photosafety testing is to detect the adverse effects of pharmaceutical products in the presence of light. This type of testing is relevant for medicinal products that enter the skin via dermal penetration or systemic circulation. The overall risk benefit assessment of a drug product whic ...
Evidence-Based Guidelines for the Classification and Management
Evidence-Based Guidelines for the Classification and Management

... The goal of photosafety testing is to detect the adverse effects of pharmaceutical products in the presence of light. This type of testing is relevant for medicinal products that enter the skin via dermal penetration or systemic circulation. The overall risk benefit assessment of a drug product whic ...
general principles of pharmacology
general principles of pharmacology

... TITRATION: experimental process of trying different doses or types of medication and evaluating therapeutic response and side effects. MAINTENANCE: periodic monitoring of the child’s functioning on the optimal dose selected during the titration stage. Adjustments in the dose or drug may be made in r ...
Innovation - Projects at Harvard
Innovation - Projects at Harvard

... And does the ‘topography’ of historical contingency change over time? ...
Safety Rating Systems for Drugs Used in Pregnancy and Lactation Chapter 2
Safety Rating Systems for Drugs Used in Pregnancy and Lactation Chapter 2

... Another source of information is the Teratogen Information System (TERIS), which catalogs risk of teratogenic effects for the offspring of exposed women as none, minimal, small, moderate, or high. When no or limited human data are available, a drug is classified as having an undetermined risk in the ...
I can’t sleep, my pee smells funny, my bones hurt AND I’m
I can’t sleep, my pee smells funny, my bones hurt AND I’m

... Kronmal RA, Cain KC, Ye Z, Omenn GS. Total serum cholesterol levels and mortality risk as a function of age. A report based on the Framingham data. Arch Intern Med 1993;153:1065-73. Lewington S, Whitlock G, Clarke R, Sherliker P, Emberson J, Halsey J, et al. Blood cholesterol and vascular mortality ...
Phases of Drug Metabolism - Thomas Jefferson University
Phases of Drug Metabolism - Thomas Jefferson University

... • Amiodarone (and many other drugs) interfere with CYP 3A4 function and may lead to statin toxicity, perhaps even to rhabdomyolysis • Simvastatin dosing should be limited to 20 mg daily or less in these circumstances ...
NEXT-GENERATION DATA ANALYSIS SOFTWARE AIDS FASTER
NEXT-GENERATION DATA ANALYSIS SOFTWARE AIDS FASTER

... Researchers studying variability in drug concentrations in patient populations use S-PLUS software to accelerate data analysis to improve the understanding of drug safety and efficacy. Faster and better drug development can reduce the time taken to make safe and effective drugs available to those wh ...
• Genetic Influences: Terms and Patterns of Transmission • Genetic
• Genetic Influences: Terms and Patterns of Transmission • Genetic

genes
genes

... • If you flip a coin three times in a row what is the probability that it will land heads up? • ½ X ½ X ½ = 1/8 • The principle of probability can be used to predict the outcomes of genetic crosses. ...
Prior Authorization Form
Prior Authorization Form

... (Please document dose reduction or reason for high dose [if applicable]) *If the above information is not available, please attach the patient’s chart notes documenting clinical improvement. *If you have any questions regarding your patient’s plan drug limits you may call us at: 1-800-711-4555. For ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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