• Study Resource
  • Explore Categories
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
The Case for Personalized Medicine
The Case for Personalized Medicine

... The life sciences community strives to improve the safety and efficacy of its products, but much more work remains. Progress in developing and adopting diagnostics to identify which medicines work best for which patients, thus reducing adverse events, has been slow. In fact, between 2000 and 2011, t ...
Mutagenesis (mutations) and Teratogenesis
Mutagenesis (mutations) and Teratogenesis

...  HIV After 35th week- Systematic Chronic infection(fungus,bacterial,viral,protozoan) ...
The long-term follow-up after idiosyncratic drug
The long-term follow-up after idiosyncratic drug

... generally have a favorable prognosis, although some patients appear to develop progressive chronic liver disease. Drugs and the liver: Patterns of drug-induced liver injury Last literature review version 18.3: 九月 2010 This topic last updated: 七月 16, 2010 ...
CYAMEMAZINE
CYAMEMAZINE

... • Lower doses should be used and patient should be monitored closely • Generally, doses above 100 mg/day are not recommended • Elderly patients with dementia-related psychosis treated with antipsychotics are at an increased risk of death compared to placebo, and also have an increased risk of cerebr ...
Designer - RTI International
Designer - RTI International

... • combat drug trafficking • assure drug availability for legitimate use • comply with international treaties o Established the process by which drugs are evaluated and regulated by their abuse liability o Classification into 5 schedules (I-V) based upon abuse liability, toxicity & medical need • man ...
Overview of Medical Toxicology and Potential for Exposures to Clandestine Drug Laboratories in California
Overview of Medical Toxicology and Potential for Exposures to Clandestine Drug Laboratories in California

... is dangerous to children, there is little published literature regarding the relationship between exposure to i11icit drug laboratories and adverse health effects. This probably reflects the clandestine nature of these operations add the fact that little research has been performed to evaluate the h ...
PowerPoint Presentation - Anticoagulants and Thrombolytics
PowerPoint Presentation - Anticoagulants and Thrombolytics

...  Active in vitro and in vivo  Administration - parenteral- Do not inject IM only IV or deep s.c.  Half-life 1 - 5 hrs - monitor aPTT  Adverse effect - hemorrhage - antidote protamine sulphate ...
IV sedation
IV sedation

... Possible side effects of intravenous sedation All medicines have effects and side effects. The drugs used for sedation are no exceptions. Fortunately, these side effects are very rare according to existing reports. In the case of intravenous sedation, the side effects can be linked to the need of a ...
1. Drug(s) which exhibit(s) a high hepatic" first
1. Drug(s) which exhibit(s) a high hepatic" first

... A 30 year old male with known tuberculosis infection and taking medication since 1 month comes to the phisician with complaint of visual disturbances including decreased visibility and slight color blindness. If these symptoms are due to his drug treatment, which one of the following antituberculosi ...
Assess-ERR - eventsential.org
Assess-ERR - eventsential.org

... How are comorbidities assessed? How are patient specific factors identified including: cognitive ability, health literacy, language, depression, dexterity limitations, and special populations? How is updated and accurate drug information disseminated? What drug references are available for infused p ...
P-RMS
P-RMS

... The initiation of Chronic Heart Failure treatment with nebivolol necessitates regular monitoring. For the posology and method of administration please refer to section 4.2. Treatment discontinuation should not be done abruptly unless clearly indicated. For further information please refer to section ...
class03.pps - CS Technion
class03.pps - CS Technion

... If a single test was to be employed to test a null hypothesis, using 0.05 as the significance level and if the null hypothesis was actually true; the probability of reaching the right conclusion (i.e., not significant) is 0.95. If two such hypotheses were tested, then the probably of reaching the ri ...
FDA Basics For Biotech Drugs, Biologics and Devices
FDA Basics For Biotech Drugs, Biologics and Devices

... packaging, holding, testing, and quality control of drugs and biologics.) Companies starting Phase I clinical trials for drugs and biologics must comply with facility and equipment qualification requirements and validate “safetyrelated processes” (e.g., sterilization, viral clearance) to ensure that ...
Full-Text  - Tropical Journal of Pharmaceutical Research
Full-Text - Tropical Journal of Pharmaceutical Research

... (> 1/10,000, < 1/1,000). Listed very rare effects (< 1/10,000) include constipation, tachycardia and palpitations. It can induce possible paradoxical excitement (e.g., restlessness, insomnia, tremors, euphoria, nervousness, delirium, palpitation, seizures), especially in children, but in general it ...
Persistent Fever by Rona Marie Leonor 111209
Persistent Fever by Rona Marie Leonor 111209

... More appropriate reference standard would be the absence of infection after extensive and thorough laboratory work-up coupled with the absence of any clinical deterioration without administration of any antibiotics on continued follow-up for at least a period of 2 weeks. Utility of Naproxen in the D ...
Medical Genetics - New York University
Medical Genetics - New York University

... mellitus presents along with her fiance for genetic counseling. During the course of the interview, we discovered that the fiance had neurofibomatosis I, a condition that was diagnosed during his physical diagnosis course in medical school. In addition, it became apparent that the young woman had hy ...
AS91157 Demonstrate understanding of genetic variation
AS91157 Demonstrate understanding of genetic variation

... A new plant variety is established that shows variation in both the pattern of the veins and the lobe shape of the leaves. The genes controlling these features are located on different pairs of homologous chromosomes. R = allele for regular patterned veins r = allele for irregular patterned veins D ...
new03
new03

... If a single test was to be employed to test a null hypothesis, using 0.05 as the significance level and if the null hypothesis was actually true; the probability of reaching the right conclusion (i.e., not significant) is 0.95. If two such hypotheses were tested, then the probably of reaching the ri ...
Prevention Links Prevention Links
Prevention Links Prevention Links

... The overwhelming variety of synthetic drugs flooding the market has been leaving law enforcement scrambling to keep up. Drug Enforcement Administration (DEA) statistics report that: Five new synthetic drugs are introduced to the U.S. market every month With more than 200 kinds identified by the DEA ...
Animal breeders use test crosses to determine whether an individual
Animal breeders use test crosses to determine whether an individual

... and Ii; the superscripts indicate that ________. ...
Triple Diagnosis - New York and New Jersey AIDS Education and
Triple Diagnosis - New York and New Jersey AIDS Education and

... 5. Personal and business activities reduced by drug use 6. Substance taken in larger amounts or for longer than intended 7. Knowledge of drug use’s negative health and personal effects, yet continuing to use drugs Source: Adapted from DSM-IV, 4th edition, 1994 ...
Transfer from Methadone To Buprenorphine - PCSS-MAT
Transfer from Methadone To Buprenorphine - PCSS-MAT

... narcotic effects (it is termed a "partial agonist") which makes it safer in case of overdose. This means that by itself, even in large doses, it doesn't suppress breathing to the point of death in the same way that heroin, methadone and other opioids could. These are some of the unusual qualities of ...
Document
Document

... Estimated total # of genes represented ~ 50 ctf genes ...
Resource pack: Human genetic variation and disease
Resource pack: Human genetic variation and disease

... Genome-wide association studies (GWAS) are used by researchers to look at genetic variations between people, determine their importance and predict risk of particular diseases and response to certain medications. To carry out a genome-wide association study (GWAS), researchers can use two groups of ...
11/10/2014 Synthetic Cannabinoids – Research Compounds
11/10/2014 Synthetic Cannabinoids – Research Compounds

... • Hallucinations • Psychosis • Aggression • Rhabdomyoloysis • Respiratory depression • Kidney failure • Deaths including suicide ...
< 1 ... 831 832 833 834 835 836 837 838 839 ... 1254 >

Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report