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acetaminophen (oral, rectal) (a-seet-a-min-oh-fen
acetaminophen (oral, rectal) (a-seet-a-min-oh-fen

... IV (Adults and Children ⱖ13 yr and ⱖ50 kg): 1000 mg q 6 hr or 650 mg q 4 hr (not to exceed 1000 mg/dose, 4 g/day, and less than 4 hr dosing interval). IV (Adults and Children ⱖ13 yr and ⬍50 kg): 15 mg/kg q 6 hr or 12.5 mg/kg q 4 hr (not to exceed 15 mg/kg/dose, 75 mg/kg/day, and less than 4 hr dosin ...
2nd Lecture 1433
2nd Lecture 1433

... To avoid constant activation of the receptor by promiscuous binding of many different ligands  It must change its function upon binding in such a way that the function of the biologic system (cell, tissue, etc) is altered  This is necessary for the ligand to cause a pharmacologic effect ...
DPP-4 INHIBITOR LINAGLIPTIN: A NEW ANTI-DIABETIC DRUG IN THE TREATMENT OF TYPE-2 DIABETES  Review Article
DPP-4 INHIBITOR LINAGLIPTIN: A NEW ANTI-DIABETIC DRUG IN THE TREATMENT OF TYPE-2 DIABETES Review Article

alleles - WordPress.com
alleles - WordPress.com

... variations, known as alleles, that express different traits. For example, 2 alleles in the gene for freckles are inherited from mum and dad: – allele from mum = has freckles (F) – allele from dad = no freckles (f) – child has the inherited gene pair of alleles, Ff (F allele from mom and f allele fro ...
26
26

... NSARD have mutations in the GJB2 gene. Three mutations are particularly common in specific populations: 30delG or 35delG in Caucasoids, 167delT in Ashkenazi Jews, and 235delC in Orientals. DFNB1-linked familial cases with no mutation in GJB2 have also been reported. Mutations in the complex DFNB1 lo ...
Sample “Content” Lesson Plan: 45 minutes total
Sample “Content” Lesson Plan: 45 minutes total

...  Phenotype: expressed/displayed traits (i.e. I actually have brown or green eyes) Q: How many genes are needed to determine one trait?  Any number of genes to determine one trait.  For example, being able to roll your tongue is determined by just one pair of genes, while height may be determined ...
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N ews R elease - Sunovion Pharmaceuticals Inc.
N ews R elease - Sunovion Pharmaceuticals Inc.

... GmbH, is fast, portable, and runs silently. The vibrating membrane device reduces the time for administration, allowing patients to receive medication in approximately two minutes compared with ...
Overview - University of Missouri
Overview - University of Missouri

... Constructed in the laboratory by assembling overlapping DNA fragments. Each fragment can be easily retrieved for experiments which can localize genes of interest. ...
Postdoctoral Research Associate
Postdoctoral Research Associate

... breast/ovarian cancer and colon cancer respectively ◦ Human knockouts for BRCA2 (primordial dwarfism) and APC (severe limb malformation) have very different phenotypes from those of the established dominant phenotype in haploinsufficient individuals ...
Gene Expression-Based Assays for Cancers of Unknown Primary
Gene Expression-Based Assays for Cancers of Unknown Primary

... The NCCN guidelines for the workup of an occult primary malignancy address the use of molecular methods in the classification of tumors. The guideline states that “Tumor sequencing and gene signature profiling for tissue of origin is not recommended for standard management at this time.” The use of ...
Medical Billing and Coding Program
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... pea plant with round seeds  Calculate the probability that an individual heterozygous for a cleft chin (Cc) and an individual homozygous for a cleft chin (cc) will produce offspring that are homozygous for a cleft chin  When analyzing a pedigree, how can you determine if an individual is a carrier ...
MYX receives first generic approval of Tikosyn
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Steroid/Sports Drug Testing FAQ

... with dual pharmacological actions: androgenic (promote development of male sexual characteristics) and anabolic (increase nitrogen retention, protein synthesis, muscle growth in the body). Testosterone, the principal endogenous AAS, is produced in the testes by males and in the adrenal glands by bot ...
Heroin and other opiates - EDAS Essential Drugs and Alcohol
Heroin and other opiates - EDAS Essential Drugs and Alcohol

... alcohol, tranquillisers or other opiates. Many regular heroin users will use other opiates or depressant drugs when they cannot get hold of heroin. It is often difficult to know exactly what is being taken because the purity of street heroin varies and it is often mixed with adulterants. Injecting i ...
Protonil Tablet - Renata Limited
Protonil Tablet - Renata Limited

... administration of Pantoprazole to neonates and children. Lactating mother: There are no data on the excretion of Pantoprazole into the breast milk. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the benefit of the drug to the mother. Pregnant ...
Herb-drug interactions
Herb-drug interactions

... (diet pills) – illegal in US but possibly obtained internationally/Internet. Increase in blood pressure, thus contraindicated with antihypertensives and stimulants (e.g. caffeine). ► Black Cohosh (menopausal symptoms but UIC trial negative) – some hepatotoxicity due to adulteration recently; use cau ...
Name
Name

... - These are alternate forms of the same gene created by mutations in the genetic code. Some genes have multiple alleles, such as blood type (three alleles), but at this point let's assume that there are just two alternate forms, or alleles, for each gene. Example: plant height in peas is either tall ...
View PPT - Indian Drug Manufacturers` Association
View PPT - Indian Drug Manufacturers` Association

... • It ranks 3rd in terms of volume of products with 10% global share and 14th largest by value (1.5%). This is because drug prices are lower in India to the extent of 25-50% compared to developed countries • The country has more then 100 manufacturing facilities approved by US FDA. The US FDA officia ...
Characterization of Gene Expression Profiles Associated with
Characterization of Gene Expression Profiles Associated with

... • The authors did not use any sample replicates in their study(may be due to prohibitive costs). This raises a question mark on the reliability of their statistical data. • The authors show a slight bias while selecting genes for RT-PCR validation (are more concerned about the targets they have in m ...
6Control Drug Delivery System
6Control Drug Delivery System

... ii) Distribution: It not only lowers the concentration of circulating drug but it also can be rate limiting in its equilibration with blood and extracellular fluid. The Vd and the ratio of drug in tissue to that of plasma at steady state is an important parameters to be considered in determining the ...
chapter 11 - MissDutka
chapter 11 - MissDutka

... •  Example: Humans have one gene that controls whether they will have attached or detached earlobes. That one gene has two alleles. One allele that codes for attached earlobes, and one allele that codes for detached earlobes. ...
SODIUM-GLUCOSE COTRANSPORTER
SODIUM-GLUCOSE COTRANSPORTER

... were from the following pharmacotherapeutic groups; nonsteroidal anti-inflammatory agents (NSAIDs) (21.7%), antibiotics (22%), cardiac therapy agents (7.6%), analgesics and antipyretics (7.6%) and contrast agents (1.6%) (Figure 2). This constituted more than half of the total volume of reports recei ...
Evidence-Based Practice CME ▲
Evidence-Based Practice CME ▲

... or institutionalized individuals aged 60 or older. Studies that focused on patients with unstable health states, alcoholism, or patients recently discharged from a hospital were excluded. Five RCTs were identified that met inclusion/exclusion criteria, for a total of 1,237 individuals (mean age, 70) ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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