• Study Resource
  • Explore Categories
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Forced Drugging Defense Package - Law Project for Psychiatric Rights
Forced Drugging Defense Package - Law Project for Psychiatric Rights

... (a) Neuroleptics, also called antipsychotics, increase the likelihood that a person will become chronically ill. (b) Long-term recovery rates are much higher for unmedicated patients than for those who are maintained on neuroleptic drugs. (c) Neuroleptics cause a host of debilitating physical, emoti ...
education subcommittee - Hamilton Health Sciences
education subcommittee - Hamilton Health Sciences

... contributes to further stimulate the vomiting reflex. Vomiting can also occur by mechanisms other than direct gastrointestinal irritation. It can be caused by stimulation of an area in the brain known as the chemoreceptor trigger zone (CTZ). Certain medications, infections, and toxins can stimulate ...
Slide 1
Slide 1

Nonstationary Functional Optimization
Nonstationary Functional Optimization

... tested with four and six optional spaces respectively, where each solution space consisted of the total objects i.e each bit represented one object. Our experiments required a speci ed number of high level genes active (one here) in a chromosome at any one time according to the number of parameters ...
Acetylsalicylsyra Hexal 75 mg gastro
Acetylsalicylsyra Hexal 75 mg gastro

... acute conditions, the indication “Acute myocardial infarction” is not included in the approval. As pointed out by the applicant, there are no regular dose-finding studies for ASA available in these indications. Over time, the recommended dose for the prevention of cardiovascular events has been adju ...
Prof_S._Brennecke_s_abstract
Prof_S._Brennecke_s_abstract

... to pre-eclampsia has been recognised for many years, the mode of inheritance remains a topic of debate. Increasingly, there is consensus that mother and fetus both contribute to the genetic risk for pre-eclampsia, with the fetal contribution reflecting the influence of paternal genes. This degree of ...
Antipsychotic Drugs: Prolonged QTc Interval, Torsade de Pointes
Antipsychotic Drugs: Prolonged QTc Interval, Torsade de Pointes

... twice as often in populations treated with antipsychotics as in normal populations, there are still only 10–15 such events in 10,000 person-years of observation. Conclusions: Although pimozide, sertindole, droperidol, and haloperidol have been documented to cause torsade de pointes and sudden death, ...
Genetic mapping and manipulation: Chapter 6
Genetic mapping and manipulation: Chapter 6

... autonomous pieces of DNA derived from normal chromosomes. They are usually relatively small as compared with full-length chromosomes and exhibit segregation properties that are independent of other chromosomes, including the chromosome from which they were derived. In many ways they most resemble ex ...
PDF Version - InsideHealthPolicy.com
PDF Version - InsideHealthPolicy.com

... Senators Ask Agency Heads If They Need Help Limiting Animal Antibiotics Democratic Sens. Elizabeth Warren (D-MA), Dianne Feinstein (D-CA) and Kirsten Gillibrand (D-NY) sent a letter on Dec. 15 asking the heads of a newly-formed inter-agency council if they need congressional help as they develop a n ...
Investor Presentation
Investor Presentation

... could cause actual results to differ materially from expected results, performance or achievements expressed or implied by statements made herein. Our actual results could differ materially from those anticipated in forward-looking statements for many reasons, including, but not limited to, uncertai ...
VANDERBILT STUDENT VOLUNTEERS
VANDERBILT STUDENT VOLUNTEERS

... genotype - genetic traits that are coded in our DNA phenotype - physical traits that are shown in our physical person Ask: Can a person’s genotype, or genetic traits, be different from their phenotype, or physical traits? Yes, because not all genes are expressed. Genes for one trait can interfere wi ...
Updates in Oncology JM.ONS.2017
Updates in Oncology JM.ONS.2017

... Oct. 2016: Met. NSCLC progressed during or following platinumcontaining chemotherapy. • EGFR or ALK genomic tumor alterations should have disease progression on FDA-approved therapy prior to atezolizumab May 2016: locally advanced or met. Urothelial carcinoma (UC) progressed during or following plat ...
1 Drug Absorption, Distribution and Elimination
1 Drug Absorption, Distribution and Elimination

... where [BH+ ] and [B] are the concentrations of the ionized and the non-ionized forms and pKa is the pH value at which [BH+ ] = [B]. If the pKa of the basic drug is 7, at pH 2 (e.g. in the stomach), almost 100% is present as the ionized form BH+ (Fig. 1.3). At pH 5.5 (e.g. in the small intestine), on ...
Cannabis sativa - Bakersfield College
Cannabis sativa - Bakersfield College

... In order for a psychoactive drug to have an effect, it must get to the brain – it must pass through the blood-brain barrier Action of most drugs terminated by enzymes in the liver – drug metabolism Small amounts may also be excreted in urine, sweat, feces, breath, and mother’s milk Copyright © 2009 ...
Pharmaceutical Care Practice
Pharmaceutical Care Practice

... and safety of a patient’s drug therapy he must understand all the steps of the steps above. •Drug therapy problems can occur anywhere in the patient’s drug use process ...
Pharmacokinetics and doses of anti-TB drugs in children
Pharmacokinetics and doses of anti-TB drugs in children

... • To rapidly kill most bacilli in order to: - prevent disease progression - prevent transmission of infection - prevent development of drug resistance Continuation phase • To effect cure and prevent relapse (eliminate dormant bacilli) ...
Predicting drug-target interaction in cancers using homology
Predicting drug-target interaction in cancers using homology

... response to drugs. Our aim was towards the understanding of the possible role of structural variations in breast cancer drug metabolising gene such as MTHFR that closely interact with the neoplastic drugs viz. Cyclophosphamide, 5-Fluorouracil, Methotrexate and others. We investigated the polymorphis ...
Understanding dual diagnosis
Understanding dual diagnosis

... itself, can cause a long-term mental illness, despite press reports to the contrary. This isn’t to say cannabis can’t be harmful. Heavy and frequent use can cause dependence, and some individuals tend to become lethargic and unmotivated. Alcohol can also cause the symptoms of psychosis, particularly ...
BI321F12 Review Lecture 01 Model organisms etc
BI321F12 Review Lecture 01 Model organisms etc

... Mendel’s lines were true-breeding for either purple flowers or white flowers. These are alternative phenotypes. A gene is defined by specific phenotypic differences. ...
Urine Drug Testing Clinical Practice
Urine Drug Testing Clinical Practice

... The immunoassay drug tests, which are designed to classify substances as either present or absent according to a predetermined cutoff threshold, remain the most common methods used in clinical care. Immunoassays are based on the principle of competitive binding, and use antibodies to detect the pres ...
Chapter 17 Antipsychotic Agents
Chapter 17 Antipsychotic Agents

Potential relationship between genotype and clinical
Potential relationship between genotype and clinical

... 37 Spanish PA patients in relation to the mutations found in both PCCA and PCCB genes. We have detected 27 early-onset and 10 late-onset cases, showing remarkably similar biochemical features without relation to either the age of onset of the disease or the defective gene they have. Twenty-one of th ...
ADENOSINE (Adenocard) - Department of Emergency Management
ADENOSINE (Adenocard) - Department of Emergency Management

...  No major contraindications for administration to most patients.  D50W should be used cautiously in patients with increased intracranial pressure as the dextrose load can theoretically worsen cerebral edema. POTENTIAL SIDE EFFECTS:  Hyperglycemia.  Tissue necrosis if extravasation occurs. DOSAGE ...
Baclofen Tablets - Upsher
Baclofen Tablets - Upsher

... intervals, since deterioration in seizure control and EEG have been reported occasionally in patients taking baclofen. It is not known whether this drug is excreted in human milk. As a general rule, nursing should not be undertaken while a patient is on a drug since many drugs are excreted in human ...
TURKU – FINLAND and OSAKA - JAPAN Press release on February
TURKU – FINLAND and OSAKA - JAPAN Press release on February

... subsequent to the Letter of Intent which was concluded on December 28th 2010 and the financial details of the agreement were not disclosed. Faron’s leading drug candidate FP-1201 is the main target of this collaboration and is currently in phase II in the UK. The trial FPCLI001 (see www.clinicaltria ...
< 1 ... 634 635 636 637 638 639 640 641 642 ... 1254 >

Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
  • studyres.com © 2026
  • DMCA
  • Privacy
  • Terms
  • Report