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Disseminated superficial actinic porokeratosis: A case report
Disseminated superficial actinic porokeratosis: A case report

... prescribed in the morning and afternoon. The patient was advised to have regular follow ups. Discussion Disseminated superficial actinic porokeratosis (DSAP) is the most common form of porokeratosis, and may account for almost half of all cases. Patients develop a few to several dozen tan, annular m ...
幻灯片 1
幻灯片 1

... JH, a 63-year-old architect, complains of urinary symptoms to his family physician. He has hypertension and the last 8 years, he has been adequately managed with a thiazide diuretic and an angiotensin-converting enzyme inhibitor. During the same period, JH developed the signs of benign prostatic hyp ...
Local anaesthetics
Local anaesthetics

... the least toxicity The length of the two terminal groups on the tertiary amino-N group are similarly important The addition of a butyl group to mepivacaine results in bupivacaine, which differs by, a. increased lipid solubility & protein binding b. greater potency c. a longer duration of action ...
Microsponge Delivery System: An updated review, current status
Microsponge Delivery System: An updated review, current status

... into the epidermis such that the drug remains primarily localized with only a restricted amount entering the systemic circulation, is a means of controlling side-effects. Thus, the need exists for delivery systems to maximize the period of time that an active ingredient is present, either on the ski ...
Arimidex (anastrozole)
Arimidex (anastrozole)

... Second Line Therapy in Postmenopausal Women with Advanced Breast Cancer who had Disease Progression following Tamoxifen Therapy: Anastrozole was studied in two well-controlled clinical trials (0004, a North American study; 0005, a predominately European study) in postmenopausal women with advanced b ...
Unit 6 Genetics and Heredity
Unit 6 Genetics and Heredity

... • What causes genetic disorders? – DNA mutation (usually recessive) or chromosome abnormalities (in # or structure) that cause the production of abnormal proteins ...
PHARMACEUTICAL STUDIES ON FLASH TABLETS OFA HIGHLY SOLUBLE METFORMIN HYDROCHLORIDE
PHARMACEUTICAL STUDIES ON FLASH TABLETS OFA HIGHLY SOLUBLE METFORMIN HYDROCHLORIDE

... Metformin is a biguanide type insulin sensitizing drug used to treat type-2 diabetes [1]. It is used in drug discovery in vivo models to assess the anti-diabetic potential of other drugs. Metformin became commercially available in 1957.Therapeutic doses of metformin do not produce hypoglycemia, and ...
Essay B5 Chem 151 Professor Whitesell Amphetamines Honestly
Essay B5 Chem 151 Professor Whitesell Amphetamines Honestly

... of red phosphorous. This method results in a much greater yield but is also exponentially more dangerous as toxic phosphine gas is a byproduct of the reaction. Another procedure uses phenylacetone and reductive amination with methylamine. Another simple method is a one-pot synthesis using groud pseu ...
Reference ID: 3953274
Reference ID: 3953274

... • Pharmacies must be certified with the POMALYST REMS program, must only dispense to patients who are authorized to receive POMALYST, and comply with REMS requirements. Further information about the POMALYST REMS program is available at www.CelgeneRiskManagement.com or by telephone at 1-888-423-5436 ...
Glivec
Glivec

... may be influenced by imatinib. This would occur particularly in pre-pubertal period. The long term effects on growth in children due to prolonged treatment is still not known. However, these patients should be closely monitored. Due to limited number of events obtained from literature and spontaneou ...
The molecular basis of phenylketonuria in Koreans
The molecular basis of phenylketonuria in Koreans

... The BH4 response pattern between the PTPS-deficient patient and the PKU patient are somewhat different (Fig. 1). Phenylalanine levels of the PTPS patient was dramatically and completely decreased to the normal level after administration of BH4; in the PKU patient, the decrease was relatively retarded ...
Biol-1406_Ch12.ppt
Biol-1406_Ch12.ppt

... Polygenic Inheritance ...
Ethylone Critical Review Report
Ethylone Critical Review Report

... Ethylone is (RS)-1-(1,3-benzodioxol-5-yl)-2-(ethylamino)propan-1-one (aka, 3,4methylenedioxy-N-ethylcathinone). It has a chiral center with two stereoisomers. Ethylone has no authorizations as a medicinal product/medication. Ethylone is a slight chemical modification of methylone (3,4-methylenedioxy ...
Promise of Pharmacogenomics - Academy of Managed Care
Promise of Pharmacogenomics - Academy of Managed Care

... raised by the development and use of genetic technologies and their integration into clinical and public health practice. Because the scope of its charge encompasses a broad range of issues, the Committee undertook a prioritization process during its first year to help focus on areas in which policy ...
ISIS 301012: The Reduction of Atherogenic Lipids in
ISIS 301012: The Reduction of Atherogenic Lipids in

...  Not well studied in children; no registration  Mechanism of action is complex and largely unknown  Decreased production of very low-density lipoprotein cholesterol (VLDL-C) and an increased clearance of triglycerides  Adverse reactions are similar to those of statins  In children, fibrates are ...
Key Area 6 Genetic Engineering
Key Area 6 Genetic Engineering

... ask you to write your report, in class. • It should be between 50 and 100 words and include: 1. A description and the biology involved in the chosen application being investigated. 2. The impact it has on the environment or society. 3. Your references. ...
Blaylock Wellness Report
Blaylock Wellness Report

... problems and delayed reflexes, something you would not want to have driving or operating dangerous machinery. Researchers found that the lower the cholesterol, the worse the effects. Other studies on people taking these drugs also have reported difficulty thinking and remembering. In fact, memory lo ...
Formulation, Development and Characterization of Emulgel of
Formulation, Development and Characterization of Emulgel of

... amount of a gelating substance present. In spite of many advantages of gels a major limitation is their inability to delivery hydrophobic drugs. To overcome this curb an emulsion based approach is being used so that a hydrophobic therapeutic moiety can be fruitfully incorporated and delivered throug ...
ParameciumDB - Nucleic Acids Research
ParameciumDB - Nucleic Acids Research

... assay. The entity in this case can be found in GO. The attributes and values we have used to describe Paramecium phenotypes come from the Phenotype Attribute Ontology (PATO, http://obo.sourceforge.net/). We have begun to develop a Paramecium Anatomy Ontology, since we need more granular ‘cellular co ...
Consumer Updates > Antibacterial Soap? You Can Skip It -
Consumer Updates > Antibacterial Soap? You Can Skip It -

Ch 23 Evolution - philipdarrenjones.com
Ch 23 Evolution - philipdarrenjones.com

... •  with  respect  to  whether  or  not   an  individual  is  a  carrier  for  the   PKU  allele   ...
facts about statins - Heart Protection Study
facts about statins - Heart Protection Study

Less mastitis through targeted selective breeding Why a reduction of
Less mastitis through targeted selective breeding Why a reduction of

... To complement these studies and to gain further insight into the genetic background for mastitis-related traits, genome-wide expression analyses of udder and liver tissues during infection were applied. These analyses further increased our understanding of the disease pathogenesis of mastitis. Globa ...
Ocular Pain Management for Primary Care OD
Ocular Pain Management for Primary Care OD

... right eye” yesterday. He is a mechanic. He was working underneath a car and something, “maybe rust” fell into his eyes while he was working. It has happened several times before. +pain 2-3 out of 5 on the severity scale, +mild watering, no photophobia, no discharge, +redness, +mild blur to vision. P ...
In-Vitro-In-Vivo Correlation Definitions and Regulatory
In-Vitro-In-Vivo Correlation Definitions and Regulatory

... less than 10 percent. However, the IVIVC was unable to accurately estimate the rate of drug absorption, Cmax. Prediction errors were found to be greater than 20 %. These results support the contention that IVIVCs are product specific. IVIVC is usually developed when drug dissolution is a rate-limiti ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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