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Profile Documents Logout
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Newsletter
Newsletter

... GREECE and ASIA The fame of Cannabis as a medicine spread with the plant. Soon after its introduction to India, it began to spread to other countries such as Assyria, where it was referred to as "azallu" in BC 650. The progression of marijuana across the Middle and Near East was accompanied by tales ...
- Atherosclerosis
- Atherosclerosis

... make all decisions transparent to the user. The recommendations for formulating and issuing ESC Guidelines can be found on the ESC website ( http://www.escardio.org/Guidelines-&-Education/ Clinical-Practice-Guidelines/Guidelines-development/WritingESC-Guidelines). ESC Guidelines represent the officia ...
united states district court
united states district court

... since 1982. I have been Board Certified in Family Medicine and a Diplomate of the American Board of Family Practice since 1982. I graduated cum laude from Harvard College in 1970 with a degree in Social Relations. I attended Dartmouth Medical School and graduated with a degree in Medicine from Brown ...
MARTINDALE - The Complete Drug Reference Danazol
MARTINDALE - The Complete Drug Reference Danazol

... adhesions can develop. Endometriosis is also strongly associated with infertility. Severe endometriosis can distort the pelvic anatomy and thereby reduce fecundity, but how minimal and mild disease might affect fertility is unclear. Management will depend in part on the presenting complaint, the ext ...
German S3-guidelines on the treatment of psoriasis vulgaris (short
German S3-guidelines on the treatment of psoriasis vulgaris (short

... A further version of the guidelines, designed for use by the patient, is currently being developed. The aim is to give patients an overview of possible therapies in terms of complications and optimal usage. Enhancing compliance Adequate patient compliance/adherence are often related to a good ratio ...
PDF
PDF

... In a diverse range of species, local rates of crossing-over correlate with genetic diversity but not with genetic divergence [28,29]. These correlations are inferred to be due to an indirect effect of recombination due to the interaction between selection and linkage and their strength can be used t ...
Handbook of Drug-Nutrient Interactions, 2nd Edition (Nutrition and
Handbook of Drug-Nutrient Interactions, 2nd Edition (Nutrition and

... administration, types of enteral formulas and their nutritional components and importantly, a comprehensive tabulation, in 12 tables, of practice guidelines and data on the drugs and their components, such as sorbitol, that may require careful administration to the tube fed patient. Intravenous deli ...
Prescribing Information as of XXXX ALLEGRA (fexofenadine hydrochloride)
Prescribing Information as of XXXX ALLEGRA (fexofenadine hydrochloride)

... daily doses of 20 and 40 mg fexofenadine hydrochloride demonstrated that the drug exhibits an antihistamine effect by 1 hour, achieves maximum effect at 2 to 3 hours, and an effect is still seen at 12 hours. There was no evidence of tolerance to these effects after 28 days of dosing. Histamine skin ...
Tetracycline Phosphate Complex
Tetracycline Phosphate Complex

... have deteriorated has been associated with the development of a reversible Fanconi-type syndrome characterised by polyuria and polydipsia with nausea, glycosuria, aminoaciduria, hyperphosphaturia, hypokalaemia, and hyperuricaemia with acidosis and proteinuria; these effects have been attributed to t ...
drugs used in migraine
drugs used in migraine

... drugs for migraine prevention: • Following appropriate management of acute migraine, patients should be evaluated for initiation of preventive therapy. Factors that should prompt consideration of preventive therapy include- the occurrence of two or more migraines per month with disability lasting th ...
Familial idiopathic methemoglobinemia revisited: original
Familial idiopathic methemoglobinemia revisited: original

... control subjects, with a significance level of 0.05. Allele frequencies were compared between subjects with glaucoma and control subjects, with the ␹2 test for 2 ⫻ n tables, where n is the number of alleles. Rare alleles were pooled so that all expected cell values were greater than 2. P ⬍ 0.05 was ...
Secundum Artem
Secundum Artem

... samples should be performed; more if feasible. 5. Conclusions must fit the obtained data. It is improper to expand the results into areas not covered by the project. For example, stability studies done in glass containers cannot be extrapolated or applied to plastic containers. STABILITY STUDY DESIG ...
clinical pharmacology of a urotensin-II receptor antagonist in Type 2
clinical pharmacology of a urotensin-II receptor antagonist in Type 2

... hypoglycemic agents, used either as mono- or combination therapy. Table 1 provides an overview of treatments available for Type 2 DM. Though most antidiabetic drugs are in general well tolerated, some risks remain. While serious side effects can be monitored and are infrequent, less serious side eff ...
Medication incidents related to the use of fentanyl transdermal systems
Medication incidents related to the use of fentanyl transdermal systems

... Need for coordinated, system-based solutions Coordinated, systems-based solutions are needed to ensure the safe use of transdermal fentanyl. The first step in the development of effective solutions is to understand the circumstances, conditions and contributing factors associated with inappropriate ...
Free PDF - European Review for Medical and
Free PDF - European Review for Medical and

... caused by a prolongation of the action potential (phase 3) and the prolongation of the effective refractory period10. Therefore amiodarone is included among class III anti-arrhythmic drugs. It is known that torsades de pointes are the classic form of proarrhythmia observed during therapy with any dr ...
Product Monograph
Product Monograph

... hepatocellular pattern of liver damage with significant increases of transaminases, which is typically reversible, but may result in hepatic failure and death. Increases in bilirubin and INR may also occur. The incidence of severe drug-induced liver injury, defined as elevated transaminase levels ab ...
and 7-hydroxymethotrexate
and 7-hydroxymethotrexate

... The elevation in metabolite plasma concentration cannot be only attributed to the increase in metabolic clearance of MTX, but also to the decrease in the total body clearance of the metabolite. The total body clearance of the major metabolite 7-OHMTX in the PIP-treated rabbits significantly decreas ...
Albuterol Sulfate Inhalation Solution 0.083%*
Albuterol Sulfate Inhalation Solution 0.083%*

... It has been demonstrated that following oral administration of 4 mg albuterol, the elimination half-life was five to six hours. Animal studies show that albuterol does not pass the blood-brain barrier. Recent studies in laboratory animals (minipigs, rodents, and dogs) recorded the occurrence of card ...
STUDY OF THE ROLE OF THE BED NUCLEUS OF
STUDY OF THE ROLE OF THE BED NUCLEUS OF

... present study, the effects of bilateral intracranial injections of the D1- dopamine receptor antagonist SCH-23390 (1.6, 3.2, and 6.4 µg total bilateral dose) , the D2- dopamine receptor antagonist Sulpiride (3.2 µg total bilateral dose), and D2- dopamine receptor agonist Quinpirole (3.0µg total bila ...
Primary amenorrhea
Primary amenorrhea

... Who should be evaluated for amenorrhea ? 1 – An adolescent who has not had menarche by age 15 years 2 – An adolescent who has not had menarche and more than 3 years have ...
London 2012 Paralympic Games Pharmacy Guide
London 2012 Paralympic Games Pharmacy Guide

... competing in the Games, and the import and export of medicines for personal use, including the specific requirements for controlled drugs, is contained in the London 2012 Customs and Freight Forwarding Guide. The guide may be accessed through The Exchange, LOCOG’s secure extranet for NPCs, at https: ...
09107sgp04
09107sgp04

... transient effects that resolved with regular dosing. In dogs, heart rate increases were greater after co-administration than after salmeterol alone. ...
Assistance With Self-Administered Medications
Assistance With Self-Administered Medications

... Assisted living facility legislation effective July 1, 2015[1a] The governor has signed HB 1001 into law regarding assisted-living facility regulation. The new law includes several provisions affecting the regulations and enforcement of assisted living facilities (ALF). Additional key components con ...
PRESCRIBING INFORMATION AND CONSUMER
PRESCRIBING INFORMATION AND CONSUMER

... Animal studies do not indicate direct or indirect harmful effects with respect to reproductive toxicity. There is insufficient information on the excretion of hyoscine butylbromide and its metabolites in human milk. As a precautionary measure, it is preferable to avoid the use of hyoscine butylbromi ...
results - Pakistan Journal of Pharmaceutical Sciences
results - Pakistan Journal of Pharmaceutical Sciences

... Fredholm et al., 2013 reported accumulation of 1mg/kg P.O. (Per Oss) meloxicam in plasma up to 5 days and suggested a washout period of 10 days with meloxicam. In the present case on day 10 as the drug is almost completely eliminated from the body the values returned to normal. Musa and Ibrahim (201 ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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