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secnidazole
secnidazole

... A) Hypersensitivity phenomena during therapy with other 5-nitroimidazole compounds, such as ornidazole, metronidazole, or tinidazole (potential for cross-sensitivity) B) Central nervous system disorders (dizziness/vertigo and ataxia have been observed with secnidazole) C) Renal or hepatic impairment ...
Uveitis and Topamax – Dr. Amir Hadayer
Uveitis and Topamax – Dr. Amir Hadayer

... Topiramate (brand name Topamax) is an anticonvulsant (antiepilepsy) drug. In late 2012, topiramate was approved by the United States Food and Drug Administration (FDA) in combination with phentermine for weight loss. It is also Food and Drug Administration (FDA) approved for, and most frequently pre ...
The Apothecary`s Cabinet 16pp - UW
The Apothecary`s Cabinet 16pp - UW

... from opium.) And while opium and its preparations were used for the relief of pain, they were also the sedatives and hypnotics of choice two hundred years ago. About the same time as the Lewis and Clark Expedition, German pharmacist Friedrich Sertürner was developing the method to extract morphine f ...
gene - Mrs. GM Biology 300
gene - Mrs. GM Biology 300

... Expression of Genes • Genes can interact with one another to control various other patterns of inheritance – Most characteristics that make up individual’s phenotype not inherited in Mendelian patterns • Ex. Modifier genes affect eye color – influence amount, intensity, & distribution of melanin (c ...
Genetic issues in cerebral palsy
Genetic issues in cerebral palsy

... • First cousin marriage is most popular • Some are double first cousins (i.e. your partner’s mother and father are both blood relatives) • Even if not cousins, many marriages are within the biraderi or clan. These may show a founder effect (c.f. Amish) ...
Malignant Hyperthermia: Investigation for the Uninitiated
Malignant Hyperthermia: Investigation for the Uninitiated

... An MH reaction is a clinical chameleon, with fulminant clinical presentations marked by variable non-specific signs that have historically resulted in up to 70% mortality. Susceptibility cannot be diagnosed by clinical examination, and it demonstrates considerable genetic heterogeneity with variable ...
this PDF
this PDF

... • EGFR+ lung cancer patients that relapse have either a T790M- mutation or T790M+ mutation • Roci beats Tagrisso® in T790M- patients • Roci’s ORR in this subset of patients is 37%, which makes doctors optimistic that Roci may be used in all EGFR+ lung cancer patients that relapse (i.e. T790M+ and T7 ...
IOSR Journal of Dental and Medical Sciences (JDMS)
IOSR Journal of Dental and Medical Sciences (JDMS)

... inseparable”.Lignocaine hydrochloride has been the gold standard in local anaesthesia and has proven its efficacy and efficiency to provide a pain free environment. However, newer drugs are currently available that overcome some of the potential drawbacks of Lignocaine and give us more focused relie ...
Preventative therapy - Amazon Web Services
Preventative therapy - Amazon Web Services

... a candidate for daily therapy to prevent the attacks. The first agents to consider would be baby aspirin or propranolol. In evaluating the results of preventative therapy the following factors must be remembered. About one forth of adolescent males with episodic migraine note a spontaneous terminati ...
PRODUCT INFORMATION JONCIA 25, 50, 100 mg Capsules NAME
PRODUCT INFORMATION JONCIA 25, 50, 100 mg Capsules NAME

... disorders. Antidepressants increased the risk compared to placebo of suicidal thinking and behaviour (suicidality) in children, adolescents, and young adults in short-term studies of major depressive disorder (MDD) and other psychiatric disorders. The risk of suicide attempt is inherent in depressio ...
Conversion verapamil to diltiazem
Conversion verapamil to diltiazem

... fibrillation have expanded significantly, and new drugs for ventricular rate control and rhythm conversion have been. Atrial fibrillation is the most common arrhythmia in patients visiting a primary care practice. Although many patients with atrial fibrillation experience relief of. The primary trea ...
Full Prescribing Information
Full Prescribing Information

... This medication can cause urine and sometimes stools to turn blue to blue-green. This effect is harmless and will subside after medication is stopped. Call your doctor or physician for medical advice about side effects. To report SUSPECTED ADVERSE REACTIONS, contact Stellar Pharmacal at 1-800-845-78 ...
Journal of Medical Genetics: Large
Journal of Medical Genetics: Large

... CACNB4, encoding the beta subunit of the P/Q-type calcium channel has been described in one family with an EA2 type phenotype (termed EA5) and also in another family with juvenile myoclonic epilepsy [16]. SLC1A3, encoding the excitatory amino acid transporter EAAT1 has been associated with EA2 in th ...
Medication Management for Attention Deficit Hyperactivity Disorder
Medication Management for Attention Deficit Hyperactivity Disorder

... pressure. This is extremely unlikely to cause any problems for children with normal hearts. In certain situations children may require a heart evaluation prior to commencing stimulant medication: ¾ Children with a known heart or blood vessel abnormality ¾ Family history of sudden unexplained death u ...
- CSHL Institutional Repository
- CSHL Institutional Repository

... as electronically inferred from InterPro domains that are signatures of the tubulin superfamily. The inset GBrowse frame shows some of the annotation information and results of some computational analyses. Each of these, when clicked, brings up the corresponding sequence feature page. Match scores a ...
Pharmacology - premedication
Pharmacology - premedication

... Respiratory effects include decreased respiratory rate, with a variable effect on tidal volume, but at clinically useful dose it is of minor concern. Other effects of clinical importance are increasing blood glucose level, decreasing intestinal motility, increasing urine production, increasing uteri ...
pharmacology 2008 - addiction education home
pharmacology 2008 - addiction education home

... alcohol use for men but not women with co-occurring cocaine and alcohol dependence. The present study is an exploratory investigation of predictors that explain the different gender responses to naltrexone, with a particular focus on differential predictors of treatment attrition. No significant pre ...
Alzheimer`s Disease SCG
Alzheimer`s Disease SCG

... The use of three AChE inhibitors Donepezil, Galantamine and Rivastigmine for Alzheimer’s disease was reviewed by NICE in March 2011. NICE recommends that these drugs should be available in the NHS as one component of the management of people with mild to moderate Alzheimer’s disease. AChE inhibitors ...
Medical Model of Addiction
Medical Model of Addiction

... nucleus accumbens = highly addictive ...
Patient Selection for Medtronic Pain Therapies
Patient Selection for Medtronic Pain Therapies

... • Definitions include the following:1 – “It is not the duration of pain that distinguishes acute from chronic pain, but more importantly, the inability of the body to restore its physiological functions to normal homeostatic levels.” – Chronic pain is commonly triggered by disease or injury. – Stres ...
CHAPTER 11 MENDELIAN PATTERNS OF INHERITANCE
CHAPTER 11 MENDELIAN PATTERNS OF INHERITANCE

... 4) Such variation is called variable expressivity. e. The gene that codes for neurofibromatosis was discovered in 1990 to be on chromosome 17. 1) The gene controls production of neurofibromin protein that normally blocks growth signals for cell division. 2) Many types of mutations result in this eff ...
Introduction: Barking Up the Genetic Tree
Introduction: Barking Up the Genetic Tree

... Dog breeds are the result of artificial selection ...
Status Report on the NHLBI-Sponsored CVD Prevention Guidelines
Status Report on the NHLBI-Sponsored CVD Prevention Guidelines

... Comparisons of Diuretics and ACE Inhibitors Legend: Circle = Primary outcome; Triangle = Secondary outcome or not specified, - Color: Green = Statistically significant where the ACE inhibitor did better (p < 0.05), Red = Statistically significant where the ACE inhibitor did worse, Yellow = p ≥ 0.05 ...
Formulation and Evaluation of Fast Dissolving Oral Films of
Formulation and Evaluation of Fast Dissolving Oral Films of

... Fast dissolving drug delivery systems came into existence in the late 1970’s as an alternative to tablets, capsules and syrups for pediatric and geriatric patients who experience difficulties in swallowing traditional oral solid dosage forms. These systems consist of the solid dosage forms that disi ...
Refining prognosis in BCR
Refining prognosis in BCR

... to some degree with TKI therapy, the presence of an IKZF1 deletion did not alter prognosis further, which again suggests that other underlying pathogenic factors are likely to be present in this group. Alternatively, perhaps more prolonged imatinib exposure could have improved outcomes for poor-risk ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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