• Study Resource
  • Explore Categories
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Combination therapy versus monotherapy for the treatment of
Combination therapy versus monotherapy for the treatment of

... control the inflammatory process, prevent articular lesions, preserve functioning, minimize toxic effects, and be economically accessible to the majority of patients. The therapeutic pyramid model had been accepted for years as the conventional therapy for RA, but in the past decade clinicians have ...
WHO Guide lines Inner soreads
WHO Guide lines Inner soreads

... and other local issues. A governmental department (health authority, drug regulatory agency) can be a good host for a pharmacovigilance centre. However, any department in a hospital or academic environment, working in clinical pharmacology, clinical pharmacy, clinical toxicology or epidemiology, may ...
Hospital brochure - LMA™ Better by design
Hospital brochure - LMA™ Better by design

... The plug forms a seal with the nostril preventing expulsion of fluid. ...
Chapter 6 - Diabetes and Endocrinology
Chapter 6 - Diabetes and Endocrinology

שקופית 1
שקופית 1

... - failure of the clinical trial team to elicit participant's symptoms - Steps the volunteer or family may take to prevent or minimize AEs - Explanation of how and by whom the AE will be treated, and to what medical and chronological extent - Explanation of how the study drug affects the standard tre ...
Perioperative anesthesia clinical considerations of
Perioperative anesthesia clinical considerations of

... The use of gingko biloba is on the rise in the United States. In the year 1997, it was one of the best selling herbs on the United States market, with sales exceeding 240 million dollars [33]. The most important components of gingko are flavinoids, terpenoids, and organic acids. Metabolic pathways v ...
AMERICAN ACADEMY OF PEDIATRICS “Inactive” Ingredients in
AMERICAN ACADEMY OF PEDIATRICS “Inactive” Ingredients in

... (Subject Review) ABSTRACT. Because of an increasing number of reports of adverse reactions associated with pharmaceutical excipients, in 1985 the Committee on Drugs issued a position statement1 recommending that the Food and Drug Administration mandate labeling of over-thecounter and prescription fo ...
NEUROMUSCULAR COUNCIL CONSENSUS STATEMENT
NEUROMUSCULAR COUNCIL CONSENSUS STATEMENT

... This wide acceptance is based largely upon case series and retrospective studies which have suggested that thymectomy may be beneficial. However, many of these studies have shown variable results. Moreover, the absence of controlled, prospective trials casts some doubt regarding effectiveness of the ...
New Concepts in Pain Management
New Concepts in Pain Management

... citizens of TX who suffer pain and other distressing symptoms should be adequately relieved so that their quality of life is as optimum as can be.” “The TSBME recognizes that opioids and other Scheduled Controlled substances, are indispensable for the treatment of pain…” “It is the position of the b ...
Slide 1
Slide 1

... If the renal clearance is greater than 120 ml/min then active tubular secretion must be contributing to the elimination process (total renal clearance > fu x GFR) It is also possible that all three processes are occurring simultaneously. Renal clearance is then:- ...
MHC2TA Single Nucleotide Polymorphism and Genetic Risk for
MHC2TA Single Nucleotide Polymorphism and Genetic Risk for

... and Alberto Falorni, on behalf of the Italian Addison Network Department of Clinical Pathology and Cytology (M.G.), Karolinska University Hospital, SE-141 86 Stockholm, Sweden; Department of Internal Medicine (G.G., C.T., A.B., A.F.), Section of Internal Medicine and Endocrine and Metabolic Sciences ...
DESIGN AND EVALUATION OF CONTROLLED RELEASE TABLETS OF LIPID LOWERING
DESIGN AND EVALUATION OF CONTROLLED RELEASE TABLETS OF LIPID LOWERING

... IR dosage form of NA is required to administer three times per day after meals. While such a regimen does produce cutaneous flushing. A method of avoiding or reducing the side effects associated with immediate release of drugs like NA is the use of CR formulations. CR formulations are designed to sl ...
Human Genetics - Home | Banff International Research Station
Human Genetics - Home | Banff International Research Station

... Simpson's paradox: If we mix two populations that have both different disease prevalence and different marker allele prevalence, and there is no association between the disease and marker allele in each population, there will be an association between the disease and the marker allele in the mixed p ...
Gemcitabine
Gemcitabine

... survived for three months longer than patients who received paclitaxel alone. Results from this study were not helpful in establishing the therapeutic value of gemcitabine. This is because the study had used paclitaxel as a comparator, while the standard therapy used in Canada is docetaxel. A study ...
Answers to Mastering Concepts Questions
Answers to Mastering Concepts Questions

... 1. How do incomplete dominance and codominance increase the number of phenotypes? Incomplete dominance and codominance produce phenotypes that are intermediate between or combinations of those produced by homozygous dominant or homozygous recessive individuals. 2. What is pleiotropy? Pleiotropy occu ...
inheritance jeopardy
inheritance jeopardy

... A frog with striped feet mates with a frog with spotted feet, producing babies whose feet have both stripes and spots. It’s an example of this kind of inheritance pattern. ...
Lecture 4
Lecture 4

... of the world. In parts of Africa frequencies of 20% to 40% are often found for the HbS allele. It was found however that in areas in which there was a high HbS allelic frequency, that there was also a corresponding high frequency of mosquitoes infected with the protozoan parasite, ...
Research On Research: Learning About Phase 1 Trials
Research On Research: Learning About Phase 1 Trials

... Futhermore, sliced and diced data could be exported to Excel or other tools for other analyses. Dr. Emanuel is particularly interested in this collaborative effort as a way to build on the earlier published research on safety and response that was conducted on non-pediatric oncology Phase 1 trials. ...
MENDELIAN GENETICS
MENDELIAN GENETICS

... Genetics of ABO Blood Types: Three Alleles • Gene that controls ABO type codes for enzyme that dictates structure of a glycolipid on blood cells • Two alleles (IA and IB) are codominant ...
Molecular analysis of patients suspected of Fragile X Syndrome
Molecular analysis of patients suspected of Fragile X Syndrome

... The phenotypic manifestations of FXS are usually late; therefore, these are of little diagnostic value in children. On the other hand, the behavioral characteristics and cognitive manifestations occur early, and are more constant, thereby facilitating diagnosis of the disease (Collins et al., 2010). ...
Unit 04 Part I - yayscienceclass
Unit 04 Part I - yayscienceclass

... important because carried out the first important studies of heredity. He studied plants because plants have male & female parts so that they can reproduce ...
Proposed 2015 Update to the ASCO/ONS Standards with Current
Proposed 2015 Update to the ASCO/ONS Standards with Current

... consent is obtained and documented for chemotherapy. The  practice/institution may provide options for consent (eg, use of  chart documentation of patient consent or a signed patient  consent form) that allow for variation among practitioners in the  practice/institution.  19. Informed consent for c ...
Austrian Gene Technology Act – Provisions on Genetic Testing
Austrian Gene Technology Act – Provisions on Genetic Testing

... c) to a person stated in art. 69 para. 2 d) to the physician who has initiated the genetic tests and to the attending physician e) to another person only if the tested person has explicitly given a written consent to do so, whereupon a written revocation of this consent is possible at any time. 5. D ...
A Review of the Management of Gastric Acid
A Review of the Management of Gastric Acid

... measurements after 713 or 814 days treatment than homozygous and heterozygous extensive metabolizers. The largely non-enzymatic metabolism of rabeprazole partially accounts for fewer drug–drug interactions between this PPI and other P450 isoenzyme dependent medications. ­Co-administration of rabepra ...
Product Monograph - Paladin Labs Inc.
Product Monograph - Paladin Labs Inc.

... dependence, and severe social disability can occur. Patients have been reported to increase their dosage to many times the recommended level. The smallest possible amount of the drug should be prescribed or dispensed at one time. The possibility of tolerance and psychological dependence, particularl ...
< 1 ... 526 527 528 529 530 531 532 533 534 ... 1254 >

Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report