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Presse Release European Approval Zolmitriptan
Presse Release European Approval Zolmitriptan

... 2,5 mg and 5 mg dosage strengths, respectively. Once placed in the mouth, it dissolves in a few seconds and is swallowed with the saliva without the need of water. The Zolmitriptan ODF not only avoids the risk of aspiration but also improves patient compliance by reducing swallowing difficulties exp ...
Presentazione di PowerPoint
Presentazione di PowerPoint

... First drug developed for TB in forty years  Only data from Phase IIb trials available , further efficacy and safety data needed from rigorously conducted Phase III trials  On December 28, 2012, the U.S. FDA approved BDQ  In early 2013, WHO commissioned independent review of data, assessment of va ...
Datasheet Methylprednisolone Sodium Succinate
Datasheet Methylprednisolone Sodium Succinate

... Convulsions have been reported with concurrent use of methylprednisolone and cyclosporin. Since concurrent administration of these agents results in a mutual inhibition of metabolism, it is possible that convulsions and other adverse events associated with the individual use of either drug may be mo ...
Research and Development at Sun Pharma
Research and Development at Sun Pharma

...  Key Features of technology developed  Can produce controlled particle size for facile injection through conventional needle to reduce patient trauma and pain  No local anaesthetic required while delivering the drug  Closed semi-automatic process to give kilogram scale, reproducible, consistent ...
Terminology and information on drugs
Terminology and information on drugs

... listings, but selections. Street names are highly ambiguous, and should never be relied upon to characterize a given drug. 2. The sections on chemical constituents of cannabis plant, coca bush and opium poppy are not comprehensive listings, but focus on those substances which are of interest from a ...
Commonly Used Chemotherapy Drugs Part 1
Commonly Used Chemotherapy Drugs Part 1

... sensitivities. The therapeutic margin is very narrow for these drugs, and toxicity can be fatal. Although not addressed in this review, chemotherapy should never be given without considering the safety of staff, pet owners, and ...
pamidronate - Cancer Care Ontario
pamidronate - Cancer Care Ontario

... patients may have had pre-existing renal dysfunction or be dehydrated. Hypocalcemia has been reported, and is usually asymptomatic, but may be more common in patients with prior thyroid surgery. Osteonecrosis of the jaw has been reported, especially in patients also receiving steroids, radiotherapy, ...
Pharmacological Treatment of Bulimia Nervosa
Pharmacological Treatment of Bulimia Nervosa

... one-third to one-half of patients who present for treatment of BN would have been excluded from treatment studies because of accompanying substance abuse, personality disorders, current or earlier use of psychotropic medication, and other factors.5 SSRIs With their relatively benign adverse-effect p ...
Pharmaceuticals utilized in stem cell transplant
Pharmaceuticals utilized in stem cell transplant

... Traditionally, dosed based on AUC in solid tumor and lymphoma regimens to limit toxicities Targeted AUC dosing is less well documented in stem cell transplant regimens Utilized in a variety of solid tumor regimens Toxicities: Ototoxicity, hepatoxicity, renal, ...
Introduction - Harvard DASH
Introduction - Harvard DASH

... Defective genes cause approximately 5000 hereditary human diseases such as Huntington’s disease, and over 1,000 disorders have already been mapped to specific chromosome regions.45 A single misplaced nucleotide among billions may lead to lethal ailments.46 It is estimated that printing out the geno ...
IOSR Journal Of Pharmacy And Biological Sciences (IOSRJPBS)
IOSR Journal Of Pharmacy And Biological Sciences (IOSRJPBS)

... mixed ethnicity samples were also screened in another study that demonstrated monomorphic results for these three SNPs [17]. Based on these explicative results by various studies, the previously documented study has been attributed to sequencing errors and cloning artifacts [19]. In a study on ethni ...
of dog and human
of dog and human

... Academy of Science. The report’s findings underscore our scientists’ concerns about canine cancer: • Comparative oncology can help accelerate drug development and FDA approval, as well as save time, costs and risks to patients by providing early assessments of clinical trials. • Scientists should ...
Anticholinergics for Overactive Bladder
Anticholinergics for Overactive Bladder

... urine secondary to intra-abdominal pressure such as occurs with coughing, sneezing and exercise.9 • Anticholinergics (ACs) are useful drugs for treating OAB, however their use is limited by the side effects of dry mouth and constipation. ...
the role of statins in the prevention of coronary heart disease
the role of statins in the prevention of coronary heart disease

... prescriptions account for 94% of all lipid lowering drugs prescribed and 1.8% of the total GMS spend on medicines in 1997. Stain expenditure is expected to increase to over £5 million for 1998. ADVERSE EFFECTS The statins are generally very well-tolerated.62-3 In major trials, tolerability and drug ...
Hyoscine Butylbromide
Hyoscine Butylbromide

... Disposition in the Body Poorly absorbed after oral administration. About 90% of an oral dose is eliminated in the faeces and <10% is excreted in the urine. After IV administration, about 40% of a dose is excreted in the urine. Half­life Plasma half­life, about 8 h. Protein Binding About 10%. Dose 2 ...
No Slide Title
No Slide Title

... effect for another ‘Motivational interviewing’ techniques may be used to enhance compliance through collaboration, education and empowerment When two different anti-psychotic medications have been tried over a period of 6-8 weeks, the person might be considered ‘treatment resistant’ and as a result ...
genes
genes

... • Sex linked traits – some inherited traits are located on the chromosomes that determine gender, the X or Y. • Females have two X chromosomes: XX genotype • Males have one of each: XY genotype – EX. Hemophilia is an X-linked recessive disorder. This means… • If you’re a make, XY, and you inherit a ...
Equianalgesic Dosing of Opioids for Pain Management
Equianalgesic Dosing of Opioids for Pain Management

... Equianalgesic Dosing of Opioids for Pain Management Equianalgesic doses contained in this chart are approximate, and should be used only as a guideline. Dosing must be titrated to individual response. There is often incomplete cross-tolerance among these drugs. It is, therefore, recommended to begin ...
Lecture 15 Quantitative Genetics II
Lecture 15 Quantitative Genetics II

...  When there is genetic variation for a character there will be a resemblance between relatives.  Relatives will have more similar trait values to each other than to unrelated individuals. ...
Guidelines on Male Sexual Dysfunction: Erectile Dysfunction and
Guidelines on Male Sexual Dysfunction: Erectile Dysfunction and

... Testosterone replacement restores efficacy in hypogonadic nonresponders to PDE5-Is. Apomorphine can be used in mild to moderate ED, psychogenic ED, or in patients with contraindications to PDE5-Is. A vacuum constriction device can be used in patients with stable relationship. Intracavernous injectio ...
Methadone
Methadone

... for arrythmia: CHF or other medications that predispose to arrythmia Generally the risk is small and balanced by need for steady pain control ...
Supplemental Figure and Methods
Supplemental Figure and Methods

... network database (BIND) (22) and the human protein reference database (HPRD) (23) to create three lists of annotated genes. Each extracted gene was given the same weight. We added two gene lists to the seven described above: (a) genes located on chromosome 10 from ~120-130 cM, a region implicated by ...
Drug target for lymphatic filariasis
Drug target for lymphatic filariasis

... filarial parasites of Bm (95-Mb) has been reported, which contains 88, 363, 057 bp of assembled sequence with 17.84% of protein coding sequence26. The full genome data are available at the recent release of NEMBASE4 database. Analysis of these data using genomics approach can provide significant enr ...
WHO Guide lines Inner soreads
WHO Guide lines Inner soreads

... and other local issues. A governmental department (health authority, drug regulatory agency) can be a good host for a pharmacovigilance centre. However, any department in a hospital or academic environment, working in clinical pharmacology, clinical pharmacy, clinical toxicology or epidemiology, may ...
Hospital brochure - LMA™ Better by design
Hospital brochure - LMA™ Better by design

... The plug forms a seal with the nostril preventing expulsion of fluid. ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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