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BER02-021 BETASERON PI
BER02-021 BETASERON PI

... injection site necrosis occurs within the first 4 months of therapy, although post-marketing reports have been received of ISN occurring over 1 year after initiation of therapy. Necrosis may occur at single or multiple injection sites. The necrotic lesions are typically 3 cm or less in diameter, but ...
Ultrasound-triggered image-guided therapy
Ultrasound-triggered image-guided therapy

... contrast agents into temperature-sensitive drug vehicles will not only offer the possibility of guiding and controlling the temperature in the lesion, but can also be used to visualize and quantify the drug delivery process. However, MRI contrast agents have an effect on the relaxation phenomena, wh ...
CLINICAL EVALUATION OF CERTAIN UNANI MEDICINE FOR THE
CLINICAL EVALUATION OF CERTAIN UNANI MEDICINE FOR THE

... assigned to abnormal ties of the factors involved in blood pressure, cardiac output peripheral resistance which ultimately converge structural thickening of the vessel walls of functional vasoconstriction. Essential hypertension is quite prevalent in Pakistani population and cause complex biochemica ...
Understanding Prescriptions
Understanding Prescriptions

... health management regimens.” Their findings suggest a number of strategies that healthcare providers can use to improve adherence. Most academic literature on adherence, especially as it pertains to strategies for improvement, addresses itself to physicians and pharmacists. Patients and their doctor ...
Sample pages 1 PDF
Sample pages 1 PDF

... v­ ariation in the pharmacokinetic processes of absorption, distribution, metabolism, and excretion; that is why, average doses will produce average responses, and for many drugs with wide safety margins, this is sufficient. However, some drugs do not have wide safety margins and knowledge of clinic ...
BUSULFEX (BUSULFAN) INJECTION IS A POTENT CYTOTOXIC
BUSULFEX (BUSULFAN) INJECTION IS A POTENT CYTOTOXIC

... Busulfan may be a human carcinogen. Several cases of leukemia have occurred 5-8 years following oral busulfan treatment. Ovarian suppression and amenorrhea commonly occur in premenopausal women undergoing chronic, low-dose busulfan therapy for chronic myelogenous leukemia. Sterility, azoospermia, an ...
The information in this document is meant to cover topic 4 and topic
The information in this document is meant to cover topic 4 and topic

... The  sex  chromosomes  are  responsible  for  controlling  gender.    In  humans,  females  have  two   “X”  chromosomes,  while  males  have  one  “X”  and  one  “Y”  chromosome.    Alleles  located  on   one  of  these  two  chromos ...
Increased Risk of CHD in the Presence of rs7865618 (A allele
Increased Risk of CHD in the Presence of rs7865618 (A allele

... 1 (PP1) which is a regulator enzyme for endothelial nitric oxide and is known as an important modulator of CHD. In addition, it has been shown that the activity of PP1 increases in patients with end-stage heart failure. The rs12526453, a variant in the 3rd intron of the PHACTR1 gene is associated wi ...
Lenny Moss (2001) "DECONSTRUCTING THE GENE"
Lenny Moss (2001) "DECONSTRUCTING THE GENE"

... this gene concept, but that it getting into the area of prescription, rather than description. What I’d like more clarification on is the difference between the explanatory model that Ken thinks underlies the Mendelian concept as deployed by molecular biologists today and the explanatory model that ...
Angelman Syndrome - Manchester Centre for Genomic Medicine
Angelman Syndrome - Manchester Centre for Genomic Medicine

... Our genes are the unique set of instructions inside every cell of our body. Genes determine our personal characteristics such as eye colour and hair colour. There are many thousands of genes, each carrying a different instruction. As well as determining how we look, our genes control the way each ce ...
Lipid Excipients in Self Emulsifying Drug
Lipid Excipients in Self Emulsifying Drug

... govern the selection of a surfactant are its HLB and safety. For imparting high self-emulsifying properties to the SEDDS formulation, the surfactant should have a relatively high HLB (i.e., high hydrophilicity) for immediate formation of o/w droplets, and/or rapid spreading of the formulation in the ...
RIA Reaching Others: `Molly` Who? The New Ecstasy
RIA Reaching Others: `Molly` Who? The New Ecstasy

... version of 3-4 methylenedioxy-methamphetamine (MDMA), more commonly known as Ecstasy. It is believed O to be a “purer” form of MDMA – as compared to Ecstasy, MDMA which is often combined with other substances, such as caffeine, the diet drug ephedrine or cocaine. However, some Molly capsules have be ...
Assessment and management of chronic pain in the older adult
Assessment and management of chronic pain in the older adult

... Objective: To review the assessment and recommended management of mild to moderate chronic pain in the older adult. Data sources: Medline search using the terms pain, older adult, and analgesics, current national guidelines, and authors’ case experiences. Data synthesis: Assessing pain in cognitivel ...
St.eroid Anesthetics: Old Compounds, New Drugs
St.eroid Anesthetics: Old Compounds, New Drugs

... for the use of Althesin in humans, because the drug caused only minimal cardiovascular depression when given at doses up to twice the ED,, induction dose (100 @/kg compared with 50 $/kg Althesin).13 At the higher dose, the steroid caused decreases in systolic (SBP) and diastolic blood pressures (DBP ...
Genetics Session 5 Handout
Genetics Session 5 Handout

... F1 Generation Gametes from Father ...
32. MaryAnn O   Hara et al. A review of 12 commonly used medicinal
32. MaryAnn O Hara et al. A review of 12 commonly used medicinal

... day at the clinic. Prompted by your patients’ questions, you wonder if any herbal remedies might benefit your family. Popular use of medicinal herbs makes it necessary for physicians to become aware of their health benefits, risks, and uncertainties so that they can educate their patients about thes ...
Identification of a cystic fibrosis mutation W19X in Tunisia
Identification of a cystic fibrosis mutation W19X in Tunisia

... transmembrane conductance regulator gene (CFTR). The frequencies of mutations vary according to the ethnic origin of populations. We describe in this study a patient with cystic fibrosis. She was homozygous for a new nonsense mutation identified for the first time in Tunisia: W19X, which expected to ...
Topiramate in Migraine Prevention
Topiramate in Migraine Prevention

... Chronic migraine sufferers are already costing insurers a lot of money by the time they are referred for Botox treatment, and the additional costs are seen as marginal and the potential gains large. ...
Genetic Codes Explained
Genetic Codes Explained

... Holstein Friesian Federation (WHFF) recommendations. Some foreign Herdbooks also use different coding. Where animals are imported, or have semen imported and are thus are registered with Holstein UK, their codes will be recorded according to the WHFF format. When making breeding decisions based on g ...
But what are genomic (additive) relationships?
But what are genomic (additive) relationships?

... • Explain why “all genomic relationships are equal” ...
Medication Administration - Alaska Department of Commerce
Medication Administration - Alaska Department of Commerce

...  The Medication Administration Record (MAR) is used to document the administration of all medications  After the medication is given, your initials are written in the correct box to note the time it was given  If the medication is NOT given, circle your initials and document in the narrative why ...
ANTISEPSIS Aspects of history: Since the middle of XIX century the
ANTISEPSIS Aspects of history: Since the middle of XIX century the

... gram-negative aerobes has led to their increasing use throughout the world. In many instancies they have been used in combination with penicillins or cephalosporins. An inhibition of protein synthesis is the main action of aminoglycosides. They are poorly absorbed orally, and usually are administere ...
Pharmacodynamics
Pharmacodynamics

... Spare Receptors • Max response elicited by [agonist] that doesn’t occupy all avail receptors • Exper’l: high [agonist] prod’s max response in presence of irrev antagonist • Receptors may be extra (spare) in number – Make tissue more sensitive to agonist w/ no change in char affinity of agonist for ...
Document
Document

... Treatment Program application to ensure compliance with Michigan law. This application can be downloaded from our website at www.michigan.gov/healthlicense by selecting the Pharmacy link and then Pharmacy Licensing Forms and Applications. Please note that failure to apply for this license within 30 ...
REMERON  ® (mirtazapine) Tablets
REMERON ® (mirtazapine) Tablets

... Patients with major depressive disorder, both adult and pediatric, may experience worsening of their depression and/or the emergence of suicidal ideation and behavior (suicidality), whether or not they are taking antidepressant medications, and this risk may persist until significant remission occur ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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