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Profile Documents Logout
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Oxycodone - Thblack.com
Oxycodone - Thblack.com

... The only published clinical study on spinal oxycodone is by Backlund et al.,7 who compared epidural morphine and oxycodone in a randomized, double-blind study for pain after abdominal surgery. Thirty-three patients participated in the epidural part and a further 11 patients were given i.v. oxycodone ...
Taclonex - LEO Pharma
Taclonex - LEO Pharma

... Betamethasone dipropionate was evaluated for effects when orally administered to pregnant rats from gestation day 6 through day 20 postpartum at dosages of 0, 100, 300, and 1000 mcg/kg/day. Mean maternal body weight was significantly reduced on gestation day 20 in animals dosed at 300 and 1000 mcg/k ...
Hard Shell Capsules
Hard Shell Capsules

Management of Hypertension  Clinical Practice Guidelines
Management of Hypertension Clinical Practice Guidelines

... the Third National Health and Morbidity Survey of 2006, close to two thirds of individuals with hypertension in Malaysia were unaware that they have hypertension. Although there was an increase in the treatment rate among those who have been diagnosed, the control rate is still poor. The Third Natio ...
Carbonic Anhydrase Inhibitors and Activators: Small
Carbonic Anhydrase Inhibitors and Activators: Small

... Cytosol Cytosol Membrane-bound Cytosol Cytosol Membrane-bound Unknown Membrane-bound ...
POPULATION GENETICS – BIOL 101
POPULATION GENETICS – BIOL 101

... phenotype have two possible genotypes, we will direct our attention to recessive individuals. A Punnett-square will be used to understand the computation procedure below. In the example presented, we want to know the recessive and dominant allele frequencies when we only know the recessive phenotype ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)

... . Intrathecal administration of midazolam produces antinociceptive effects through GABA_A receptors in spinalcord which are in highest concentration in lamina – II or the dorsal horn ganglia. The safety of neuraxial administration of Midazolam in humans has been demonstrated by several studies. Besi ...
Clinical Practice Guideline on the Management of Hypertension
Clinical Practice Guideline on the Management of Hypertension

... the Third National Health and Morbidity Survey of 2006, close to two thirds of individuals with hypertension in Malaysia were unaware that they have hypertension. Although there was an increase in the treatment rate among those who have been diagnosed, the control rate is still poor. The Third Natio ...
Marijuana: The Facts - Drug Policy Alliance
Marijuana: The Facts - Drug Policy Alliance

... Does marijuana affect mental health? The majority of adults who use marijuana do not have adverse mental health issues. Many opponents of medical marijuana make much of the purported link between marijuana use and mental illness. But there is simply no compelling evidence to support the claim that m ...
Fonat - Medicines.org.au
Fonat - Medicines.org.au

... Following a single 10 mg IV dose of [14C] alendronate, approximately 50% of the radioactivity was excreted in the urine within 72 hours and little or no radioactivity was recovered in the faeces; the renal clearance of alendronate was 71 mL/min. Plasma concentrations fell by more than 95% within 6 h ...
MESOTHERAPY - ozone
MESOTHERAPY - ozone

... Injection of small doses of medications in the mesoderm with very good effect on treating dermatological lesions (ectoderm) or even internal lesions as GIT (endermic).  This term is suggested by Dr.Michel Pistor (French doctor 1958).  Meso.= Middle; since we are aiming at correct location. OR = me ...
[4] The Liposomal Formulation of Doxorubicin
[4] The Liposomal Formulation of Doxorubicin

... Pieter R. Cullis, Thomas D. Madden, and Marcel B. Bally Abstract ...
Ketorolac Tromethamine Injection, USP
Ketorolac Tromethamine Injection, USP

... Ketorolac tromethamine is indicated for the short-term (≤5 days) management of moderately severe acute pain that requires analgesia at the opioid level, usually in a postoperative setting. Therapy should always be initiated with IV or IM dosing of ketorolac tromethamine, and oral ketorolac trometham ...
Morphine Sulfate Extended-Release Tablets Page 1 of 22
Morphine Sulfate Extended-Release Tablets Page 1 of 22

... prescribed morphine sulfate extended-release tablets and in those who obtain the drug illicitly. Addiction can occur at recommended doses and if the drug is misused or abused. Assess each patient’s risk for opioid addiction, abuse, or misuse prior to prescribing morphine sulfate extended-release tab ...
acris combi
acris combi

... develop osteonecrosis of the jaw while on bisphosphonate therapy, dental surgery may exacerbate the condition. For patients requiring dental procedures, there are no data available to suggest whether discontinuation of bisphosphonate treatment reduces the risk of osteonecrosis of the jaw. Clinical j ...
metronidazole
metronidazole

... (e.g. nitroreductases such as ferredoxin) to unidentified polar product(s) which lack the nitro group. The reduction product(s) appears to be responsible for the cytotoxic and antimicrobial effects of the drug which include disruption of DNA and inhibition of nucleic acid synthesis. ...
APO–KETOCONAZOLE
APO–KETOCONAZOLE

... indication for termination of therapy. Deaths have been reported with therapeutic doses of ketoconazole associated with evidence of hepatotoxicity. Clinical studies in men have shown that single doses of ketoconazole at 200, 400 and 600 mg caused a dose–related decrease in serum testosterone levels, ...
Product Monograph
Product Monograph

... hazardous machinery until they are reasonably certain that Cipralex does not affect them adversely. Bone Fracture Risk: Epidemiological studies show an increased risk of bone fractures following exposure to some antidepressants, including SSRIs/SNRIs. The risks appear to be greater at the initial st ...
Adverse effects and Drug Interactions Associated with Inhaled
Adverse effects and Drug Interactions Associated with Inhaled

... animal models has shown that prolonged use of marijuana may lead to physical dependence and a withdrawal syndrome upon discontinuation. Several mechanisms are thought to play a part in the drug reward system, and the resulting cannabis abuse or dependence. There are two types of cannabinoid receptor ...
Acetaminophen
Acetaminophen

... the cascade of events leading to acetaminophen hepatotoxicity; in the absence of this cytochrome P450 enzyme, toxicity will only be apparent at high concentrations.  The N-hydroxyamide is then converted to a reactive toxic metabolite, an acetimidoquinone, which has been suggested to produce the nep ...
CYANOKIT® Administration Guide
CYANOKIT® Administration Guide

... Usage may interfere with some clinical laboratory evaluations. Also, because of its deep red color, hydroxocobalamin may cause hemodialysis machines to shut down due to an erroneous detection of a “blood leak.” This should be considered before hemodialysis is initiated in patients treated with hydro ...
Type I Factor XI11 Deficiency Is Caused By a
Type I Factor XI11 Deficiency Is Caused By a

... exactly the same as predicted from the normal genomic sequence.” These resultsconfirmedthat there was no gross change(s) in the patient’s gene for the b subunit. Nucleotide sequences of the six amplified fragments were then examined to find any possible small difference(s) from the normalsequence. W ...
PRODUCT MONOGRAPH Pr PERIDEX ORAL RINSE
PRODUCT MONOGRAPH Pr PERIDEX ORAL RINSE

... Both stain and tartar can be removed by your dentist or hygienist. Peridex may cause permanent discolouration of some front-tooth fillings. To minimize discolouration, you should brush and floss daily, emphasizing areas which begin to discolour. In some cases discolouration may be permanent. Peri ...
(tazarotene) Gel,...TAZORAC
(tazarotene) Gel,...TAZORAC

... Some individuals may experience excessive pruritus, burning, skin redness or peeling. If these effects occur, the medication should either be discontinued until the integrity of the skin is restored, or the dosing should be reduced to an interval the patient can tolerate. However, efficacy at reduce ...
Analgesia en pacientes con ERC
Analgesia en pacientes con ERC

... Central nervous system: Dizziness, lightheadedness, false feeling of well being, malaise, headache, restlessness, paradoxical CNS stimulation, confusion Dermatologic: Rash, urticaria Gastrointestinal: Dry mouth, anorexia, nausea, vomiting Genitourinary: Urination decreased, ureteral spasm Hepatic: L ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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