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Fluticasone Propionate Ointment, 0.005%
Fluticasone Propionate Ointment, 0.005%

... Pediatric Use - Use of Fluticasone Propionate Ointment, 0.005% in pediatric patients is not recommended. In a study of 35 pediatric patients treated with fluticasone propionate ointment 0.005% for atopic dermatitis over at least 35% of body surface area, subnormal adrenal function was observed with ...
O v e r d o s e and Response
O v e r d o s e and Response

... The great majority of our respondents tried to help when witnessing an overdose, by giving rescue breathing or through physical stimulation. Very few people reported doing nothing, though in only 25 percent of cases did people call an ambulance. Perhaps surprisingly, when we asked if people had enco ...
Disposition of Morphine in the Rat Isolated Perfused Kidney
Disposition of Morphine in the Rat Isolated Perfused Kidney

... solutions were stored frozen at 220°C. On the day of a perfusion experiment, the concentration of BSA in the perfusion medium was adjusted to 65 g/l, and the three amino acids and glucose were added. Perfusate was then filtered successively through 1.2-mm and 0.45-mm filters (Millipore, Bedford, MA) ...
REVIEWS
REVIEWS

... lesions either induced or exacerbated by IFN-α requiring discontinuation of IFN therapy for the eruption to subside; three similar cases were added in 1996,64-68 and additional cases were reported in 2000, 2005, and 2007.69-71 IFN-α was also found to induce a seronegative arthritis in two patients.7 ...
Comparing Inhaled Corticosteroids
Comparing Inhaled Corticosteroids

... receptors. The corticosteroid-receptor complexes translocate to the nucleus, bind to recognition sequences on corticosteroid responsive genes, and directly affect transcription of genomic content. However, the anti-inflammatory effects of corticosteroids probably cannot be explained entirely by thei ...
29th International Conference on Animal Genetics ISAG2004/TOKYO
29th International Conference on Animal Genetics ISAG2004/TOKYO

... 1) Creating the ultimate maps: Genomic sequencing of domesticated animals (P005) Lawrence B. Schook (Institute for Genomic Biology, University of Illinois, USA) ...
Ketorolac Tromethamine
Ketorolac Tromethamine

... Ketorolac tromethamine is indicated for the short-term (≤5 days) management of moderately severe acute pain that requires analgesia at the opioid level, usually in a postoperative setting. Therapy should always be initiated with IV or IM dosing of ketorolac tromethamine, and oral ketorolac trometham ...
Benzoyl Peroxide Cleansers for the Treatment of Acne Vulgaris: Status D
Benzoyl Peroxide Cleansers for the Treatment of Acne Vulgaris: Status D

... number of antibiotic-resistant P acnes organisms? This question was addressed in a 3-week study evaluating P acnes reduction in participants who exhibited either high-level or low-level P acnes antibiotic resistance to tetracycline, doxycycline, minocycline, and/or erythromycin at baseline and were ...
National Medical Policy
National Medical Policy

... Psoriasis is a life long disease that remits and relapses unpredictably. Psoriasis can range from mild to severe, with the severity of psoriasis usually defined by the percentage of body surface area (BSA) involved. Mild psoriasis generally affects less than 3% of the BSA while moderate psoriasis is ...
Carprofen Caplets Brochure (for Pet Owners)
Carprofen Caplets Brochure (for Pet Owners)

... as safety has not been established in dogs with these disorders. The safe use of Carprofen Caplets in animals less than 6 weeks of age, pregnant dogs, dogs used for breeding purposes, or in lactating bitches has not been established. Studies to determine the activity of carprofen when administered c ...
Selective breeding for differential saccharin intake as an animal
Selective breeding for differential saccharin intake as an animal

... as a major factor that would predict the initial development and progression of drug abuse through critical phases (acquisition, escalation, relapse, treatment) that characterize the etiology of drug addiction in humans. The rationale for these studies was that if a major factor related to drug abus ...
Glycyl-Glutamine, an Endogenous ß-Endorphin
Glycyl-Glutamine, an Endogenous ß-Endorphin

... immune (McCain et al., 1987) effects in peripheral tissues. The simple observation that Gly-Gln is synthesized with ␤-endorphin1-27, an opioid receptor antagonist, prompted us to investigate whether it might also influence the pharmacological effects of opioids. We found that Gly-Gln effectively inh ...
C 2:  A A -
C 2: A A -

... GES /IBC types reported from France, Greece and South Africa, respectively (14, 33, 37-39, 41, 48, 52). These five types of enzymes are remotely related, both from a genetic point of view and similarities in hydrolytic profiles. Recent studies indicated that these enzymes may play an important role ...
Review Use of doping agents, particularly anabolic steroids, in sports and society
Review Use of doping agents, particularly anabolic steroids, in sports and society

... the use of performance-enhancing (ergogenic) drugs, commonly referred to as “doping”.6 After the reunification of Germany, the horrifying features of the doping of Olympian competitors in the former East Germany were revealed.7 The use of doping agents is no longer restricted to competing athletes; y ...
Telfast 180mg
Telfast 180mg

... There are no data on the content of human milk after administering fexofenadine hydrochloride. However, when terfenadine was administered to nursing mothers fexofenadine was found to cross into human breast milk. Therefore fexofenadine hydrochloride is not recommended for mothers breast feeding thei ...
Hydrochlorothiazide / Olmesartan medoxomil / Amlodipine
Hydrochlorothiazide / Olmesartan medoxomil / Amlodipine

... approximately linearly with increasing single oral doses up to about 80 mg. Food has minimal effect on the bioavailability of olmesartan medoxomil and therefore olmesartan medoxomil may be administered with or without food. Distribution The mean volume of distribution after intravenous dosing is in ...
Spiractin - Medicines.org.au
Spiractin - Medicines.org.au

... Dosage should be adjusted according to response but it should be noted that maximum effect of spironolactone therapy may not occur for up to 2 weeks after starting treatment. Spironolactone may potentiate the action of diuretics or other antihypertensive drugs, and their dosage should first be reduc ...
AusPAR: Pitavastatin - Therapeutic Goods Administration
AusPAR: Pitavastatin - Therapeutic Goods Administration

... muscle cells and hepatocytes with IC50s of 5.8, 3.4 and 24.5nM, respectively. The IC50 ratio of 1/3/6 obtained for pitavastatin, simvastatin and atorvastatin in HepG2 cells is close to the respective clinical dose ratios of 2 mg/5 mg/10 mg. In guinea pig livers, the 50% effective doses (ED50s) for i ...
EFAVIRENZ RAT MODEL  Research Article   
EFAVIRENZ RAT MODEL  Research Article   

... metabolism  of  other  drugs  metabolized  by  the  same  enzyme.  The  decreased metabolism can result in higher drug levels and increased  potential for toxicity. When drugs that induce CYP450 enzymes are  administered  to  a  patient,  the  body  responds  by  increasing  the  production of speci ...
Alcohol Withdrawal Syndrome: Benzodiazepines and Beyond
Alcohol Withdrawal Syndrome: Benzodiazepines and Beyond

... in common clinical practices is the Clinical Institutes Withdrawal Assessment - Alcohol Revised (CIWA-Ar) scale [21]. It is used to measure the severity of alcohol withdrawal in a patient diagnosed to have AWS. The CIWA-Ar is a 10-item scale used to quantify the severity of alcohol withdrawal. It ca ...
Zebrafish as tools for drug discovery
Zebrafish as tools for drug discovery

... favouring the publication of cases in which pharmacology is conserved, these examples suggest a high probability of direct correlation between effects in humans and zebrafish. In our laboratories, we have tested ten compounds discovered via diverse zebrafish screens in corresponding rodent disease m ...
Efficacy of Lasers and PDT for the Treatment of Acne Vulgaris*
Efficacy of Lasers and PDT for the Treatment of Acne Vulgaris*

... following their last laser therapy session. Results showed a 98% reduction in inflammatory acne vulgaris lesions after four treatments. At follow-up, 100% lesion clearance was seen in all but one of the study participants. A second trial by Friedman, et al.20 studied facial acne vulgaris in 19 patie ...
Quetiapine and sleep apnoea syndrome Introduction Reports
Quetiapine and sleep apnoea syndrome Introduction Reports

... sleep apnoea syndrome. Freudenmann et al. describe moderate to severe respiratory dysfunction after normal oral doses of quetiapine in two obese patients. In the first case, acute respiratory failure and coma occurred after a single dose of quetiapine in combination with lorazepam in a 59 year old f ...
Oxycodone - Thblack.com
Oxycodone - Thblack.com

... The only published clinical study on spinal oxycodone is by Backlund et al.,7 who compared epidural morphine and oxycodone in a randomized, double-blind study for pain after abdominal surgery. Thirty-three patients participated in the epidural part and a further 11 patients were given i.v. oxycodone ...
Compatibility and stability studies of levadopa, carbidopa
Compatibility and stability studies of levadopa, carbidopa

... goal of these stability studies is to obtain information about different factors such as temperature, pH, humidity, light that affect the stability of the drug substance, potential degradation pathways of the substance, main degradation products that appear under degradation of the substance at diff ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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