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Fabrazyme Billing Guide
Fabrazyme Billing Guide

... Fabry disease is a rare, inherited lysosomal storage disorder caused by an enzyme deficiency. Deficiency of the lysosomal enzyme alpha-galactosidase A (alpha-GAL) leads to progressive accumulation of glycosphingolipids, predominantly globotriaosylceramide (GL-3), in many body tissues, occurring over ...
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... cholinergic synapses. Acetylcholine receptors that cause excitatory responses lasting only milliseconds are called nicotinic acetylcholine receptors. They are so named because nicotine, like acetylcholine, causes a rapid depolarization . These receptors are ligand-gated channels for Na+ and K+ ions. ...
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... There are no adequate and well-controlled studies evaluating Qutenza in pregnant women. There was no evidence of fetal teratogenicity in embryofetal developmental toxicological studies conducted in pregnant rats and rabbits in which Qutenza patches (rats) or liquid (rabbits) were applied once daily ...
Randomized Comparison Of Antiarrhythmic Drug Therapy With
Randomized Comparison Of Antiarrhythmic Drug Therapy With

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Pharmacology and the Nursing Process, 4th ed. Lilley/Harrington
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... Many stimulants have a legitimate medical use for the treatment of conditions such as obesity, narcolepsy, and attention deficit and hyperactivity disorder. Such stimulants vary in their level of control from Schedules II to IV, depending on their potential for abuse and dependence. A number of stim ...
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Managing the Patient with

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Opioids - David Kan, MD

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... identify new gene targets for metabolic syndrome using high throughput DNA-sequencing and genome wide association studies (GWAS). While these studies have provided insight into the nature of human sequence variation, it is not known at present whether these variations are truly significant and how m ...
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Geodon (ziprasidone)

... should avoid potentially dangerous activities, such as driving a car or operating machinery, until they are sure that these side effects will not affect their ability to perform these tasks. Tardive dyskinesia (TD) is a potential adverse reaction from antipsychotic medications. It consists of abnorm ...
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Real life utilization data for Lucentis in wAMD

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1. dia - MAGYOSZ
1. dia - MAGYOSZ

... Semmelweis University, Department of Organic Chemistry „On target” toxicity: exaggerated pharmacological effects „Off target” toxicity: undesired effect, not predicted from pharmacology Can deleterious site where the therapeutic target is located be IDENTIFIED? ...
RrYy
RrYy

... Thus, the frequency of PP in the F2 is: (1/2)(1/2 ) = 1/4 Frequency of pp = (1/2)(1/2) = 1/4, Frequency of Pp = 2(1/2)(1/2) = 1/2 ...
< 1 ... 470 471 472 473 474 475 476 477 478 ... 1254 >

Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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