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the file - General Practice
the file - General Practice

...  Do you have the relevant knowledge, skills and access to equipment to allow you to monitor treatment as indicated in this shared care guideline?  Have you been provided with relevant clinical details including monitoring data? If you can answer YES to all these questions (after reading this share ...
Document
Document

... Worked at the monastery in the garden Noticed that there were patterns in the ways that the peas reproduced Noticed that some parent plants looked like the offspring and other did not He wanted to know why!!! ...
PPR N P S Medication review for your patients with heart failure
PPR N P S Medication review for your patients with heart failure

... Would the patient benefit from beta-blocker therapy? Some beta-blockers have been shown to improve prognosis in patients with mild to moderate heart failure. They are increasingly being used in combination with ACE inhibitors and diuretics in the treatment of chronic stable heart failure 1,4. Carved ...
Strategies and Challenges Involved in the Discovery of
Strategies and Challenges Involved in the Discovery of

... progressing a series from hit to lead and from lead to candidate to diminish polypharmacy potential or unwanted safety issues being encountered in later-stage drug development. The experience of this approach when applied to antibiotic and antituberculosis drug discovery in particular has not yet yi ...
Full text
Full text

... This section presents adverse reactions to influenza vaccine reported from October 2012 through the end of March 2013 (the 2012 season). In the 2012 season, vaccination with trivalent influenza vaccine (including 2009 influenza [H1N1] and influenza A/H3N2 and B) was started in October. Based on the ...
Mendelian Genetics
Mendelian Genetics

... which both alleles of a gene are expressed. a. A person with AB blood has both A and B antigens on their red blood cells. b. With codominance, both alleles produce and effective product. B. Genes That Interact 1. More than one pair of genes may interact to produce the phenotype. 2. Epistasis: absenc ...
Addiction and Recovery 101
Addiction and Recovery 101

... The Genes Early investigators were struck by the results of studies involving potential genetic influences on the development of alcoholism. Many studies using twins were conducted. In 1960, Kaij conducted a study using identical twins with the same genes. When one twin was alcoholic the other was a ...
- ePrints Soton
- ePrints Soton

... by genetic testing. In particular, an insulin pump is an apt choice of treatment for permanent NDM, but not so for TNDM given that it is very likely to remit after a few months. Moreover, treatment of adolescents/adults in the relapse phase that occurs in many patients will be influenced by genetic ...
Sample Chapter
Sample Chapter

... of the last menstrual period; this is about 2 weeks before ovulation and fertilization and almost 3 weeks from the time of implantation in the uterus. Pregnancy is also dated by ultrasonography in the second and third trimesters. Ultrasonography is used clinically to correct mistaken dates and disce ...
Pharmacy Bulletin - Hospital Putrajaya
Pharmacy Bulletin - Hospital Putrajaya

... adenovirus infection has been limited by adverse effects, the most significant of which is nephrotoxicity.3, 7 In addition, there are two other antiviral agents including ganciclovir and vidarabine, which have been used to treat severe adenovirus infections, especially in immunocompromised patients. ...
High frequency of voriconazole-related phototoxicity in cystic fibrosis patients
High frequency of voriconazole-related phototoxicity in cystic fibrosis patients

... concerned children were aged less than 9 yrs. Multivariate analysis showed that photosensitivity was only independently associated with DF508/DF508 genotype (OR 24.5, 95% CI 2.2– 272.9; p50.009). Seven patients were also given ciprofloxacin, and only one of them belonged to the photosensitivity grou ...
Taking Heredity to Heart and Head: Cardiovascular Disease Genetics
Taking Heredity to Heart and Head: Cardiovascular Disease Genetics

... atherosclerosis as related to stroke and coronary heart disease; pedigree examples will be included ...
Pharmacological Conversion of Atrial Fibrillation in the Patients of
Pharmacological Conversion of Atrial Fibrillation in the Patients of

... unknown, because she died before the first follow-up date. Although an autopsy was not performed and the cause of death is unknown, a bepridil-related event cannot be ruled out. None of the patients experienced any other adverse effects, such as gastrointestinal discomfort or liver or kidney damage. ...
Perspectives in Drug Discovery A Collection of Essays on the History
Perspectives in Drug Discovery A Collection of Essays on the History

... This collection of short essays deal with the history of drug discovery and covers a wide range of pharmaceutical substances, including prescription medication as well as illicit recreational drugs of abuse. Consideration was also given to the plethora of drugs encountered in routine forensic casewo ...
The rise and fall of the COX-2 inhibitors
The rise and fall of the COX-2 inhibitors

... patients aged over 65 years, patients who are taking other medicines which increase the risk of gastrointestinal effects, patients who are debilitated or those receiving long-term treatment with maximal doses of standard NSAIDs) and always after an assessment of cardiovascular risk. • MHRA Guideline ...
U.S. FDA APPROVES ANTIEMETIC AGENT AKYNZEO FOR PREVENTION OF
U.S. FDA APPROVES ANTIEMETIC AGENT AKYNZEO FOR PREVENTION OF

... U.S. FDA APPROVES ANTIEMETIC AGENT AKYNZEO® FOR PREVENTION OF CHEMOTHERAPY-INDUCED NAUSEA AND VOMITING (CINV) World’s First Oral Fixed Combination Targeting Two Critical Pathways Involved in CINV Eisai Co., Ltd. (Headquarters: Tokyo, CEO: Haruo Naito, “Eisai”) announced today that Helsinn Healthcare ...
Drug Slides Ch. 3
Drug Slides Ch. 3

IN VITRO RELEASE OF SODIUM DICLOFENAC FROM POLOXAMER 188 MODIFIED
IN VITRO RELEASE OF SODIUM DICLOFENAC FROM POLOXAMER 188 MODIFIED

... Employing the batch method, the adsorption behaviour of diclofenac sodium on F-68-Mt was investigated as a function of pH of the aqueous drug solution, contact time for batch adsorption and concentration of the aqueous drug solution. Each experiment was performed using 0.05 g of adsorbent at 30 °C. ...
Chronic idiopathic axonal neuropathy and pain, treated with the
Chronic idiopathic axonal neuropathy and pain, treated with the

... The use of palmitoylethanolamide (PEA) in patients suffering from neuropathic pain due to CIAP In the absence of clinical guidelines on how to treat neuropathic pain in CIAP patients, many physicians prescribe the classical analgesics such as amitriptyline, pregabalin, and gabapentin. In our clinic, ...
Using uniformat and Gene[rate] to analyse data with ambiguities in
Using uniformat and Gene[rate] to analyse data with ambiguities in

... ambiguities and, therefore, are not appropriate to handle ambiguous data. A common approach is to pre–process the data in order to eliminate ambiguities and hence obtain single two–allele genotypes [10]. The problem with such approaches is that they always involve arbitrary decisions that, at least ...
HTH 102TA Pharmacology
HTH 102TA Pharmacology

... Students enrolled in credit-bearing courses at Lackawanna College will fail any course(s) in which they accumulate absences beyond the maximum number allowed. This pertains to online classes as well. Attendance is tracked by instructors, so be sure to log on and adhere to the following scale: If you ...
New Oncology Drugs 2004: A Year in Review
New Oncology Drugs 2004: A Year in Review

What maintains genetic variation? - Carol Lee Lab
What maintains genetic variation? - Carol Lee Lab

... across the southern United States. The largest woodpecker north of Mexico and the third largest in the world, the Ivorybilled Woodpecker inhabits mature swampy forests, roaming large areas in search of dead and dying trees infested with beetle larvae, its primary food. Ivorybilled Woodpeckers were p ...
History
History

... • Alternative versions of genes (alleles) account for ...
Efficacy of low to moderate doses of oxcarbazepine in adult patients
Efficacy of low to moderate doses of oxcarbazepine in adult patients

... and clinical characteristics of the included patients are summarized in Table 1. The mean age of all of the patients was 30.1  12.1 years. The mean age at seizure onset was 25.6  12.7 years. For the brain MRI/CT results, 82 (80.4%) were normal and the other 20 (19.6%) were abnormal. For seizure ty ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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