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Issues in Anesthesia for the Post
Issues in Anesthesia for the Post

... hepatotoxicity and neurotoxicity. These toxicities are largely dose related and can be reduced by monitoring blood levels10 and minimizing the dose of CSA through the use of multiple drug immunosuppressive regimens.10,11 Nephrotoxicity is dose related, partially reversible and the most frequent and ...
Effexor/Effexor XR (venlafaxine)
Effexor/Effexor XR (venlafaxine)

... Most cases of major depression can be treated successfully, usually with medication, psychotherapy, or both. The combination of psychotherapy and antidepressants is very effective in treating moderate to severe depression. The medications improve mood, sleep, energy, and appetite, while therapy stre ...
WHO Drug Information - World Health Organization
WHO Drug Information - World Health Organization

... although other groups of non-homogenous established products, including from natural sources, were also considered. When substances which had already been named by the INN Programme became available through new biotechnological processes, earlier decisions on naming non-homogenous products had an in ...
Acute lung injury as a possible adverse drug reaction related... gefitinib CASE STUDY R. Ieki, E. Saitoh, M. Shibuya
Acute lung injury as a possible adverse drug reaction related... gefitinib CASE STUDY R. Ieki, E. Saitoh, M. Shibuya

... incidence of dyspnoea, which was considered to be disease related. Preliminary data from a phase-II study with gefitinib showed an 18.7% response rate in 210 patients with NSCLC who had progressed after first- or second-line chemotherapy. In addition, it was reported that gefitinib was well tolerate ...
Managing Patients Taking Novel Oral Anticoagulants (NOAs)
Managing Patients Taking Novel Oral Anticoagulants (NOAs)

... dabigatran in 88 to 98 % of patients in an initial clinical study.[15] The approval of idarucizumab will substantially influence the approach to haemorrhagic complications related to dabigatran probably solving the concerns that had been raised for the lack of a proven reversal strategy with respect ...
(VHL) for families - Cancer Council Australia
(VHL) for families - Cancer Council Australia

... It is possible to test a person's blood in order to find out whether they have an inherited mutation in the VHL gene. The current laboratory techniques that are used can detect over 80% of VHL mutations. Once a mutation has been ...
Inhibition and induction of human cytochrome P450 (CYP) enzymes
Inhibition and induction of human cytochrome P450 (CYP) enzymes

... metabolic routes of a compound have been elucidated and a method is available for their quantitation in in vitro incubations, it is possible to employ ` diagnostic ’ inhibitors (table 2) and to look which of them, and at which concentrations, inhibit metabolic routes. It is also possible to use enzy ...
Genetic Characterization of Insulin Growth Factor
Genetic Characterization of Insulin Growth Factor

... be in linkage disequilibrium with polymorphism affecting these traits. Curi et al. [18] observed two genetic variants (A and B) of the IGF-1/SnaB1 polymorphism in four cattle breeds. Genotype AA was characterized by the presence of two digested fragments at 226- and 23-bp, while genotype BB was dete ...


... systemic effects. We are, however, unaware of the evidence showing that the fine particle fraction does not contribute to the overall anti-asthma effect. On the contrary, budesonide Turbuhaler has a higher fine particle dose than budesonide P-MDI and evidence of a better clinical effect [2, 6]. If t ...
insulin, regular (injection, concentrated)
insulin, regular (injection, concentrated)

... trimethoprim/sulfamethoxazole. ● Additive Compatibility: May be added to total parenteral nutrition (TPN) solutions. ...
schering-plough gmp consent decree puts drug
schering-plough gmp consent decree puts drug

... wait for the FDA to catch up to them. I have no facts to support it, but in my opinion, these companies appear to be making a calculated decision.” Pharmaceutical companies are quickly learning that a sanguine attitude about inspection reports and warning letters is a costly mistake. Under the new e ...
Experiment Designs for the Assessment of Drug Combination
Experiment Designs for the Assessment of Drug Combination

... introduce another term, “multiplicative neutral”; together the two terms, additive neutral and multiplicative neutral, will complete the description of neutral effects in drug combinations. The evaluation process for drug combinations consists of two steps: (1) to establish potencies of both agents, ...
2015 Annual Drug Report - Alaska Department of Public Safety
2015 Annual Drug Report - Alaska Department of Public Safety

... contributing cause of death. The number of Medicaid health care services payment requests for heroin poisoning increased almost ten-fold from 2004 to 2013. During the years 2009–2013, heroin-related admissions to publicly- funded substance use treatment centers nearly doubled, and the majority of pa ...
The effects of herbal teas on drug permeability
The effects of herbal teas on drug permeability

... Herbal teas such as those made from Houttuynia cordata have been consumed for generations for health promotion. Herbal teas contain many ingredients, and there is concern that herbal teas can affect the pharmacokinetics of drugs. In this study we examined the effect of herbal teas on drug permeabili ...
Sex-linked traits
Sex-linked traits

... Law of Independent AssortmentSeparate genes for separate traits are passed independently of one another from parents to offspring. These allele pairs are then randomly united at fertilization. ...
Pregnancy & Renal Transplantation
Pregnancy & Renal Transplantation

... during pregnancy Methylprednisolone is the recommended treatment of rejection IVIg has been used a fair amount without problems Need to include causes specific to transplant as well as causes specific to pregnancy Ureteral obstruction from a gravid uterus is not common, but has been reported TTP-HUS ...
Antiproteinuric effect of add-on paricalcitol in
Antiproteinuric effect of add-on paricalcitol in

... with many patients being left with significant residual proteinuria [6]; therefore, novel ways of proteinuria treatment are being studied. Recent studies have shown broad-ranging activities of vitamin D that extend beyond the regulation of calcium and phosphorus metabolism mediated by vitamin D recep ...
Hypertension
Hypertension

... during anesthesia •Effect of light on drug ...
Current Concepts on Drug Abuse and Dependence
Current Concepts on Drug Abuse and Dependence

... Date of submission: 2014-10-15; Date of acceptance: 2014-12-11 ...
FORMULATION AND EVALUATION OF TASTE MASKED ORAL DISPERSIBLE TABLETS OF
FORMULATION AND EVALUATION OF TASTE MASKED ORAL DISPERSIBLE TABLETS OF

... Oral route of drug administration have wide acceptance, up to 5060% of oral solid dosage forms are popular because of natural, uncomplicated, convenient, ease of administration, accurate dosage, self medication, pain avoidance and most importantly patient compliance. The most popular solid dosage fo ...
Prioritizing risk pathways: a novel association
Prioritizing risk pathways: a novel association

... The KEGG pathway is a network in which a node represents the metabolite and one edge represents an enzyme or a gene cluster. First, each KEGG pathway was translated into a graph whose edge was a metabolite and the node was an enzyme or a gene cluster. An ‘entity-relationship graph’ K of enzymes/gene ...
1 NAME OF THE MEDICINAL PRODUCT Maalox Suspension 2
1 NAME OF THE MEDICINAL PRODUCT Maalox Suspension 2

... with the risk of osteomalacia. Medical advice is recommended in case of long-term use or in patients at risk of phosphate depletion. Magnesium salts may cause central nervous depression in the presence of renal insufficiency and should be used with caution in patients with advance renal disease. In ...
Short term outcomes of topiramate monotherapy as a first
Short term outcomes of topiramate monotherapy as a first

... seizures24) and for Lennox-Gastaut syndrome. Sachdeo et al.25) reported that TPM as adjunctive therapy for the management of Lennox-Gastaut syndrome reduced seizure rates by 33%. Recently, a few trials for TPM as a first-line drug for West syndrome have been reported. Glauser et al.14) conducted a p ...
14_Lecture_Stock - Arlee School District
14_Lecture_Stock - Arlee School District

... • Second: for each character, an organism inherits two alleles, one from each parent • Mendel made this deduction without knowing about the role of chromosomes • The two alleles at a particular locus may be identical, as in the true-breeding plants of Mendel’s P generation • Alternatively, the two ...
Visions 4.2 - Medications
Visions 4.2 - Medications

... abnormal brain function. The journey Since the early 1950s, management of psychiatric disorders has included medication. For over 60 years, mental health and addictions researchers have been searching for ‘ideal’ medications. Medications identified during the first 30 years were far from ideal. They ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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