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Integrated analysis of whole-exome sequencing and transcriptome
Integrated analysis of whole-exome sequencing and transcriptome

Prescription Drug Use Among Midlife and Older Americans
Prescription Drug Use Among Midlife and Older Americans

... increase in the proportion Americans age 45 and older who say they have health insurance for prescription drugs (51% in 1986 and 76% in 2002).1 On average, people age 45 and older say they take four prescription medications daily. It is clear that Americans turn to prescription medications to help t ...
Smoking Cessation for the Busy Clinician
Smoking Cessation for the Busy Clinician

... Yet for most, the process of quitting is characterized by a series of quit attempts and subsequent relapses - on average, former smokers report 11 quit attempts over a period of almost 19 years before quitting for good.7 Effective treatments are available, but few smokers use them, and more than 95% ...
Epilepsy
Epilepsy

... Desired Outcome  Accurately diagnose seizure type and determine the etiology.  Identify and eliminate patient-specific seizure precipitants.  Select optimal AED based on seizure type, patient age, sex, and concomitant medical conditions.  Therapy should be individualized to attain best possible ...
The Role of the Susceptibility Gene in the Pathogenesis of Age
The Role of the Susceptibility Gene in the Pathogenesis of Age

ANTIRETROVIRAL (ARV) TREATMENT OF ADULT HIV INFECTION
ANTIRETROVIRAL (ARV) TREATMENT OF ADULT HIV INFECTION

... of HIV was also demonstrated.3 A similar benefit was previously documented within cohorts of injection drug users.7 8 There is no CD4 count threshold above which starting therapy is contraindicated. However, it is noteworthy that the strength of the evidence in support of starting ART increases as t ...
Treating Anxiety with either Beta Blockers or Antiemetic
Treating Anxiety with either Beta Blockers or Antiemetic

... Propranolol has been delivered sublingually at 10 and 40 mg per dose [12,13], although this can produce mouth paresthesia, an undesirable effect. Also, propranolol has been delivered by rectal administration in mammals [15]. It does not demonstrate chemical dependence or sedation that are common sid ...
Controlled Substance Prior Authorization
Controlled Substance Prior Authorization

... This pharmacy policy document describes the status of pharmaceutical information and/or technology at the time the document was developed. Since that time, new information relating to drug efficacy, interactions, contraindications, dosage, administration routes, safety, or FDA approval may have chan ...
effects of cytochrome p450 enzyme inhibitors and inducers
effects of cytochrome p450 enzyme inhibitors and inducers

... The human body eliminates foreign compounds primarily by metabolizing them to hydrophilic forms to facilitate effective excretion through the kidneys. Cytochrome P450 (CYP) enzymes in the liver and intestine contribute to the metabolism of many drugs. Pharmacokinetic drugdrug interactions occur if t ...
Introduction - KSU Faculty Member websites
Introduction - KSU Faculty Member websites

... Vitamin D is essential for the utilization of calcium, and it may be prudent for women at highest risk, such as those older than 65 who are housebound, reside in nursing homes or live in areas where winters are long with minimal sun exposure, to take 200-400 I.U. of vitamin D daily. It has been foun ...
adis drug evaluation Drugs 1998 Apr 55 (d): 563-584 0012
adis drug evaluation Drugs 1998 Apr 55 (d): 563-584 0012

... clearance decreased from 3 to 0.6 L/h, the t'/2 was unaffected. The urinary excretion of Ml may be reduced, but no other pharmacokinetic changes are known to occur during liver disease. Glimepiride does not appear to have clinically significant interactions with warfarin, cimetidine, ranitidine or ...
Diagnosis 10
Diagnosis 10

... However, the basic compound is still a basic compound with a high PH, but now it is suitable for injection because we added the hydrophilic part, but it’s still poorly soluble in water, and unstable upon exposure to air. So again, we have to think of another material to add in order to improve those ...
Poisoning.Comm Volume 1 , Issue 4 (OCT 2006)
Poisoning.Comm Volume 1 , Issue 4 (OCT 2006)

... bruising at injection site). ...
FLURBIPROFEN FAST DISINTEGRATING TABLETS Research Article  AMAL S. M. ABU EL-ENIN
FLURBIPROFEN FAST DISINTEGRATING TABLETS Research Article AMAL S. M. ABU EL-ENIN

... Tablets are the most widely used dosage form because of its convenience in terms of self-administration, compactness and easy in manufacturing [1]. Fast disintegrating tablets are gaining prominence as new drug delivery systems. These dosage forms dissolve or disintegrate in oral cavity within a min ...
6.3 Mendel and Heredity
6.3 Mendel and Heredity

... • Mendel then allowed the resulting plants to self-pollinate. – Among the F1 generation, all plants had purple flowers – this is the phenotype (describes physical traits, what we can see) – F1 plants are all heterozygous this is the genotype (describes the internal makeup of the genes, what we ...
PPT
PPT

... • 1st drug used to treat narcolepsy was ephedrine in 1931. Followed by the amphetamines. • In 1959, methylphenidate was introduced and extensive use proceeded. • Modafinil originated in the late 1970’s and approved by the U.S. Food and Drug administration in 1998 for administration. • Modafinil is n ...
Concepts and relevance of genome
Concepts and relevance of genome

... GWAS was initially developed to study the human genome. The human genome is a sequence of more than three billion DNA bases that can be represented by one of four letters: A, C, G or T. Much of the genome sequence is identical or highly conserved across the human population, but every person’s genom ...
1334 Journal of Hypertension 1997, Vol 15 No 11
1334 Journal of Hypertension 1997, Vol 15 No 11

... Main results of the losartan versus amiodipine (LOA) study on drug tolerability and psychological general well-being Björn Dahlöf, Lars H. Lindholm*, Shane Carney †, Pertti J. Pentikäinen‡ and Jan Östergren § for the LOA Study group Objective To compare two losartan regimens (with and without hydroc ...
Hepatotoxicity associated with glucosamine and chondroitin sulfate
Hepatotoxicity associated with glucosamine and chondroitin sulfate

... the drug[5]. Two cases of probable hepatotoxicity were described in 2010 in relation to the consumption of a dietetic supplement (move free advanced) which contained glucosamine and chondroitin sulfate. The first of these cases presented diarrhea with an elevation in aminotransferases and alkaline p ...
Product Monograph - Ask Novartis Pharma
Product Monograph - Ask Novartis Pharma

... include dehydration, pre-existing renal impairment, multiple cycles of ZOMETA or other bisphosphonates, or using a shorter infusion time than currently recommended (the 4 mg dose is given as a single dose intravenous infusion over not less than 15 minutes in not less than 100 mL diluent). Concomitan ...
Diterpenes-A Review on Therapeutic uses with special emphasis on
Diterpenes-A Review on Therapeutic uses with special emphasis on

... Nutritional products for human health and treatments for diseases are ever increasing (Zhao, 2007; Black et al., 2008). Awareness for healthy food over junk food is gaining importance due to complications arising out of the newer food habits and lifestyle changes (Hardy, 2000) leading to renewed int ...
Attachment 1. Product Information - Therapeutic Goods Administration
Attachment 1. Product Information - Therapeutic Goods Administration

... addition a number of functional characterisation assays were conducted on rFVIIIFc drug substance. The primary structure agreed with the predicted amino acid sequence. Sites of glycosylation were confirmed by peptide mapping. rFVIIIFc post translational modifications include N linked glycosylation s ...
Attachment 1. Product Information for cobicistat
Attachment 1. Product Information for cobicistat

... patients receiving medications metabolized by CYP3A or initiating medications metabolized by CYP3A in patients already receiving TYBOST may result in increased plasma concentration of these concomitant medications. Higher plasma concentrations of concomitant medications can result in increased or pr ...
Carbon Monoxide poisoning
Carbon Monoxide poisoning

... e) If bradycardia develops, an external pacemaker may be necessary f) If sever hypotension develops, an Intra-Aortic Balloon Pumps (IABP) is inserted into the aorta to help maintaining blood pressure g) If hyperthermia develops (ASA & salicylates can produce hyperthermia & may lead to seizers in chi ...
4 2. LITERATURE REVIEW: Ariyana, et al (2014), developed
4 2. LITERATURE REVIEW: Ariyana, et al (2014), developed

... Raghavendra N, et al (2012), reported formulation, in vitro characterization and clinical evaluation of ofloxacin medicated dental gels for periodontal infections. The ofloxacin dental gels were prepared with different hydrophilic polymers methyl cellulose, hydroxy propyl methyl cellulose, hydroxy ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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