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ITP - Dr/Mervat Hesham
ITP - Dr/Mervat Hesham

... Recently, The ASH guidelines endorse the use of : A - Prednisone: 4 mg/kg/day on days 1–7, 2 mg/kg/day on days 8–12, 1 mg/kg/day on days 13–17, tapered on days 18–20 with discontinuation at day 21 or prednisone 4 mg/kg/day for 4 days B - Dexamethasone: 20 mg/m2/day for 4 days every 28 days for six ...
Managing Medication for Adults with AD/HD
Managing Medication for Adults with AD/HD

... treatment of AD/HD in children, is the cornerstone of treatment for adults.6-8 Although there is a significant amount of research in children, there is much less controlled research data on medication therapy in adults.4,9 Regarding the use of medication in the treatment of AD/HD, it has been said t ...
CHAPTER 13 Gene Mapping in Eukaryotes
CHAPTER 13 Gene Mapping in Eukaryotes

... 1. Genes on non-homologous chromosomes assort independently, but genes on the same chromosome (syntenic genes) may instead be inherited together (linked), and belong to a linkage group. 2. Classical genetics analyzes the frequency of allele recombination in progeny of genetic crosses. a. New associa ...
The CHARGE Targeted Sequencing Study
The CHARGE Targeted Sequencing Study

... (FHS).6 The CHARGE Targeted Sequencing Study included a cohort random sample and selected case groups from a variety of related cardiometabolic phenotypes, including a sample of ≈200 participants (100 ARIC study, 50 CHS, 50 FHS) from the high extremes of FI (≥8-hour fast) in individuals without diab ...
CLEXANE and CLEXANE FORTE
CLEXANE and CLEXANE FORTE

Theranostics Limited Tumor Tissue Drug Penetration Contributes to
Theranostics Limited Tumor Tissue Drug Penetration Contributes to

... well-differentiated pancreatic neuroendocrine tumors and gastrointestinal stromal tumors after disease progression, or intolerance to imatinib mesylate [4]. The two not yet approved drugs, motesanib and vatalanib, are currently investigated in clinical trials. The only study completed so far with mo ...
SCIENTIFIC DISCUSSION 1. Introduction
SCIENTIFIC DISCUSSION 1. Introduction

... storage conditions. Some changes related to water content and to hydrolysis to different extents were observed. However, this observation is in agreement with other stability findings that dictated the use of packaging material with very low water permeability. The results from photostability studie ...
For those mutants where the enhancement bred true, if
For those mutants where the enhancement bred true, if

... and the absence of the p[w+] marker, and used to create independent stocks. Those mutants which segregated with the X chromosome were discarded. ...
If you have issues viewing or accessing this file contact...
If you have issues viewing or accessing this file contact...

... is the determining factor. On the other hand, very high SAC levels can result in extremely defensive actions. Effects/Alcohol and Other Substances Alcohol is very commonly used with other substances. ~~e primary combination, alcohol/marijuana, is more hazardous than using either substance alone, due ...
Chapter 13 lesson 2 - ROP Pharmacology for Health Care
Chapter 13 lesson 2 - ROP Pharmacology for Health Care

... All Rights Reserved ...
AlcDrugPrimer
AlcDrugPrimer

... • Codeine 1 - 25% ...
highlights of prescribing information
highlights of prescribing information

... to overgrowth of C. difficile. C. difficile produces toxins A and B, which contribute to the development of CDAD. Hypertoxin-producing isolates of C. difficile cause increased morbidity and mortality, as these infections can be refractory to antimicrobial therapy and may require colectomy. CDAD must ...
OTHER DIURETICS
OTHER DIURETICS

... hypertension i.e. blood pressure above target despite three drugs at full doses in combination and including a thiazide. The added blood pressure reduction may be the result of increased diuresis or inhibition of unsuspected hyperaldosteronism in resistant hypertension. At present, the evidence supp ...
EA_QA214.4_COCandSJW - Specialist Pharmacy Service
EA_QA214.4_COCandSJW - Specialist Pharmacy Service

...  Women on short term treatment with SJW (defined arbitrarily as ≤2 months) may continue using the combined patch, ring or standard strength combined pill, but they should be advised to use additional contraceptive precautions (e.g. condoms) while taking SJW and for 28 days after stopping [21].  To ...
Children are not just small adults!
Children are not just small adults!

... related decline in the first order elimination rate constant (k, h-1) with age in all three groups ...
SYLLABUS FOR B. PHARM. - All India Council For Technical
SYLLABUS FOR B. PHARM. - All India Council For Technical

... All India Council for Technical Education (AICTE) established as a statutory body by the Government of India through Act No.52 of 1987 has been broadly vested with the responsibility of coordinated and integrated development of technical education in the country. ...
Cannabinoids in bipolar affective disorder: a review and
Cannabinoids in bipolar affective disorder: a review and

... control to prevent skin complications, which may prove to be serious. Conventional antidepressants and electroconvulsive therapy can induce mood elevation, which may progress to rapid mood cycling. Antipsychotic drugs have many undesirable effects and the atypical antipsychotics quetiapine, olanzapi ...
lactic acidosis with chloramphenicol treatment in a child with cystic
lactic acidosis with chloramphenicol treatment in a child with cystic

... syndrome, and the availability of safer alternatives have precluded its general use. Its one-dose regimen is, however, still considered as a first-line therapy for the treatment of meningococcal meningitis in developing countries where alternatives are not readily available.14 Exposure to chloramphe ...
Hyperlipidemia
Hyperlipidemia

... patients with muscle Sx ASAP hold drug and obtain CK. It may be as simple as lowering the dose. Signs and symptoms: myalgia, muscle weakness, CK, rarely progressing to rhabdomyolysis, myoglobinemia, renal failure and death. – Cerivistatin (Baycol) was taken off market because of 31 ...
Integrating information - from char strings to SAS data libs.
Integrating information - from char strings to SAS data libs.

... The usual way to concatenate character strings is to bring together the values of several variables from the same record. For example, COMMENT1 and COMMENT2 can be joined into ALL_COMM like this: ...
Chapter 3 Mendelism: The Basic Principles of Inheritance
Chapter 3 Mendelism: The Basic Principles of Inheritance

... – Incomplete family records – Small number of progeny – Uncontrolled environment ...
Gentamicin – Therapeutic drug monitoring
Gentamicin – Therapeutic drug monitoring

... Most patients will need ONLY ONE DOSE of gentamicin when given in this way and in combination with a -lactam or other appropriate agent (the latter agent should be continued as clinically indicated). ...
click on dosing chart to download.
click on dosing chart to download.

... neutrophil function. These infections may be mild to severe, and, with increasing doses of corticosteroids, the rate of occurrence of infectious complications increases. Corticosteroids may also mask some signs of infection after it has already started. Infections (Viral): Chicken pox and measles, f ...
Stroke Prevention in Atrial Fibrillation
Stroke Prevention in Atrial Fibrillation

... warfarin [8]. There have not been many recent advances in warfarin; however, it remains one of the dominant strategies to prevent stroke in atrial fibrillation. There were attempts to analyze genetic variation in response to warfarin [9]; however, when used in a prospective clinical trial, there was ...
Treating Anxiety with either Beta Blockers or Antiemetic
Treating Anxiety with either Beta Blockers or Antiemetic

... Propranolol has been delivered sublingually at 10 and 40 mg per dose [12,13], although this can produce mouth paresthesia, an undesirable effect. Also, propranolol has been delivered by rectal administration in mammals [15]. It does not demonstrate chemical dependence or sedation that are common sid ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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