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Herbal medicine for treatment and prevention of liver diseases
Herbal medicine for treatment and prevention of liver diseases

... The rising number of patients with liver dysfunction due to overwhelming usage of drugs and alcohol has paved the path for researchers in an interest in herbal medicine. This is because there are only a few universally effective and available options for the treatment of common liver diseases, such ...
Propranolol - Plymouth | Veterinary Surgeons
Propranolol - Plymouth | Veterinary Surgeons

... Tell your vet if you are giving your pet any other medications, even if you think they already know. This includes herbal or offthe-shelf remedies from a pet shop or pharmacy. Do not give propranolol to your pet if they are already taking any of a group of drugs called sympathomimetics (these includ ...
Procedure
Procedure

... wheal develop, injection was given too deeply. ...
Statistic and Analytical Strategies for HLA Data
Statistic and Analytical Strategies for HLA Data

... Genetic heterogeneity: Individuals with consistent phenotypes or identical clinical symptoms of a specific type of disease may have different genotypes. If they are not strictly distinguished, the Hardy-Weinberg equilibrium will likely become complex. ...
Differin - Galderma
Differin - Galderma

... For external use only. Avoid contact with the eyes, lips, angles of the nose, mucous membranes and open wounds. Certain cutaneous signs and symptoms such as erythema, dryness, scaling, burning or pruritus are associated with the topical application of retinoids and can also be expected with the use ...
Procedure
Procedure

... certain forces act on the population. Dominant alleles will not replace recessive alleles, and the ratio of heterozygous and homozygous individuals does not change over the course of several generations. This theory has come to be known as the Hardy-Weinberg principal; it is the basis of the study o ...
Efficacy, safety and tolerability of linezolid containing regimens in treating MDR-TB
Efficacy, safety and tolerability of linezolid containing regimens in treating MDR-TB

... Nevertheless, clinical experience on linezolid has been mainly restricted to case reports and small case series including both non-tuberculous mycobacterial diseases and TB [22–29]. Due to the lack of available antibiotics to treat such difficult cases, linezolid is already used off-label to treat M ...
Click here B. Pharmacy Syllabus
Click here B. Pharmacy Syllabus

... (INTRODUCTION TO DOSAGE FORMS) THEORY Max. Marks: 80 Total Hours: 50 (2hrs/week) Note: Examiner to set eight questions and the candidates are required to attempt any five. 1. Introduction: Importance and classification of Pharmaceutical dosage forms, Sources of information required for Pharmacists. ...
Chronic Urticaria and Angioedema - The Division of Allergy and
Chronic Urticaria and Angioedema - The Division of Allergy and

... recommended doses of these agents. A study of 439 patients revealed that fexofenadine, at a dose of 60, 120, or 240 mg per day, was significantly more efficacious than placebo, as assessed by the mean pruritus score, the mean number of wheals per day, the mean daily symptom score (the sum of the whe ...
Toxic epidermal necrolysis and Stevens
Toxic epidermal necrolysis and Stevens

... Toxic epidermal necrolysis (TEN) and Stevens Johnson Syndrome (SJS) are severe adverse cutaneous drug reactions that predominantly involve the skin and mucous membranes. Both are rare, with TEN and SJS affecting approximately 1or 2/1,000,000 annually, and are considered medical emergencies as they a ...
An evaluation of the histological effects of intra
An evaluation of the histological effects of intra

... Canines, aged 1.5 to 4 years, weighing 20 to 23 kg were used for this study because they mimic the age at which anterior cruciate ligament reconstruction is generally done in humans and because the knee joint space can accommodate a 5-mL injectate. Additionally, the canines’ immune mechanisms and bi ...
Thyroid and Parathyroid Agents
Thyroid and Parathyroid Agents

... Because the signs and symptoms of thyroid disease mimic many other problems that are common to older adults—hair loss, slurred speech, fluid retention, heart failure, and so on it is important to screen older adults for thyroid disease carefully before beginning any therapy. The dose should be start ...
IN SITU  Research Article SANTHOSH KUMAR.J*
IN SITU Research Article SANTHOSH KUMAR.J*

... The present study deals with the formulation and evaluation of cytarabine in situ implants. Cytarabine is a synthetic pyrimidine nucleoside. Cytarabine is most commonly used to treat acute myeloid leukaemia.The purpose of this research is to minimize the frequency of doses and toxicity and to improv ...
Selective Inhibition of Human Solute Carrier Transporters by
Selective Inhibition of Human Solute Carrier Transporters by

... Eighteen MKIs were tested for the capacity to modulate substrate uptake by 13 SLC transporters expressed in HEK293 cells (Fig. 1). Initial screening at the 10 mM concentration identified a number of potent inhibitory interactions (.50% inhibition); IC50 values were determined for these interactions ...
INTRODUCTION: - PharmaStreet
INTRODUCTION: - PharmaStreet

... are resistant to clarithromycin also. ...
Publication
Publication

... zz Reduced drug use: MMT was associated with a dramatic reduction in percentage of participants using drugs, from 100% of participants using drugs at program enrollment to 34- 36% after 3 months and 19%-26% of participants after 6 months of treatment. This low prevalence of drug use then persisted i ...
Safety of Zopiclone or Trazodone versus
Safety of Zopiclone or Trazodone versus

... Three systematic reviews and one clinical practice guideline that examined the clinical effectiveness of BZs and Z-drugs in patients with insomnia were identified from the literature search.2,3,11,12 The Dündar review3 included clinical trials with various study designs; while the others included ra ...
this PDF file - E-Journal Faculty of Medicine Universitas
this PDF file - E-Journal Faculty of Medicine Universitas

... Median Range ...
Sedation Practice Checklist (Word)
Sedation Practice Checklist (Word)

... verbal contact with the patient is maintained throughout the period of sedation. The drugs and techniques used to provide conscious sedation for dental treatment should carry a margin of safety wide enough to render loss of consciousness unlikely. The level of sedation must be such that the patient ...
lntraclonal mating in Trypanosoma brucei is
lntraclonal mating in Trypanosoma brucei is

... However, further analysis of cloned progeny trypanosomes from one of the out-crosses using RFLP markers, molecular karyotyping and RAPD (random amplification of polymorphic DNA) produced unequivocal evidence that intraas well as interclone mating had occurred. The progeny of interclone mating were d ...
Drug Information Letter  New Drug Evaluation Multaq (dronedarone) Tablets
Drug Information Letter New Drug Evaluation Multaq (dronedarone) Tablets

... Study 4 – ANDROMEDA5 In ANDROMEDA patients were either randomized to dronedarone (n = 310) or placebo (n = 317) who were recently hospitalized with symptomatic heart failure and severe left ventricular systolic dysfunction. The primary composite end point was all-cause mortality or hospitalization f ...
here - Genetics
here - Genetics

... C. Alleles. The nature of any particular mutational change is not indicated by the genotypic symbol. For example, araBl might be a base-pair substitution or a small deletion. In each case, however, the symbol indicates the presence of a unique nucleotide sequence for the locus in question, and thus ...
Type XVII collagen gene mutations in junctional epidermolysis
Type XVII collagen gene mutations in junctional epidermolysis

... after transcription the premtRNA still contains the intronic sequences, which are cleaved by a process called splicing, i.e. before the mature RNA enters the cytoplasm for translation. For clarity, the introns surrounding the targeted exon, exon 52, are depicted separately. The position of a common ...
(HMG-CoA) REDUCTASE INHIBITORS ON THE CYP3A4
(HMG-CoA) REDUCTASE INHIBITORS ON THE CYP3A4

... values of itraconazole using human liver microsomes and applied them to a pharmacokinetic model (Ito et al., 1998), together with pharmacokinetic parameters for itraconazole. As a result, we have found that the predicted increase in plasma levels of simvastatin by concomitant administration of itrac ...
The impact of polypharmacology on chemical biology Albert Antolín Hernández
The impact of polypharmacology on chemical biology Albert Antolín Hernández

... In fact, it was not until the mid-19th century that truly scientific studies of drug action began,6 and we had to wait until the 20th century before therapeutics started being developed in a scientific manner.6 In this last century, the discovery and synthesis of new drugs has contributed to the pro ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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