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Profile Documents Logout
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• Definition of TDM
• Definition of TDM

... Dr Arif Hashmi Objectives Review the therapeutic monitoring of drugs with low therapeutic indices. • Indications of Therapeutic drug monitoring. • Clinical significance of therapeutic drug monitoring. • Give example of drugs that needs therapeutic drug monitoring. ...
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... Folk remedies Home remedies Use of nonprescription drugs and herbal remedies • OTC treatments ...
TACROLIMUS prepared by Turkeyah Al
TACROLIMUS prepared by Turkeyah Al

... cytoplasmic phosphatase. *Calineurin regulates the ability of the nuclear factor of activated T cells to translocate the nucleus and increase the production of cytokines. ...
References - Society of Anesthesia and Sleep Medicine
References - Society of Anesthesia and Sleep Medicine

... and functional limitation for at least 7 days after T&A9. A parent’s inability to assess pain and/or their unwillingness to administer an analgesic at home is part of the problem10. In addition, many of the analgesics we administer in children are considered “off-label”. Hence there is limited pedia ...
Word Definition 1 non-Mendelian genetics rules for inheritance that
Word Definition 1 non-Mendelian genetics rules for inheritance that

... genetic traits that are controlled by many genes 6 sex-linked gene a gene that is carried on the X or Y chromosome 7 carrier a person who has one dominant and one recessive allele for a trait 8 genetic disorder an abnormal condition that a person inherits through genes a genetic disorder that causes ...
MAST-321, Introduction to Pharmacology 2003
MAST-321, Introduction to Pharmacology 2003

... 6. Providing the necessary information to patients regarding safe administration of medications, side effects and interactions. ...
Evolution: three coordinated legs
Evolution: three coordinated legs

... • Environments can be “stable” or fluctuating, and this affects evolutionary rate and direction; different variations can be selected in each generation. • What evidence do you have from the Grant’s finch study to support this claim? ...
Antiviral and Anti
Antiviral and Anti

... b. The cell has CCR5 (chemokine receptor 5) and CXCR4 receptor. c. Some patient’s virus use CXCR4, other patient’s virus use CCR5, and some patient’s virus use a combination of both. d. This drug will only work on patient’s whose virus uses CCR5 to enter the cell. e. A test is needed to determine wh ...
April 2007 FDA Announces Drug Withdrawals, Recalls
April 2007 FDA Announces Drug Withdrawals, Recalls

... adverse events associated with its use. Zelnorm is approved for short-term treatment of women with irritable bowel syndrome with constipation and for patients younger than 65 years with chronic constipation. This action was based on the analysis of 29 short-term, randomized, controlled trials involv ...
Tuberculosis
Tuberculosis

... generally results in the formation of slowgrowing granulomatous lesions that are responsible for major tissue destruction. The most widely encountered mycobacterial infection is tuberculosis but can also cause leprosy ...
PHARMACOKINETICS
PHARMACOKINETICS

... The Partition coefficient (Po/w) and can be used to determine where a drug likes to go in the body Any drug with a Po/w greater than 1(diffuse through cell membranes easily) is likely be ...
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... utilization of drugs properly and protecting the public from exposure to unnecessary drug residues. Drugs should be used only when required at the required amount and combination. Improper use of drugs may result in ineffective treatment, unnecessary wastage of resources, and may harm the patient. I ...
GENETICS OF MYOCARDIAL INFARCTION
GENETICS OF MYOCARDIAL INFARCTION

... prevention of CAD will require treating genetic and environmental risk factors. Polygenic diseases are due to multiple genes each contributing only minimally or moderately to the phenotype. The genome wide association study, initiated only 2 years ago has been extremely productive. The first common ...
dairy “moos”letter - Medford Veterinary Clinic
dairy “moos”letter - Medford Veterinary Clinic

... in Colby for cows and horses. This is especially useful in down cows with suspected milk fever. Be sure to pull a blood sample BEFORE you treat her and we can run it if the cow doesn’t respond. Keep the blood sample refrigerated. We can then check calcium, phosphorus, and magnesium levels to ensure ...
Express Scripts Drug Information & Wellness Center Drug Information Updates
Express Scripts Drug Information & Wellness Center Drug Information Updates

... been fully studied. Currently, the synthetic methamphetamine and cocaine are not regulated by the DEA. The process to restrict and schedule these types of drugs can be a very time consuming process at the federal level. Banning the products at the state and local level is a much faster proposition. ...
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Routes of Administration

... Drug is rapidly absorbed into the bloodstream More potent than oral route because drug directly enters the blood and bypasses the liver ...
United States Food and Drug Administration Increases Enforcement
United States Food and Drug Administration Increases Enforcement

... United States Food and Drug Administration Increases Enforcement Efforts Against Common Cough, Cold and Allergy Drugs, Warns FDAImports.com In early March 2011 , the U.S. Food and Drug Administration (“FDA”) significantly increased its enforcement rhetoric against all companies manufacturing, import ...
Principal Investigator Professor Cathryn Lewis
Principal Investigator Professor Cathryn Lewis

... metabolites will provide insight into the benefits of activity, and may inform drug prescription and reveal new drug (and exercise) targets. To move the concept of personalised medicine into clinical practice we need to link all an individual's ...
3.fibromil weight reductor
3.fibromil weight reductor

... Relief of fibromyalgia symptoms were noticeable after one week in the group of patient responders. In addition, Fibromil exerted a favorable effect on reducing daytime fatigue and memory/concentration difficulties. One of the desirable side effects of the drug is weight loss of about one to two poun ...
1 Take-Home Medications
1 Take-Home Medications

... To enable patients to receive initial doses of medication until such time as they can fill their prescription at a pharmacy, or for short term treatment requirements in specific situations as below To facilitate the administration of medications in a manner that minimises the risk of harm for the pa ...
Introduction - Indian Pharmacopoeia Commission
Introduction - Indian Pharmacopoeia Commission

... Formulary of India 2015. This edition follows the 4th edition which was published in 2011. The principal objective of the 5th edition continues to be promotion of rational use of medicines. To achieve this objective, the monographs of drugs comprise the clinical indications, strengths and major adve ...
Med-Administration-2of-3-FINAL-DRAFT
Med-Administration-2of-3-FINAL-DRAFT

... When one medication modifies the action of another, this can occur  Synergistic ...
Medication Administration
Medication Administration

... When one medication modifies the action of another, this can occur  Synergistic ...
week3pm
week3pm

... ◦ 2nd messenger systems ◦ more than 50 G protein coupled receptors have been identified (large and diverse family) ◦ control many cellular processes ◦ Involved in synaptic effects of many nt ...
Int J Med Toxicol 2003
Int J Med Toxicol 2003

... prescription or OTC medications • Has no known drug allergies ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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