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Seeking Insight - sun pharma advanced research company
Seeking Insight - sun pharma advanced research company

... Seeking Insight An Investor Update on Innovation May 2010 ...
Gene Interaction that produces novel Phenotype
Gene Interaction that produces novel Phenotype

... • Genomic imprinting: differential expression of genetic material depending on whether it is inherited from the male or female parent. • Epigenetics: Phenomena due to alterations to DNA that do not include changes in the base sequence; often affect the way in which the DNA sequences are expressed. ...
The Future of the Gene -
The Future of the Gene -

... Genetic testing of the unborn raises different concerns: It is performed with the intention to avoid certain hereditary diseases. But most health problems occurring in the newborn, including very severe ones, are not determined by genetic defects but by other, environmental pre- and perinatal condi ...
New Drug Update
New Drug Update

... dosing, drug interactions) for each drug presented; 2. Compare and contract each new drug to any existing drugs in the same therapeutic class; and 3. Determine place in therapy of each new drug as compared to currently available modalities for the indicated ...
company announcement
company announcement

... FDA advisory committees are panels of independent experts who advise the FDA on specific questions raised by the FDA as they consider regulatory decisions. The FDA is not bound by the committee's recommendation, but it takes its advice into consideration when reviewing new drug applications. Accordi ...
NNFA Las Vegas 2005 Herb-Drug Interactions Dr. Arthur M. Presser
NNFA Las Vegas 2005 Herb-Drug Interactions Dr. Arthur M. Presser

... Cyto= cell, chrome= color Absorb light at particular frequencies (450nm) Various isoforms (isozymes) ...
Position Paper on Procedural Sedation
Position Paper on Procedural Sedation

... state of total unconsciousness resulting from anesthetic drug(s)”, and distinct from “analgesia”, which is described as the “reduction of or insensibility to pain without loss of consciousness”. The provision of therapeutic sedation may make unpleasant health care procedures more acceptable to patie ...
Medication Therapy Adherence Clinic: RHEUMATOLOGY PROTOCOL
Medication Therapy Adherence Clinic: RHEUMATOLOGY PROTOCOL

... Inflammatory Arthritis Registry (NIAR) 2009, 52% of the patients in the study (n=1000) attributed their unemployment to their disease, thus confirming that RA has a socioeconomic impact to the society. Nearly 70% (n=697) of the patients recruited in NIAR 2009 are on combination DMARD therapy and the ...
Reporting Status or Progress - Tourette Syndrome Association
Reporting Status or Progress - Tourette Syndrome Association

... – MZ twins 77% – DZ twins 23% ...
It is generally expected that Rohypnol ampoules will be
It is generally expected that Rohypnol ampoules will be

... Since the risk of withdrawal and rebound phenomena is greater after abrupt discontinuation of treatment, it is recommended that the dosage be decreased gradually. Amnesia Benzodiazepines may induce anterograde amnesia. The condition most often occurs within the first few hours after administration o ...
Sequence Variants
Sequence Variants

...  Discuss the possibility of finding VUSs with your patients before ordering testing, including the accuracy, limitations and implications of these results.  Information such as clinical findings, family history, ethnic background, and other laboratory data must be effectively communicated to the l ...
Protein binding of drugs
Protein binding of drugs

... E.g. Adm. Of Phenylbutazone to Warfarine therapy patient, result  in Hemorrhagic reaction. ...
Amyotrophic Lateral Sclerosis (ALS)
Amyotrophic Lateral Sclerosis (ALS)

... Amyotrophic Lateral Sclerosis (ALS) is a progressive neuromuscular condition characterized by weakness, muscle wasting and increased reflexes. ALS involves degeneration of upper and lower motor neurons. Fifty percent of patients die within 18 months after diagnosis, and only 10% of patients live lon ...
New oral anticoagulants in severe trauma patients: Enemy at the
New oral anticoagulants in severe trauma patients: Enemy at the

... reducing the risk of embolic events.8,9 Between 1989 and 1993 a total of 6 clinical trials evaluated the usefulness of warfarin versus aspirin or placebo in preventing stroke in patients with arrhythmias of this kind. The data obtained from the global 2900 patients enrolled in these trials showed wa ...
SPARC Investor Presentation
SPARC Investor Presentation

... Days ...
TERAPI BIOLOGIK (Kuliah Umum Psikiatri Mhs.tk
TERAPI BIOLOGIK (Kuliah Umum Psikiatri Mhs.tk

...  Therapeutic Principal: - do not use high dosage - do not use more than 1 month ...
Pharmaceutical Slides - Public Health and Social Justice
Pharmaceutical Slides - Public Health and Social Justice

... • Profile of users’ parents: -better educated -uninsured • Provider visits reduce use • Provider phone calls do not ...
Autism and public health
Autism and public health

... grandchildren with autism spectrum disorder and included a promise to “to do more testing for autism” in her campaign. She has representatives of a company that has a panel of markers for autism asking to schedule a meeting with you so that you can become her state professional advocate to add this ...
GENETICS
GENETICS

... Incomplete dominance – A form of dominance occurring in heterozygotes in which the dominant allele is only partially expressed, and usually resulting in an offspring with an intermediate phenotype. Alleles blend to create a new phenotype in the heterozygote! Example: In snapdragons, flower color can ...
π S-18034 1 GALLON GLASS JUGS
π S-18034 1 GALLON GLASS JUGS

... Type III Manufactured Soda Lime Glass ...
5. Genetics
5. Genetics

... When two loci are known to be carried on the same chromosome and to be within measurable distance of each other they are said to be linked. The nearer their loci are together the closer the linkage. Two alleles whose loci are closely linked may travel together through many generations without being ...
Conjugative DNA transfer, antibiotic resistance and MDR bacteria
Conjugative DNA transfer, antibiotic resistance and MDR bacteria

... Elements are also key to antibiotic resistance Transposable genetic elements (transposons) = DNA segments that can insert themselves at one or more sites in a genome. Remarkably, almost 50% of our chromosomes consist of transposable elements ...
Ototoxic Medications
Ototoxic Medications

... of the medications. Often these problems are reversible upon discontinuation of the drug. Occasionally there are times when this change in hearing can be permanent. If you are experiencing a hearing problem, or if there is a hearing disorder in your family, it is imperative that your treating physic ...
Population Genetics & Evolution
Population Genetics & Evolution

... • Gene flow - transport of genes by migrating individuals Genes are lost from the gene pool when an individual leaves a population; genes are added when an individual enters a population QuickTime™ and a decompressor are needed to see this picture. ...
Drug Interactions in the Heart and Lung Transplant Patient
Drug Interactions in the Heart and Lung Transplant Patient

... pharmacies sell over the counter. These all contain stimulants which will cause your heart rate and blood pressure to soar! – Caffeine ingestion can lead to an increase in heart rate and blood pressure as well. Caffeine is also found in many migraine medications including Excedrin®. ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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