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Essential Questions
Essential Questions

... genetic information to their offspring. (secondary to MS- LS3-2) Genes are located in the chromosomes of cells, with each chromosome pair containing two variants of each of many distinct genes. Each distinct gene chiefly controls the production of specific proteins, which in turn affects the traits ...
Unsafe Drugs: Congressional Silence is Deadly
Unsafe Drugs: Congressional Silence is Deadly

... drugs is not even addressed. To the extent that recent drug withdrawals raise questions about FDA's premarket consideration of drug risks or its will to prevent the marketing of distinctly and highly toxic but questionably necessary drugs, the changes mandated by that law are largely beside the poin ...
Click here to download
Click here to download

... Lamotragine Extensively studied in peripheral neuropathic states Dizzyness, somnolence and peripheral edema ...
$doc.title

... hypotension. This further demonstrates that health professionals do not rely solely on the drug's label for dosage information. Second, at least three health professionals review the dosage regimen for each instance of prescribed amifostine, thus further preventing any chance of a medication error. ...
Protocol - Doncaster LMC
Protocol - Doncaster LMC

... When a patient is prescribed a DMARD there are significant issues regarding pregnancy and family planning posed by the potency and potential teratogenic potential of these drugs. The decision about when and what drugs should be stopped is a decision that needs to be taken in secondary care. The deci ...
Next-Generation NNRTIs: Etravirine and Rilpivirine
Next-Generation NNRTIs: Etravirine and Rilpivirine

... in treatment-naive individuals more than doubled between 1996 and 2006, increasing from 5% to more than 10% in a single decade. In addition to resistance, serious side effects represent a major limitation of first-generation NNRTIs. Although the class as a whole is generally well tolerated, some bot ...
Clomipramine Fact Sheet - The Main Line Center for the Family
Clomipramine Fact Sheet - The Main Line Center for the Family

... Most cases of major depression can be treated successfully, usually with medication, psychotherapy, or both. The combination of psychotherapy and antidepressants is very effective in treating moderate to severe depression. The medications improve mood, sleep, energy, and appetite, while therapy stre ...
Prescriptions – Chapter 5
Prescriptions – Chapter 5

... Patient Name Patient data What is the medication? When was the Rx written? Is the drug available? Does the drug need compounding? Is the Rx suspicious in any way? ...
Opioid Analgesics
Opioid Analgesics

... Does not cause N & V or GI bleeding Does not interfere with clotting Lacks anti-inflammatory activity Metabolized in liver ...
STATEMENT OF JOHN ERICKSON, PhD
STATEMENT OF JOHN ERICKSON, PhD

... Norvir has the unexpected property of inhibiting its own metabolism, which makes it stay in circulation longer. Since it inhibits the same metabolic enzymes that are responsible for breaking down and eliminating many other drugs, including competitors’ protease inhibitors, co-administration of Norv ...
Chapter 3 Genetics
Chapter 3 Genetics

... - he crossed purebred plants which had opposite traits -in first filial generation, one trait was evident and the other had disappeared - in the second filial generation (F2), one trait showed up in ¾ of the offspring, and the other trait reappeared but only in ¼ of the offspring. Conclusion: - indi ...
File - Riske Science
File - Riske Science

... diseases/conditions to go after; want to make money off of investment • Downside to universal healthcare? • The average time for development of a drug from its first identification to the market is about 10–12 years. – Patent issues ...
Updated 2013 - Auburn University at Montgomery
Updated 2013 - Auburn University at Montgomery

... stimulant and is being recognized as a “date rape drug” by many law enforcement entities. It is usually found in tablet form with a variety of different imprints ranging from the design of a butterfly to the word: SEX. Ecstasy can be deadly when mixed with alcohol. Other effects include anxiety, ina ...
Antiepileptic Drugs
Antiepileptic Drugs

... • TONIC PHASE (up to 1 min): an initial strong contraction of the whole musculature, causing a rigid extensor spasm and fall. Respiration stops and defecation, micturation and salivation often occur. • CLONIC PHASE (2-4 min): a series of violent, synchronous jerks. • The patient gradually recovers, ...
Prototype drug - Nursing Pharmacology
Prototype drug - Nursing Pharmacology

...  Patient will exhibit therapeutic outcome based on specific drug  Patient will demonstrate an understanding of drug’s activity  Patient will accurately describe drug side effects and precautions  Patient will demonstrate proper administration technique ...
Checklist unit 14: Mendel and the gene idea
Checklist unit 14: Mendel and the gene idea

... The two genes may or may not contain the same information. If the two genes for a trait are identical, the individual is called homozygous for that trait. If the two genes have different information, the individual is called heterozygous with regards to that trait. The different possible forms of a ...
Rimadyl – Reproduced with permission of Canine Health Concern©
Rimadyl – Reproduced with permission of Canine Health Concern©

... monitoring as suggested by Pfizer? Some Important Issues that have arisen from information received by the Senior Dogs Project 1. Is Pfizer doing enough to inform and educate veterinarians and the public about the administration and possible side effects of Rimadyl? 2. Should Rimadyl be recommended ...
Oral	laquinimod	therapy	in relapsing	multiple	sclerosis Drug Evaluation Jana Preiningerova
Oral laquinimod therapy in relapsing multiple sclerosis Drug Evaluation Jana Preiningerova

... CNS. Early treatment reduces the number of relapses, limits progression of disability, and improves quality of life; however, existing therapies are only partially effective and require parenteral administration. Objective: To review current experience with laquinimod as a novel immunomodulatory the ...
September 2015 - Institute For Safe Medication Practices
September 2015 - Institute For Safe Medication Practices

... For our 2014 annual report issue the objective was to identify drug safety issues from different perspectives. Measured by sheer numbers of reports, the anti-TNF products place first, in part because of their potent effects on the immune system that increase the risks of invasive fungal and opportun ...
Introduction to Antimicrobial Therapy
Introduction to Antimicrobial Therapy

... therapy. Surgical intervention. Vancomycin discontinued. ...
Letter for Users to carry with them at all times
Letter for Users to carry with them at all times

... Addictive disease can be characterized as a chronic, relapsing, progressive, probably incurable, and often fatal (if untreated) disorder. The principle diagnostic features are obsession, compulsion, and “continued use despite adverse consequences“ (loss of control). Methadone has been used in the tr ...
Similarities and Differences Between US and Japan as to
Similarities and Differences Between US and Japan as to

... Therapeutic areas were defined following the classifications in the table by the FDA, i.e., analgesics, antifungals, antimalarials/antiarrhythmics, antivirals, cardiovascular, dermatology-dental, gastroenterology, hematology, metabolicendocrinology, neurology, oncology, psychiatry, reproductive, repro ...
Science Hand Out 7 - Literacy Action Network
Science Hand Out 7 - Literacy Action Network

... QUESTION: What kind of genotypes and phenotypes will result from crosses of dominant red and recessive white flowers? BACKGROUND INFORMATION:  A gene is a section of DNA that holds hereditary information. It is a code for traits & characteristics. Genes come in pairs.  The two genes in a pair are ...
Neurofibromatosis and Seizures *Knowledge is Power*
Neurofibromatosis and Seizures *Knowledge is Power*

...  Medications specific for type of seizure  Different medications for focal onset vs. generalized seizures  Age and developmental status of patient  Administration of medication ...
The Effects of a Required Autopsy Exercise on Medical
The Effects of a Required Autopsy Exercise on Medical

... dangerous complication of over anticoagulation. ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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