Exploiting single-cell quantitative data to map genetic
... be a quantitative trait that can be measured at the level of individual cells. X is affected by the genotype of the cells and by their environmental context. However, even for isogenic cells sharing a common, supposedly homogeneous environment, X may differ between the cells. To describe the statist ...
... be a quantitative trait that can be measured at the level of individual cells. X is affected by the genotype of the cells and by their environmental context. However, even for isogenic cells sharing a common, supposedly homogeneous environment, X may differ between the cells. To describe the statist ...
A Cladistic Analysis of Phenotype Associations with
... taining genes with known biochemical functions. By simultaneously studying traits that are related to the genes’ known biochemical or physiological functions, it is possible to assign phenotypic effects to specific alleles or haplotypes at or near the genes of knownfunction. This measured genotype a ...
... taining genes with known biochemical functions. By simultaneously studying traits that are related to the genes’ known biochemical or physiological functions, it is possible to assign phenotypic effects to specific alleles or haplotypes at or near the genes of knownfunction. This measured genotype a ...
Silene sex chromosome genetic map, p. 1 Expansion of
... pairs (and of the W in ZW pairs), and to accumulation of repetitive sequences, and, ultimately, heterochromatinisation (e.g. Charlesworth and Charlesworth 2000; Charlesworth et al. 2005; Bachtrog 2006; Bergero and Charlesworth 2009). It is now understood that the large non-recombining regions of sex ...
... pairs (and of the W in ZW pairs), and to accumulation of repetitive sequences, and, ultimately, heterochromatinisation (e.g. Charlesworth and Charlesworth 2000; Charlesworth et al. 2005; Bachtrog 2006; Bergero and Charlesworth 2009). It is now understood that the large non-recombining regions of sex ...
Directional Positive Selection on an Allele of Arbitrary
... recessive alleles. As a result, the genealogy is shallower for smaller h. This effect on the genealogy is most notable in the value of up rather than uw and uH because this statistic is most sensitive to the height of the genealogy (Tajima 1989b). The second result stems from the difference in the s ...
... recessive alleles. As a result, the genealogy is shallower for smaller h. This effect on the genealogy is most notable in the value of up rather than uw and uH because this statistic is most sensitive to the height of the genealogy (Tajima 1989b). The second result stems from the difference in the s ...
The molars of the tabby mouse, and a test of the
... concept. An autosomal mimic of tabby, called crinkled (cr; linkage group 14), with the same dental syndrome, offers opportunities for further tests of the hypothesis. It will be seen that, contrary to first impressions, the quantitative study reveals a situation which is not in agreement with the Ly ...
... concept. An autosomal mimic of tabby, called crinkled (cr; linkage group 14), with the same dental syndrome, offers opportunities for further tests of the hypothesis. It will be seen that, contrary to first impressions, the quantitative study reveals a situation which is not in agreement with the Ly ...
Blueprint of life
... distinguish between homozygous and heterozygous genotypes in monohybrid crosses ...
... distinguish between homozygous and heterozygous genotypes in monohybrid crosses ...
The long-term evolution of multi- locus traits under
... and xlk denote the kth allele at the lth locus and its phenotypic effect (allelic effect), respectively. We initially assume that loci are unlinked and that alleles interact additively at each locus and between loci. Hence, for an individual carrying alleles alk ′ and alk ′′ at the lth locus, the ph ...
... and xlk denote the kth allele at the lth locus and its phenotypic effect (allelic effect), respectively. We initially assume that loci are unlinked and that alleles interact additively at each locus and between loci. Hence, for an individual carrying alleles alk ′ and alk ′′ at the lth locus, the ph ...
Na concentration (root and shoot) (15%)
... LOD score compares the likelihood of obtaining the test data if the two loci are indeed linked, to the likelihood of observing the same data purely by chance Positive LOD/LRS scores favor the presence of linkage, whereas negative LOD scores indicate that linkage is less likely By convention, a ...
... LOD score compares the likelihood of obtaining the test data if the two loci are indeed linked, to the likelihood of observing the same data purely by chance Positive LOD/LRS scores favor the presence of linkage, whereas negative LOD scores indicate that linkage is less likely By convention, a ...
Positive Selection of Deleterious Alleles through Interaction with a
... population, by contrasting the essentially BTB-negative northern region with the BTB-positive southern region. We hypothesized low heterozygosity among BTB-positive individuals and among individuals of low body condition (LBC) relative to those of high body condition (HBC). We included body conditio ...
... population, by contrasting the essentially BTB-negative northern region with the BTB-positive southern region. We hypothesized low heterozygosity among BTB-positive individuals and among individuals of low body condition (LBC) relative to those of high body condition (HBC). We included body conditio ...
artificial selection
... the response to selection, and other traits can also evolve due to genetic correlations with the selected trait. Artificial selection can directly answer the question of how quickly a trait will evolve under a given strength of selection. This kind of result can help ecologists determine whether ran ...
... the response to selection, and other traits can also evolve due to genetic correlations with the selected trait. Artificial selection can directly answer the question of how quickly a trait will evolve under a given strength of selection. This kind of result can help ecologists determine whether ran ...
Pedigree Analysis Introduction Developing Conclusions About
... and other physical traits, scientists can examine generations within a family and discover the mode of inheritance f human traits. To do this, scientists create family trees, called pedigrees, showing as many generations of a family as they can and marking who had which phenotype. In order for scien ...
... and other physical traits, scientists can examine generations within a family and discover the mode of inheritance f human traits. To do this, scientists create family trees, called pedigrees, showing as many generations of a family as they can and marking who had which phenotype. In order for scien ...
jsm2003 - University of Wisconsin–Madison
... additive effects may be most important (Wright/Fisher debate) statistical goal: maximize number of correctly identified QTL ...
... additive effects may be most important (Wright/Fisher debate) statistical goal: maximize number of correctly identified QTL ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
... complexity and diversity of the mechanisms involved at molecular level during embryogenesis with both genetic and environmental factors playing an important and influential role. With recent advances in genetics, progress has been made in identifying genes associated with this anomaly and their infl ...
... complexity and diversity of the mechanisms involved at molecular level during embryogenesis with both genetic and environmental factors playing an important and influential role. With recent advances in genetics, progress has been made in identifying genes associated with this anomaly and their infl ...
Sager JJ, Bai Q, Burton EA
... and analysis has been developed. Recently it has become apparent that these powerful methodologies might be deployed in order to elucidate the pathogenesis of human neurodegenerative diseases and to identify candidate therapeutic approaches. In this article, we consider evidence that the zebrafish c ...
... and analysis has been developed. Recently it has become apparent that these powerful methodologies might be deployed in order to elucidate the pathogenesis of human neurodegenerative diseases and to identify candidate therapeutic approaches. In this article, we consider evidence that the zebrafish c ...
The Effects of Selective History and Environmental
... selection, regardless of their effects in the novel environment. In contrast, alleles that are strongly selected in the novel environment but neutral or very weakly selected in the standard environment will not have been eliminated by past selection and so will be able to add substantially to inbree ...
... selection, regardless of their effects in the novel environment. In contrast, alleles that are strongly selected in the novel environment but neutral or very weakly selected in the standard environment will not have been eliminated by past selection and so will be able to add substantially to inbree ...
Three autism candidate genes: a synthesis of human genetic
... since been cloned (FOXP2) (Lai et al., 2001). However, studies have failed to detect defects in FOXP2 that are associated with autism, though one group demonstrated linkage to the region (Newbury et al., 2002; Wassink et al., 2002; Gauthier et al., 2003). Some evidence for linkage to the more distal ...
... since been cloned (FOXP2) (Lai et al., 2001). However, studies have failed to detect defects in FOXP2 that are associated with autism, though one group demonstrated linkage to the region (Newbury et al., 2002; Wassink et al., 2002; Gauthier et al., 2003). Some evidence for linkage to the more distal ...
Karma - (dr.) sohan raj tater e
... the whole puzzle, regarding all the traits of human beings, has not been fully solved. But the Jaina karma theory—describes elaborately about the karma particles—and these karma particles determine not only the characteristics of the body of jīva but also its happiness, sorrow, perception, age and g ...
... the whole puzzle, regarding all the traits of human beings, has not been fully solved. But the Jaina karma theory—describes elaborately about the karma particles—and these karma particles determine not only the characteristics of the body of jīva but also its happiness, sorrow, perception, age and g ...
Determinant of Caenorhabditis elegans Growth and
... The NIL results indicate that the smallest region covered by the two NILs likely contains the gene with a causal role in the three phenotypic differences. The qgIR1 NIL has the smallest introgressed region, with seven genes from the Hawaii strain in an otherwise Bristol genetic background. Of these ...
... The NIL results indicate that the smallest region covered by the two NILs likely contains the gene with a causal role in the three phenotypic differences. The qgIR1 NIL has the smallest introgressed region, with seven genes from the Hawaii strain in an otherwise Bristol genetic background. Of these ...
GENETIC GUIDELINES for - Lake Superior State University
... aimed at relatively short-term goals. The long-term effect on the perpetuation of free-roaming fish populations is often uncertain and could be detrimental in many cases. It is important, therefore, to rationally integrate genetic conservation into the management of fisheries resources. This manual ...
... aimed at relatively short-term goals. The long-term effect on the perpetuation of free-roaming fish populations is often uncertain and could be detrimental in many cases. It is important, therefore, to rationally integrate genetic conservation into the management of fisheries resources. This manual ...
Genetics and statistical association between lethal alleles and
... Castelar (Argentina) by Favret and Godeck (1959), and Favret and Ryan (1966), in barley. In 1978, we began the present study in maize; some of our findings have been partly reported by Salerno (1981), Salerno and Favret (1984), Salerno and Gardner (1985), and Salerno et al. (1986), with similar conc ...
... Castelar (Argentina) by Favret and Godeck (1959), and Favret and Ryan (1966), in barley. In 1978, we began the present study in maize; some of our findings have been partly reported by Salerno (1981), Salerno and Favret (1984), Salerno and Gardner (1985), and Salerno et al. (1986), with similar conc ...
Genetics 1 - National Open University of Nigeria
... characteristics such as well-developed muscles acquired by parents in the course of their life can be transmitted to their offspring. This idea was formalized by Charles Darwin (1809-1822) as the “Provisional Hypothesis of Pangenesis.” According to Darwin, exact miniature replicas, called gemmules, ...
... characteristics such as well-developed muscles acquired by parents in the course of their life can be transmitted to their offspring. This idea was formalized by Charles Darwin (1809-1822) as the “Provisional Hypothesis of Pangenesis.” According to Darwin, exact miniature replicas, called gemmules, ...
Association of KCNQ1, KCNE1, KCNH2 and SCN5A Polymorphisms
... rs1805127 (G38S)) showed a 2-fold increased risk of QTc lengthening when carrying the haplotype combining alleles rs2236609 C and rs1805127 A. In our previous study, there was no evidence that SNP rs1805127 was associated with QTc length16, as recently reported in a large population sample17, while ...
... rs1805127 (G38S)) showed a 2-fold increased risk of QTc lengthening when carrying the haplotype combining alleles rs2236609 C and rs1805127 A. In our previous study, there was no evidence that SNP rs1805127 was associated with QTc length16, as recently reported in a large population sample17, while ...
Plant Genetics 2003 - Biology Department | UNC Chapel Hill
... – This would give the false appearance of clustering – Conservative set of QTLs chosen to reduce problems of pleotropic QTL (one per trait category per locus) ...
... – This would give the false appearance of clustering – Conservative set of QTLs chosen to reduce problems of pleotropic QTL (one per trait category per locus) ...
View PDF - Genetics
... to real data, and their performance on complex SVs is unreported. Despite this, there may still be strong evidence from readmapping anomalies that an SV of some sort segregates at a locus. Furthermore, if the intensity of its anomaly signature can be used as a proxy for the purposes of testing genet ...
... to real data, and their performance on complex SVs is unreported. Despite this, there may still be strong evidence from readmapping anomalies that an SV of some sort segregates at a locus. Furthermore, if the intensity of its anomaly signature can be used as a proxy for the purposes of testing genet ...
attached / unattached earlobes
... X to her. It is for that reason that males are more commonly affected by sex-X-linked conditions than females. ...
... X to her. It is for that reason that males are more commonly affected by sex-X-linked conditions than females. ...
Twin study
Twin studies reveal the absolute and relative importance of environmental and genetic influences on individuals in a sample. Twin research is considered a key tool in behavioral genetics and in content fields, from biology to psychology. Twin studies are part of the methods used in behavior genetics, which includes all data that are genetically informative – siblings, adoptees, pedigree data etc.Twins are a valuable source for observation because they allow the study of varying family environments (across pairs) and widely differing genetic makeup: ""identical"" or monozygotic (MZ) twins share nearly 100% of their genes, which means that most differences between the twins (such as height, susceptibility to boredom, intelligence, depression, etc.) is due to experiences that one twin has but not the other twin. ""Fraternal"" or dizygotic (DZ) twins share only about 50% of their genes. Thus powerful tests of the effects of genes can be made. Twins share many aspects of their environment (e.g., uterine environment, parenting style, education, wealth, culture, community) by virtue of being born in the same time and place. The presence of a given genetic trait in only one member of a pair of identical twins (called discordance) provides a powerful window into environmental effects.The classical twin design compares the similarity of monozygotic (identical) and dizygotic (fraternal) twins. If identical twins are considerably more similar than fraternal twins (which is found for most traits), this implicates that genes play an important role in these traits. By comparing many hundreds of families of twins, researchers can then understand more about the roles of genetic effects, shared environment, and unique environment in shaping behavior.Modern twin studies have shown that almost all traits are in part influenced by genetic differences, with some characteristics showing a strong influence (e.g. height), others an intermediate level (e.g. personality traits) and some more complex heritabilities, with evidence for different genes affecting different aspects of the trait — as in the case of autism.