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Pre-Lecture Quiz
Pre-Lecture Quiz

... 5. A patient with pulmonary edema should be positioned upright, preferably with the legs dangling over the side of the bed, if possible. ...
PERIPARTUM CARDIOMYOPATHY
PERIPARTUM CARDIOMYOPATHY

... heart failure secondary to LV systolic dysfunction towards the end of pregnancy or in the months following delivery, where no other cause of heart failure is found. It is a diagnosis of exclusion. The LV may not be dilated but the ejection fraction is nearly always reduced below ...
Long-term effects of non-excitatory cardiac contractility modulation
Long-term effects of non-excitatory cardiac contractility modulation

... The results of this study indicate that long-term therapy with non-excitatory CCM signals attenuates progressive LV dysfunction and remodeling in dogs with HF. These findings are supported by observations of improved LV function evidenced by improvement in LV ejection fraction, stroke volume, and LV ...
Slide () - AccessAnesthesiology
Slide () - AccessAnesthesiology

... The Frank-Starling curves depicted here relate the loading conditions of the left ventricle (preload—as measured by left ventricular end-diastolic pressure [LVEDP]) and stroke volume. Stroke volume (SV) is the amount of blood ejected into the aorta by the heart with each beat. Changes in afterload ( ...
Slide 1 - AccessAnesthesiology
Slide 1 - AccessAnesthesiology

... The Frank-Starling curves depicted here relate the loading conditions of the left ventricle (preload—as measured by left ventricular end-diastolic pressure [LVEDP]) and stroke volume. Stroke volume (SV) is the amount of blood ejected into the aorta by the heart with each beat. Changes in afterload ( ...
Transcript of video
Transcript of video

... The role of the Community Heart Failure Service, is to support patients with a diagnosis heart failure. We also help them manage their condition in the community. We offer up titration of their medications, and we monitor that. We also prevent unnecessary hospital admissions for deterioration in the ...
Electrocardiography
Electrocardiography

... • Passes to bundle of His, down Purkinje fibres • Action potential restarts ...
Effects of Exercise on the Heart
Effects of Exercise on the Heart

New Analysis of Reverse Trial Shows Medtronic CRT Devices Cost
New Analysis of Reverse Trial Shows Medtronic CRT Devices Cost

... Journal of the American College of Cardiology: Heart Failure. CRT is an established treatment for indicated patients with heart failure that has been demonstrated to improve survival and quality of life, and reduce hospitalizations. However, despite significant clinical evidence and guideline recomm ...
Early Treatment of Atrial Fibrillation for Stroke Prevention Trial (EAST)
Early Treatment of Atrial Fibrillation for Stroke Prevention Trial (EAST)

... - Clinically relevant hepatic dysfunction requiring specific therapy - Severe renal dysfunction (Stage V, requiring or almost requiring dialysis) - Clinically manifest thyroid dysfunction requiring therapy. After successful treatment of thyroid dysfunction, patients may be enrolled when their thyroi ...
Enhanced Inotropic State of the Failing Left Ventricle by Cardiac
Enhanced Inotropic State of the Failing Left Ventricle by Cardiac

... have been reported with cardiac resynchronization therapy. This increase in peak LV þ dP/dt were also associated with no change in MVO2. Although the changes are somewhat larger than observed in the present study with CCM therapy, preliminary findings indicate that LV ejection fraction increases by ...
central issue in cardiac resynchronization therapy (CRT) is the
central issue in cardiac resynchronization therapy (CRT) is the

... narrow QRS may be candidates for CRT due to significant mechanical DYS. On the other hand, although short-term experimental studies have shown that patients with wider QRS complexes have a greater immediate mechanical response to CRT, most long-term studies have shown that QRS duration does not pred ...
Eur J Heart Fail
Eur J Heart Fail

... Doppler E/A ratio (p=0.01) increased in the CHF group, with no changes in left ventricular volumes. The healthy subjects had similar responses, but also displayed an increase in cardiac output (p<0.01) and left ventricular volumes (p<0.001). Exercise. Cardiac output and systolic blood pressure incre ...
Independent influence of previous myocardial infarction
Independent influence of previous myocardial infarction

Emergency Department use of Esmolol in Refractory Ventricular
Emergency Department use of Esmolol in Refractory Ventricular

... – Activates α-1 receptors: this is probably helpful – Activates β-1 and β-2 receptors: this is probably harmful ...
Properties of Cardiac Muscle
Properties of Cardiac Muscle

...  From AVN (slowest) → atrioventricular (AV) bundle (bundle of His) →left & right bundles →purkinje fibres (fastest) ...
Sudden Cardiac Arrest Provider Fact Sheet
Sudden Cardiac Arrest Provider Fact Sheet

... optimal medical therapy alone or optimal medical therapy plus implantable cardioverter defibrillator (ICD), with follow-up for 20 months – Significant reduction in all-cause mortality seen with ICD versus optimal medical therapy alone4 • SCD-HeFT (Sudden Cardiac Death in Heart Failure Trial): 2,521 ...
Cardiac Cycle
Cardiac Cycle

... complete heartbeat. • These phases are controlled by the contraction of myocardial cells which are stimulated by the ...
A1979HZ24300001
A1979HZ24300001

... implementation was complex. It was well known that electricity could injure as well as stop the heart entirely. The question therefore was not only whether the concept was correct but how to make electricity safe for human use. After a year of arduous effort, we found that an underdamped sine wave w ...
Flecainide Considerations for Use
Flecainide Considerations for Use

... 1. American College of Cardiology (ACC), American Heart Association (AHA), and the European Society of Cardiology (ESC). ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation. Washington, DC: American College of Cardiology. 2. Heart Rhythm Society. AF360 Pocket Guide: P ...
ECG of the Month - STA HealthCare Communications
ECG of the Month - STA HealthCare Communications

... the frontal plane to approximately -45º. A single ventricular extrasystole, with a right bundle branch block (RBBB) morphology, has been recorded in precorFigure 2. Follow-up ECG dial leads V1 to V3. LBBB is an uncommon finding in healthy individuals without structural heart disease. It occurs more ...
HeartMate II Fact Sheet-B100-0812-final
HeartMate II Fact Sheet-B100-0812-final

... On January 20, 2010, FDA approval was received for Destination Therapy (DT), or long-term support, for those who do not qualify for heart transplantation due to age or other circumstances. ...
Materials and Methods
Materials and Methods

... location, the patient’s sex and the level of left ventricular ejection fraction were not yet being well studied. Aim: To evaluate the outcomes and prognostic significance of patients with AMI depending on it’s location, patient sex, the level of left ventricular ejection fraction and the relation be ...
End stage CHF
End stage CHF

... broad population of patients ...
4_control_of_heart_contraction
4_control_of_heart_contraction

... Atrioventricular node (AVN) • The AVN picks up electrical impulses through the atrial wall and then generates its own • Impulses travel as a wave of excitation along specialised conducting tissue in the septum Purkinje (purkyne) fibres • Fibres from the RHS and LHS form a bundle of ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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