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Electrical Treatment for Cardiac Abnormalities ACPF – 1-0
Electrical Treatment for Cardiac Abnormalities ACPF – 1-0

... Source: American Heart Association, 1994 ...
Heart Failure - Tower Hamlets
Heart Failure - Tower Hamlets

... disease (CHD), the prevalence of which is increasing rapidly in the UK despite the declining overall mortality  from CHD.  The incidence of Heart Failure can be reduced by modifying simple life‐style risk factors but once  diagnosed is a progressive condition causing a range of disabilities which af ...
GDF15, a Cardioprotective TGF-ß Superfamily Protein
GDF15, a Cardioprotective TGF-ß Superfamily Protein

... downstream targets of GDF15 should be useful for further elucidation of the cardioprotective mechanism in various pathological conditions. It is advisable that the long-term protective effects of GDF15 overexpression on cardiac function after MI should be confirmed using GDF15 overexpression mice. R ...
The Impact of Verapamil on Catecholamine Polymorphic Ventricular
The Impact of Verapamil on Catecholamine Polymorphic Ventricular

... therapy including aggressive suppression of polymorphic ventricular tachycardia (PVT) by anti-arrhythmia drugs such as calcium-channel blocker 5 and bilateral thoracic sympathectomy have been found to be effective.6 This patient’s ECG (Figure 1A) showed CRBBBlike pattern, and atypical Brugada syndro ...
Impedance cardiography in uncomplicated pregnancy and pre-eclampsia: correlation between diurne- and
Impedance cardiography in uncomplicated pregnancy and pre-eclampsia: correlation between diurne- and

... (PCC). The contractility parameters acceleration index, velocity index and heather index consistently showed PCC ≥ 0.80 in the three groups. This was also true for thoracic fluid content and -index in healthy and pre-eclamptic pregnant women, but not for cardiovascular patients (PCC ≥ 0.60). For tim ...
Document
Document

... • Sequence of blood flow: venous blood enters the right atrium through the superior and inferior venae cavae—passes from the right atrium through the tricuspid valve to the right ventricle; from the right ventricle through the pulmonary semilunar valve to the pulmonary artery to the lungs—blood from ...
ONLINE APPENDIX Supplemental Table 1. Participating centers
ONLINE APPENDIX Supplemental Table 1. Participating centers

... Supplemental Table 2. Detailed inclusion and exclusion criteria Inclusion:  Subject with chronic functional mitral regurgitation (FMR)  Subject is ≥18 years old  Documented symptoms of CHF (NYHA II-IV)  Symptomatic despite stable (at least 30 day’s duration) optimal medical regimen per applicab ...
MITRAL VALVE DISEASE AND HEART FAILURE IN DOGS What is
MITRAL VALVE DISEASE AND HEART FAILURE IN DOGS What is

... What is the mitral valve? The heart has four chambers. The upper chambers are called atria (singular: atrium), and the lower chambers are called ventricles. The heart is also divided into right and left sides. Blood flows from the body into the right atrium. It is stored there briefly then pumped in ...
ECG of thE Month Irregular Rhythm in a 25-Year
ECG of thE Month Irregular Rhythm in a 25-Year

... however, thinks that separating atrial fibrillation into coarse and fine forms is not justified clinically in the current era.4 Coarse atrial fibrillation is sometimes mistaken for atrial flutter. Atrial flutter waves, however, all have the same morphology, including the same height and width, and t ...
THE AFIB REPORT
THE AFIB REPORT

... heartbeat. These general ectopic beats were not related to the alcohol or caffeine, or any other food as far as I could tell. Only the Afib episodes were related to the alcohol/caffeine. Fortunately the Afib episodes always remit an hour or so after I take 2 Flecainide tablets (pill in the pocket). ...
DIAGNOSIS AND TREATMENT OF ACUTE by
DIAGNOSIS AND TREATMENT OF ACUTE by

... ADHF in the ED. Treatment should start as soon as a diagnosis is made, and therapy should follow the hypotensive, normotensive, or hypertensive treatment pathways ...
Cardiac resynchronization therapy: a meta
Cardiac resynchronization therapy: a meta

... Background: Studies of cardiac resynchronization therapy in addition to an implantable cardioverter defibrillator in patients with mild to moderate congestive heart failure had not been shown to reduce mortality until the re cent RAFT trial (Resynchronization/ Defibrillation for Ambulatory Heart Fai ...
Early and mid-term outcomes of percutaneous mitral valve repair
Early and mid-term outcomes of percutaneous mitral valve repair

... our institution were prospectively collected in a computerised database and analysed. The indication for treatment of MR was according to current guidelines5 and was discussed in an interdisciplinary cardiology-cardiac-surgeon heart team. Surgical risk was assessed with the Finnish modified version ...
Powerpoint - Circulation: Arrhythmia and Electrophysiology
Powerpoint - Circulation: Arrhythmia and Electrophysiology

... Cardiac tracings (left) and fluoroscopic images (right) exhibiting the successful ablation site of the PVCs originating from the LV PPM. The first beat is a sinus beat and the second a PVC. Note that at the successful ablation site, no Purkinje potentials were observed during sinus rhythm, and a sp ...
Frog Heart Physiology
Frog Heart Physiology

... arises in pacemaker cells in the tissue of all the major chambers of the heart. † The membrane potential of these cells fluctuates spontaneously and when their depolarization reaches the threshold value, action potentials are generated which are propagated amongst the muscle cells to initiate their ...
How to tell heart rate from an ECG?
How to tell heart rate from an ECG?

... How to tell heart rate from an ECG? E.S.Prakash, MD; and Madanmohan, MD Department of Physiology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), ...
The Client with Altered Cardiac Output
The Client with Altered Cardiac Output

... • Activity intolerance related to fatigue (secondary to an imbalance between oxygen supply and demand). • Knowledge deficit related to CAD /angina / MI and its treatments. ...
AF –pathophysiology and medical management
AF –pathophysiology and medical management

... • Triggering foci of rapidly firing cells within the sleeve of atrial myocytes extending into the pulmonary veins - shown to be the underlying mechanism of most paroxysmal AF ...
Pediatric Cardiology
Pediatric Cardiology

... In cardiac transplant medicine there are both multi-institutional trials and local investigative efforts to evaluate ABO incompatibility, drug therapies, markers for cardiac transplant rejection and the role of pulmonary hypertension. It is anticipated that a recently completed multicenter trial of ...
Sheep Heart Dissection Lab
Sheep Heart Dissection Lab

... 5. On the dorsal surface of the heart are the stumps of two relatively large but thin-walled blood vessels that enter the right atrium. They are connected, and you would be able to pass a slender probe continuously through them. The upper vessel is the superior vena cava, and the lower one is the in ...
Dual Chamber Pacemakers: Fact Sheet
Dual Chamber Pacemakers: Fact Sheet

... Dual-Chamber Pacemakers: Fact Sheet 13. Prophylactic pacemaker use following recovery from acute myocardial infarction during which there was temporary complete (third-degree) and/or Mobitz Type II second-degree AV block in association with bundle branch block; 14. In patients with recurrent and ...
Side Effects of Vasodilator Therapy
Side Effects of Vasodilator Therapy

... few minutes after administration when the protein reaches an equilibrium state, only 3% is free, and 97% is bound to albumin. Thus, in a few minutes, there is a 30-fold reduction of vasodilatory activity after a rapid bolus injection. To minimize the possibility of drastic blood pressure reduction, ...
1 - madskamper.dk
1 - madskamper.dk

... Department of Internal Medicine III, Cardiology, Angiology and Intensive Care Medicine, Saarland University Hospital, Kirrberger Strasse 1, Homburg/Saar 66424, Germany; Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany; 3Kardiologische Praxis, Dessau, Germany; 4Cardi ...
7 CRRT_ It`s Not Just For Renal Failure Anymore Sue Fallone
7 CRRT_ It`s Not Just For Renal Failure Anymore Sue Fallone

... diastolic failure is a syndrome consisting of symptoms and signs of heart failure with preserved left ventricular ejection fraction above 45–50% and abnormal left ventricular relaxation assessed by echocardiography systolic failure is when the left ventricle loses it’s ability to contract normally, ...
as a PDF
as a PDF

... annexin A5 uptake in the left ventricular myocardium; no uptake was observed in the right ventricle. The uptake was focal in 1 patient (patient 6), multifocal in 2 patients (patients 3 and 7) (Fig. 1A), and diffuse in 1 patient (patient 9) (Fig. 1B). Myocardial perfusion was essentially normal in th ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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