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Heart Disease and Stroke
Heart Disease and Stroke

... The CDC reported in 2007 that U.S. adults reached an average cholesterol level in the ideal range (below 200) for the first time in 50 years. Authors of the report attribute the drop to the increased use of cholesterol-lowering medicines in the over-60 population. Also, research has shown that stati ...
Bradycardia - Arrhythmia Alliance
Bradycardia - Arrhythmia Alliance

... In Syncope there are many causes of syncope, some common and some rare. Most cases of syncope are due to the ‘common’ faint. However other important causes include defects of the ‘wiring’ of the heart. Syncope can occur when the heart slows or momentarily stops (asystole). Therefore oxygenated blood ...
5. General Information Relating to Terms
5. General Information Relating to Terms

... heart disease, and device implantation including permanent pacemakers, implantable cardioverter-defibrillators and cardiac resynchronisation therapy. The acquisition of the UK’s first Stereotaxis system will facilitate catheter ablation for atrial fibrillation and LV lead placement for cardiac resyn ...
HEART FAILURE
HEART FAILURE

... cardiac dilation and the failing pump problems due to the inadequate stroke volume and perceived hypotension produced by the failing heart.  Sympathetic nerve activity is chronically elevated in CHF. o The worse the heart failure, the higher the sympathetic nervous system activity. o INCREASED plas ...
PBLD: 16-year-old Female, S/p TOF Repair for Laparoscopic
PBLD: 16-year-old Female, S/p TOF Repair for Laparoscopic

... (PI) and leads to RV dilation and dysfunction [4]. 4. What is the overall survival and functional status of these repaired patients? 30-year survival rates have been reported at approximately 90%.[5] Most individuals remain in NYHA functional class I or II. Pulmonary insufficiency resulting from tra ...
Elasticity-based determination of isovolumetric phases in the human
Elasticity-based determination of isovolumetric phases in the human

... are deducible across the cardiac cycle. This wave-amplitude-sensitive MRE technique cannot measure absolute elasticity values; however, relative elasticity ratios are provided with an excellent time resolution of approximately 5 ms, which we will exploit in this study for deriving elasticity-based i ...
What is hypertrophic cardiomyopathy?
What is hypertrophic cardiomyopathy?

... For children with HCM, medical therapy aims to control symptoms related to heart obstruction, improve filling of the heart chambers and prevent arrhythmias. With optimal treatment, symptoms can be improved or eliminated in many children with HCM. Several types of medications are used to control HCM ...
Document
Document

... standstill or ventricular fibrillation may occur when serum levels reach 10 to 12 mEq/L. ...
Prognostic Impact of New-Onset Atrial Fibrillation in - J
Prognostic Impact of New-Onset Atrial Fibrillation in - J

... β-blockers or RAS inhibitors. As compared with patients without AF, AF patients had higher NYHA functional class, increased BNP and larger LA dimension, but had similar LVEF. Table 1B lists the baseline characteristics of patients in the 4 groups defined as (–) new AF, (+) new AF, pAF and cAF. Among ...
Echocardiography in heart failure – a guide for general practice
Echocardiography in heart failure – a guide for general practice

... difficult to diagnose as the symptoms and signs can be nonspecific – it is important to confirm a clinical diagnosis by demonstrating cardiac dysfunction. All major heart failure guidelines, including the Australian guidelines developed by the National Heart Foundation and Cardiac Society of Austral ...
Clinical Determinants of Left Ventricular Ejection Fraction
Clinical Determinants of Left Ventricular Ejection Fraction

... by NYHA classification), and cardiac ischemic event can predispose LBBB patients to LV dysfunction indicated by decline LVEF. In fact, as confirmed by some previous studies, some cardiovascular risk profile leading to elevated LV mass, shortening LV filling time, prolongation of relaxation times, in ...
Efficacy, Safety, and Outcomes of Catheter Ablation of Atrial
Efficacy, Safety, and Outcomes of Catheter Ablation of Atrial

... time that result in a reduced cardiac output. Besides LV diastolic dysfunction, recent data demonstrated a primary abnormality in left atrial (LA) function in HFPEF (6). AF exaggerates LA dysfunction through LA remodeling and loss of effective atrial contraction. Thus, AF is a consequence as well as ...
Bradycardia Booklet
Bradycardia Booklet

... there are many causes of syncope, some common and some rare. Most cases of syncope are due to the ‘common’ faint however other important causes includes defects of the ‘wiring’ of the heart. Syncope can occur when the heart slows or momentarily stops (asystole) therefore oxygenated blood is not pump ...
Heart valve disease in general practice:
Heart valve disease in general practice:

... pain, breathlessness, or syncope and also non-specifically reduced exercise capacity. Any first-degree relative of someone with a bicuspid aortic valve has a 10% chance of having either a bicuspid valve or dilated aorta and should be offered echocardiography. Valve disease was thought to be the caus ...
Elasticity-based determination of isovolumetric
Elasticity-based determination of isovolumetric

... are deducible across the cardiac cycle. This wave-amplitude-sensitive MRE technique cannot measure absolute elasticity values; however, relative elasticity ratios are provided with an excellent time resolution of approximately 5 ms, which we will exploit in this study for deriving elasticity-based i ...
Anti anginal drugs
Anti anginal drugs

... however, there is a greater effect on large arteries and veins compared to arterioles. • This means that low concentrations of GTN dilates veins first. In order to dilate arterioles, larger concentrations are needed. • However, the main target to reduce preload is the effects on the veins • GTN dila ...
14-2
14-2

... – cluster of cells in wall of Rt. Atria – begins heart activity that spreads to both atria – excitation spreads to AV node ...
Chapter 18- The Heart
Chapter 18- The Heart

... deposits), the arteries supplying the heart muscle become clogged causing chest pain. The heart cells are weaken by reduced oxygen amounts causing a pain called angina pectoralis. The pain can also come from stress spasm. A heart attack occurs when the cardiac cells die (myocardial infarction). Card ...
Beta-blockers Versus ACE Inhibitors in Heart Failure
Beta-blockers Versus ACE Inhibitors in Heart Failure

... oxide stimulation, causing positive outcomes on endothelial function by halting the breakdown of bradykinin.42 Additionally, cardiac hemodynamics and exercise capacity are improved by decreasing systemic vascular resistance.43,44 However, it is important to keep in mind that not all patients will to ...
External-Defibrillators
External-Defibrillators

... Recipients with nonischemic dilated cardiomyopathy for greater than 3 months, New York Heart Association Class II and III heart failure, and measured left ventricular ejection fraction ≤ 35% Recipients who meet one or more of the previous criteria and have New York Heart Association Class IV heart f ...
Heart Attack Overview
Heart Attack Overview

... the heart muscle before entering the heart muscle itself (figure 1). Myocardial infarction, or MI (commonly known as a "heart attack"), is damage or death of part of the heart muscle. The damage is caused by lack of blood flow through the coronary arteries. For this reason, an MI is sometimes also c ...
rheumatic stenoses of all four cardiac valves: a case report
rheumatic stenoses of all four cardiac valves: a case report

... Quadrivalvular rheumatic damage is more rare[1]. The few reports are available in the literature describing of patients with rheumatic lesions of all four heart valves [2,3]. To our knowledge, only 12 cases have been reported in the literature [110]. Echocardiography provides crucial information in ...
Overview of Inherited Heart Rhythm Disorders for Patients
Overview of Inherited Heart Rhythm Disorders for Patients

... A small proportion of patients who die suddenly remain unexplained after autopsy, that have presumed primary electrical disease attributed to inherited heart rhythm disorders28. This type of sudden presumed electrical death is termed sudden arrhythmic death syndrome – SADS. Sudden death is a tragic ...
Science Of Ultra UCD 27 Heart Health
Science Of Ultra UCD 27 Heart Health

... clinician. There are two categories of atrial fibrillation in athletes, slow heart rate and fast heart rate. The slow heart rate atrial fibrillation athletes go into atrial fibrillation when resting, such as during sleep while the high heart rate athletes have atrial fibrillation when their heart ra ...
Energy metabolism in the heart of the diabetic patient
Energy metabolism in the heart of the diabetic patient

... only men with short duration (3–4 years) type 2 diabetes were included [18]. In this population, in which the extent of left ventricular dysfunction was limited to subtle abnormalities in diastolic function, the PCr to ATP ratio was similar to that observed in normal controls, and no correlation wa ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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