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Outcomes of noncardiac, nonobstetric surgery in patients with PAH: an
Outcomes of noncardiac, nonobstetric surgery in patients with PAH: an

... associated with perioperative complications were lower preoperative 6MWD, higher right atrial pressure and the requirement for catecholamines during the perioperative period. The mortality rates observed in this survey appear somewhat lower than those reported in previous series of patients with PH ...
Implantable Defibrillators
Implantable Defibrillators

... low-voltage electrode for pacing and detection, and a pair of high-voltage defibrillation electrodes spaced for replacement in the right ventricle and in the superior vena cava (Figure 3 a). A more recent approach parallels that used for unipolar pacemakers. A single right-ventricular catheter havin ...
Lesson №1 Anatomy of cardiovascular system. The coronary
Lesson №1 Anatomy of cardiovascular system. The coronary

... 7. Lower blood pressure on the legs than on the hands is characteristic of: 1) aortic insufficiency; 2) coarctation of aorta; 3) health people; 4) patients with heart failure 8. A positive venous pulse is observed at: 1) aortic insufficiency; 2) stenosis of left atrioventricular aperture; 3) trikusp ...
Figure 8.2 Pressure Balance Diagram
Figure 8.2 Pressure Balance Diagram

... Previous Approaches to Estimating PELAST. Sunagawa assumed that the isovolumic contraction and relaxation phases of an ejecting beat could be used to predict the pressure waveform of an isovolumic beat. He used an inverted cosine function and adjusted its amplitude, PMAX, its duration, T and its pha ...
Clinical Phenotype and Outcome of Hypertrophic Cardiomyopathy
Clinical Phenotype and Outcome of Hypertrophic Cardiomyopathy

... OBJECTIVES This study aimed to assess clinical features and outcomes in a large cohort of patients with HCM associated with thin-filament mutations compared with thick-filament HCM. METHODS Adult HCM patients (age >18 years), 80 with thin-filament and 150 with thick-filament mutations, were followed for ...
Arrhythmias in the Elderly: Modern Management
Arrhythmias in the Elderly: Modern Management

... fibrillation nowadays only has a place in cases where there are already other indications for pacing. Tachyarrythmias Supraventricular tachycardias The most common supraventricular tachyarrhythmia in the elderly is atrial fibrillation (~10% in those aged >75 years). With the exception of atrial fibr ...
Chapter 15 Heart Physiology PPT
Chapter 15 Heart Physiology PPT

... •cardiac center regulates autonomic impulses to the heart ▪ parasympathetic impulses decrease heart action ▪ sympathetic impulses increase heart action ▪ concentration of various ions ▪ potassium and sodium decrease heart action ▪ calcium increases heart action • physical exercise increases heart ac ...
Cardiac Imaging at 3.0T - SCBT-MR
Cardiac Imaging at 3.0T - SCBT-MR

... • Investigational Pulse Sequences ...
Cardioversion of acute atrial fibrillation in the emergency department
Cardioversion of acute atrial fibrillation in the emergency department

... hemmorrhage, which is the most feared complication of anticoagulation therapy and confers a high risk of death and disability. HAS-BLED score which is a formal bleeding risk assessment (Table 3) is recommended for all patients with AF, and in patients with a HASBLED score ≥3, caution and regular rev ...
the new zealand medical journal
the new zealand medical journal

... STEMI patients received thrombolytic therapy. Of 77 STEMI patients who were admitted within 12 hours of symptom onset, 53 (69%) received thrombolytic therapy and 3 (3.9%) received primary PCI. Sixty-four percent of non-STEMI patients were treated with low molecular weight heparin (54% enoxaparin, 12 ...
Principles of Isolated Heart Perfusion
Principles of Isolated Heart Perfusion

... 1. Preparation of the Donor The anesthetic(s) used will depend on the donor, potential problems with side effects in the experimental protocol, the extent of the surgical procedures and the regulations of your Animal Care and Use committee. The most common are barbiturates, such as nembutal or thiop ...
Heart Block Complicating Acute Inferior Wall Myocardial Infarction*
Heart Block Complicating Acute Inferior Wall Myocardial Infarction*

... period of 1970 to 1974. Most patients were monitored in the coronary care unit for four to six days, except those who required longer periods because of various complications. Daily 12-lead electrocardiograms and determinations of serum creatine phosphokinase levels were performed during this period ...
Table 2 - JACC: Heart Failure
Table 2 - JACC: Heart Failure

... (14,15). Despite its prevalence, due to its more recent recognition as a clinical entity (16), there are considerably fewer data on the role of physical training in HFPEF than in systolic CHF. However, 7 controlled trials (5 randomized, 1 multicenter) of physical training in HFPEF patients (17–24) ( ...
Carcinoid Heart Disease (CHD)
Carcinoid Heart Disease (CHD)

... - Somatostatin analogues and other antitumour therapies may theoretically protect the valve from deposition of further carcinoid plaques. - They do not require anticoagulation and consequently lower the risk of bleeding in patients with hepatic dysfunction and also reduce the risk of valve thrombosi ...
Jorgensen_J1010 Manual_0211.indd
Jorgensen_J1010 Manual_0211.indd

... As lead II may not align with the cat’s axis, the signal is small and sometimes cancels. Therefore, by moving RA more centrally onto the cat’s body above the top, and LL onto the cat’s body below the bottom of the heart, a much larger signal will be obtained. The plane in which the cat’s heart lies ...
management of patients with repaired congenital heart disease
management of patients with repaired congenital heart disease

... compensatory mechanism is the formation of collateral blood vessels in the intercostals arteries to supply blood to the descending aorta therefore bypassing the coarct site5. The presence of such collaterals should be kept in mind when performing procedures such as epidural anesthesia in patients wi ...
Assessment of Heart and Neck Vessels ANATOMY AND
Assessment of Heart and Neck Vessels ANATOMY AND

... and anxiety. Nurses must thoroughly evaluate the nature and characteristics of the chest pain. Because chest pain resulting from myocardial ischemia is life threatening and can lead to serious complications, its cause should be considered ischemic (reduced or obstructed blood flow to the myocardium) ...
Not just the powerhouse of the cell: emerging
Not just the powerhouse of the cell: emerging

... Hoppel,10 respectively. The molecular mechanisms underlying this mitochondrial dysfunction are described in detail for both diabetic animal models and diabetic patients. Remarkably, efficient mitochondrial oxidative phosphorylation does not exclusively rely on the activities of individual electron t ...
ESC Core Curriculum for the General Cardiologist (2013)
ESC Core Curriculum for the General Cardiologist (2013)

... the Core Curriculum, the ESC is setting a standard that national societies can use in their dealings with political institutions and national authorities. A deliberate decision was taken to outline an optimal rather than a minimum standard, allowing for the fact that not every training system will b ...
15 Complete Heart Block—Third
15 Complete Heart Block—Third

... TABLE 2. Disorders that Can Cause Third-Degree Heart Block Fibrosis and Sclerosis: Fibrosis and sclerosis of the conduction system accounts for about one-half of cases of AV block. Lenegre’s disease has been traditionally used to describe a progressive, fibrotic, sclerodegenerative affliction of the c ...
Cardioprotective Effects of Acute Normovolemic
Cardioprotective Effects of Acute Normovolemic

... stenotic and collateral vessels, thereby counteracting the reduced blood oxygen-carrying capacity.8 To date, although ischemic cardiac dysfunction has not been detected during moderate normovolemic hemodilution (reduction of hemoglobin concentrations to 90 g/L or hematocrit levels of 28%) even in an ...
Incidence of Rearrest After Return of Spontaneous Circulation in Out
Incidence of Rearrest After Return of Spontaneous Circulation in Out

... of survival to hospital discharge and ROSC. A metaanalysis of published studies reporting outcomes after emergency medical services (EMS)-treated OHCA indicates that the median rate of survival to hospital discharge is 6.4%.1 However, the reported incidence of ROSC in OHCA, while variable, is genera ...
ESC Core Curriculum for the General Cardiologist
ESC Core Curriculum for the General Cardiologist

... the Core Curriculum, the ESC is setting a standard that national societies can use in their dealings with political institutions and national authorities. A deliberate decision was taken to outline an optimal rather than a minimum standard, allowing for the fact that not every training system will b ...
Hopelessness Is Associated With Decreased Heart Rate
Hopelessness Is Associated With Decreased Heart Rate

... positive emotions (29, 30). Further research indicated (31–33) that depression is linked to reduced HRV. Reduced HRV may indicate autonomic nervous system abnormalities of potential importance to coronary heart disease. A temporary decrease in parasympathetic tone after acute myocardial infarction w ...
Is the 6-minute walk test a reliable substitute for peak oxygen uptake
Is the 6-minute walk test a reliable substitute for peak oxygen uptake

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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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