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Low to High Frequency Ratio of Heart Rate Variability Spectra Fails
Low to High Frequency Ratio of Heart Rate Variability Spectra Fails

... function, as well as in most clinical conditions characterised by a decrease in overall HRV7,10,16–20, but such »paradoxical« findings were not addressed by their authors. In the study made by Bigger and co-workers16, healthy subjects, patients with old and those with recent myocardial infarction, w ...
Contemporary Management of Acute Right Ventricular Failure: A
Contemporary Management of Acute Right Ventricular Failure: A

... positive inotrope effect on the RV without the deleterious effects on pulmonary vascular resistance that occur with catecholemines. Similar to dobutamine, these drugs may aggravate arterial hypotension and should be combined with norepinephrine if needed. Levosimendan or phosphodiesterase-III inhibi ...
Rapid Heart Beat or Tachycardia
Rapid Heart Beat or Tachycardia

Clinical Indications for Echocardiography Echocardiography is
Clinical Indications for Echocardiography Echocardiography is

... M-mode echocardiography, tissue velocity imaging, 2D and 3D echocardiography, and contrast echocardiography). It does not include recommendations specifically relating to the practice of transoesophageal echocardiography and stress echocardiography, although attention is drawn where utilisation of o ...
Doubly Committed Ventricular Septal Defect: Single
Doubly Committed Ventricular Septal Defect: Single

... male/female ratio of 74:46 for operated dcVSD. A possible explanation could be the observation of a higher incidence of aortic prolapse and AR in male patients with dcVSD [8]. dcVSD Closure Small defects having small left-to-right shunts, no left ventricle volume overload and no PAH usually present ...
JAOK HAN, MD, PH.D.
JAOK HAN, MD, PH.D.

... disparity of recovery of refractory periods increased in half of the animals tested. Thus, our results clearly indicate that during acute coronary occlusion in the dog, increasing heart rate within a range similar to that present during acute myocardial infarction in man causes electrophysiologic ef ...
Long-term outcome of the Mustard/Senning operations.
Long-term outcome of the Mustard/Senning operations.

... Dubin et al, Circulation 2003 Janousek et al, JACC 2004 Jauvert et al, Europace 2009 ...
A Simulink Hybrid Heart Model for Quantitative Verification of
A Simulink Hybrid Heart Model for Quantitative Verification of

... the stochasticity in the timing that is characteristic in a heart rhythm and varies from patient to patient. Following a suggestion in [6] that physiologically-relevant heart models are needed to establish the correctness of more complex properties for pacemakers, we earlier proposed a realistic hea ...
heart center - Intermountain Healthcare
heart center - Intermountain Healthcare

... contacts throughout their treatment—familiar faces to guide patients and their families every step of the way. Our collaborative spirit has paid tremendous dividends, not only in patient outcomes, but in many other areas as well. The bond between departments has grown stronger, and our relationships ...
A rare cause of neonatal bradycardia: Blocked atrial bigeminal beat
A rare cause of neonatal bradycardia: Blocked atrial bigeminal beat

... ed. On follow-up Holter monitor recordings, the prevalence of premature beats decreased and the mean heart rate increased to 128 bpm. All of the PACs were monitored on ECG (Figure 2). Premature beats were not observed on the ECG obtained 2 months after discharge and normal sinus rhythm was restored. ...
Effect of Atropine on Bradycardia and Hypotension in Acute
Effect of Atropine on Bradycardia and Hypotension in Acute

Procoralan Article-20 procedure - EMA
Procoralan Article-20 procedure - EMA

... diltiazem is contraindicated (see sections 4.3 and 4.5). No safety issue has been raised on the combination of ivabradine with nitrates and dihydropyridine calcium channel blockers such as amlodipine. Additional efficacy of ivabradine in combination with dihydropyridine calcium channel blockers has ...
Prevalence and Clinical Predictors of Right Ventricular Dysfunction
Prevalence and Clinical Predictors of Right Ventricular Dysfunction

... Background and Objectives: Numerous clinical studies have demonstrated chronic right ventricular (RV) pacing induced left ventricular (LV) dyssynchrony and LV systolic dysfunction in patients with permanent pacemaker. However, only a limited number of studies have focused on RV dysfunction. We sough ...
Arrhythmias 101
Arrhythmias 101

... Event Monitors • Holter monitoring: Document symptomatic and asymptomatic arrhythmias over 24-48 hours. Can also evaluate treatment effectiveness in a-fib, pacemaker effectiveness and identify silent MIs. • Trans-telephonic event recording: patient either wears monitor for several days or attaches ...
When CRT May Run Proarrhythmic Effect?
When CRT May Run Proarrhythmic Effect?

... • Significant differences in the EP properties between the endocardial, epicardial and M cells • M cells prolong the action potential out of proportion to that of epicardium and endocardium in response to slowing of the heart rate or agents that prolong the action potential • The duration of action ...
25 The Fourth Heart Sound
25 The Fourth Heart Sound

... the left ventricle is most readily carried out with the patient in the left lateral recumbent position . Inspection and palpation are employed first to identify the apex impulse, where the fourth heart sound is usually most prominent . These techniques are not used just to identify a site for carefu ...
arrhythmias following cardiac surgery
arrhythmias following cardiac surgery

... post-operative pericarditis, a third had a pulmonary on the fifth day, and 10 grains every two hours for four doses on the sixth day. An electrocardiogram infarct, and a fourth developed thrombosis of is taken before treatment on the sixth day and tranmposed anomalous veins. The age and sex of again ...
to the S-ICD Brochure
to the S-ICD Brochure

... automobile ignition systems. Cell phones should be kept at least 15 centimeters, or 6 inches, from the S-ICD System. Strong electromagnetic devices may cause interference with the S-ICD System, such as running motors and large magnets. Most medical equipment will not interfere with the S-ICD System, ...
Original Article Alcoholic Cardiomyopathy In A 39 Year Old Female
Original Article Alcoholic Cardiomyopathy In A 39 Year Old Female

... asymptomatic ventricular dysfunction1. With abstinence from alcohol, left ventricular systolic and diastolic function often improves. The earlier in the course of ethanol consumption that abstinence is initiated, the more pronounced the benefit. Even subjects with markedly symptomatic ethanol induce ...
GENERAL ANESTHESIA FOR A PATIENT WITH BRUGADA SYNDROME K -K
GENERAL ANESTHESIA FOR A PATIENT WITH BRUGADA SYNDROME K -K

... function of the sodium channel, which leads to both accelerated and prolonged refractory periods, which can cause reentrant arrhythmias2. The syndrome occurs more commonly in men than in woman. Additionally, there is a higher incidence of ventricular fibrillation and sudden death in Brugada patients ...
treating atrial fibrillation with catheter ablation
treating atrial fibrillation with catheter ablation

... rhythm. The AF may last for seconds, minutes, hours, or up to seven days before the heart returns to its normal rhythm. People with this type of AF usually have more symptoms than others. As the heart goes in and out of AF, the pulse rate may change from slow to fast and back again in short periods ...
Comparative study of electrocardiographic
Comparative study of electrocardiographic

... The Electrocardiogram (ECG or EKG) is a graphic recording of electric potentials generated by the heart. It is a simple and noninvasive, inexpensive test helps in assessing the cardiovascular status. Alcohol consumption causes ECG changes. Therefore this study is undertaken to detect the ECG changes ...
Methods for Assessment of Left Ventricular Systolic Function in
Methods for Assessment of Left Ventricular Systolic Function in

... of physicians, sonographers, and nurses, have been introduced in recent guidelines.4 Briefly, contrast enhancement is indicated in difficult-to-image patients at rest when echocardiographic image ...
looking eastwards in cardiac genetics finding heart disease
looking eastwards in cardiac genetics finding heart disease

... and a mean life expectancy seven years longer than that of their physically inactive counterparts. Furthermore, large-scale prospective observational studies have also clearly demonstrated a doseresponse relation between physical activity and the risk of cardiovascular disease and premature mortalit ...
impact of diabetes on heart rate variability and left ventricular
impact of diabetes on heart rate variability and left ventricular

... the state of activity of the autonomic nervous system is heart rate variability, which is a predictor of cardiac mortality. The aim of this study was to determine a possible influence of diabetes mellitus on the left ventricular function and the parameters of heart rate variability, as well as the r ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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