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Cardiovascular Pharmacology
Cardiovascular Pharmacology

... atria in the mechanism of the tachycardia. Many SVTs are due to extra, abnormal electrical connections between the atria and the ventricles. Individuals with SVT are often born with these extra pathways. The existence of such extra pathways (often called “bypass tracts”) allow the formation of “reen ...
Structural and functional assessment of small arteries in patients
Structural and functional assessment of small arteries in patients

... vasoconstrictor responses to endothelin-1 were significantly reduced, although plasma endothelin-1 levels were increased. Arteries from heart failure patients also showed evidence of an impaired neuronal uptake mechanism, since blockade by cocaine had no effect on noradrenaline-induced vasoconstrict ...
Cardiovascular System
Cardiovascular System

... Coronary Arteries: – Provides blood that oxygenates and nourishes the heart. – Branches from the base of the aorta and encircle the heart – They are compressed when the ventricles contract and fill with blood when they are relaxed. ...
61 Case Report SUDDEN DEATH DUE TO VENTRICULAR SEPTAL
61 Case Report SUDDEN DEATH DUE TO VENTRICULAR SEPTAL

... presented frequently with breathing difficulties died suddenly and VSD with cardiomegaly was diagnosed at autopsy. [7]. There are studies which suggest that patients with VSD have impaired sexual life in both sexes but especially in males who reports a larger incidence of erectile dysfunction.[8]On ...
Aorto-Left Atrial Fistula
Aorto-Left Atrial Fistula

... ably a complication of aortic valvular endocarditis, are rare and infrequently diagnosed premortem. We describe a patient who presented with this entity and review the reports of five other patients for whom a diagnosis was made premortem. A number of causative organisms have been identi¬ fied. The ...
Aorto-Left Atrial Fistula
Aorto-Left Atrial Fistula

... ably a complication of aortic valvular endocarditis, are rare and infrequently diagnosed premortem. We describe a patient who presented with this entity and review the reports of five other patients for whom a diagnosis was made premortem. A number of causative organisms have been identi¬ fied. The ...
Cardiorespiratory Response to Exercise Transposition of the Great
Cardiorespiratory Response to Exercise Transposition of the Great

... absent in normal subjects. However, peak Vo2 decrease (.27%) is only partially explained by chronotropic alteration ( 12%) after atrial repair. This chronotropic limitation may not be specific to atrial repair but might be a common denominator to all intracardiac repair, as the cardiopulmonary bypas ...
DOC
DOC

... perpendicular to the long axis of the muscle cell. They are found in striated and cardiac muscle but not in smooth muscle. Striated muscle is also called voluntary muscle. It is found attached to the bones of the skeleton by tendons. A tendon is a connective structure composed of dense connective ti ...
A case of biventricular endomyocardial fibrosis complicated by right
A case of biventricular endomyocardial fibrosis complicated by right

... which was due to diastolic distention of the RVOT based on flouroscopy.[5,6] This feature was present in this case. The presence of focal, tubular aneurysms of the RVOT, however, is unique. These may have arisen owing to high RV diastolic pressures related to reduced RV volume, decreased RV complian ...
Euro Heart Survey - European Society of Cardiology
Euro Heart Survey - European Society of Cardiology

... x There is still a significant variation in the burden of cardiovascular diseases across the ESC member countries, with low mortality in Southern and Western Europe, and high mortality in Eastern Europe. x Clinical practice varies significantly among hospitals in Europe, both with regard to patien ...
Effects of garJ ic (Allium sativulIl) extract on the heart rate, rhythm
Effects of garJ ic (Allium sativulIl) extract on the heart rate, rhythm

... Cardiac arrhythmias are disruption s in the natural rhythm of the heartbeat normally caused by improper functioning of the electrical system of cells in the heart and are cause of almost half of the deaths in patients with heart failure. It is seen that ventricular premature systoles and tachycardia ...
Pro_ ACE Inhibitors Should Be Continued Perioperatively and Prior
Pro_ ACE Inhibitors Should Be Continued Perioperatively and Prior

... cardiopulmonary bypass (CPB). However, this group also required significantly more vasodilators secondary to hypertension after separation from CPB and in the postoperative period. There was no significant difference between the 2 groups in either inotrope or vasopressor use after separation from CPB ...
A “Poly-Portfolio” for Secondary Prevention: A Strategy to Reduce
A “Poly-Portfolio” for Secondary Prevention: A Strategy to Reduce

... lifestyle therapies has not been determined in clin- study entry experience similar relative risk reductions ical trials. Therefore, estimates of benefit for pri- from statin therapy as younger persons.15 Because mary and secondary prevention polypills and life- long-term efficacy and safety data ar ...
Full Paper - Daniel Burkhoff MD PhD
Full Paper - Daniel Burkhoff MD PhD

... Background: A treatment based on an interatrial shunt device has been proposed for counteracting elevated pulmonary capillary wedge pressure (PCWP) in patients with heart failure and mildly reduced or preserved ejection fraction (HFpEF). We tested the theoretical hemodynamic effects of this approach ...
Cardiovascular Complications of Cocaine Abuse
Cardiovascular Complications of Cocaine Abuse

... Increased incidence in younger patients ...
Assessment of Right Ventricular Function by Tissue Doppler, Strain
Assessment of Right Ventricular Function by Tissue Doppler, Strain

... right ventricular free wall in patients with left-sided valvular heart disease and pulmonary hypertension. Indeed, we sought to investigate whether we can guess the presence of pulmonary hypertension through the measurement of the TDI of the tricuspid annulus and the deformity indices of the basal s ...
Cardiovascular Exam Benchmarks
Cardiovascular Exam Benchmarks

... Telling systole from diastole. At heart rate < 100, systole is substantially shorter than diastole. The carotid pulse can also be used to time systole, which is concurrent with the carotid upstroke. ...
Angina pectoris
Angina pectoris

... Not vasodilators Used in prophylactic treatment of angina through : Decrease in both heart rate & myocardial contractility that decrease myocardial oxygen requirement at rest & in exercise so improve exercise tolerance. ...


... cardiotoxicity, there is a need for a reliable and noninvasive method of early detection and serial monitoring for cardiotoxicity [2]. This may then guide early management and medical therapy in attempt to delay the onset of clinical cardiotoxicity. Current oncology guidelines for the follow up of a ...
Back to the Basics: EKG Interpretation
Back to the Basics: EKG Interpretation

... The presence of electrical activity without a pulse. The heart muscle loses its ability to contract even though electrical conductivity is maintained. •  Rhythm: rhythm can be seen but the patient is pulseless. ...
Intra Aortic Ballon Pump
Intra Aortic Ballon Pump

... Although the incidence of complications has decreased significantly as experience with the device has increased, IABP therapy in today’s patients` population does still hold a risk for complications (Tab.4). Because today’s patient population is elderly (68 - 80 years), very often female and may suf ...
Can Intense Endurance Exercise Cause Myocardial Damage and
Can Intense Endurance Exercise Cause Myocardial Damage and

Prevalence of heart failure in the spanish general
Prevalence of heart failure in the spanish general

... its incidence and prevalence are high. Nevertheless, comprehensive data on this condition in Spain are lacking. The aim of this study was to determine the prevalence of congestive heart failure in Spain. Methods. A demographic study which involved the participation of 15 healthcare centers throughou ...
Arrhythmogenic Right Ventricular
Arrhythmogenic Right Ventricular

... Risk stratification is imperfect. Patients who have documented or even borderline criteria for ARVC are usually treated with ICD’s. In the North American ARVC Registry 77% of newly diagnosed probands or affected family members received this therapy.19 Although it is well documented from other studie ...
full text pdf
full text pdf

... Anabolic androgenic steroids (AAS), synthetic derivatives of testosterone, were created as an attempt to synthesize a testosterone-like steroid that would have strong anabolic effects (1). Because of these anabolic effects, AAS became very popular among professional and recreational athletes, even t ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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