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A Note from the Chief 3 CIVT 5 Heart Failure and Transplant
A Note from the Chief 3 CIVT 5 Heart Failure and Transplant

... The blood vessels in the heart aren’t the only ones that can become clogged and need to be reopened. Throughout the body—mainly in the arteries that lead to the brain, kidneys, and legs—fatty deposits can build up, restricting circulation. Approximately 20% of people over age 55 have such blockages ...
The DAVID (Dual Chamber and VVI Implantable Defibrillator) II Trial
The DAVID (Dual Chamber and VVI Implantable Defibrillator) II Trial

... Statistical design and analysis. The DAVID II trial was designed as a 1-sided (noninferiority) trial testing the null hypothesis that the effect of atrial pacing, like DDDR-70 in the DAVID trial, will worsen the combined end point of total mortality and heart failure hospitalization, as compared wit ...
Intramural Myocardial Shear During the Cardiac Cycle
Intramural Myocardial Shear During the Cardiac Cycle

... much larger and caution should be used in interpreting surface measurements from these periods. Overall, the variability encountered in the measurements made in this study was too great to demonstrate differences in shear due to position or direction. In an organ as complex as the heart it is quite ...
Sick Sinus Syndrome
Sick Sinus Syndrome

... therapy of cardiac rhythm abnormalities: a report of the American College of Cardiology/ American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices). J Am Coll Car ...
Exercise ECG - cardiologycmc.in
Exercise ECG - cardiologycmc.in

... Class IIb 1. Patients with a high pretest probability of CAD 2. Patients with a low pretest probability of CAD ...
Integrating Complementary Medicine Into Cardiovascular Medicine
Integrating Complementary Medicine Into Cardiovascular Medicine

... health- and illness-related experiences. The findings are yielding (and will continue to yield, through future analyses) a wealth of information on who uses CAM, what they use, and why. In addition, researchers can examine CAM use as it relates to many other factors such as age, race/ethnicity, plac ...
Autonomic function in congenital heart defects Alexandra Pintér MD
Autonomic function in congenital heart defects Alexandra Pintér MD

... cardiovascular risk factor. Beyond the hemodynamic significance the elastic properties of the great vessels determine the baroreflex-sensitivity substantially. The change in blood pressure is followed by an alteration of the vascular diameter; consequently the adequate stimulus for the baroreceptors ...
De novo sirolimus with low-dose tacrolimus versus full
De novo sirolimus with low-dose tacrolimus versus full

... study protocols were approved by the local ethics committee and conformed to the Declaration of Helsinki. All patients gave written informed consent before inclusion and underwent routine follow-up examinations according to center practice as described previously.11–14 Of these 171 study patients, 1 ...
Relationship between electrolytes and heart rate variability
Relationship between electrolytes and heart rate variability

... documented to be closely related to VA in ESRD. The most important three factors for cardiac arrhythmias genesis are modulating factor, arrhythmia triggers, and substrate (4-6). The modulating factors can be detected by the HRV for the evaluation of autonomic function. Whereas, signal-averaged elect ...
Relation of plasma matrix metalloproteinase
Relation of plasma matrix metalloproteinase

... the early and late post-MI period.[3,4] Among MMP types, MMP-8 and MMP-9 exhibit significantly higher levels in the early post-MI period. Increased early levels of these two MMPs have been associated with early remodeling and even infarct rupture.[5,6] However, these MMPs may have a biphasic plasma ...
Cardiovascular - Aurora Health Care
Cardiovascular - Aurora Health Care

... MD, and Masood Akhtar, MD, of Aurora Cardiovascular Services. Aurora faculty invited to present are: Arshad Jahangir, MD, David C. Kress, MD, and Imran Niazi, MD. The course is attended by electrophysiologists, cardiologists, fellows and other health care personnel interested in cardiac arrhythmias. ...
Secondary prevention through cardiac rehabilitation: physical
Secondary prevention through cardiac rehabilitation: physical

... Cardiac patients after an acute event and/or with chronic heart disease deserve special attention to restore their quality of life and to maintain or improve functional capacity. They require counselling to avoid recurrence through a combination of adherence to a medication plan and adoption of a he ...
Pediatric emergency case conference
Pediatric emergency case conference

...  0.1mg/kg, doubled if no response in 2 minutes  0.05mg/kg, increase by 0.05mg/kg every 2 minutes to total maximal dose of 0.25 to 0.35mg/kg or total 12mg is given ...
Document
Document

... palpitations. A 12-lead electrocardiogram (ECG) revealed a wide-complex tachycardia with a heart rate of 128 beats per minute (fig. 1a). ...
Clinical significance of positive inotropic action of - Heart
Clinical significance of positive inotropic action of - Heart

... The results of this study show a significant reduction in QA1 interval 4 to 6 hours after an oral dose of digoxin, indicating an increase in the force of left ventricular contraction. This occurred approximately 2 hours after peak plasma concentrations had been reached so that the delay probably ref ...
Spectral characteristics of ventricular response to atrial fibrillation
Spectral characteristics of ventricular response to atrial fibrillation

... real time and digitized to 12-bit data at a sampling frequency of 128 Hz. QRS complexes were detected and labeled automatically. The results of the automatic analysis were reviewed, and any errors in R wave detection and QRS labeling were edited manually. The labels of each QRS complex and the prece ...
Tumor Necrosis Factor - National Psoriasis Foundation
Tumor Necrosis Factor - National Psoriasis Foundation

... PSORIASIS FORUM, VOL. 19, NO. 1 | Leon et al ...
cardiovascular complications of scorpion stings and the effects of
cardiovascular complications of scorpion stings and the effects of

... The study was designed to evaluate (1) the frequency and types of cardiovascular complications caused by scorpion stings and (2) the effects of cardiovascular morbidity and mortality caused by changes in antivenom policy instituted in mid-1991 from an optimal treatment of none or 1 ampoule to the cu ...
Back
Back

... First-degree heart block, or first-degree AV block, is the condition under which the electrical impulse moves through the AV node at a slower rate than normal. The cause of first degree heart block is not always known since in some cases it can be intermittent. However, in many cases, it may be to a ...
Loss of Cardiac Magnesium in Experimental Heart Failure
Loss of Cardiac Magnesium in Experimental Heart Failure

... correlation between total cellular magnesium measured in the sublingual epithelium and free cardiac levels. Finally, the APD and beat to beat variability appear to be sensitive to changes in cytosolic Mg21 over a narrow range; thus, prolongation and instability in APD seen in heart failure may be pa ...
Secondary prevention through cardiac rehabilitation: physical
Secondary prevention through cardiac rehabilitation: physical

... Assess: Functional capacity and exercise-induced ischaemia by maximal symptom-limited exercise stress testinga Recommend: refer to ‘Post-ACS and post primary PCI’ issues Assess: functional capacity (usually markedly impaired, often ,50% of the predicted value) and cause of exercise limitation (e.g. ...
Neurocardiogenic syncope
Neurocardiogenic syncope

... Passive phase min 20 minutes, max 45 minutes Use either intravenous isoprenaline or sublingual GTN if passive phase is negative Pharmacological phase – 15 to 20 minutes End-point; induction syncope or completion planned tilt ...
Cardiac Autonomic Nervous Dysfunction in Diabetic
Cardiac Autonomic Nervous Dysfunction in Diabetic

... peripheral nerves, in addition to brain and muscles, was recently reported to be common (2). Some patients who had symptoms of autonomic dysfunction, such as gastrointestinal dysmotility, were also reported (3). Left ventricular hypertrophy (LVH) is recognized to be the clinical feature of cardiac i ...
to First Heart Sound and Opening Snap in Patients with Mitral Stenosis
to First Heart Sound and Opening Snap in Patients with Mitral Stenosis

... stenosis, this component was later than the high frequency component of the first sound maximal at the image intensifier using a 35 mm. cine camera at 44 frames lower left sternal edge and attributed to tricuspid closure. per second, or a 9-inch image intensifier using a 16 mm. This technique (Leath ...
Effect of Heart Rate Increase on Dorsal Aortic Flow in the
Effect of Heart Rate Increase on Dorsal Aortic Flow in the

... output is similar to the mature animal. The early chick embryo did not respond like the late gestation fetal lamb to a spontaneous increase in heart rate. Rather, the chick embryo behaved more like the fetal lamb paced from the left atrium (8). We found that as heart rate increased above intrinsic, ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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