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- ScienceCentral
- ScienceCentral

... variables cannot be measured in real time. Pulsed TDI can estimate myocardial motion without post-processing procedures, but simultaneous analysis of multiple segments cannot be performed. Nevertheless, pulsed TDI has been used in humans to evaluate systolic and diastolic left ventricle (LV) functio ...
The Architecture of the Right Ventricular Outflow Tract
The Architecture of the Right Ventricular Outflow Tract

... right ventricle were performed on 15 dog hearts and seven normal human hearts. The hearts in six cases of ventricular septal defect were dissected completely, and partially in four others, including two cases of truncus arteriosus. Twenty-two additional human hearts with cono-truncal abnormalities f ...
Atrial Defects
Atrial Defects

... wide compared with the stenotic pulmonary artery • The aorta over-rides the VSD and so receives blood from both ventricles. CH0576/RHY ...
Investigation of Blood Flow through the Mitral Valve
Investigation of Blood Flow through the Mitral Valve

... surgeons cannot test these methods on patients. According to the Hippocratic Oath which states that as medical professionals, they should first do no harm [3], therefore surgeons are not to treat patients with any method that they do not consider the best. There have been attempts to test the effect ...
The haplotype of the growth-differentiation factor 15 gene is
The haplotype of the growth-differentiation factor 15 gene is

... GDF15 (growth-differentiation factor 15) is a novel antihypertrophic factor which is induced in the heart in response to pressure overload and plays an important regulatory role in the process of hypertrophy. In the present study, we have investigated the relationship between GDF15 gene variants and ...
Arrhythmogenic right ventricular dysplasia: from
Arrhythmogenic right ventricular dysplasia: from

... The Armadillo repeat proteins, associated with ARVD 9 and 10, connect desmoplakin, and in turn desmin and the cytoskeleteon to the desmosomal cadherins, desmocollin and desmoglein (13, 14). ARVD 11 and 12 affects desmoglein-2 and desmocollin, respectively (15, 16). These cadherins extend through the ...
Lab #10: Cardiovascular Physiology
Lab #10: Cardiovascular Physiology

... blood through the body. It does so by undergoing a cycle of contraction and relaxation called the cardiac cycle. During the initial portion of the cardiac cycle, an electrical signal is generated in so-called “pacemaker cells” that is distributed through the heart through an electrical conduction sy ...
Full Text - Crescent Journal of Medical and Biological Sciences
Full Text - Crescent Journal of Medical and Biological Sciences

... Based on the World Health Organization (WHO), cardiovascular diseases are the leading cause of death around the world. Most of those who die annually, suffer from these diseases than any other reason. In 2008, 17.5 million people died of this disease in the world (about 30% of all deaths). Intervent ...
Changes in left ventricular filling dynamics with treadmill exercise in
Changes in left ventricular filling dynamics with treadmill exercise in

... R. M. Peters, T. Silberstein In patients with resting left ventricular diastolic abnormalities, it is not known if their transmitral diastolic flow velocity patterns in response to exercise are different from the response seen in normal subjects. Treadmill stress echocardiography was performed on 31 ...
1999-2011 An Update on the Impact of Sudden Cardiac Death
1999-2011 An Update on the Impact of Sudden Cardiac Death

... Based on expert review of selected Michigan SCDY cases from 2006-2008, 21 strategies to prevent SCDY were identified and in 2008, approximately 60 stakeholders from diverse organizations gathered to recommend next steps. From 2009-2011, significant progress has occurred with many of the strategies i ...
Cardiac Murmurs
Cardiac Murmurs

... • HCM is frequently a hereditary disorder, with transmission to first-degree relatives in 50% of cases. The most common location of ventricular hypertrophy is subaortic, septal, and anterior wall hypertrophy. • Traditionally, dynamic left ventricular outflow tract obstruction has been considered as ...
D7-1 UNIT 7. DISSECTION: HEART STRUCTURES TO IDENTIFY
D7-1 UNIT 7. DISSECTION: HEART STRUCTURES TO IDENTIFY

... in the anterior and posterior walls of the atrium. The posterior wall is smooth; this is the sinus venarum and is continuous with the two venae cava. The anterior wall is rough with the pectinate muscles, which contribute to its strength in contraction. The two walls are joined at a ridge, the cris ...
An MRI Comparison of Quantitative Left Ventricular Structure
An MRI Comparison of Quantitative Left Ventricular Structure

... carefully defined as follows: (i) CHF cohort – only those individuals undergoing stable and optimally tolerated therapy for clinically diagnosed chronic heart failure, together with an echocardiography report confirming an EF of 40 percent or lower; (ii) LVH cohort - only those individuals with a no ...
Modeling Pathologies of Diastolic and Systolic Heart Failure
Modeling Pathologies of Diastolic and Systolic Heart Failure

... all human mortality.4 Despite tremendous scientific efforts during the past 20 years, heart failure remains one of the most common, costly, disabling, and deadly medical conditions affecting more than 25 million people worldwide.40 Heart failure usually worsens over time; it is the major cause of hos ...
Echocardiographic Evaluation of Aortic Valve Stenosis
Echocardiographic Evaluation of Aortic Valve Stenosis

... patients the primary problem is the valvular disease and the LV dysfunction is secondary and is due to the increased afterload (inadequate compensatory LV hypertrophy: afterload mismatch11), so that replacement of the AV will lead to an improvement in LV performance. In the remaining patients the LV ...
ECG Assignment
ECG Assignment

... time available for diastolic filling and ejection as the rate continues to increase? If cardiac output drops does oxygen supply to the heart drop? Why are heart attacks likely if your rate goes beyond 200 bpm? Somewhere around 180 to 200 beats per minute is the upper limit of what the heart can do f ...
Ventriculocoronary connections in hypoplastic right heart syndrome
Ventriculocoronary connections in hypoplastic right heart syndrome

... Coronary artery branrher. Epicardi-I and penetrating branches oi coronary arteries were often unusually thickwalled. Penetrating branches, distributed throughout both compact and disarrayed myocardium ofthe right ventricular free wall and interventricular septum, showed primarily hypenrophy of the m ...
Congestion in Heart Failure - Open Secret Communications
Congestion in Heart Failure - Open Secret Communications

... starts days or weeks prior to hospitalization  May occur in the absence of signs (rales, JVD, edema) or symptoms of clinical congestion  Early treatment of hemodynamic congestion may prevent hospitalization and progression of heart failure  Improved methods of monitoring hemodynamic congestion ma ...
ASD, Ostium secundum
ASD, Ostium secundum

... – May passively occur in patients with left atrial hypertension and left ventricular dysfunction, mitral valve disease and hose with aortic stenosis ...
L3-IHD,angina, MI 2..
L3-IHD,angina, MI 2..

... lumen i.e. (critical stenosis) fixed chronic stable stenosis.  This significant reduction of coronary perfusion makes the heart vulnerable to further ischemia whenever there is increased demand, such as that produced by physical activity, emotional excitement, or any other cause of increased cardia ...
Anatomy of the Heart
Anatomy of the Heart

... bulbus cordis forms the trabeculated part of the right ventricle; the midportion, or conus cordis, forms the outflow tracts of both ventricles; and the distal part, the truncus arteriosus, forms the proximal parts of the aorta and pulmonary artery. The junction between the primitive ventricle and th ...
results
results

... significantly higher body weight and body mass index. This was the result of a nonsignificant increase in both body fat mass and fat free mass. The specific physical training experienced by the elite military divers could explain the anthropometric differences between the two groups. Indeed, the mil ...
Cardiomyopathies as a Cause of Sudden Cardiac Death (SCD) in
Cardiomyopathies as a Cause of Sudden Cardiac Death (SCD) in

... In Egypt, forensic autopsy is requested for sudden deaths that raise suspicion of criminal activity. Such deaths are referred to the Forensic Medicine Authority that is the part of the Ministry of Justice in Cairo, and their autopsied hearts are referred to the Forensic Pathology unit. All autopsied ...
CIL-03_Passen - Advocatehealth.com
CIL-03_Passen - Advocatehealth.com

... as well as adjacent structures. To take full advantage of the technology requires additional training and an advanced level of competency. Moreover, image analysis from multiple planes by the cardiologist or cardiac surgeon guides management of complex cardiac conditions. ...
Lipomatous Hypertrophy of the Interatrial Septum Accompanied By
Lipomatous Hypertrophy of the Interatrial Septum Accompanied By

... and most of them form myxsomas. Lipomas are rarely encountered non-malignant cardiac tumors. Cardiac lipoma incidence is between 0.001 % and 0.03 % in autopsy series.4 They are more often asymptomatic and they can be seen in all four chambers of the heart. Lipomas are most frequently encountered in ...
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Hypertrophic cardiomyopathy



Hypertrophic cardiomyopathy (HCM) is a primary disease of the myocardium (the muscle of the heart) in which a portion of the myocardium is hypertrophied (thickened) without any obvious cause, creating functional impairment of the cardiac muscle. It is a leading cause of sudden cardiac death in young athletes.The occurrence of hypertrophic cardiomyopathy is a significant cause of sudden unexpected cardiac death in any age group and as a cause of disabling cardiac symptoms. Younger people are likely to have a more severe form of hypertrophic cardiomyopathy.HCM is frequently asymptomatic until sudden cardiac death, and for this reason some suggest routinely screening certain populations for this disease.A cardiomyopathy is a disease that affects the muscle of the heart. With HCM, the myocytes (cardiac contractile cells) in the heart increase in size, which results in the thickening of the heart muscle. In addition, the normal alignment of muscle cells is disrupted, a phenomenon known as myocardial disarray. HCM also causes disruptions of the electrical functions of the heart. HCM is most commonly due to a mutation in one of nine sarcomeric genes that results in a mutated protein in the sarcomere, the primary component of the myocyte (the muscle cell of the heart). These are predominantly single-point missense mutations in the genes for beta-myosin heavy chain (MHC), myosin-binding protein C, cardiac troponinT, or tropomyosin. These mutations cause myofibril and myocyte structural abnormalities and possible deficiencies in force generation. Not to be confused with dilated cardiomyopathy or any other cardiomyopathy.While most literature so far focuses on European, American, and Japanese populations, HCM appears in all ethnic groups. The prevalence of HCM is about 0.2% to 0.5% of the general population.
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