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Cardiomyocyte Hypertrophy, Oncosis, and Autophagic
Cardiomyocyte Hypertrophy, Oncosis, and Autophagic

... study. CMD and fibrosis did not show correlations among them and with oncosis and AuV. Outcomes. A total of 27 deaths were recorded, 13 attributable to progressive HF, 8 to sudden cardiac death, and 3 to noncardiac causes. In 3 patients, the cause of death could not be determined. Twelve patients un ...
Clinical and Genetic Heterogeneity of Right Bundle Branch Block
Clinical and Genetic Heterogeneity of Right Bundle Branch Block

... with a structurally normal heart. The disease is inherited as an ...
Review Article Ventricular Tachycardia in the Absence of Structural
Review Article Ventricular Tachycardia in the Absence of Structural

... Treatment of ILVT In the acute setting, this tachycardia responds to intravenous verapamil. Termination with adenosine is rare, except for cases in which isoproterenol is used for induction of the tachycardia. Long-term therapy with verapamil is useful in mild cases and RF ablation is highly effecti ...
Influence of Patern and Degree of Left Ventricular Hypertrophy on
Influence of Patern and Degree of Left Ventricular Hypertrophy on

... factors (repeted expression of fetal genome isoforms, heme oxygenase-1[35]). These factors may differ in individual LVH forms. Measurement of left atrial size from the parasternal long axis view using the 2-dimensional “M-mode” method is limited in accuracy for LA size quantification because of the ...
Left atrial myxoma with aortic regurgitation - Heart
Left atrial myxoma with aortic regurgitation - Heart

... though this was less well defined (Fig. 1A, right). The mitral valve echogram, recorded nearer to the tip of the anterior leaflet of the mitral valve (Fig. 1B), shows a fine fluttering movement in diastole which is not seen in the abnormal echo posterior to it. The diastolic closure rate of the ante ...
A Simplified Rotational Spring Model for Mitral Valve Dynamics
A Simplified Rotational Spring Model for Mitral Valve Dynamics

... used as the input into the model, which represents an applied torque to the valve chords. Various damping and hysteresis states were investigated to find a model that best matches reported animal data of chord movement during a heartbeat. The study is limited by the use of one dataset from the liter ...
Non-Invasive Assessment of Left Ventricular Diastolic (Dys) Function
Non-Invasive Assessment of Left Ventricular Diastolic (Dys) Function

... disease or LV hypertrophy (hypertension) and common in the elderly because ageing causes stiffening of the arterial system with an increase in systolic arterial pressure. This causes myocardial hypertrophy and prolonged relaxation.(2) Common conditions associated with diastolic dysfunction and heart ...
Myocardium 2013
Myocardium 2013

... – embolization from the mural thrombi, – infective endocarditis on the mitral valve, – intractable cardiac failure, – sudden death (most common cause of death and particularly likely in young males with familial HCM or with a family history of sudden death). Myocardium ...
CARDIAC POWER OUTPUT, ITS ROLE IN DEFINING HEART
CARDIAC POWER OUTPUT, ITS ROLE IN DEFINING HEART

... concise marker that defines when further intervention is required to support the failing heart. The present study retrospectively analyzes prior MCS patient’s hemodynamic values to determine which hemodynamic parameter, if any, provided signs of a regressing “reserve” and whether this could have pre ...
Cardiac function in diabetic and non
Cardiac function in diabetic and non

... Left ventricular abnormalities are common in type 2 diabetic patients, especially left ventricular hypertrophy and diastolic filling abnormalities.6,16 High diastolic LV stiffness is recognised as the earliest manifestation of diabetes-induced LV dysfunction6,17-23 and frequently becomes the main fu ...
PDF
PDF

... is a common problem, and one that increases markedly with advancing age. The prevalence of heart failure is also increasing as the population ages and the proportion of the population Submit Manuscript | http://medcraveonline.com ...
Double heart rupture after acute myocardial infarction: A
Double heart rupture after acute myocardial infarction: A

... presence of blood clot, although it is not enough for a complete diagnosis without direct view of the rupture. This emphasizes the need for better education and best echo machines in intensive care units for better and faster diagnosis of acute myocardial infarction complications. VSR as a mechanica ...
Site-Specific Transseptal Puncture for Emerging Structural Heart
Site-Specific Transseptal Puncture for Emerging Structural Heart

... patients who are at high surgical risk.2,3 Precision in transseptal puncture is critical for procedural success. Three views are used to guide puncture for appropriate steerable guiding catheter placement: bicaval, short-axis at the base (SAX-B), and four-chamber views. X-plane can be used to simult ...
Impact of surgical ventricular reconstruction on stroke volume in
Impact of surgical ventricular reconstruction on stroke volume in

... Results: Overall, surgical ventricular reconstruction resulted in reductions in end-diastolic volume index (–30%  18%) and end-systolic volume index (–37%  20%), and increases in ejection fraction (21%  18% relative increase). However, stroke volume index decreased from 35  8 mL/m2 preoperativel ...
Heart failure from heart muscle disease in childhood: a 5–10 year
Heart failure from heart muscle disease in childhood: a 5–10 year

... or recovery during the follow-up period. Survival was defined either as overall survival, that is, freedom from death, or event-free survival, that is, freedom from death or transplant. Recovery was defined as normalization of echocardiographic findings with cessation of all cardiac medications. Statis ...
How the python heart separates pulmonary and systemic blood
How the python heart separates pulmonary and systemic blood

... The multiple convergent evolution of high systemic blood pressure among terrestrial vertebrates has always been accompanied by lowered pulmonary pressure. In mammals, birds and crocodilians, this cardiac separation of pressures relies on the complete division of the right and left ventricles by a co ...
Hemodynamic and functional assessment of mechanical aortic
Hemodynamic and functional assessment of mechanical aortic

... when well visualized,4 and it may be able to identify AVR complications that include pannus formation, vegetations, and thrombus.5–9 In addition, because ECG-gated multidetector CT can directly visualize the cross-sectional area of the aortic sinotubular junction,10 it may permit improved correction ...
Advances in Genetics - Circulation: Cardiovascular Genetics
Advances in Genetics - Circulation: Cardiovascular Genetics

... phenotype-negative (G+ P−) individuals. These G+ P− individuals present a completely new spectrum of patients in all of the genetic heart diseases, with relatively little known about the natural history and outcomes in these patients.33–35 The issue of exercise recommendations in this subgroup remai ...
Print - Circulation Research
Print - Circulation Research

... changes. They also demonstrated that trigeminal stimulation in the rabbit sent cliencephalic impulses down through the spinal lateral tracts, the spinal roots, and the upper dorsal sympathetic nerves, and was thus producing bigeminal ventricular premature systoles Neurologic mechanisms in human vent ...
Cardiovascular Effects of Weight Reduction
Cardiovascular Effects of Weight Reduction

... remaining two subjects underwent both right and left heart catheterization. Retrograde catheterization of the left ventricle was performed through a brachial arteriotomy. In those instances in which left ventricular diastolic pressure was not measured directly, the mean pulmonary capillary wedge pre ...
Can Intense Endurance Exercise Cause Myocardial Damage and
Can Intense Endurance Exercise Cause Myocardial Damage and

... There is now reasonably compelling evidence that some cardiac arrhythmias are associated with long-standing endurance training. In the general population, AF is the most common sustained arrhythmia, with a prevalence of approximately 0.5% in middle-aged subjects increasing to 10% in those in their 8 ...
Four-dimensional ultrasonography of the fetal heart with
Four-dimensional ultrasonography of the fetal heart with

... Examination of the normal fetal heart The four-chamber view. Multiplanar slicing of a volume acquired with a transverse sweep of the fetal chest is depicted in Fig 1, A. The left upper panel shows the conventional four-chamber view, the right upper panel shows a sagittal section through the interven ...
d) Left axis deviation
d) Left axis deviation

... RV hypertrophy occurs over time in response to pressure or volume overload in conditions such as; 1. Primary pulmonary hypertension 2. Chronic obstructive pulmonary disease (COPD) 3. Pulmonic stenosis 4. Atrial septal defect (ASD). This patient was diagnosed with PAH ...
The Frank-Starling Curve
The Frank-Starling Curve

... completely activated by calcium ions. Since the activation system is dependent on depolarization of the cell membrane, the problem of incomplete activation can be overcome by removing it. In such a 'skinned' preparation, Fabiato & Fabiato (1975) showed that the relationship between tension and sarco ...
Name of presentation
Name of presentation

... But this is not easy to accomplish in very sick hearts Big dogs with normal hearts – primary Afib Medical conversion with quinidine Anesthesia and conversion with electric shock ...
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Hypertrophic cardiomyopathy



Hypertrophic cardiomyopathy (HCM) is a primary disease of the myocardium (the muscle of the heart) in which a portion of the myocardium is hypertrophied (thickened) without any obvious cause, creating functional impairment of the cardiac muscle. It is a leading cause of sudden cardiac death in young athletes.The occurrence of hypertrophic cardiomyopathy is a significant cause of sudden unexpected cardiac death in any age group and as a cause of disabling cardiac symptoms. Younger people are likely to have a more severe form of hypertrophic cardiomyopathy.HCM is frequently asymptomatic until sudden cardiac death, and for this reason some suggest routinely screening certain populations for this disease.A cardiomyopathy is a disease that affects the muscle of the heart. With HCM, the myocytes (cardiac contractile cells) in the heart increase in size, which results in the thickening of the heart muscle. In addition, the normal alignment of muscle cells is disrupted, a phenomenon known as myocardial disarray. HCM also causes disruptions of the electrical functions of the heart. HCM is most commonly due to a mutation in one of nine sarcomeric genes that results in a mutated protein in the sarcomere, the primary component of the myocyte (the muscle cell of the heart). These are predominantly single-point missense mutations in the genes for beta-myosin heavy chain (MHC), myosin-binding protein C, cardiac troponinT, or tropomyosin. These mutations cause myofibril and myocyte structural abnormalities and possible deficiencies in force generation. Not to be confused with dilated cardiomyopathy or any other cardiomyopathy.While most literature so far focuses on European, American, and Japanese populations, HCM appears in all ethnic groups. The prevalence of HCM is about 0.2% to 0.5% of the general population.
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