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Stroke volume-to-wall stress ratio as a load
Stroke volume-to-wall stress ratio as a load

... volume-to-wall stress ratio was normal in compensated POH, markedly decreased in POH with heart failure, and, in contrast with LV ejection fraction, normal in VOH. Our results support stroke volumeto-wall stress ratio as a load-adjusted and stiffness-adjusted indicator of systolic function in models ...
Pitfalls of Atrial Advancement Using a Ventricular Extra
Pitfalls of Atrial Advancement Using a Ventricular Extra

... enough time to reach the AP and affect the AVRT circuit when delivered late enough to be His-refractory. For example, failing to demonstrate a left lateral AP by a VES from the RV apex frequently occurs in clinical electrophysiological studies. On the contrary, the development of bundle branch block ...
WQRS-internist
WQRS-internist

... Tracing from a young boy with congenital long-QT syndrome. The QTU interval in the sinus beats is at least 600 milliseconds. Note TU wave alternans in the first and second complexes. A late premature complex occurring in the downslope of the TU wave initiates an episode of ventricular tachycardia ...
36th Bethesda Conference - American College of Cardiology
36th Bethesda Conference - American College of Cardiology

... This 36th Bethesda Conference report is the result of a consensus conference held on November 6, 2004, in New Orleans, Louisiana. Consensus conferences are designed to facilitate consideration of significant and timely issues regarding the practice of cardiovascular medicine and matters affecting pa ...
Independent effects of preload, afterload, and contractility on left
Independent effects of preload, afterload, and contractility on left

... should be predictable. However, volume-independent behavior of torsion has been observed, and the effects of load on this deformation remain controversial. We used magnetic resonance imaging (MRI) with tagging to study the relationships between load and contractility, and torsion. In ten isolated, b ...
Open and Thoracoscopic Approaches to Treat Atrial Fibrillation and
Open and Thoracoscopic Approaches to Treat Atrial Fibrillation and

... these studies. Relevant outcomes are overall survival, medication use, and treatment-related morbidity. The most direct evidence comes from several small RCTs confirming the benefit of a modified maze procedure for patients with AF who are undergoing mitral valve surgery. These trials establish that ...
Increased Susceptibility of the Heart to Ventricular Fibrillation During
Increased Susceptibility of the Heart to Ventricular Fibrillation During

... in origin, were produced in anesthetized dogs; ventricular fibrillation thresholds were determined during these conditions. During metabolic acidosis, we found that the heart became more susceptible to ventricular fibrillation, as indicated by a decrease in the ventricular fibrillation threshold val ...
Cardiac Hypertrophy: A Review on Pathogenesis and Treatment
Cardiac Hypertrophy: A Review on Pathogenesis and Treatment

... are mainly activated by stress type stimuli. [28-29] There is the activation of the MKK6 and MKK3 that gives rise to the signals of hypertrophy. [30] JNK is also activated by the pressure overload and Ras that also induce hypertrophic response by the activation of the adrenergic system. [31] Thus it ...
Chronic intermittent hypercapnic hypoxia increases pulmonary
Chronic intermittent hypercapnic hypoxia increases pulmonary

... twice per min, 6–8 h per day for 35 consecutive days. One major difference between the present model and patients with OSA is that during the obstructed breaths, marked negative intrathoracic pressures are generated [2]. This causes acute haemodynamic changes which may also result in chronic cardiov ...
Reversible Cardiac Failure During Angina Pectoris
Reversible Cardiac Failure During Angina Pectoris

... ANGINA PECTORIS, precipitated by exercise or occurring spontaneously, is generally, but not always, associated with an elevation of left ventricular filling pressure.'-1 Our investigations have consistently shown a high left ventricular end-diastolic pressure during exertional angina, averaging 34 m ...
Evaluation of the CO2 Rebreathing Cardiac Output
Evaluation of the CO2 Rebreathing Cardiac Output

... duplicate by the dye-dilution method injecting 4 mg of indocyanine-green into the right atrium or pulmonary artery and sampling from the brachial artery through a Gilford densitometer connected to the Hewlett-Packard recorder. Direct Fick method cardiac outputs were measured in six patients, two of ...
Cellular Biology
Cellular Biology

...  Erythema of oral mucosa (strawberry tongue)  Changes in the extremities, such as peripheral edema and erythema with desquamation of palms and soles  Polymorphous rash  Cervical lymphadenopathy ...
stabilization of extracellular matrix components in
stabilization of extracellular matrix components in

... Bioprosthetic heart valves (BHVs) fail within 12-15 years of implantation due to limited durability. This limits their application to elderly population. Younger patients with contraindications for long-term anticoagulant therapy necessary for mechanical heart valves may also receive BHVs. Investiga ...
Heart Disease and Stroke
Heart Disease and Stroke

... from heart disease and stroke are falling. According to the National Heart, Lung and Blood Institute (NHLBI), if death rates were the same as those of 30 years ago, 815,000 more Americans would die of heart disease annually and 250,000 more would die of stroke. This reduction in death rates is “one ...
Right Ventricular Dilatation on Bedside Echocardiography
Right Ventricular Dilatation on Bedside Echocardiography

... diagnosed until autopsy.1-4 An estimated 1.35 million Americans have a pulmonary embolism every year.5 Short-term mortality estimates vary widely, from 2.5% to as high as 33%.6-8 Twentyfive thousand pulmonary embolism–related deaths are recorded annually in the United States,9 but this is likely an u ...
Questions Remaining About the Surgical Correction of Tetralogy of
Questions Remaining About the Surgical Correction of Tetralogy of

... right ventricular diastolic dysfunction,60-62 probably related to the hypertrophy that accompanies the condition or to some degree of residual stenosis of the right ventricular outflow tract. In any case, diastolic dysfunction may to some extent serve a protective function against pulmonary valve in ...
Myocardial Infarct Size-Limiting Effect of Chronic
Myocardial Infarct Size-Limiting Effect of Chronic

... Introduction Since the first reports in the late 1950s (Kopecký and Daum 1958, Hurtado 1960), adaptation to chronic hypoxia has been recognized as an efficient protective phenomenon, which increases cardiac ischemic tolerance. Similarly as the later discovered ischemic preconditioning, chronic hypox ...
Practice Guideline: Focused Update
Practice Guideline: Focused Update

... health care providers in clinical decision making by describing a range of generally acceptable approaches for the diagnosis, management, and prevention of specific diseases or conditions. The guidelines attempt to define practices that meet the needs of most patients in most circumstances. The ulti ...
Case-Based Curriculum in Clinical Electrophysiology
Case-Based Curriculum in Clinical Electrophysiology

... is difficult in some patients due to anatomic constraints, as can also be encountered in other areas of the heart. Piorkowski et al show the first human case of catheter ablation guided by real time magnetic resonance imaging (MRI), which has the promise of facilitating ablation through better under ...
Left Ventricular Volume and Function Assessment: A Comparison
Left Ventricular Volume and Function Assessment: A Comparison

... The LVEF assessment has a critical role in the diagnosis, management, and prognosis of patients with different cardiovascular diseases. Echocardiography by itself plays a pivotal role in assessing the LV systolic function, mainly by calculating the LVEF, and is as such deemed the most widely employe ...
Left Ventricular Volume and Function Assessment: A Comparison
Left Ventricular Volume and Function Assessment: A Comparison

... The LVEF assessment has a critical role in the diagnosis, management, and prognosis of patients with different cardiovascular diseases. Echocardiography by itself plays a pivotal role in assessing the LV systolic function, mainly by calculating the LVEF, and is as such deemed the most widely employe ...
ventricular septal defect in infants and children with increased
ventricular septal defect in infants and children with increased

... is one of the most common open heart procedure performed in paediatric cardiac surgery 1 . Large VSD with large left to right shunts commonly present in infants with respiratory symptoms and poor growth 2 . Large VSD usually results in PVR in later life. The closure of a large VSD is performed in de ...
Mechanism of Ventricular Fibrillation in Hypothermia
Mechanism of Ventricular Fibrillation in Hypothermia

... base of the right ventricle for the measurement of ventricular threshold and refractory period as previously described.5 Duration of the test stimuli was 3 msec, and maximal current strength was 30 ma. Conduction time in ventricular muscle (MCT) was taken as the time interval between the stimulus ar ...
Arrhythmogenic right ventricular cardiomyopathy/dysplasia
Arrhythmogenic right ventricular cardiomyopathy/dysplasia

... occurs, mimicking dilated cardiomyopathy. Endocavitary mural thrombosis may occur, especially within aneurysms or in the atrial appendages when heart failure is complicated by atrial fibrillation, as to account for thromboembolism. In such conditions, contractile dysfunction may be so severe as to r ...
Advances in Arrhythmia and Electrophysiology
Advances in Arrhythmia and Electrophysiology

... In many patients, the onset of frequent PVCs relative to the onset of LV dysfunction is unknown.47 It is particularly important to identify the primary disorder because of the potential reversibility of PVC-induced cardiomyopathy.48,49 Patients can present with debilitating symptoms, particularly pa ...
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Mitral insufficiency



Mitral insufficiency (MI), mitral regurgitation or mitral incompetence is a disorder of the heart in which the mitral valve does not close properly when the heart pumps out blood. It is the abnormal leaking of blood backwards from the left ventricle, through the mitral valve, into the left atrium, when the left ventricle contracts, i.e. there is regurgitation of blood back into the left atrium. MI is the most common form of valvular heart disease.
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