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Molecular Basis for Induction of Ocular Dominance
Molecular Basis for Induction of Ocular Dominance

... In their original studies, Wiesel and Hubel monocularly deprived animals for months. In later work, they found that robust effects were observed with as little as a week of deprivation (Hubel and Wiesel, 1970). Subsequent studies by many other investigators showed that as few as 8 h of deprivation c ...
Synaptic Responses of Cortical Pyramidal Neurons to Light
Synaptic Responses of Cortical Pyramidal Neurons to Light

... activity in mammalianvisual cortex during patterned light stimulation have revealed a complex array of receptive-field properties (Hubel and Wiesel, 1977). Local cortical inhibition mediated by GABA appearsto determine someof theseresponse properties (Sillito, 1984). A more detailed analysisof the s ...
This Week in The Journal - The Journal of Neuroscience
This Week in The Journal - The Journal of Neuroscience

... The glutamatergic subthalamic nucleus (STN) exerts control over motor output through nuclei of the basal ganglia. High-frequency electrical stimuli in the STN effectively alleviate motor symptoms in movement disorders, and cholinergic stimulation boosts this effect. To gain knowledge about the mecha ...
Kardinia International College
Kardinia International College

... presynaptic neurons less likely to fire in the brain. • GABA inhibitory action counterbalances the excitatory action of glutamate (that makes presynaptic neurons more likely to fire). • It is found in the CNS (brain and spinal cord). ...
Slide 1
Slide 1

... FIGURE 1-13: The axon is constricted at the peripheral node of Ranvier. Top panel: Low-power electron micrograph of a node of Ranvier in longitudinal section. Note the abrupt decrease in axon diameter and the attendant condensation of axoplasmic constituents in the paranodal and nodal regions of th ...
CHAPTER 10 THE SOMATOSENSORY SYSTEM
CHAPTER 10 THE SOMATOSENSORY SYSTEM

... As mentioned above, the sensation of pain is caused by activation of very small diameter nerve endings. When tissue is damaged, chemical substances are released that stimulate these fibers. Many different chemical substances (e.g., aspirin) have an analgesic (pain-killing) effect. Different analgesi ...
animal_responses_to_the_environment
animal_responses_to_the_environment

... J Gerber and J Goliath ...
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2.1 Resonding for change

... Objectives Why do you need a nervous system? What is a receptor? How do you respond to changes in your surroundings? ...
Building silicon nervous systems with dendritic tree neuromorphs
Building silicon nervous systems with dendritic tree neuromorphs

... It is clear from a growing body of physiological work on neurons from many areas of the brain that dendritic membranes contain ionic channels that are voltage−dependent or influenced by intracellular second messenger systems [Hille, 1992]. Such mechanisms allow for non−linear operations, such as the ...
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A soft-wired hypothalamus

... circadian feeding and metabolic patterns. An important question is whether these synaptic alterations influence neuronal activity and, consequently, metabolic phenotype. Although this remains to be proven, these changes occur both before and during the various behavioral and endocrine outputs24. Eve ...
Chapter Three Biological Aspects of Psychology
Chapter Three Biological Aspects of Psychology

... Myelin is a fatty substance that wraps around some axons and speeds action potentials. (Chapter 3, Action Potentials section) ...
Network Self-Organization Explains the Statistics and
Network Self-Organization Explains the Statistics and

... The information processing abilities of neural circuits arise from their synaptic connection patterns. Understanding the laws governing these connectivity patterns is essential for understanding brain function. The overall distribution of synaptic strengths of local excitatory connections in cortex ...
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How does an axon know where to go?

... 1. neurons are intrinsically different from one another 2. Differences in position are biochemical in nature 3. Differences are acquired early in development ...
Physiology SENSORY PHYSIOLOGY Sensory Receptors Martin Paré
Physiology SENSORY PHYSIOLOGY Sensory Receptors Martin Paré

... Sensory transduction converts stimuli into graded potentials. Such changes in receptor membrane potential are known as the receptor potential and the generator potential. ...
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Serotonin Receptors – From Molecular Biology to

... 5-HT1D receptors. Trials with selective 5-HT1D agonist (identified so far as PNU 109291) showed significant suppression of meningeal neurogenic inflammation and nociception in trigeminic ganglia (Cutrer et al. 1999). The function of the 5-HT1E receptor is unknown due to the lack of selective pharmac ...
Regents Biology
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... nerves that your go from spinal the cord called central spinal nervous nerves. to system Spinal your nerves are skeletal made up of muscles. bundles of The sensory autonomic and motor system neurons controls bound involuntary together by actionsconnective those not tissue. For under this conscious R ...
Serotonin 1B Receptor Modulates Frequency Response Curves and
Serotonin 1B Receptor Modulates Frequency Response Curves and

... Neuromodulatory signals such as serotonin are broadly released in the brain in response to changes in internal state (Trulson and Jacobs 1979, 1981) but transform the response properties of sensory neurons in highly specific ways (Hurley et al. 2004; Mooney et al. 1996; Xiang and Prince 2003). This ...
make motor neuron posters now
make motor neuron posters now

... open as Ca+ flows inward. This causes synaptic vesicles to fuse with the membrane and release neurtotransmitters that bind with receptors on adjacent neurons. B. Endocytosis eventually returns neurotransmitters to the cytoplasm. 1. Enzymes may break down neurotransmitters to stop signal transmission ...
Brain Receptor Imaging - Society of Nuclear Medicine
Brain Receptor Imaging - Society of Nuclear Medicine

... the pathologic process in Parkinson’s disease and, therefore, the assessment of disturbed dopamine synthesis is the main target for clinical studies (19). Postsynaptic receptors may also be involved in neurodegenerative disorders; they are functionally changed in the course of Parkinson’s disease an ...
Drugs and Toxins
Drugs and Toxins

... causes flexor muscles to contract and extensor muscles to relax, then viceversa, so you can walk. • If you have a toxin that prohibits release of inhibitory NT, then excitatory will override, and cause more muscle contraction. • That is what happens with tetanus toxin. When all of the NT is excitato ...
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... indirect, methods to measure dopamine concentration in the striatum. By contrast, many other studies track the firing of dopaminergic neurons by recording electrical activity in the midbrain, where the cell bodies lie (Fig. 1a). Such recordings from rats running through mazes have yet to be reported ...
neocortex-basic neuron types
neocortex-basic neuron types

... dendrites and axonal arbors that remain almost exclusively within a column (hence they are also known as local circuit neurons or interneurons; but see exceptions below). Instead of an apical dendrite projecting towards the pia, many interneurons have a prominent dendrite (with more branches) extend ...
Ch. 2 - 서울대 Biointelligence lab
Ch. 2 - 서울대 Biointelligence lab

... ♦ Be synthesized by and localized within the presynaptic neuron, and stored in the presynaptic terminal. ♦ Be released by the presynaptic neuron when action potentials invade and depolarize the terminal. ♦ Contain receptors that are specific for the substance. ♦ When applied to the postsynaptic cell ...
PAX: A mixed hardware/software simulation platform for
PAX: A mixed hardware/software simulation platform for

... computing the neurons‟ asynchronous spikes. Neuron models can precisely describe the biophysics of spikes (action potentials) by computing the currents flowing through cell membrane and synaptic nodes. It is possible to reduce the size of these models to facilitate their computation. Other popular m ...
Chapter 11
Chapter 11

...  Na+ more concentrated outside & K+ more inside  Inside more negative than outside  Resting membrane potential  -70mv ...
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Neurotransmitter

Neurotransmitters are endogenous chemicals that enable neurotransmission. They transmit signals across a chemical synapse, such as in a neuromuscular junction, from one neuron (nerve cell) to another ""target"" neuron, muscle cell, or gland cell. Neurotransmitters are released from synaptic vesicles in synapses into the synaptic cleft, where they are received by receptors on other synapses. Many neurotransmitters are synthesized from simple and plentiful precursors such as amino acids, which are readily available from the diet and only require a small number of biosynthetic steps to convert them. Neurotransmitters play a major role in shaping everyday life and functions. Their exact numbers are unknown but more than 100 chemical messengers have been identified.
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