Nephrotoxicity as a cause of acute kidney injury in children
... Table 1 illustrates a classification of drugs known to cause AKI regarding pathophysiologic mechanisms (from Porter et al. in [24]). The following text reviews in more depth the aspects of the most common substances at risk for causing AKI in children. NSAIDs NSAIDs possess antipyretic, analgesic, a ...
... Table 1 illustrates a classification of drugs known to cause AKI regarding pathophysiologic mechanisms (from Porter et al. in [24]). The following text reviews in more depth the aspects of the most common substances at risk for causing AKI in children. NSAIDs NSAIDs possess antipyretic, analgesic, a ...
Carisoprodol: an underrecognized drug of abuse in north India
... higher age of initiating substance abuse (18.8 vs. 17 years), a longer period for shifting from initial drug abuse to carisoprodol intake (4.5 vs. 3.5 years), and a longer period of carisoprodol intake (61 vs. 33 months). Also in comparison to our previous study [12] the most common initiator to car ...
... higher age of initiating substance abuse (18.8 vs. 17 years), a longer period for shifting from initial drug abuse to carisoprodol intake (4.5 vs. 3.5 years), and a longer period of carisoprodol intake (61 vs. 33 months). Also in comparison to our previous study [12] the most common initiator to car ...
FOOD AND DRUG ADMINISTRATION, et al
... dictionary to show that "intended" use is what "manufacturers 'have in mind.'" Id. at 44,637. It said standardized nicotine levels and internal manufacturer documents [*5] show that manufacturers "have in mind" "drug-like" uses. Id. at 44,637, 44,642. Third, FDA stated, "Where consumers use a produc ...
... dictionary to show that "intended" use is what "manufacturers 'have in mind.'" Id. at 44,637. It said standardized nicotine levels and internal manufacturer documents [*5] show that manufacturers "have in mind" "drug-like" uses. Id. at 44,637, 44,642. Third, FDA stated, "Where consumers use a produc ...
Clarithromycin increases linezolid exposure in multidrug-resistant tuberculosis patients
... tests were carried out at least weekly as part of continued standard care including monitoring for hyperlactataemia and haematological abnormalities such as thrombocytopaenia and anaemia. All patients received epoetine-a (Eprex; Janssen-Cilag, Leiden, The Netherlands) pre-emptively in a dose of 2000 ...
... tests were carried out at least weekly as part of continued standard care including monitoring for hyperlactataemia and haematological abnormalities such as thrombocytopaenia and anaemia. All patients received epoetine-a (Eprex; Janssen-Cilag, Leiden, The Netherlands) pre-emptively in a dose of 2000 ...
Key Test Findings Affiliated Genetics
... regulated under the Clinical Laboratory Improvement Amendments of 1988 (CLIA) as qualified to perform high-complexity clinical testing and has established and verified the test’s accuracy. This test has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined ...
... regulated under the Clinical Laboratory Improvement Amendments of 1988 (CLIA) as qualified to perform high-complexity clinical testing and has established and verified the test’s accuracy. This test has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined ...
Drugs of Abuse in Saliva: A Review
... centration of the analyte of interest, urine permits measurement of the accumulated concentration of analytes since the last void of the bladder. Unfortunately, the concentration of substances in urine is also dependent on fluid intake, which call vary substantially. Although more information is ava ...
... centration of the analyte of interest, urine permits measurement of the accumulated concentration of analytes since the last void of the bladder. Unfortunately, the concentration of substances in urine is also dependent on fluid intake, which call vary substantially. Although more information is ava ...
How should I prescribe methadone for detoxification
... group and none in the PB group, while only one patient dropped out in the PB group on day 8. Throughout the 8-day study, patients in both groups received similar amount of adjunct medication: 0.64 +/- 0.07 mg (NB group) of clonidine vs 0.73 +/- 0.15 mg (PB group; NS). Only 25% of patients required u ...
... group and none in the PB group, while only one patient dropped out in the PB group on day 8. Throughout the 8-day study, patients in both groups received similar amount of adjunct medication: 0.64 +/- 0.07 mg (NB group) of clonidine vs 0.73 +/- 0.15 mg (PB group; NS). Only 25% of patients required u ...
Chestal ® Cough Monograph - Boiron USA for Health Care
... The formula for Chestal and Children’s Chestal combines several homeopathic medicines. These medicines are manufactured according to the Homeopathic Pharmacopoeia of the United States’ guidelines, using the highest standards of production and quality control. Indications for homeopathic medicines ha ...
... The formula for Chestal and Children’s Chestal combines several homeopathic medicines. These medicines are manufactured according to the Homeopathic Pharmacopoeia of the United States’ guidelines, using the highest standards of production and quality control. Indications for homeopathic medicines ha ...
Plasma Pharmacokinetics of Adriamycin and
... Table 2 shows the total body clearance and steady-state consists of a very rapid decline in plasma Adriamycin concentra tions. Initial concentrations are 50-fold higher than those ob volume of distribution of Adriamycin and the AUC of adriamycinol and Adriamycin for the 2 groups. Similar values were ...
... Table 2 shows the total body clearance and steady-state consists of a very rapid decline in plasma Adriamycin concentra tions. Initial concentrations are 50-fold higher than those ob volume of distribution of Adriamycin and the AUC of adriamycinol and Adriamycin for the 2 groups. Similar values were ...
Modification of Microbial Polyacids for Drug Delivery Systems U
... Assays of drug encapsulation and release were also performed and cytotoxicity tests were done on cancer cell lines. Nanoparticles (100-300 nm aprox.) were obtained from all PMLA derivatives, except for the ionic complex which formed microparticles. Nanoparticles showed potential as drug delivery sys ...
... Assays of drug encapsulation and release were also performed and cytotoxicity tests were done on cancer cell lines. Nanoparticles (100-300 nm aprox.) were obtained from all PMLA derivatives, except for the ionic complex which formed microparticles. Nanoparticles showed potential as drug delivery sys ...
Antiepileptic drugs for neuropathic pain and fibromyalgia
... Antiepileptic drugs to treat neuropathic pain or fibromyalgia- an overview of Cochrane reviews Neuropathic pain is pain coming from damaged nerves. It is different from pain messages carried along healthy nerves from damaged tissue (eg a fall, cut, or arthritic knee). Neuropathic pain is treated by ...
... Antiepileptic drugs to treat neuropathic pain or fibromyalgia- an overview of Cochrane reviews Neuropathic pain is pain coming from damaged nerves. It is different from pain messages carried along healthy nerves from damaged tissue (eg a fall, cut, or arthritic knee). Neuropathic pain is treated by ...
development, characterisation and evaluation of sildenafil aspirin co
... basic, or ionizable groups, could potentially be co crystallized. This aspect also helps in complement the existing methods by reintroducing molecules that had limited pharmaceutical profiles based on their non ionizable functional groups. The stoichiometric ratio of active ingredient and the cocrys ...
... basic, or ionizable groups, could potentially be co crystallized. This aspect also helps in complement the existing methods by reintroducing molecules that had limited pharmaceutical profiles based on their non ionizable functional groups. The stoichiometric ratio of active ingredient and the cocrys ...
The Background and Chemistry ofMDMA
... rats (oral administrations daily in increasing increments of 25 mg/kg per day for 13 days), survivors were sacrificed for tissue and brain pathology studies after a three-week wait. There were blood indicators of damage to both liver and kidney, but histological studies of brain tissue revealed no p ...
... rats (oral administrations daily in increasing increments of 25 mg/kg per day for 13 days), survivors were sacrificed for tissue and brain pathology studies after a three-week wait. There were blood indicators of damage to both liver and kidney, but histological studies of brain tissue revealed no p ...
lustral - Pharmaline
... should be used during pregnancy only if the perceived benefits outweigh the risks.. Exposure during late pregnancy to SSRIs may have an increased risk for persistent pulmonary hypertension of the newborn (PPHN). PPHN occurs in 1-2 per 1,000 live births in the general population and is associated wit ...
... should be used during pregnancy only if the perceived benefits outweigh the risks.. Exposure during late pregnancy to SSRIs may have an increased risk for persistent pulmonary hypertension of the newborn (PPHN). PPHN occurs in 1-2 per 1,000 live births in the general population and is associated wit ...
Routine analysis of amphetamine class drugs as their
... HPLC methods have been developed for the simultaneous analysis of other amphetamines that are abused extensively such as MDMA, MDA and MDEA. Recently Bogusz et al. reported an HPLC method for the simultaneous detection of these amines in urine as their phenylisothiocyanate derivatives using a diode ...
... HPLC methods have been developed for the simultaneous analysis of other amphetamines that are abused extensively such as MDMA, MDA and MDEA. Recently Bogusz et al. reported an HPLC method for the simultaneous detection of these amines in urine as their phenylisothiocyanate derivatives using a diode ...
FDA Regulation: 21 – CFR – 314 New Drug Application
... applicant from FDA usually describing all of the deficiencies that the agency has identified in an application or abbreviated application that must be satisfactorily addressed before it can be approved. Drug product means a finished dosage form, for example, tablet, capsule, or solution, that contai ...
... applicant from FDA usually describing all of the deficiencies that the agency has identified in an application or abbreviated application that must be satisfactorily addressed before it can be approved. Drug product means a finished dosage form, for example, tablet, capsule, or solution, that contai ...
product monograph
... All patients treated with antiepileptic drugs, irrespective of indication, should be monitored for signs of suicidal ideation and behaviour and appropriate treatment should be considered. Patients (and caregivers of patients) should be advised to seek medical advice should signs of suicidal ideation ...
... All patients treated with antiepileptic drugs, irrespective of indication, should be monitored for signs of suicidal ideation and behaviour and appropriate treatment should be considered. Patients (and caregivers of patients) should be advised to seek medical advice should signs of suicidal ideation ...
How do you switch between tricyclic, SSRI and related
... Few studies have specifically examined the best strategy for switching between antidepressants. The following advice is based on available information, theoretical concerns and clinical experience. It is intended for general guidance only. For patients with complex medical or drug histories, specia ...
... Few studies have specifically examined the best strategy for switching between antidepressants. The following advice is based on available information, theoretical concerns and clinical experience. It is intended for general guidance only. For patients with complex medical or drug histories, specia ...
Overcoming the Stratum Corneum: The Modulation of Skin Penetration
... 1980s. They can be used as penetration enhancers for hydrophilic and lipophilic substances and for peptide molecules as well, e.g. insulin and vasopressin. Interestingly, Azone and derivatives are effective penetration enhancers when used in low concentrations (1–5%). Their activity can be increased ...
... 1980s. They can be used as penetration enhancers for hydrophilic and lipophilic substances and for peptide molecules as well, e.g. insulin and vasopressin. Interestingly, Azone and derivatives are effective penetration enhancers when used in low concentrations (1–5%). Their activity can be increased ...
Recovery of Locomotion After Ventral and Ventrolateral Spinal
... lesion. Early after the lesion (early period), none of the cats could walk or support the weight of their hindquarters, and they moved around using only the forelimbs. During the recovery period, which lasted from 3 days up to 3 wk depending on the extent of the spinal lesion, the cats gradually reg ...
... lesion. Early after the lesion (early period), none of the cats could walk or support the weight of their hindquarters, and they moved around using only the forelimbs. During the recovery period, which lasted from 3 days up to 3 wk depending on the extent of the spinal lesion, the cats gradually reg ...
Switching between tricyclic, SSRI and related antidepressants
... Few studies have specifically examined the best strategy for switching between antidepressants. The following advice is based on available information, theoretical concerns and clinical experience. It is intended for general guidance only. For patients with complex medical or drug histories, specia ...
... Few studies have specifically examined the best strategy for switching between antidepressants. The following advice is based on available information, theoretical concerns and clinical experience. It is intended for general guidance only. For patients with complex medical or drug histories, specia ...
Selective breeding for differential saccharin intake as an animal
... discover other major variables that covaried with the excessive intake of sweet substances and to examine their cumulative influence as predictors of drug abuse. Selectively breeding laboratory animals based on differential phenotypes has been critical to our understanding of genetic susceptibility ...
... discover other major variables that covaried with the excessive intake of sweet substances and to examine their cumulative influence as predictors of drug abuse. Selectively breeding laboratory animals based on differential phenotypes has been critical to our understanding of genetic susceptibility ...
Eryped 200 (erythromycin ethylsuccinate) Suspension
... Erythromycin crosses the placental barrier, but fetal plasma levels are low. The drug is excreted in human milk. Microbiology Erythromycin acts by inhibition of protein synthesis by binding 50 S ribosomal subunits of susceptible organisms. It does not affect nucleic acid synthesis. Antagonism has be ...
... Erythromycin crosses the placental barrier, but fetal plasma levels are low. The drug is excreted in human milk. Microbiology Erythromycin acts by inhibition of protein synthesis by binding 50 S ribosomal subunits of susceptible organisms. It does not affect nucleic acid synthesis. Antagonism has be ...
Drug formulary - Johns Hopkins University
... sure that you are totally familiar with the agent(s) that you intend to use. While many will provide anesthesia (unconsciousness) and analgesia (absence of pain) they may also have profound effects on the biologic parameters that you intend to study. Drug dosages are usually based on body weight-be ...
... sure that you are totally familiar with the agent(s) that you intend to use. While many will provide anesthesia (unconsciousness) and analgesia (absence of pain) they may also have profound effects on the biologic parameters that you intend to study. Drug dosages are usually based on body weight-be ...
Resistant Bugs and Antibiotic Drugs
... crowded, stressful, and often unhygienic conditions on industrial-scale farms. Many of the drugs used for these "nontherapeutic" purposes are identical or related to those used in human medicine, but their use as feed additives requires no prescription. Growing evidence links use of these antibiotic ...
... crowded, stressful, and often unhygienic conditions on industrial-scale farms. Many of the drugs used for these "nontherapeutic" purposes are identical or related to those used in human medicine, but their use as feed additives requires no prescription. Growing evidence links use of these antibiotic ...