Investigation of a Zα-like Peptide Motif in Koi Herpesvirus
... protein causes an immediate inversion of CD bands from 250-265 nm, whereas in the wild type, inversion did not occur until titration to the ratio of 1:3. At a ratio of 1:5, the highest peak is observed at about 275 nm, whereas in the wild type, the greatest peak was consistently around 280 nm and me ...
... protein causes an immediate inversion of CD bands from 250-265 nm, whereas in the wild type, inversion did not occur until titration to the ratio of 1:3. At a ratio of 1:5, the highest peak is observed at about 275 nm, whereas in the wild type, the greatest peak was consistently around 280 nm and me ...
FINAL-FTDMulticenterStudy_R - ORBi
... Images obtained with positron emission tomography and the (18F)fluorodeoxyglucose method (FDG-PET) and clinical data were collected in a population of 41 fv-FTD patients diagnosed according to international clinical criteria [2]. Patients with progressive aphasia and semantic dementia were not inclu ...
... Images obtained with positron emission tomography and the (18F)fluorodeoxyglucose method (FDG-PET) and clinical data were collected in a population of 41 fv-FTD patients diagnosed according to international clinical criteria [2]. Patients with progressive aphasia and semantic dementia were not inclu ...
Whey Protein: A Functional Food
... lipids and blood pressure would be affected . The placebo group received only unfermented milk. After eight weeks, the fermented milk group demonstrated comparatively higher HDLs, lower triglycerides and reduced systolic blood pressure. The effect of whey alone was not studied. ...
... lipids and blood pressure would be affected . The placebo group received only unfermented milk. After eight weeks, the fermented milk group demonstrated comparatively higher HDLs, lower triglycerides and reduced systolic blood pressure. The effect of whey alone was not studied. ...
Heterogeneity of the Population of Command Neurons in the Lamprey
... MNs exhibited only the first or the second component of the response observed in the whole branch. We therefore conclude that individual RS neurons exert a uniform action on the majority of MNs projecting through a given branch. This finding suggests that each of the four MN pools in a segment repre ...
... MNs exhibited only the first or the second component of the response observed in the whole branch. We therefore conclude that individual RS neurons exert a uniform action on the majority of MNs projecting through a given branch. This finding suggests that each of the four MN pools in a segment repre ...
The Nervous System
... do and think. Neuropsychologists, along with neuroscientists from other disciplines, study the brain and the rest of the nervous system in hopes of gaining a better understanding of consciousness, perception, memory, emotion, stress, mental disorders, and even self-identity. At this very moment, you ...
... do and think. Neuropsychologists, along with neuroscientists from other disciplines, study the brain and the rest of the nervous system in hopes of gaining a better understanding of consciousness, perception, memory, emotion, stress, mental disorders, and even self-identity. At this very moment, you ...
Cerebellum: Movement Regulation and Cognitive Functions
... of Purkinje cells (PCs in Figure 1). The PCs have elaborate dendritic fields that are specialized for receiving more inputs (over 100 000 to each PC) than any other cell type in the human brain. Each region of the cerebellar cortex contains a large array of PCs that process their parallel fibres’ dive ...
... of Purkinje cells (PCs in Figure 1). The PCs have elaborate dendritic fields that are specialized for receiving more inputs (over 100 000 to each PC) than any other cell type in the human brain. Each region of the cerebellar cortex contains a large array of PCs that process their parallel fibres’ dive ...
Neuroscience Newsletter, May 2015 - MSc/PhD/MD
... on the role of MBP in extruding proteins with large cytoplasmic domains from the compacted areas (Aggarwal et al 2011), as well as on the molecular basis that drive myelin membrane assembly by a phase transition of the MBP into a cohesive protein meshwork. (Aggarwal et al 2013). In addition, we coul ...
... on the role of MBP in extruding proteins with large cytoplasmic domains from the compacted areas (Aggarwal et al 2011), as well as on the molecular basis that drive myelin membrane assembly by a phase transition of the MBP into a cohesive protein meshwork. (Aggarwal et al 2013). In addition, we coul ...
Pathways for emotions and memory
... and anterior ventral (AV) nuclei of the anterior thalamic complex originate from the ipsilateral medial mammillary body and projections to the anterior dorsal (AD) nucleus originate from the lateral mammillary body bilaterally (for review see Steriade et al., 1997). Moreover, lesions or pathology th ...
... and anterior ventral (AV) nuclei of the anterior thalamic complex originate from the ipsilateral medial mammillary body and projections to the anterior dorsal (AD) nucleus originate from the lateral mammillary body bilaterally (for review see Steriade et al., 1997). Moreover, lesions or pathology th ...
Long-term use of psychedelic drugs is associated with differences in
... J.C. Bouso et al. transcription factors associated with synaptic plasticity. These data suggest that psychedelics could potentially induce structural changes in brain tissue. Here we looked for differences in cortical thickness (CT) in regular users of psychedelics. We obtained magnetic resonance im ...
... J.C. Bouso et al. transcription factors associated with synaptic plasticity. These data suggest that psychedelics could potentially induce structural changes in brain tissue. Here we looked for differences in cortical thickness (CT) in regular users of psychedelics. We obtained magnetic resonance im ...
THE AREA POSTREMA: A POTENTIAL SITE FOR CIRCADIAN REGULATION BY
... hour self-sustaining autoregulatory delayed feedback loop in which the protein products of three period (Per) genes and two cryptochrome (Cry) genes negatively regulate their own transcription. Transcription of the Per and Cry genes is driven by heteromeric complexes formed by Clock and Bmal1 prote ...
... hour self-sustaining autoregulatory delayed feedback loop in which the protein products of three period (Per) genes and two cryptochrome (Cry) genes negatively regulate their own transcription. Transcription of the Per and Cry genes is driven by heteromeric complexes formed by Clock and Bmal1 prote ...
On-line, voluntary control of human temporal lobe
... Daily life continually confronts us with an exuberance of external, sensory stimuli competing with a rich stream of internal deliberations, plans and ruminations. The brain must select one or more of these for further processing. How this competition is resolved across multiple sensory and cognitive ...
... Daily life continually confronts us with an exuberance of external, sensory stimuli competing with a rich stream of internal deliberations, plans and ruminations. The brain must select one or more of these for further processing. How this competition is resolved across multiple sensory and cognitive ...
Characterization of Critical Reagents for Ligand Binding Assays
... robustness, accuracy and reproducibility depend on the quality of critical reagents. The unique characteristics of these reagents are crucial to assay performance, and require careful characterization. To ensure their consistent characterization in bioanalytical laboratories, a team of pharmaceutica ...
... robustness, accuracy and reproducibility depend on the quality of critical reagents. The unique characteristics of these reagents are crucial to assay performance, and require careful characterization. To ensure their consistent characterization in bioanalytical laboratories, a team of pharmaceutica ...
Comparison of Sympathetic and Parasympathetic Divisions
... The two primary types of visceral receptors, mechanoreceptors and chemoreceptors, are distributed throughout the body. Mechanoreceptors sense pressure, stretch, or tension. Slow-adapting mechanoreceptors sense fullness in the bowel, bladder, and stomach. Fast-adapting mechanoreceptors sense the move ...
... The two primary types of visceral receptors, mechanoreceptors and chemoreceptors, are distributed throughout the body. Mechanoreceptors sense pressure, stretch, or tension. Slow-adapting mechanoreceptors sense fullness in the bowel, bladder, and stomach. Fast-adapting mechanoreceptors sense the move ...
Basal Ganglia and Cerebellar Inputs to `AIP`
... as well as to the act of grasping them. We used retrograde transneuronal transport of rabies virus to examine subcortical inputs to AIP in the monkey. Virus transport labeled substantial numbers of neurons in the substantia nigra pars reticulata (SNpr), as well as in the dentate nucleus of the cereb ...
... as well as to the act of grasping them. We used retrograde transneuronal transport of rabies virus to examine subcortical inputs to AIP in the monkey. Virus transport labeled substantial numbers of neurons in the substantia nigra pars reticulata (SNpr), as well as in the dentate nucleus of the cereb ...
Meninges,Cerebrospinal Fluid, and the spinal cord
... (fans out into dorsal rootlets) Ventral root (derived from several ventral rootlets) ...
... (fans out into dorsal rootlets) Ventral root (derived from several ventral rootlets) ...
Protein digestion in poultry – the value of an
... • Protein digestion in poultry (and other animals) is a complex process of hydrolysis of incoming proteins, absorption, further processing and the concurrent secretion and recovery of endogenous protein • Endogenous proteins are often less well recovered that exogenous proteins and ProAct may assist ...
... • Protein digestion in poultry (and other animals) is a complex process of hydrolysis of incoming proteins, absorption, further processing and the concurrent secretion and recovery of endogenous protein • Endogenous proteins are often less well recovered that exogenous proteins and ProAct may assist ...
- Princeton University
... of the biochemical signals associated with dendritic excitability (Helmchen et al., 1999; Svoboda et al., 1997), and the tracking of the activity of hundreds of neurons simultaneously (Ohki et al., 2005). However, because high-resolution imaging requires mechanical stability, all previous in vivo mo ...
... of the biochemical signals associated with dendritic excitability (Helmchen et al., 1999; Svoboda et al., 1997), and the tracking of the activity of hundreds of neurons simultaneously (Ohki et al., 2005). However, because high-resolution imaging requires mechanical stability, all previous in vivo mo ...
Impact of thousand-and-one amino acid 2 kinase
... neurodevelopmental disorders with delayed onset, such as autism spectrum disorders (ASDs) might be a consequence of aberrant dendritic arborization. This review is dedicated toward the discussion of a new pathway that specifically affects the formation of basal dendrites and axonal projections in co ...
... neurodevelopmental disorders with delayed onset, such as autism spectrum disorders (ASDs) might be a consequence of aberrant dendritic arborization. This review is dedicated toward the discussion of a new pathway that specifically affects the formation of basal dendrites and axonal projections in co ...
Key Residues Controlling Binding of Diverse Ligands to Human
... (Protein Data Bank code 1Z11) (Yano et al., 2005). Mutations of CYP2A13 were performed in silico via the Biopolymer suite in Insight-II (Accelrys, San Diego, CA), and each unique mutant protein was allowed to relax via CHARMM simulations (Brooks et al., 1983), entailing a 100-step molecular mechanic ...
... (Protein Data Bank code 1Z11) (Yano et al., 2005). Mutations of CYP2A13 were performed in silico via the Biopolymer suite in Insight-II (Accelrys, San Diego, CA), and each unique mutant protein was allowed to relax via CHARMM simulations (Brooks et al., 1983), entailing a 100-step molecular mechanic ...
Reward-Dependent Spatial Selectivity of Anticipatory Activity in
... of the previous studies were not designed to differentiate between these possibilities, since the task-related events were, typically, behaviorally significant in that they were followed by reward. Although some recent studies have provided an experimental condition in which different events (stimul ...
... of the previous studies were not designed to differentiate between these possibilities, since the task-related events were, typically, behaviorally significant in that they were followed by reward. Although some recent studies have provided an experimental condition in which different events (stimul ...
COMMUNICATION Engineering the Amine Transaminase from
... effort has been undertaken to engineer transaminases of fold class I in such a way that the small binding pocket can accept bulky moieties like an ethyl (Scheme 1, 2b), propyl (3b) or ethanol side chain, albeit with limited success, especially if larger substituents are present.[4b, 5] Recently, we ...
... effort has been undertaken to engineer transaminases of fold class I in such a way that the small binding pocket can accept bulky moieties like an ethyl (Scheme 1, 2b), propyl (3b) or ethanol side chain, albeit with limited success, especially if larger substituents are present.[4b, 5] Recently, we ...
Loss of Neurons in Magnocellular and Parvocellular Layers of the
... OLLOWING the loss of afferent fibers in the central nervous system, target neurons are known first to become atrophic and then die by the process of transneuronal degeneration.1-3 In neurodegenerative diseases and brain trauma, the primary injury triggers transneuronal degeneration; this causes exte ...
... OLLOWING the loss of afferent fibers in the central nervous system, target neurons are known first to become atrophic and then die by the process of transneuronal degeneration.1-3 In neurodegenerative diseases and brain trauma, the primary injury triggers transneuronal degeneration; this causes exte ...
Clinical neurochemistry
Clinical neurochemistry is the field of neurological biochemistry which relates biochemical phenomena to clinical symptomatic manifestations in humans. While neurochemistry is mostly associated with the effects of neurotransmitters and similarly-functioning chemicals on neurons themselves, clinical neurochemistry relates these phenomena to system-wide symptoms. Clinical neurochemistry is related to neurogenesis, neuromodulation, neuroplasticity, neuroendocrinology, and neuroimmunology in the context of associating neurological findings at both lower and higher level organismal functions.